AU680020B2 - Spiro-substituted azacycles as neurokinin antagonists - Google Patents

Spiro-substituted azacycles as neurokinin antagonists

Info

Publication number
AU680020B2
AU680020B2 AU72011/94A AU7201194A AU680020B2 AU 680020 B2 AU680020 B2 AU 680020B2 AU 72011/94 A AU72011/94 A AU 72011/94A AU 7201194 A AU7201194 A AU 7201194A AU 680020 B2 AU680020 B2 AU 680020B2
Authority
AU
Australia
Prior art keywords
spiro
piperidine
dichlorophenyl
methylamino
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU72011/94A
Other languages
English (en)
Other versions
AU7201194A (en
Inventor
Yuan-Ching P Chiang
Patrick T Dunn
Paul E. Finke
Hiroo Koyama
Malcolm Maccoss
Sander G. Mills
Hongbo Qi
Albert J Robichaud
Shrenik K. Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU7201194A publication Critical patent/AU7201194A/en
Application granted granted Critical
Publication of AU680020B2 publication Critical patent/AU680020B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU72011/94A 1993-06-07 1994-05-17 Spiro-substituted azacycles as neurokinin antagonists Ceased AU680020B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7290493A 1993-06-07 1993-06-07
US072904 1993-06-07
PCT/US1994/005545 WO1994029309A1 (fr) 1993-06-07 1994-05-17 Azacycles spirosubstitues antagonistes de la neurokinine

Publications (2)

Publication Number Publication Date
AU7201194A AU7201194A (en) 1995-01-03
AU680020B2 true AU680020B2 (en) 1997-07-17

Family

ID=22110458

Family Applications (1)

Application Number Title Priority Date Filing Date
AU72011/94A Ceased AU680020B2 (en) 1993-06-07 1994-05-17 Spiro-substituted azacycles as neurokinin antagonists

Country Status (8)

Country Link
EP (1) EP0702681A1 (fr)
JP (1) JPH08511522A (fr)
AU (1) AU680020B2 (fr)
CA (1) CA2163995A1 (fr)
HR (1) HRP940337A2 (fr)
IL (1) IL109836A0 (fr)
WO (1) WO1994029309A1 (fr)
ZA (1) ZA943946B (fr)

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US5795894A (en) * 1995-05-02 1998-08-18 Schering Corporation Piperazino derivatives as neurokinn antagonists
US5654316A (en) * 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
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EP0906315A1 (fr) * 1996-06-21 1999-04-07 MERCK SHARP & DOHME LTD. Derives spiro-piperidine et leur utilisation comme agents therapeutiques
US6046333A (en) * 1996-10-25 2000-04-04 Merck & Co., Inc. Convergent process for the preparation of a growth hormone secretagogue
US5789422A (en) * 1996-10-28 1998-08-04 Schering Corporation Substituted arylalkylamines as neurokinin antagonists
ATE248818T1 (de) * 1996-10-28 2003-09-15 Schering Corp Substituierte arylalkylamine als neurokinin- antagonisten
US5945428A (en) * 1996-11-01 1999-08-31 Schering Corporation Substituted oximes, hydrazones and olefins as neurokinin antagonists
US5962462A (en) * 1996-12-13 1999-10-05 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
US5783579A (en) * 1996-12-20 1998-07-21 Schering Corporation Spiro-substituted azacyclic-substituted piperazino derivatives as neurokinin antagonists
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US6013644A (en) * 1997-12-12 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
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EP0360390A1 (fr) * 1988-07-25 1990-03-28 Glaxo Group Limited Dérivés de spirolactames

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0431943A2 (fr) * 1989-12-08 1991-06-12 Merck & Co. Inc. Spirocycles azotés
EP0450761A1 (fr) * 1990-03-02 1991-10-09 Merck & Co. Inc. Antagonistes d'oxytocine spirocycliques
EP0518805A1 (fr) * 1991-06-13 1992-12-16 H. Lundbeck A/S Dérivés de la pipéridine

Also Published As

Publication number Publication date
CA2163995A1 (fr) 1994-12-22
AU7201194A (en) 1995-01-03
JPH08511522A (ja) 1996-12-03
ZA943946B (en) 1995-01-20
HRP940337A2 (en) 1997-04-30
EP0702681A1 (fr) 1996-03-27
WO1994029309A1 (fr) 1994-12-22
IL109836A0 (en) 1994-08-26

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