IL130572A0 - Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) - Google Patents

Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors)

Info

Publication number
IL130572A0
IL130572A0 IL13057298A IL13057298A IL130572A0 IL 130572 A0 IL130572 A0 IL 130572A0 IL 13057298 A IL13057298 A IL 13057298A IL 13057298 A IL13057298 A IL 13057298A IL 130572 A0 IL130572 A0 IL 130572A0
Authority
IL
Israel
Prior art keywords
terbenzimidazoles
useful
topoisomerase inhibitors
medical therapy
therapy
Prior art date
Application number
IL13057298A
Other languages
English (en)
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers filed Critical Univ Rutgers
Publication of IL130572A0 publication Critical patent/IL130572A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL13057298A 1997-01-21 1998-01-21 Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) IL130572A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/786,629 US5770617A (en) 1996-03-20 1997-01-21 Terbenzimidazoles useful as antifungal agents
PCT/US1998/001005 WO1998031673A1 (en) 1997-01-21 1998-01-21 Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors)

Publications (1)

Publication Number Publication Date
IL130572A0 true IL130572A0 (en) 2000-06-01

Family

ID=25139154

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13057298A IL130572A0 (en) 1997-01-21 1998-01-21 Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors)

Country Status (10)

Country Link
US (1) US5770617A (https=)
EP (1) EP0960103A1 (https=)
JP (1) JP2002513399A (https=)
KR (1) KR20000070359A (https=)
AU (1) AU746663B2 (https=)
CA (1) CA2278452A1 (https=)
IL (1) IL130572A0 (https=)
NZ (1) NZ336606A (https=)
PL (1) PL334662A1 (https=)
WO (1) WO1998031673A1 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU753268B2 (en) * 1997-12-31 2002-10-10 Jun Sung Kim Heterocyclic topoisomerase poisons
IL137351A0 (en) 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons
JP2003501488A (ja) * 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
EP1390081A2 (en) 2001-01-08 2004-02-25 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
JP4789414B2 (ja) * 2001-11-14 2011-10-12 ラトガーズ，ザ ステイト ユニバーシティ 可溶化トポイソメラーゼ毒性剤
WO2003041660A2 (en) * 2001-11-14 2003-05-22 Rutgers, The State University Solubilized topoisomerase poisons
ES2311639T3 (es) * 2001-11-14 2009-02-16 Rutgers, The State University Agentes citotoxicos.
ATE390923T1 (de) * 2001-11-14 2008-04-15 Univ Rutgers Topoisomerase-giftmittel
WO2003051403A1 (en) 2001-12-13 2003-06-26 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
WO2004014918A1 (en) * 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted topoisomerase agents
US6992089B2 (en) * 2002-08-09 2006-01-31 Rutgers, The University Of New Jersey Nitro and amino substituted topoisomerase agents
WO2004014862A1 (en) * 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted heterocycles as topoisomerase i targeting agents
AU2003290818A1 (en) * 2002-11-12 2004-06-03 Edmond J. Lavoie Topoisomerase-targeting agents
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
GB0821913D0 (en) 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
DK2403856T3 (da) 2009-03-06 2013-04-08 Univ Rutgers Methylendioxybenzo[i]phenanthridinderivater anvendt til behandling af cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
ES2803556T3 (es) * 2010-06-01 2021-01-27 Summit Oxford Ltd Compuestos para el tratamiento de enfermedades asociadas a clostridium difficile
US9920014B2 (en) 2013-09-19 2018-03-20 The Florida International University Board Of Trustees Selective inhibition of bacterial topoisomerase I
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
WO2017125944A1 (en) * 2016-01-23 2017-07-27 Jawaharlal Nehru University (Jnu) Broad spectrum antibacterial activity of novel bisbenzimidazoles targeting topoisomerase ia and the synergistic composition of bisbenzimidazole with efflux pump inhibitors against pathogenic bacteria
JP2019515025A (ja) 2016-04-04 2019-06-06 ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー トポイソメラーゼ毒
WO2019004254A1 (ja) 2017-06-27 2019-01-03 株式会社Ｋｙｕｌｕｘ 発光材料、化合物、遅延蛍光体および発光素子
JP7267563B2 (ja) 2017-06-27 2023-05-02 株式会社Kyulux 発光材料、化合物、遅延蛍光体および発光素子

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2221248A1 (en) * 1995-05-17 1996-11-21 Leroy Fong Liu Tribenzimidazoles useful as topoisomerase i inhibitors
US5643935A (en) * 1995-06-07 1997-07-01 The University Of North Carolina At Chapel Hill Method of combatting infectious diseases using dicationic bis-benzimidazoles

Also Published As

Publication number Publication date
NZ336606A (en) 2001-04-27
KR20000070359A (ko) 2000-11-25
EP0960103A1 (en) 1999-12-01
CA2278452A1 (en) 1998-07-23
AU6132798A (en) 1998-08-07
PL334662A1 (en) 2000-03-13
US5770617A (en) 1998-06-23
JP2002513399A (ja) 2002-05-08
AU746663B2 (en) 2002-05-02
WO1998031673A1 (en) 1998-07-23

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