AU711539B2 - Novel aryl-pyridazines - Google Patents

Novel aryl-pyridazines Download PDF

Info

Publication number
AU711539B2
AU711539B2 AU38736/97A AU3873697A AU711539B2 AU 711539 B2 AU711539 B2 AU 711539B2 AU 38736/97 A AU38736/97 A AU 38736/97A AU 3873697 A AU3873697 A AU 3873697A AU 711539 B2 AU711539 B2 AU 711539B2
Authority
AU
Australia
Prior art keywords
chlorophenyl
tetrahydro
represent
benzopyrano
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU38736/97A
Other languages
English (en)
Other versions
AU3873697A (en
Inventor
John Bantick
Simon Hirst
Matthew Perry
Eifion Phillips
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astra Pharmaceuticals Ltd
Original Assignee
Astra Pharmaceuticals Ltd
Astra Pharmaceutical Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9618487.4A external-priority patent/GB9618487D0/en
Priority claimed from GBGB9619122.6A external-priority patent/GB9619122D0/en
Priority claimed from GBGB9619642.3A external-priority patent/GB9619642D0/en
Application filed by Astra Pharmaceuticals Ltd, Astra Pharmaceutical Products Inc filed Critical Astra Pharmaceuticals Ltd
Publication of AU3873697A publication Critical patent/AU3873697A/en
Application granted granted Critical
Publication of AU711539B2 publication Critical patent/AU711539B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/36—Benzo-cinnolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU38736/97A 1996-09-05 1997-08-19 Novel aryl-pyridazines Ceased AU711539B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9618487 1996-09-05
GBGB9618487.4A GB9618487D0 (en) 1996-09-05 1996-09-05 Pharmaceutically active compounds
GB9619122 1996-09-12
GBGB9619122.6A GB9619122D0 (en) 1996-09-12 1996-09-12 Pharmaceutically active compounds
GBGB9619642.3A GB9619642D0 (en) 1996-09-20 1996-09-20 Compounds
GB9619642 1996-09-20
PCT/SE1997/001359 WO1998009969A1 (fr) 1996-09-05 1997-08-19 Nouveaux aryle-pyridazines

Publications (2)

Publication Number Publication Date
AU3873697A AU3873697A (en) 1998-03-26
AU711539B2 true AU711539B2 (en) 1999-10-14

Family

ID=27268459

Family Applications (1)

Application Number Title Priority Date Filing Date
AU38736/97A Ceased AU711539B2 (en) 1996-09-05 1997-08-19 Novel aryl-pyridazines

Country Status (6)

Country Link
JP (1) JP2001501180A (fr)
AR (1) AR009322A1 (fr)
AU (1) AU711539B2 (fr)
CA (1) CA2263586A1 (fr)
ID (1) ID17393A (fr)
WO (1) WO1998009969A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101541757A (zh) 2006-10-31 2009-09-23 辉瑞产品公司 作为盐皮质激素受体拮抗剂的吡唑啉类化合物
US7999107B2 (en) 2007-01-31 2011-08-16 Merck Sharp & Dohme Corp. Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators
CN102372710A (zh) 2010-08-18 2012-03-14 山东轩竹医药科技有限公司 作为盐皮质激素受体拮抗剂的并环类化合物
EP3954688A1 (fr) * 2012-12-22 2022-02-16 Kbp Biosciences Pte. Ltd. Formes cristallines de composé utilisé comme antagoniste de récepteur minéralocorticoïde et leur procédés de préparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0351435B1 (fr) * 1987-11-02 1993-08-04 Yoshitomi Pharmaceutical Industries, Ltd. Composes de pyridazine fusionnes et leurs utilisations medicales
GB8818895D0 (en) * 1988-08-09 1988-09-14 Boots Co Plc Therapeutic agents
EP0539372A1 (fr) * 1990-02-02 1993-05-05 The Boots Company PLC Agents therapeutiques

Also Published As

Publication number Publication date
AR009322A1 (es) 2000-04-12
WO1998009969A1 (fr) 1998-03-12
AU3873697A (en) 1998-03-26
JP2001501180A (ja) 2001-01-30
ID17393A (id) 1997-12-24
CA2263586A1 (fr) 1998-03-12

Similar Documents

Publication Publication Date Title
US4690930A (en) Pyrazolo[4,3-c]quinoline-3-one and imidazo[4,3-c]cinnolin-3-one derivatives and their use as psychotropic agents
DE60219672T2 (de) Imidazopyridine, -pyrimidine und -triazine als gaba-a alpha 5 rezeptor subtyp liganden zur verbesserung kognitiver eigenschaften
JP2002533465A (ja) Ｘａ因子阻害剤としての窒素を含む複素二環類
Russo et al. Synthesis of new thienopyrimidobenzothiazoles and thienopyrimidobenzoxazoles with analgesic and antiinflammatory properties
NO178697B (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive pyrazolopyridin-forbindelser
US5965730A (en) Pyridine derivatives
JP2003516989A (ja) Ｇａｂａ受容体リガンドとしてのピラゾロ−ピリジン誘導体
US6103736A (en) Fused imidazo[1,2-a]pyridines
AU711539B2 (en) Novel aryl-pyridazines
EP0239191A2 (fr) Dérivés de pyrazolo[4,3-b]pyridine, procédé pour leur préparation et compositions pharmaceutiques les contenant
JP4693410B2 (ja) 修飾ラクトン環を有するカンプトテシン
US4801590A (en) Pyrido(1,8)naphthyridinones, and their use as pharmaceuticals
EP0556813B1 (fr) Composés amphotères tricycliques comme agents antihistaminiques et antiallergiques
US4268513A (en) Pyrrolo [3,4-c]quinoline compounds and pharmaceutical compositions, methods for their use and preparation
AU708882B2 (en) Novel compounds
JP2969911B2 (ja) チオフェン化合物、その医薬用途およびその合成中間体
AU617775B2 (en) Heterocyclic substituted 5,7-dihydropyrrolo (3,2-f)- benzoxazol-6-ones, processes for the preparation thereof and pharmaceutical compositions containing them
US4440768A (en) Hexahydropyrrolo[3,4-c]quinoline compounds and pharmaceutical compositions, and methods for their use
JPH0762017B2 (ja) 多環式キノリン、ナフチリジンおよびピラジノピリジン誘導体
US4350814A (en) Pyrrolo [3,4-c]quinoline compounds
AU705938B2 (en) Pyridazino quinoline compounds
JPS61227584A (ja) ポリアザ複素環誘導体
US6214826B1 (en) Pyridazino quinoline compounds
KR930002730B1 (ko) 티오펜 화합물 및 그의 의약용도
MXPA99000337A (en) Compounds of pyrimidine, methods for its preparation, its use as medicines and pharmaceutical formulations that contains them

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired