AU731860B2 - Recombinant pox virus for immunization against tumor-associated antigens - Google Patents

Recombinant pox virus for immunization against tumor-associated antigens Download PDF

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Publication number
AU731860B2
AU731860B2 AU37268/97A AU3726897A AU731860B2 AU 731860 B2 AU731860 B2 AU 731860B2 AU 37268/97 A AU37268/97 A AU 37268/97A AU 3726897 A AU3726897 A AU 3726897A AU 731860 B2 AU731860 B2 AU 731860B2
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AU
Australia
Prior art keywords
virus
recombinant
gene
tumor
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU37268/97A
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English (en)
Other versions
AU3726897A (en
Inventor
Linda R. Gritz
Gail P. Mazzara
Dennis L. Panicali
Jeffrey Schlom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
Therion Biologics Corp
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therion Biologics Corp, US Department of Health and Human Services filed Critical Therion Biologics Corp
Publication of AU3726897A publication Critical patent/AU3726897A/en
Application granted granted Critical
Publication of AU731860B2 publication Critical patent/AU731860B2/en
Priority to AU54194/01A priority Critical patent/AU767562B2/en
Priority to AU2003266471A priority patent/AU2003266471A1/en
Assigned to THERION BIOLOGICS CORPORATION, GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE reassignment THERION BIOLOGICS CORPORATION Request to Amend Deed and Register Assignors: THERION BIOLOGICS CORPORATION, United States Government as represented by the Department of Health and Human Services, The
Assigned to GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE reassignment GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE Alteration of Name(s) in Register under S187 Assignors: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE, THERION BIOLOGICS CORPORATION
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/24011Poxviridae
    • C12N2710/24041Use of virus, viral particle or viral elements as a vector
    • C12N2710/24043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU37268/97A 1996-07-25 1997-07-15 Recombinant pox virus for immunization against tumor-associated antigens Ceased AU731860B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU54194/01A AU767562B2 (en) 1996-07-25 2001-07-04 Recombinant pox virus for immunization against tumor-associated antigens
AU2003266471A AU2003266471A1 (en) 1996-07-25 2003-12-04 Recombinant pox virus for immunization against tumor-associated antigens

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68628096A 1996-07-25 1996-07-25
US08/686280 1996-07-25
PCT/US1997/012203 WO1998004727A1 (en) 1996-07-25 1997-07-15 Recombinant pox virus for immunization against tumor-associated antigens

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU54194/01A Division AU767562B2 (en) 1996-07-25 2001-07-04 Recombinant pox virus for immunization against tumor-associated antigens

Publications (2)

Publication Number Publication Date
AU3726897A AU3726897A (en) 1998-02-20
AU731860B2 true AU731860B2 (en) 2001-04-05

Family

ID=24755674

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37268/97A Ceased AU731860B2 (en) 1996-07-25 1997-07-15 Recombinant pox virus for immunization against tumor-associated antigens

Country Status (6)

Country Link
US (1) US7410644B2 (enExample)
EP (2) EP0954593A1 (enExample)
JP (2) JP4475683B2 (enExample)
AU (1) AU731860B2 (enExample)
CA (1) CA2261989C (enExample)
WO (1) WO1998004727A1 (enExample)

