AU676993B2 - Sigma receptor ligands and the use thereof - Google Patents
Sigma receptor ligands and the use thereofInfo
- Publication number
- AU676993B2 AU676993B2 AU22945/92A AU2294592A AU676993B2 AU 676993 B2 AU676993 B2 AU 676993B2 AU 22945/92 A AU22945/92 A AU 22945/92A AU 2294592 A AU2294592 A AU 2294592A AU 676993 B2 AU676993 B2 AU 676993B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- substituted
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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WO1994014786A1 (en) * | 1992-12-22 | 1994-07-07 | Smithkline Beecham Plc | Piperidine derivatives as calcium channel antagonists |
AU7177694A (en) * | 1993-06-23 | 1995-01-17 | Cambridge Neuroscience, Inc. | Sigma receptor ligands and the use thereof |
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GB9416571D0 (en) * | 1994-08-16 | 1994-10-12 | Battelle Memorial Institute | Novel alkylamino derivatives as sigma 2 selective ligands |
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ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
ZA9610738B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
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AU722015B2 (en) * | 1996-05-13 | 2000-07-20 | Zeneca Limited | Bicyclic amines |
HUP9601331A3 (en) * | 1996-05-17 | 2000-06-28 | Egyt Gyogyszervegyeszeti Gyar | Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them |
GB9623944D0 (en) * | 1996-11-15 | 1997-01-08 | Zeneca Ltd | Bicyclic amine derivatives |
GB9624114D0 (en) * | 1996-11-20 | 1997-01-08 | Zeneca Ltd | Pesticidal bicyclic amine derivatives |
GB9624611D0 (en) | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Bicyclic amine compounds |
BR9713136A (pt) | 1996-11-26 | 2000-02-08 | Zeneca Ltd | Composto, composição inseticida, acaricida, ou nematicida, e, processos para combate e controle de pestes de inseto, acarino ou nematóide em um local e para preparação de um composto. |
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NZ502785A (en) * | 1997-10-24 | 2003-03-28 | Warner Lambert Co | Use of NR1A/2B site-selective NMDA receptor antagonist compounds for treating disease-related or drug-induced dyskinesias |
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FR2794742B1 (fr) * | 1999-06-11 | 2005-06-03 | Sanofi Synthelabo | Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
FR2795724B1 (fr) * | 1999-07-02 | 2002-12-13 | Sanofi Synthelabo | Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
US6875759B1 (en) | 1999-07-21 | 2005-04-05 | Kadmus Pharmaceuticals | Substituted guanidines and the use thereof |
EP1078630A1 (en) * | 1999-08-27 | 2001-02-28 | Warner-Lambert Company | Use of sigma receptor agonists for the treatment of depression |
SE9904723D0 (sv) * | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
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JP4937124B2 (ja) | 2004-06-08 | 2012-05-23 | エヌエスエービー,フィリアル アフ ニューロサーチ スウェーデン アクチボラゲット,スヴェリエ | ドーパミン神経伝達のモジュレーターとしての新規に提供されるフェニルピペリジン/ピペラジン |
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CN101084212A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶介导剂的用途 |
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CN101056854B (zh) | 2004-10-13 | 2013-06-05 | Nsab神经研究瑞典公司分公司 | 合成4-(3-甲磺酰基苯基)-1-n-丙基-哌啶的方法 |
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WO1991009594A1 (en) * | 1989-12-28 | 1991-07-11 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
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1992
- 1992-06-26 EP EP92914789A patent/EP0591426A4/en not_active Withdrawn
- 1992-06-26 PT PT100639A patent/PT100639A/pt not_active Application Discontinuation
- 1992-06-26 WO PCT/US1992/005330 patent/WO1993000313A2/en not_active Application Discontinuation
- 1992-06-26 AU AU22945/92A patent/AU676993B2/en not_active Ceased
- 1992-06-26 CA CA002111957A patent/CA2111957A1/en not_active Abandoned
- 1992-06-26 JP JP5501248A patent/JPH06509069A/ja active Pending
- 1992-07-01 IE IE211292A patent/IE922112A1/en not_active Application Discontinuation
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COULTS, R.T ET AL CAN J.MICROBIOL,26: 844-849 (1980) * |
SMITH, H.E ET AL J. ORGCHEM 40 (11): 1562-1567 (1975) * |
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JPH06509069A (ja) | 1994-10-13 |
IE922112A1 (en) | 1992-12-30 |
WO1993000313A3 (en) | 1993-03-04 |
CA2111957A1 (en) | 1993-01-07 |
WO1993000313A2 (en) | 1993-01-07 |
EP0591426A1 (en) | 1994-04-13 |
AU2294592A (en) | 1993-01-25 |
PT100639A (pt) | 1993-09-30 |
EP0591426A4 (en) | 1996-08-21 |
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