AU713530B2 - Beta-sheet mimetics and use thereof as protease inhibitors - Google Patents

Beta-sheet mimetics and use thereof as protease inhibitors Download PDF

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Publication number
AU713530B2
AU713530B2 AU53729/96A AU5372996A AU713530B2 AU 713530 B2 AU713530 B2 AU 713530B2 AU 53729/96 A AU53729/96 A AU 53729/96A AU 5372996 A AU5372996 A AU 5372996A AU 713530 B2 AU713530 B2 AU 713530B2
Authority
AU
Australia
Prior art keywords
sheet
mimetic
sheet mimetic
integer
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU53729/96A
Other languages
English (en)
Other versions
AU5372996A (en
Inventor
Michael Kahn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecumetics Ltd
Original Assignee
Molecumetics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecumetics Ltd filed Critical Molecumetics Ltd
Priority claimed from PCT/US1996/004115 external-priority patent/WO1996030396A1/en
Publication of AU5372996A publication Critical patent/AU5372996A/en
Application granted granted Critical
Publication of AU713530B2 publication Critical patent/AU713530B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Paper (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU53729/96A 1995-03-24 1996-03-25 Beta-sheet mimetics and use thereof as protease inhibitors Ceased AU713530B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41051895A 1995-03-24 1995-03-24
US08/410518 1995-03-24
US54900695A 1995-10-27 1995-10-27
US08/549006 1995-10-27
PCT/US1996/004115 WO1996030396A1 (en) 1995-03-24 1996-03-25 β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS

Publications (2)

Publication Number Publication Date
AU5372996A AU5372996A (en) 1996-10-16
AU713530B2 true AU713530B2 (en) 1999-12-02

Family

ID=27021026

Family Applications (2)

Application Number Title Priority Date Filing Date
AU53729/96A Ceased AU713530B2 (en) 1995-03-24 1996-03-25 Beta-sheet mimetics and use thereof as protease inhibitors
AU53714/96A Ceased AU712581B2 (en) 1995-03-24 1996-03-25 Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU53714/96A Ceased AU712581B2 (en) 1995-03-24 1996-03-25 Beta-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins

Country Status (8)

Country Link
EP (2) EP0815123B1 (https=)
JP (4) JPH10508034A (https=)
AT (1) ATE206433T1 (https=)
AU (2) AU713530B2 (https=)
CA (2) CA2215695C (https=)
DE (1) DE69615671T2 (https=)
ES (1) ES2161354T3 (https=)
WO (1) WO1996030035A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016425A1 (en) * 1995-10-30 1997-05-09 Merck & Co., Inc. Novel inhibitors of peptide binding to mhc class ii proteins
US5719296A (en) * 1995-10-30 1998-02-17 Merck & Co., Inc. Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
US5840835A (en) * 1995-10-30 1998-11-24 Merck & Co., Inc. Inhibitors of peptide binding to MHC class II proteins
US5817757A (en) * 1995-10-30 1998-10-06 Merck & Co., Inc. Inhibitors of peptide binding to MHO class II proteins
GB9702377D0 (en) * 1996-02-23 1997-03-26 Zeneca Ltd Peptide derivatives
WO1997046578A1 (en) 1996-06-07 1997-12-11 Zeneca Limited Peptide derivatives
NZ332740A (en) 1996-06-18 2000-05-26 Warner Lambert Co heterocyclically substituted carbamate or sulphonamide derivatives
NZ334227A (en) * 1996-08-05 2000-10-27 Molecumetics Ltd Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
GB9621836D0 (en) 1996-10-19 1996-12-11 Zeneca Ltd Peptide compounds
GB9624562D0 (en) 1996-11-27 1997-01-15 Zeneca Ltd Peptide derivatives
GB9625865D0 (en) * 1996-12-12 1997-01-29 Zeneca Ltd Peptides
DE69810513T2 (de) * 1998-02-12 2004-03-18 Molecumetics, Ltd., Bellevue Mimetika von beta-faltblatt und verfahren zur verwendung davon
US6323219B1 (en) 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
US8093293B2 (en) 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
CZ20012722A3 (cs) 1999-01-27 2002-08-14 Ortho-Mcneil Pharmaceutical, Inc. Peptidylové heterocyklické ketony pouľitelné jako inhibitory typtasy
US7309688B2 (en) 2000-10-27 2007-12-18 Johnson & Johnson Consumer Companies Topical anti-cancer compositions and methods of use thereof
EP1261611A2 (en) * 2000-02-29 2002-12-04 Bristol-Myers Squibb Pharma Company Inhibitors of hepatitis c virus ns3 protease
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
US7192615B2 (en) 2001-02-28 2007-03-20 J&J Consumer Companies, Inc. Compositions containing legume products
CN102906566A (zh) 2010-02-03 2013-01-30 株式会社棱镜生物实验室 与天然变性蛋白质结合的化合物及其筛选方法
MX378266B (es) 2014-10-06 2025-03-10 Lighthouse Pharmaceuticals Inc Inhibidores de gingipaina de lisina.
CN108602787A (zh) 2015-11-09 2018-09-28 库特克希米公司 精氨酸牙龈卟啉菌蛋白酶的抑制剂
CN109983012B (zh) 2016-09-16 2023-12-01 莱特豪斯制药公司 赖氨酸牙龈蛋白酶的酮抑制剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA896851B (en) * 1988-09-14 1990-06-27 Hoffmann La Roche Use of ace-inhibitors

Also Published As

Publication number Publication date
EP0815123A1 (en) 1998-01-07
WO1996030035A1 (en) 1996-10-03
JPH10508035A (ja) 1998-08-04
JP2004131511A (ja) 2004-04-30
AU712581B2 (en) 1999-11-11
DE69615671D1 (de) 2001-11-08
CA2215695A1 (en) 1996-10-03
JP2000319295A (ja) 2000-11-21
EP0815123B1 (en) 2001-10-04
ATE206433T1 (de) 2001-10-15
AU5372996A (en) 1996-10-16
EP0817642A1 (en) 1998-01-14
JPH10508034A (ja) 1998-08-04
CA2215695C (en) 2003-09-16
JP4152900B2 (ja) 2008-09-17
DE69615671T2 (de) 2002-08-08
ES2161354T3 (es) 2001-12-01
CA2215720A1 (en) 1996-10-03
AU5371496A (en) 1996-10-16

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired