AU714837B2 - In vitro models of CNS function and dysfunction - Google Patents

In vitro models of CNS function and dysfunction Download PDF

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Publication number
AU714837B2
AU714837B2 AU35152/95A AU3515295A AU714837B2 AU 714837 B2 AU714837 B2 AU 714837B2 AU 35152/95 A AU35152/95 A AU 35152/95A AU 3515295 A AU3515295 A AU 3515295A AU 714837 B2 AU714837 B2 AU 714837B2
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cells
cell
biological agent
proliferated
neural cells
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AU35152/95A
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AU3515295A (en
Inventor
Brent Reynolds
Samuel Weiss
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Neurospheres Holdings Ltd
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Neurospheres Holdings Ltd
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    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5026—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
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    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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    • C12N2501/30—Hormones
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    • C12N2503/00—Use of cells in diagnostics
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  • Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
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  • Zoology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
AU35152/95A 1994-09-23 1995-09-22 In vitro models of CNS function and dysfunction Ceased AU714837B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31109994A 1994-09-23 1994-09-23
US08/311099 1994-09-23
US48189395A 1995-06-07 1995-06-07
US08/481893 1995-06-07
PCT/CA1995/000542 WO1996009543A1 (fr) 1994-09-23 1995-09-22 Modeles in vitro de fonction et de dysfonction du systeme nerveux central

Publications (2)

Publication Number Publication Date
AU3515295A AU3515295A (en) 1996-04-09
AU714837B2 true AU714837B2 (en) 2000-01-13

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ID=26977743

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Application Number Title Priority Date Filing Date
AU35152/95A Ceased AU714837B2 (en) 1994-09-23 1995-09-22 In vitro models of CNS function and dysfunction

Country Status (14)

Country Link
EP (2) EP1130394B1 (fr)
JP (1) JPH10505754A (fr)
KR (1) KR970706490A (fr)
AT (2) ATE345496T1 (fr)
AU (1) AU714837B2 (fr)
CA (1) CA2200709A1 (fr)
DE (2) DE69535300T2 (fr)
DK (2) DK0783693T3 (fr)
ES (1) ES2167461T3 (fr)
FI (1) FI971168A0 (fr)
MX (1) MX9702126A (fr)
NO (1) NO971245D0 (fr)
PT (1) PT783693E (fr)
WO (1) WO1996009543A1 (fr)

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US7544511B2 (en) 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
US5753506A (en) * 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
CA2371260A1 (fr) * 1999-05-03 2000-11-09 Karolinska Innovations Ab Materiaux et procedes lies au developpement neuronal
US6878543B1 (en) 1999-10-25 2005-04-12 Nsgene Sa Cultures of GFAP+ nestin+ cells that differentiate to neurons
US7514259B2 (en) 2000-02-11 2009-04-07 Schepens Eye Research Institute Isolation and transplantation of retinal stem cells
EP1271145A1 (fr) * 2001-06-25 2003-01-02 Cardion AG Procédé et populations cellulaires pour l'identification et la validation de séquences génomiques et pour le criblage de médicaments
WO2003027247A2 (fr) 2001-09-24 2003-04-03 Sangamo Biosciences, Inc. Modulation de cellules souches au moyen de proteines a doigts de zinc (zfp)
US7129034B2 (en) 2001-10-25 2006-10-31 Cedars-Sinai Medical Center Differentiation of whole bone marrow
US8293488B2 (en) 2002-12-09 2012-10-23 Neuralstem, Inc. Method for screening neurogenic agents
EP1576134B1 (fr) 2002-12-09 2013-03-06 Judith Kelleher-Andersson Procede de decouverte d'agents neurogenes
WO2005010524A1 (fr) * 2003-06-04 2005-02-03 Curis, Inc. Procedes pour l'identification et la caracterisation d'agents reposant sur l'utilisation de cellules souches
US7691629B2 (en) 2004-11-17 2010-04-06 Neuralstem, Inc. Transplantation of human neural cells for treatment of neurodegenerative conditions
EP2077092A3 (fr) * 2007-10-29 2009-10-21 Taipei Veterans General Hospital Système et procédés pour le criblage ou l'analyse de cibles
GB0815224D0 (en) * 2008-08-20 2008-09-24 Eisai London Res Lab Ltd Screening assay
SG187226A1 (en) 2010-07-28 2013-03-28 Neuralstem Inc Methods for treating and/or reversing neurodegenerative diseases and/or disorders
CN104136601A (zh) 2012-02-17 2014-11-05 斯格本斯眼科研究所 人视网膜祖细胞的表型谱
KR20190060016A (ko) 2014-10-20 2019-05-31 뉴럴스템, 인크. 성장 인자를 코딩하는 외인성 폴리뉴클레오티드를 포함하는 안정한 신경 줄기세포 및 그의 사용 방법
JP6844953B2 (ja) * 2015-04-22 2021-03-17 公益財団法人東京都医学総合研究所 アルツハイマー病研究を標的にしたグリア細胞システム
CN105861482B (zh) * 2016-04-05 2019-10-11 中国科学院广州生物医药与健康研究院 体外细胞疾病模型及其制备方法
WO2018191656A1 (fr) * 2017-04-13 2018-10-18 The Board Of Trustees Of The Leland Stanford Junior University Système 3d personnalisé de culture de cellules neuronales permettant de générer des oligodendrocytes humains et d'étudier la myélinisation in vitro

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO1991009936A1 (fr) * 1989-12-26 1991-07-11 Hana Biologics, Inc. Produit cellulaire progeniteur neuronal proliferee et procede
AU5367694A (en) * 1992-10-28 1994-05-24 Neurospheres Holdings Ltd Biological factors and neural stem cells

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Publication number Priority date Publication date Assignee Title
EP0233838A3 (fr) * 1986-02-04 1990-01-31 Incyte Pharmaceuticals, Inc. Facteur stimulant les neurites, et procédé de préparation
EP0594669B9 (fr) * 1991-07-08 2008-03-19 NeuroSpheres Holdings Ltd. Cellules précurseurs neurales réagissant au facteur de croissance et capables de proliférer in vitro.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009936A1 (fr) * 1989-12-26 1991-07-11 Hana Biologics, Inc. Produit cellulaire progeniteur neuronal proliferee et procede
AU5367694A (en) * 1992-10-28 1994-05-24 Neurospheres Holdings Ltd Biological factors and neural stem cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JORDAN JP ETAL. (1992) J. NEUROONCOL. 14(1):19-35 *

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Publication number Publication date
DE69535300T2 (de) 2007-06-06
DE69523771T2 (de) 2002-08-01
EP1130394A1 (fr) 2001-09-05
DE69535300D1 (de) 2006-12-28
WO1996009543A1 (fr) 1996-03-28
EP0783693A1 (fr) 1997-07-16
KR970706490A (ko) 1997-11-03
NO971245L (no) 1997-03-18
NO971245D0 (no) 1997-03-18
FI971168A (fi) 1997-03-20
MX9702126A (es) 1997-06-28
DE69523771D1 (de) 2001-12-13
FI971168A0 (fi) 1997-03-20
EP1130394B1 (fr) 2006-11-15
EP0783693B1 (fr) 2001-11-07
DK1130394T3 (da) 2007-01-08
ES2167461T3 (es) 2002-05-16
ATE208495T1 (de) 2001-11-15
CA2200709A1 (fr) 1996-03-28
DK0783693T3 (da) 2002-01-14
JPH10505754A (ja) 1998-06-09
ATE345496T1 (de) 2006-12-15
PT783693E (pt) 2002-04-29
AU3515295A (en) 1996-04-09

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