AU719513B2 - Monoclonal antibody to CEA, conjugates comprising said antibody, and their therapeutic use in an adept system - Google Patents

Monoclonal antibody to CEA, conjugates comprising said antibody, and their therapeutic use in an adept system Download PDF

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Publication number
AU719513B2
AU719513B2 AU26455/97A AU2645597A AU719513B2 AU 719513 B2 AU719513 B2 AU 719513B2 AU 26455/97 A AU26455/97 A AU 26455/97A AU 2645597 A AU2645597 A AU 2645597A AU 719513 B2 AU719513 B2 AU 719513B2
Authority
AU
Australia
Prior art keywords
seq
antibody
ser
pro
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU26455/97A
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English (en)
Other versions
AU2645597A (en
Inventor
Clive Graham Copley
Michael Derek Edge
Stephen Charles Emery
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609405.7A external-priority patent/GB9609405D0/en
Priority claimed from GBGB9703103.3A external-priority patent/GB9703103D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of AU2645597A publication Critical patent/AU2645597A/en
Application granted granted Critical
Publication of AU719513B2 publication Critical patent/AU719513B2/en
Assigned to ASTRAZENECA AB reassignment ASTRAZENECA AB Alteration of Name(s) in Register under S187 Assignors: ZENECA LIMITED
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
AU26455/97A 1996-05-04 1997-04-29 Monoclonal antibody to CEA, conjugates comprising said antibody, and their therapeutic use in an adept system Ceased AU719513B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9609405 1996-05-04
GBGB9609405.7A GB9609405D0 (en) 1996-05-04 1996-05-04 Protein
GB9703103 1997-02-14
GBGB9703103.3A GB9703103D0 (en) 1997-02-14 1997-02-14 Protein
PCT/GB1997/001165 WO1997042329A1 (en) 1996-05-04 1997-04-29 Monoclonal antibody to cea, conjugates comprising said antibody, and their therapeutic use in an adept system

Publications (2)

Publication Number Publication Date
AU2645597A AU2645597A (en) 1997-11-26
AU719513B2 true AU719513B2 (en) 2000-05-11

Family

ID=26309272

Family Applications (1)

Application Number Title Priority Date Filing Date
AU26455/97A Ceased AU719513B2 (en) 1996-05-04 1997-04-29 Monoclonal antibody to CEA, conjugates comprising said antibody, and their therapeutic use in an adept system

Country Status (19)

Country Link
US (2) US6277599B1 (cg-RX-API-DMAC7.html)
EP (1) EP0896626B1 (cg-RX-API-DMAC7.html)
JP (1) JP2000510692A (cg-RX-API-DMAC7.html)
CN (1) CN1217750A (cg-RX-API-DMAC7.html)
AT (1) ATE350478T1 (cg-RX-API-DMAC7.html)
AU (1) AU719513B2 (cg-RX-API-DMAC7.html)
BR (1) BR9708910A (cg-RX-API-DMAC7.html)
CA (1) CA2250579A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ353698A3 (cg-RX-API-DMAC7.html)
DE (1) DE69737188T2 (cg-RX-API-DMAC7.html)
ES (1) ES2279539T3 (cg-RX-API-DMAC7.html)
HU (1) HUP9901562A3 (cg-RX-API-DMAC7.html)
IL (1) IL126772A0 (cg-RX-API-DMAC7.html)
NO (1) NO985120L (cg-RX-API-DMAC7.html)
NZ (1) NZ331978A (cg-RX-API-DMAC7.html)
PL (1) PL329871A1 (cg-RX-API-DMAC7.html)
SK (1) SK150298A3 (cg-RX-API-DMAC7.html)
TR (1) TR199802227T2 (cg-RX-API-DMAC7.html)
WO (1) WO1997042329A1 (cg-RX-API-DMAC7.html)

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CN101704892B (zh) * 2009-12-09 2014-02-12 中国人民解放军军事医学科学院生物工程研究所 一种抗uPAR人源化抗体及其编码基因与应用
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JP6400470B2 (ja) 2011-05-16 2018-10-03 ジェネロン（シャンハイ）コーポレイション リミテッド 多重特異性Ｆａｂ融合タンパク質および使用法
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CN102526707B (zh) * 2012-01-13 2015-04-22 成都博发生物技术有限公司 共刺激因子及融合蛋白的新用途
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CN106749667B (zh) * 2016-12-04 2020-07-14 深圳市国创纳米抗体技术有限公司 一种抗癌胚抗原的纳米抗体及其应用
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Also Published As

Publication number Publication date
US6903203B2 (en) 2005-06-07
ATE350478T1 (de) 2007-01-15
AU2645597A (en) 1997-11-26
EP0896626B1 (en) 2007-01-03
HUP9901562A2 (hu) 1999-08-30
WO1997042329A1 (en) 1997-11-13
NO985120L (no) 1998-12-29
NZ331978A (en) 2000-05-26
TR199802227T2 (xx) 2000-07-21
CA2250579A1 (en) 1997-11-13
ES2279539T3 (es) 2007-08-16
DE69737188T2 (de) 2007-10-11
CN1217750A (zh) 1999-05-26
SK150298A3 (en) 1999-04-13
US6277599B1 (en) 2001-08-21
CZ353698A3 (cs) 1999-02-17
NO985120D0 (no) 1998-11-03
US20020142359A1 (en) 2002-10-03
EP0896626A1 (en) 1999-02-17
HUP9901562A3 (en) 2000-06-28
BR9708910A (pt) 1999-08-03
IL126772A0 (en) 1999-08-17
PL329871A1 (en) 1999-04-12
DE69737188D1 (de) 2007-02-15
JP2000510692A (ja) 2000-08-22

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Owner name: ASTRAZENECA AB

Free format text: FORMER OWNER WAS: ZENECA LIMITED

MK14 Patent ceased section 143(a) (annual fees not paid) or expired