AU746663B2 - Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) - Google Patents
Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) Download PDFInfo
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- AU746663B2 AU746663B2 AU61327/98A AU6132798A AU746663B2 AU 746663 B2 AU746663 B2 AU 746663B2 AU 61327/98 A AU61327/98 A AU 61327/98A AU 6132798 A AU6132798 A AU 6132798A AU 746663 B2 AU746663 B2 AU 746663B2
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- Prior art keywords
- alkyl
- compound
- halo
- halogen
- acceptable salt
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/786,629 US5770617A (en) | 1996-03-20 | 1997-01-21 | Terbenzimidazoles useful as antifungal agents |
| US08/786629 | 1997-01-21 | ||
| PCT/US1998/001005 WO1998031673A1 (en) | 1997-01-21 | 1998-01-21 | Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6132798A AU6132798A (en) | 1998-08-07 |
| AU746663B2 true AU746663B2 (en) | 2002-05-02 |
Family
ID=25139154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU61327/98A Ceased AU746663B2 (en) | 1997-01-21 | 1998-01-21 | Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5770617A (https=) |
| EP (1) | EP0960103A1 (https=) |
| JP (1) | JP2002513399A (https=) |
| KR (1) | KR20000070359A (https=) |
| AU (1) | AU746663B2 (https=) |
| CA (1) | CA2278452A1 (https=) |
| IL (1) | IL130572A0 (https=) |
| NZ (1) | NZ336606A (https=) |
| PL (1) | PL334662A1 (https=) |
| WO (1) | WO1998031673A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002509858A (ja) * | 1997-12-31 | 2002-04-02 | ルトガーズ，ザ ステイト ユニバーシティ オブ ニュージャージー | 複素環式トポイソメラーゼ毒化合物 |
| US6063801A (en) * | 1998-02-12 | 2000-05-16 | Rutgers, The State University Of New Jersey | Heterocyclic topoisomerase poisons |
| WO2000076556A2 (en) * | 1999-06-11 | 2000-12-21 | Neorx Corporation | High dose radionuclide complexes for bone marrow suppression |
| US7094885B2 (en) * | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
| US6740650B2 (en) | 1999-10-29 | 2004-05-25 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| EP1390081A2 (en) | 2001-01-08 | 2004-02-25 | Neorx Corporation | Therapeutic and diagnostic compounds, compositions, and methods |
| DE60235287D1 (de) * | 2001-11-14 | 2010-03-25 | Univ Rutgers | Löslich gemachte topoisomerase-gifte |
| MXPA04004607A (es) * | 2001-11-14 | 2004-09-10 | Univ Rutgers | Agentes de venenos de topoisomerasa solubilizados. |
| EP1453812B1 (en) * | 2001-11-14 | 2008-08-20 | Rutgers, The State University | Cytotoxic agents |
| AU2002364953A1 (en) * | 2001-11-14 | 2003-06-17 | Edmond J. Lavoie | Topoisomerase poison agents |
| EP1458416A1 (en) | 2001-12-13 | 2004-09-22 | Dow Global Technologies Inc. | Treatment of osteomyelitis with radiopharmaceuticals |
| AU2003268075A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
| US6992088B2 (en) * | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
| US6989387B2 (en) * | 2002-08-09 | 2006-01-24 | Rutgers, The State University Of New Jersey | Nitro and amino substituted topoisomerase agents |
| CA2510337C (en) * | 2002-11-12 | 2013-01-08 | Rutgers, The State University Of New Jersey | Topoisomerase-targeting agents |
| GB0619325D0 (en) | 2006-09-30 | 2006-11-08 | Univ Strathclyde | New compounds |
| GB0821913D0 (en) | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
| DK2403856T3 (da) | 2009-03-06 | 2013-04-08 | Univ Rutgers | Methylendioxybenzo[i]phenanthridinderivater anvendt til behandling af cancer |
| WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
| ES2568455T3 (es) * | 2010-06-01 | 2016-04-29 | Summit Therapeutics Plc | Compuestos para el tratamiento de enfermedad asociada a Clostridium difficile |
| WO2015042438A1 (en) * | 2013-09-19 | 2015-03-26 | The Florida International Board Of Trustees Modesto A. Maidique Campus | Selective inhibition of bacterial topoisomerase i |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| US11434227B2 (en) | 2016-01-23 | 2022-09-06 | Vibha TANDON | Broad spectrum antibacterial activity of novel bisbenzimidazoles targeting topoisomerase IA and the synergistic composition of bisbenzimidazole with efflux pump inhibitors against pathogenic bacteria |
| US11091498B2 (en) | 2016-04-04 | 2021-08-17 | Rutgers, The State University Of New Jersey | Topoisomerase poisons |
| JP7267563B2 (ja) | 2017-06-27 | 2023-05-02 | 株式会社Kyulux | 発光材料、化合物、遅延蛍光体および発光素子 |
| WO2019004254A1 (ja) | 2017-06-27 | 2019-01-03 | 株式会社Ｋｙｕｌｕｘ | 発光材料、化合物、遅延蛍光体および発光素子 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ307959A (en) * | 1995-05-17 | 1998-08-26 | Univ Rutgers | Substituted tribenzimidazole derivatives where the substituent can be aryl or heteroaryl and medicaments |
| US5643935A (en) * | 1995-06-07 | 1997-07-01 | The University Of North Carolina At Chapel Hill | Method of combatting infectious diseases using dicationic bis-benzimidazoles |
-
1997
- 1997-01-21 US US08/786,629 patent/US5770617A/en not_active Expired - Lifetime
-
1998
- 1998-01-21 IL IL13057298A patent/IL130572A0/xx unknown
- 1998-01-21 CA CA002278452A patent/CA2278452A1/en not_active Abandoned
- 1998-01-21 NZ NZ336606A patent/NZ336606A/en unknown
- 1998-01-21 KR KR1019997006592A patent/KR20000070359A/ko not_active Withdrawn
- 1998-01-21 PL PL98334662A patent/PL334662A1/xx unknown
- 1998-01-21 WO PCT/US1998/001005 patent/WO1998031673A1/en not_active Ceased
- 1998-01-21 JP JP53462498A patent/JP2002513399A/ja not_active Ceased
- 1998-01-21 EP EP98905972A patent/EP0960103A1/en not_active Ceased
- 1998-01-21 AU AU61327/98A patent/AU746663B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000070359A (ko) | 2000-11-25 |
| NZ336606A (en) | 2001-04-27 |
| JP2002513399A (ja) | 2002-05-08 |
| IL130572A0 (en) | 2000-06-01 |
| EP0960103A1 (en) | 1999-12-01 |
| PL334662A1 (en) | 2000-03-13 |
| US5770617A (en) | 1998-06-23 |
| WO1998031673A1 (en) | 1998-07-23 |
| CA2278452A1 (en) | 1998-07-23 |
| AU6132798A (en) | 1998-08-07 |
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