AU718983B2 - Butyrate prodrugs of lactic acid - Google Patents
Butyrate prodrugs of lactic acid Download PDFInfo
- Publication number
- AU718983B2 AU718983B2 AU72498/96A AU7249896A AU718983B2 AU 718983 B2 AU718983 B2 AU 718983B2 AU 72498/96 A AU72498/96 A AU 72498/96A AU 7249896 A AU7249896 A AU 7249896A AU 718983 B2 AU718983 B2 AU 718983B2
- Authority
- AU
- Australia
- Prior art keywords
- patient
- pharmaceutical composition
- composition according
- straight
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
- C07C69/68—Lactic acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/540,345 US5883123A (en) | 1995-10-06 | 1995-10-06 | Butyrate prodrugs derived from lactic acid |
US08/540345 | 1995-10-06 | ||
US08/640260 | 1996-04-30 | ||
US08/640,260 US5912269A (en) | 1996-04-30 | 1996-04-30 | Butyrate prodrugs derived from lactic acid |
PCT/US1996/015660 WO1997012855A1 (en) | 1995-10-06 | 1996-09-30 | Butyrate prodrugs of lactic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
AU7249896A AU7249896A (en) | 1997-04-28 |
AU718983B2 true AU718983B2 (en) | 2000-05-04 |
Family
ID=27066414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU72498/96A Ceased AU718983B2 (en) | 1995-10-06 | 1996-09-30 | Butyrate prodrugs of lactic acid |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0863866B1 (ja) |
JP (1) | JPH11512743A (ja) |
KR (1) | KR19990063988A (ja) |
CN (1) | CN1201447A (ja) |
AT (1) | ATE200893T1 (ja) |
AU (1) | AU718983B2 (ja) |
BR (1) | BR9610850A (ja) |
CA (1) | CA2233606A1 (ja) |
DE (1) | DE69612671T2 (ja) |
DK (1) | DK0863866T3 (ja) |
ES (1) | ES2158351T3 (ja) |
GR (1) | GR3035899T3 (ja) |
HK (1) | HK1016153A1 (ja) |
IN (1) | IN181999B (ja) |
NZ (1) | NZ319877A (ja) |
PT (1) | PT863866E (ja) |
RU (1) | RU2175967C2 (ja) |
TW (1) | TW422834B (ja) |
WO (1) | WO1997012855A1 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5880152A (en) * | 1995-10-06 | 1999-03-09 | Vertex Pharmaceuticals, Inc. | Butyrate prodrugs derived from lactic acid |
US6225350B1 (en) | 1998-03-10 | 2001-05-01 | Vertex Pharmaceuticals, Inc. | Butyrate prodrugs derived from lactic acid |
US6878361B2 (en) | 2001-07-10 | 2005-04-12 | Battelle Memorial Institute | Production of stable aqueous dispersions of carbon nanotubes |
US6896864B2 (en) | 2001-07-10 | 2005-05-24 | Battelle Memorial Institute | Spatial localization of dispersed single walled carbon nanotubes into useful structures |
EP1449535B1 (en) * | 2003-02-18 | 2006-05-03 | Clinique La Prairie Research SA | Compositions comprising fetal hemoglobin and bacterial endotoxin and optionally additional fetal liver components |
WO2005011696A1 (en) * | 2003-08-01 | 2005-02-10 | Fibrogen, Inc. | Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE277700C (ja) * | ||||
DE824041C (de) * | 1945-10-22 | 1951-12-10 | Howards & Sons Ltd | Verfahren zur Herstellung von aliphatischen a -Acyloxymonocarbonsaeuren |
GB603189A (en) * | 1945-10-22 | 1948-06-10 | Howards & Sons Ltd | Manufacture of acyloxy-carboxylic acids |
US2464992A (en) * | 1946-10-10 | 1949-03-22 | Chessie E Rehberg | Esters of acyloxycarboxylic acids |
FR1578064A (ja) * | 1968-05-20 | 1969-08-14 | ||
NL9200481A (nl) * | 1992-03-13 | 1993-10-01 | Univ Groningen | Farmaceutisch preparaat met plaatsgerichte afgifte. |
JPH08113795A (ja) * | 1994-10-14 | 1996-05-07 | T Hasegawa Co Ltd | 香料組成物 |
-
1996
- 1996-09-30 JP JP9514352A patent/JPH11512743A/ja not_active Ceased
- 1996-09-30 DE DE69612671T patent/DE69612671T2/de not_active Expired - Lifetime
- 1996-09-30 CA CA002233606A patent/CA2233606A1/en not_active Abandoned
- 1996-09-30 KR KR1019980702463A patent/KR19990063988A/ko not_active Application Discontinuation
- 1996-09-30 EP EP96933967A patent/EP0863866B1/en not_active Expired - Lifetime
- 1996-09-30 PT PT96933967T patent/PT863866E/pt unknown
- 1996-09-30 WO PCT/US1996/015660 patent/WO1997012855A1/en not_active Application Discontinuation
- 1996-09-30 NZ NZ319877A patent/NZ319877A/en unknown
- 1996-09-30 AU AU72498/96A patent/AU718983B2/en not_active Ceased
- 1996-09-30 CN CN96197978A patent/CN1201447A/zh active Pending
- 1996-09-30 RU RU98108450/04A patent/RU2175967C2/ru not_active IP Right Cessation
- 1996-09-30 AT AT96933967T patent/ATE200893T1/de not_active IP Right Cessation
- 1996-09-30 BR BR9610850A patent/BR9610850A/pt not_active Application Discontinuation
- 1996-09-30 DK DK96933967T patent/DK0863866T3/da active
- 1996-09-30 ES ES96933967T patent/ES2158351T3/es not_active Expired - Lifetime
- 1996-10-04 IN IN1755CA1996 patent/IN181999B/en unknown
- 1996-10-05 TW TW085112196A patent/TW422834B/zh not_active IP Right Cessation
-
1999
- 1999-03-16 HK HK99101097A patent/HK1016153A1/xx not_active IP Right Cessation
-
2001
- 2001-05-18 GR GR20010400754T patent/GR3035899T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0863866A1 (en) | 1998-09-16 |
GR3035899T3 (en) | 2001-08-31 |
DK0863866T3 (da) | 2001-06-11 |
CA2233606A1 (en) | 1997-04-10 |
AU7249896A (en) | 1997-04-28 |
JPH11512743A (ja) | 1999-11-02 |
PT863866E (pt) | 2001-09-28 |
TW422834B (en) | 2001-02-21 |
EP0863866B1 (en) | 2001-05-02 |
NZ319877A (en) | 1999-09-29 |
DE69612671D1 (de) | 2001-06-07 |
ES2158351T3 (es) | 2001-09-01 |
WO1997012855A1 (en) | 1997-04-10 |
ATE200893T1 (de) | 2001-05-15 |
RU2175967C2 (ru) | 2001-11-20 |
BR9610850A (pt) | 1999-07-13 |
IN181999B (ja) | 1998-11-28 |
HK1016153A1 (en) | 1999-10-29 |
CN1201447A (zh) | 1998-12-09 |
KR19990063988A (ko) | 1999-07-26 |
DE69612671T2 (de) | 2004-08-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FGA | Letters patent sealed or granted (standard patent) |