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US6969609B1 (en) 1998-12-09 2005-11-29 The United States Of America As Represented By The Department Of Health And Human Serivces Recombinant vector expressing multiple costimulatory molecules and uses thereof
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US7148035B1 (en) 1998-11-18 2006-12-12 Oxford Biomedica (Uk) Limited Polypeptide
EP1865065A1 (en) * 1998-12-09 2007-12-12 The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services A recombinant vector expressing multiple costimulatory molecules and uses thereof
PT1137792E (pt) * 1998-12-09 2007-08-10 Therion Biolog Corp Vector recombinado que exprime moléculas costimulantes múltiplas e as suas utilizações
EP1496939B1 (en) * 2002-04-09 2007-08-15 Sanofi Pasteur Limited Modified cea nucleic acid and expression vectors
AU2004267117B2 (en) * 2003-08-21 2011-01-20 Virax Development Pty Ltd Poxvirus vector encoding prostate specific antigens for treatment of prostate cancer
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CN102281892A (zh) 2009-01-13 2011-12-14 特朗斯吉有限公司 酿酒酵母线粒体核酸级分用于免疫刺激的用途
HUE025015T2 (en) 2009-01-20 2016-04-28 Transgene Sa Soluble in ICAM-1 as a biomarker for predicting therapeutic response
DK2411815T3 (en) 2009-03-24 2015-11-30 Transgene Sa Biomarker MONITORING OF PATIENTS
US20120058493A1 (en) 2009-04-17 2012-03-08 Bruce Acres Biomarker for monitoring patients
CN102483405B (zh) 2009-07-10 2015-12-02 特朗斯吉有限公司 用于选择患者的生物标志物及相关方法
EP2601529B8 (en) 2010-08-06 2017-01-25 The United States of America, as represented by The Secretary, Department of Health and Human Services Biomarkers for predicting response to a cancer vaccine
US9725494B2 (en) * 2013-05-17 2017-08-08 United States Of America, As Represented By The Secretary, Department Of Health And Human Services Soluble CD27 (sCD27) and the use thereof
KR102395820B1 (ko) * 2013-11-05 2022-05-09 버베리안 노딕 에이/에스 종양 항원을 발현하는 폭스바이러스 및 면역 관문 저해제의 길항제 및/또는 효현제를 구비하는 암을 치료하기 위한 복합제 치료제
EP3142689B1 (en) 2014-05-13 2020-11-11 Bavarian Nordic A/S Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and a monoclonal antibody against tim-3
KR102504758B1 (ko) 2014-07-16 2023-02-28 트랜스진 종양 세포 붕괴성 바이러스와 면역 체크포인트 조절제의 배합물
CN107949397A (zh) 2015-02-13 2018-04-20 特兰斯吉恩股份有限公司 免疫治疗疫苗和抗体组合治疗
RU2753884C2 (ru) 2015-07-31 2021-08-24 Бавариан Нордик А/С Промоторы для усиления экспрессии в поксвирусах
EP3400009A2 (en) 2016-01-05 2018-11-14 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Combination of histone deacetylase inhibitor and immunotherapy
ES2924741T3 (es) 2016-01-28 2022-10-10 Inst Nat Sante Rech Med Métodos para incrementar la potencia de los inhibidores del punto de control inmunitario
WO2017136342A1 (en) 2016-02-02 2017-08-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Fulvestrant for inducing immune-mediated cytotoxic lysis of cancer cells
CA3023022A1 (en) 2016-05-04 2017-11-09 Transgene Sa Combination therapy with cpg tlr9 ligand
AU2017336269B2 (en) 2016-09-28 2022-06-16 Bavarian Nordic A/S Compositions and methods for enhancing the stability of transgenes in poxviruses
EP3522920A2 (en) 2016-10-10 2019-08-14 Transgene SA Immunotherapeutic product and mdsc modulator combination therapy
WO2018091680A1 (en) 2016-11-18 2018-05-24 Transgene Sa Cowpox-based oncolytic vectors
EP3562946B1 (en) 2016-12-28 2021-11-24 Transgene SA Oncolytic viruses and therapeutic molecules
CN110770345A (zh) 2017-04-14 2020-02-07 托尔奈公司 免疫调节多核苷酸、抗体缀合物及其使用方法
US11052147B2 (en) 2017-05-15 2021-07-06 Janssen Vaccines & Prevention B.V. Stable virus-containing composition
WO2018210804A1 (en) 2017-05-15 2018-11-22 Janssen Vaccines & Prevention B.V. Stable virus-containing composition
WO2019020543A1 (en) 2017-07-28 2019-01-31 Transgene Sa ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS
WO2019038388A1 (en) 2017-08-24 2019-02-28 Bavarian Nordic A/S POLYTHERAPY FOR THE TREATMENT OF CANCER BY INTRAVENOUS ADMINISTRATION OF RECOMBINANT MVA AND ANTIBODY
MX2020009262A (es) 2018-03-07 2021-01-08 Transgene Vectores de parapoxvirus.
WO2020011754A1 (en) 2018-07-09 2020-01-16 Transgene Chimeric vaccinia viruses
WO2020049151A1 (en) 2018-09-06 2020-03-12 Bavarian Nordic A/S Storage improved poxvirus compositions
US20220233607A1 (en) 2019-05-29 2022-07-28 Université De Tours Toxoplasma platform for treating cancer
EP4110830A4 (en) 2020-02-28 2024-09-11 Tallac Therapeutics, Inc. TRANSGLUTAMINASE-MEDIATED CONJUGATION
US20230114464A1 (en) 2020-03-12 2023-04-13 Bavarian Nordic A/S Conditions Improving Poxvirus Stability
JP2025528219A (ja) 2022-08-18 2025-08-26 トランジェーヌ キメラポックスウイルス

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Also Published As

Publication number Publication date
CA2261989A1 (en) 1998-02-05
JP2009278997A (ja) 2009-12-03
AU3726897A (en) 1998-02-20
EP0954593A1 (en) 1999-11-10
JP2000516459A (ja) 2000-12-12
JP4475683B2 (ja) 2010-06-09
US20030003079A1 (en) 2003-01-02
EP2112225A1 (en) 2009-10-28
US7410644B2 (en) 2008-08-12
CA2261989C (en) 2008-09-30
WO1998004727A1 (en) 1998-02-05

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