AU708715B2 - Benzoyl piperidines/pyrrolidines for enhancing synaptic response - Google Patents

Benzoyl piperidines/pyrrolidines for enhancing synaptic response Download PDF

Info

Publication number
AU708715B2
AU708715B2 AU59293/96A AU5929396A AU708715B2 AU 708715 B2 AU708715 B2 AU 708715B2 AU 59293/96 A AU59293/96 A AU 59293/96A AU 5929396 A AU5929396 A AU 5929396A AU 708715 B2 AU708715 B2 AU 708715B2
Authority
AU
Australia
Prior art keywords
accordance
alkyl
moiety
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU59293/96A
Other languages
English (en)
Other versions
AU5929396A (en
Inventor
Lena Nilsson
Gary A Rogers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of AU5929396A publication Critical patent/AU5929396A/en
Assigned to REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE reassignment REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE Alteration of Name(s) of Applicant(s) under S113 Assignors: CORTEX PHARMACEUTICALS, INC.
Application granted granted Critical
Publication of AU708715B2 publication Critical patent/AU708715B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AU59293/96A 1995-06-02 1996-05-23 Benzoyl piperidines/pyrrolidines for enhancing synaptic response Ceased AU708715B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/458967 1995-06-02
US08/458,967 US5650409A (en) 1995-06-02 1995-06-02 Benzoyl piperidines/pyrrolidines for enhancing synaptic response
PCT/US1996/007607 WO1996038414A1 (en) 1995-06-02 1996-05-23 Benzoyl piperidines/pyrrolidines for enhancing synaptic response

Publications (2)

Publication Number Publication Date
AU5929396A AU5929396A (en) 1996-12-18
AU708715B2 true AU708715B2 (en) 1999-08-12

Family

ID=23822840

Family Applications (1)

Application Number Title Priority Date Filing Date
AU59293/96A Ceased AU708715B2 (en) 1995-06-02 1996-05-23 Benzoyl piperidines/pyrrolidines for enhancing synaptic response

Country Status (13)

Country Link
US (2) US5650409A (pl)
EP (1) EP0839134B1 (pl)
JP (1) JP3464800B2 (pl)
KR (2) KR100621499B1 (pl)
AT (1) ATE259788T1 (pl)
AU (1) AU708715B2 (pl)
CA (1) CA2222976C (pl)
DE (1) DE69631588T2 (pl)
DK (1) DK0839134T3 (pl)
ES (1) ES2216048T3 (pl)
PL (1) PL187895B1 (pl)
PT (1) PT839134E (pl)
WO (1) WO1996038414A1 (pl)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU721936B2 (en) * 1996-04-03 2000-07-20 Regents Of The University Of California, The Benzoxazines for enhancing synaptic response
US5736543A (en) * 1996-04-03 1998-04-07 The Regents Of The University Of California Benzoxazines for enhancing synaptic response
EP0918518A4 (en) * 1996-04-19 2002-05-02 Univ California TREATMENT OF MIND AND MOOD DISEASES WITH GLUTAMATERGIC MODULATORS.
AU4416197A (en) * 1996-09-17 1998-04-14 Regents Of The University Of California, The Positive ampa receptor modulation to enhance brain neurotrophic factor expression
US6110935A (en) * 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
US6329368B1 (en) * 1997-05-09 2001-12-11 The Regents Of The University Of California Endocrine modulation with positive modulators of AMPA type glutamate receptors
WO1999021422A1 (en) * 1997-10-27 1999-05-06 Cortex Pharmaceuticals, Inc. Treatment of schizophrenia with ampakines and neuroleptics
US5985871A (en) * 1997-12-24 1999-11-16 Cortex Pharmaceuticals, Inc. Benzoxazine compounds for enhancing synaptic response
US6943159B1 (en) 1998-02-18 2005-09-13 Neurosearch A/S Compounds and their use as positive AMPA receptor modulators
US6124278A (en) * 1998-04-03 2000-09-26 The Regents Of The University Of California Acylbenzoxazines for enhancing synaptic response
TWI232863B (en) * 2001-06-11 2005-05-21 Akzo Nobel Nv Benzoxazepine derivatives
WO2002102808A2 (en) 2001-06-14 2002-12-27 Akzo Nobel N.V. (PYRIDO/THIENO)-[f]-OXAZEPIN-5-ONE DERIVATIVES AS POSITIVE MODULATORS OF THE AMPA RECEPTOR
MXPA04004815A (es) * 2001-11-26 2005-02-17 Cortex Pharma Inc Compuestos de carbonilbenzoxazina para mejorar respuestas sinapticas, glutamatergicas.
UA80317C2 (en) 2003-01-13 2007-09-10 Cortex Pharma Inc Method of treating cognitive decline due to sleep deprivation and stress
US20060063707A1 (en) * 2004-09-17 2006-03-23 Lifelike Biomatic, Inc. Compositions for enhancing memory and methods therefor
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
CN101626686A (zh) * 2007-01-03 2010-01-13 科泰克斯药品公司 用于提高谷氨酸性突触反应的3-取代基-1,2,3-苯并三嗪酮类化合物
MX2009007242A (es) * 2007-01-03 2009-09-02 Cortex Pharma Inc Compuesto de [1,2,3]-benzotriazinona 3-sustituida para mejorar respuestas sinapticas glutamatergicas.
TW200901974A (en) 2007-01-16 2009-01-16 Wyeth Corp Compounds, compositions, and methods of making and using them
CA2680737C (en) * 2007-03-21 2015-12-15 Emisphere Technologies, Inc. Allyloxy and alkyloxy benzoic acid delivery agents
NZ582035A (en) 2007-05-17 2012-03-30 Cortex Pharma Inc Di-substituted amides for enhancing glutamatergic synaptic responses
US8119632B2 (en) 2007-08-10 2012-02-21 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
AU2008287445A1 (en) * 2007-08-10 2009-02-19 Cortex Pharmaceuticals, Inc. Bicyclic amides for enhancing glutamatergic synaptic responses
WO2010054336A2 (en) * 2008-11-10 2010-05-14 The Regents Of The University Of California Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
EP2544688B1 (en) 2010-03-02 2016-09-07 President and Fellows of Harvard College Methods and compositions for treatment of angelman syndrome
CA2829006A1 (en) 2011-03-04 2012-09-13 The Regents Of The University Of California Locally released growth factors to mediate motor recovery after stroke
EP2948135B1 (en) 2013-01-25 2019-01-02 Case Western Reserve University Compositions and methods for the treatment of pervasive development disorders
CA2915405A1 (en) 2013-06-13 2014-12-18 Veroscience Llc Compositions and methods for treating metabolic disorders
GB201510010D0 (en) 2015-06-09 2015-07-22 King S College London PDD and BPD compounds
US20180339985A1 (en) 2015-08-21 2018-11-29 Femtogenix Limited Pdd compounds
GB201514928D0 (en) 2015-08-21 2015-10-07 King S College London PDD compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3463855A (en) * 1965-05-12 1969-08-26 Johnson & Son Inc S C Insect repellent compositions of n-(meta-toluyl)-methyl piperidines
US3406177A (en) * 1965-05-12 1968-10-15 Johnson & Son Inc S C N-(meta-toluyl)-methylpiperidines
JPH01207284A (ja) * 1987-10-06 1989-08-21 Takeda Chem Ind Ltd アミド化合物
ES2210060T3 (es) * 1992-07-24 2004-07-01 The Regents Of The University Of California Farmacos que aumentan las respuestas sinapticas mediadas por receptores ampa.

Also Published As

Publication number Publication date
CA2222976A1 (en) 1996-12-05
PT839134E (pt) 2004-07-30
AU5929396A (en) 1996-12-18
US5650409A (en) 1997-07-22
EP0839134B1 (en) 2004-02-18
JP3464800B2 (ja) 2003-11-10
DE69631588D1 (de) 2004-03-25
DE69631588T2 (de) 2004-12-16
WO1996038414A1 (en) 1996-12-05
PL323667A1 (en) 1998-04-14
KR100621499B1 (ko) 2006-09-14
ES2216048T3 (es) 2004-10-16
JP2001503012A (ja) 2001-03-06
DK0839134T3 (da) 2004-08-16
ATE259788T1 (de) 2004-03-15
EP0839134A1 (en) 1998-05-06
US5783587A (en) 1998-07-21
KR19990022249A (ko) 1999-03-25
PL187895B1 (pl) 2004-10-29
KR100444539B1 (ko) 2004-10-14
CA2222976C (en) 2001-04-24
KR20040004716A (ko) 2004-01-13

Similar Documents

Publication Publication Date Title
AU708715B2 (en) Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5962447A (en) Benzoxazines for enhancing synaptic response
AU688271B2 (en) Drugs that enhance synaptic responses mediated by ampa receptors
WO1997036907A9 (en) Benzoxazines for enhancing synaptic response
US6124278A (en) Acylbenzoxazines for enhancing synaptic response
US5852008A (en) Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors
US6274600B1 (en) Heteroatom substituted benzoyl derivatives that enhance synaptic responses mediated by AMPA receptors
US20020099050A1 (en) Drugs that enhance synaptic responses mediated by AMPA receptors
AU725127B2 (en) Drugs that enhance synaptic responses mediated by AMPA receptors
AU721936B2 (en) Benzoxazines for enhancing synaptic response