AU719122B2 - Recombinant hepatitis C virus RNA replicase - Google Patents

Recombinant hepatitis C virus RNA replicase Download PDF

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Publication number
AU719122B2
AU719122B2 AU72007/96A AU7200796A AU719122B2 AU 719122 B2 AU719122 B2 AU 719122B2 AU 72007/96 A AU72007/96 A AU 72007/96A AU 7200796 A AU7200796 A AU 7200796A AU 719122 B2 AU719122 B2 AU 719122B2
Authority
AU
Australia
Prior art keywords
rdrp
hcv
amino acids
leu
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU72007/96A
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English (en)
Other versions
AU7200796A (en
Inventor
Reinoldus H. Al
Curt H. Hagedorn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University filed Critical Emory University
Publication of AU7200796A publication Critical patent/AU7200796A/en
Application granted granted Critical
Publication of AU719122B2 publication Critical patent/AU719122B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/127—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU72007/96A 1995-09-27 1996-09-27 Recombinant hepatitis C virus RNA replicase Ceased AU719122B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US438395P 1995-09-27 1995-09-27
US60/004383 1995-09-27
PCT/US1996/015571 WO1997012033A1 (en) 1995-09-27 1996-09-27 Recombinant hepatitis c virus rna replicase

Publications (2)

Publication Number Publication Date
AU7200796A AU7200796A (en) 1997-04-17
AU719122B2 true AU719122B2 (en) 2000-05-04

Family

ID=21710540

Family Applications (1)

Application Number Title Priority Date Filing Date
AU72007/96A Ceased AU719122B2 (en) 1995-09-27 1996-09-27 Recombinant hepatitis C virus RNA replicase

Country Status (8)

Country Link
US (2) US5981247A (enExample)
EP (1) EP0859833B1 (enExample)
JP (1) JP4191797B2 (enExample)
AT (1) ATE318896T1 (enExample)
AU (1) AU719122B2 (enExample)
CA (1) CA2233309A1 (enExample)
DE (1) DE69635864T2 (enExample)
WO (1) WO1997012033A1 (enExample)

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FR2761695B1 (fr) 1997-04-04 1999-09-24 Bio Merieux Arn polymerase fonctionnant preferentiellement sur matrice d'arn, sa preparation et son utilisation
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US6639053B1 (en) 1998-06-24 2003-10-28 Tetsuya Toyoda HCV-derived RNA polymerase gene
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EP1600452A3 (en) 1999-11-12 2008-09-10 Pharmasset, Inc. Synthesis of 2'-deoxy-L-nucleosides
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GB0029539D0 (en) * 2000-12-04 2001-01-17 Isis Innovation Method for identifying modulatorss of transcription
JP2004537271A (ja) * 2001-01-31 2004-12-16 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー Ｒｎａ依存性ｒｎａポリメラーゼ（ｒｄｒｐ）ウイルスの複製のためのインビトロ系
US7452705B2 (en) * 2001-05-22 2008-11-18 The University Of Chicago N4 virion single-stranded DNA dependent RNA polymerase
AU2002325755A1 (en) * 2001-09-18 2003-04-01 Affinium Pharmaceuticals, Inc. Methods and apparatuses for purification
WO2003027330A1 (en) * 2001-09-25 2003-04-03 Xencor Rna dependent rna polymerase mediated protein evolution
EP1435974A4 (en) 2001-09-28 2006-09-06 Idenix Cayman Ltd METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEPATITIS C VIRUS USING 4 'MODIFIED NUCLEOSIDES
KR100447578B1 (ko) * 2001-11-01 2004-09-07 주식회사 이매진 Ｈｃｖ 자가 복제 효소 활성의 세포내 측정용 키트 및측정 방법
US20030114409A1 (en) * 2001-11-16 2003-06-19 Mello Craig C. Facilitation of RNA interference
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN104193791A (zh) 2002-06-28 2014-12-10 埃迪尼克斯医药公司 用于治疗黄病毒感染的修饰的2’和3’-核苷前药
WO2004046331A2 (en) 2002-11-15 2004-06-03 Idenix (Cayman) Limited 2’-branched nucleosides and flaviviridae mutation
EP2345659A1 (en) 2003-05-30 2011-07-20 Pharmasset, Inc. Modified fluorinated nucleoside analogues
DE602004028841D1 (de) 2003-07-25 2010-10-07 Centre Nat Rech Scient Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c
WO2005070957A1 (en) * 2004-01-09 2005-08-04 Merck & Co., Inc. Hcv rna-dependent rna polymerase
WO2006121468A1 (en) 2004-11-22 2006-11-16 Genelabs Technologies, Inc. 5-nitro-nucleoside compounds for treating viral infections
CA2597685A1 (en) 2005-02-28 2006-09-08 Genelabs Technologies, Inc. Tricyclic-nucleoside compounds for treating viral infections
TW200720285A (en) 2005-04-25 2007-06-01 Genelabs Tech Inc Nucleoside compounds for treating viral infections
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
WO2010014134A1 (en) 2008-07-02 2010-02-04 Idenix Pharamaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
EP2166016A1 (en) 2008-09-18 2010-03-24 Centocor Ortho Biotech Products L.P. Phosphoramidate Derivatives of Nucleosides
BRPI0923815A2 (pt) 2008-12-23 2015-07-14 Pharmasset Inc Síntese de nucleosídeos de purina
CN102695513A (zh) 2008-12-23 2012-09-26 吉利德制药有限责任公司 核苷氨基磷酸酯
AU2009329917B2 (en) 2008-12-23 2016-03-31 Gilead Pharmasset Llc Nucleoside analogs
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI583692B (zh) 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 核苷磷醯胺
WO2011023801A1 (en) 2009-08-31 2011-03-03 F. Hoffmann-La Roche Ag Hcv ns3/4a replicon shuttle vectors
MX2012005528A (es) 2009-11-14 2012-06-12 Hoffmann La Roche Biomarcadores para pronosticar rapida respuesta a tratamiento hcv.
KR20120085877A (ko) 2009-12-02 2012-08-01 에프. 호프만-라 로슈 아게 Ｈｃｖ 치료에 대한 지속된 반응을 예측하기 위한 생체마커
US20110245328A1 (en) 2010-03-31 2011-10-06 Hyunsoon Kang HCV NS5A Replicon Shuttle Vectors
SMT201700412T1 (it) 2010-03-31 2017-11-15 Gilead Pharmasset Llc Procedimento per la cristallizzazione di (s)-isopropil 2-(((s)-(perfluorofenossi)(fenossi)fosforil)ammino)propanoato
JP5872539B2 (ja) 2010-03-31 2016-03-01 ギリアド ファーマセット エルエルシー プリンヌクレオシドホスホルアミダート
BR112012024661A2 (pt) 2010-04-01 2015-09-15 Centre Nat Rech Scient composto, composição farmacêutica e método de tratamento de um hospedeiro infectado com vírus de hepatite c
US8324239B2 (en) 2010-04-21 2012-12-04 Novartis Ag Furopyridine compounds and uses thereof
BR112013001516A2 (pt) 2010-07-22 2016-06-07 Novartis Ag compostos de tiofeno 2,3,5-trissubstituídos e empregos destes
PT3042910T (pt) 2010-11-30 2019-04-16 Gilead Pharmasset Llc 2'-espiro-nucleósidos para utilização na terapia da hepatite c
EP2658857B1 (en) 2010-12-29 2016-11-02 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
AR088441A1 (es) 2011-09-12 2014-06-11 Idenix Pharmaceuticals Inc Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales
AU2012308900A1 (en) 2011-09-12 2013-05-09 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
WO2013056046A1 (en) 2011-10-14 2013-04-18 Idenix Pharmaceuticals, Inc. Substituted 3',5'-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
PL3038601T3 (pl) 2013-08-27 2020-08-24 Gilead Pharmasset Llc Formulacja złożona dwóch związków przeciwwirusowych

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5683864A (en) * 1987-11-18 1997-11-04 Chiron Corporation Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US5726155A (en) * 1993-08-02 1998-03-10 The Scripps Research Institute Regulation of oxidative burst using LMWG-derived peptides and analogs
IT1278077B1 (it) * 1995-05-25 1997-11-17 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal

Also Published As

Publication number Publication date
EP0859833A4 (en) 2001-03-28
AU7200796A (en) 1997-04-17
CA2233309A1 (en) 1997-04-03
WO1997012033A1 (en) 1997-04-03
US5981247A (en) 1999-11-09
EP0859833A1 (en) 1998-08-26
JPH11514862A (ja) 1999-12-21
ATE318896T1 (de) 2006-03-15
DE69635864D1 (de) 2006-04-27
EP0859833B1 (en) 2006-03-01
DE69635864T2 (de) 2006-10-26
US6248589B1 (en) 2001-06-19
JP4191797B2 (ja) 2008-12-03

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