AU746719B2 - Substituted 1,2,4-triazolo(3,4-a)pyridazine - Google Patents
Substituted 1,2,4-triazolo(3,4-a)pyridazine Download PDFInfo
- Publication number
- AU746719B2 AU746719B2 AU25368/99A AU2536899A AU746719B2 AU 746719 B2 AU746719 B2 AU 746719B2 AU 25368/99 A AU25368/99 A AU 25368/99A AU 2536899 A AU2536899 A AU 2536899A AU 746719 B2 AU746719 B2 AU 746719B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- triazolo
- triazol
- cognition
- methyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 239000000843 powder Substances 0.000 description 1
- 230000000216 proconvulsive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- SHNUBALDGXWUJI-UHFFFAOYSA-N pyridin-2-ylmethanol Chemical compound OCC1=CC=CC=N1 SHNUBALDGXWUJI-UHFFFAOYSA-N 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 208000018726 traumatic encephalopathy Diseases 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- RZLMQJSSMROKSS-UHFFFAOYSA-N trimethyl-[2-(triazol-1-ylmethoxy)ethyl]silane Chemical compound C[Si](C)(C)CCOCN1C=CN=N1 RZLMQJSSMROKSS-UHFFFAOYSA-N 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9803992 | 1998-02-25 | ||
| GBGB9803992.8A GB9803992D0 (en) | 1998-02-25 | 1998-02-25 | Therapeutic agents |
| PCT/GB1998/001307 WO1998050385A1 (en) | 1997-05-08 | 1998-05-06 | SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS |
| GB98/01307 | 1998-05-06 | ||
| GBGB9824896.6A GB9824896D0 (en) | 1998-11-12 | 1998-11-12 | Therapeutic compound |
| GB9824896 | 1998-11-12 | ||
| PCT/GB1999/000485 WO1999043677A1 (en) | 1998-02-25 | 1999-02-17 | SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PYRIDAZINE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2536899A AU2536899A (en) | 1999-09-15 |
| AU746719B2 true AU746719B2 (en) | 2002-05-02 |
Family
ID=27269184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU25368/99A Ceased AU746719B2 (en) | 1998-02-25 | 1999-02-17 | Substituted 1,2,4-triazolo(3,4-a)pyridazine |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1070066A1 (ru) |
| JP (1) | JP2002504554A (ru) |
| CN (1) | CN1291194A (ru) |
| AU (1) | AU746719B2 (ru) |
| BG (1) | BG104705A (ru) |
| CA (1) | CA2317416A1 (ru) |
| EA (1) | EA002824B1 (ru) |
| HR (1) | HRP20000555A2 (ru) |
| HU (1) | HUP0100647A3 (ru) |
| NZ (1) | NZ505695A (ru) |
| PL (1) | PL341975A1 (ru) |
| SK (1) | SK12772000A3 (ru) |
| TR (1) | TR200002469T2 (ru) |
| WO (1) | WO1999043677A1 (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9821179D0 (en) * | 1998-09-30 | 1998-11-25 | Merck Sharp & Dohme | Therapeutic use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH21834A (en) * | 1982-01-18 | 1988-03-17 | Lepetit Spa | New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives |
| CA2260900A1 (en) * | 1996-07-25 | 1998-02-05 | Merck Sharp & Dohme Limited | Substituted triazolo pyridazine derivatives as inverse agonists of the gabaa.alpha.5 receptor subtype |
| AU732455C (en) * | 1997-05-08 | 2002-09-05 | Merck Sharp & Dohme Limited | Substituted 1,2,4-triazolo{3,4-a}phthalazine derivatives as gaba alpha 5 ligands |
-
1999
- 1999-02-17 PL PL99341975A patent/PL341975A1/xx not_active Application Discontinuation
- 1999-02-17 WO PCT/GB1999/000485 patent/WO1999043677A1/en not_active Application Discontinuation
- 1999-02-17 EA EA200000878A patent/EA002824B1/ru not_active IP Right Cessation
- 1999-02-17 CN CN99803190A patent/CN1291194A/zh active Pending
- 1999-02-17 CA CA002317416A patent/CA2317416A1/en not_active Abandoned
- 1999-02-17 AU AU25368/99A patent/AU746719B2/en not_active Ceased
- 1999-02-17 HU HU0100647A patent/HUP0100647A3/hu unknown
- 1999-02-17 NZ NZ505695A patent/NZ505695A/en unknown
- 1999-02-17 TR TR2000/02469T patent/TR200002469T2/xx unknown
- 1999-02-17 EP EP99905069A patent/EP1070066A1/en not_active Withdrawn
- 1999-02-17 SK SK1277-2000A patent/SK12772000A3/sk unknown
- 1999-02-17 JP JP2000533432A patent/JP2002504554A/ja not_active Withdrawn
-
2000
- 2000-08-22 BG BG104705A patent/BG104705A/bg unknown
- 2000-08-25 HR HR20000555A patent/HRP20000555A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SK12772000A3 (sk) | 2001-03-12 |
| WO1999043677A1 (en) | 1999-09-02 |
| HUP0100647A2 (hu) | 2001-09-28 |
| EP1070066A1 (en) | 2001-01-24 |
| CA2317416A1 (en) | 1999-09-02 |
| PL341975A1 (en) | 2001-05-07 |
| HRP20000555A2 (en) | 2001-08-31 |
| CN1291194A (zh) | 2001-04-11 |
| NZ505695A (en) | 2002-03-01 |
| BG104705A (bg) | 2001-04-30 |
| TR200002469T2 (tr) | 2000-12-21 |
| EA200000878A1 (ru) | 2001-02-26 |
| HUP0100647A3 (en) | 2003-03-28 |
| AU2536899A (en) | 1999-09-15 |
| JP2002504554A (ja) | 2002-02-12 |
| EA002824B1 (ru) | 2002-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |