AU673419B2 - Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments - Google Patents

Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments Download PDF

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Publication number
AU673419B2
AU673419B2 AU61949/94A AU6194994A AU673419B2 AU 673419 B2 AU673419 B2 AU 673419B2 AU 61949/94 A AU61949/94 A AU 61949/94A AU 6194994 A AU6194994 A AU 6194994A AU 673419 B2 AU673419 B2 AU 673419B2
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AU
Australia
Prior art keywords
bile acid
bile
compounds
formula
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU61949/94A
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English (en)
Other versions
AU6194994A (en
Inventor
Alfons Enhsen
Heiner Glombik
Werner Kramer
Gunther Wess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU6194994A publication Critical patent/AU6194994A/en
Application granted granted Critical
Publication of AU673419B2 publication Critical patent/AU673419B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU61949/94A 1993-05-08 1994-05-06 Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments Ceased AU673419B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4315439 1993-05-08
DE4315439 1993-05-08

Publications (2)

Publication Number Publication Date
AU6194994A AU6194994A (en) 1994-11-10
AU673419B2 true AU673419B2 (en) 1996-11-07

Family

ID=6487634

Family Applications (1)

Application Number Title Priority Date Filing Date
AU61949/94A Ceased AU673419B2 (en) 1993-05-08 1994-05-06 Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments

Country Status (18)

Country Link
US (1) US5610151A (cg-RX-API-DMAC10.html)
EP (1) EP0624594B1 (cg-RX-API-DMAC10.html)
JP (1) JP3424978B2 (cg-RX-API-DMAC10.html)
KR (1) KR100333151B1 (cg-RX-API-DMAC10.html)
AT (1) ATE183191T1 (cg-RX-API-DMAC10.html)
AU (1) AU673419B2 (cg-RX-API-DMAC10.html)
CA (1) CA2123052C (cg-RX-API-DMAC10.html)
CZ (1) CZ289209B6 (cg-RX-API-DMAC10.html)
DE (1) DE59408602D1 (cg-RX-API-DMAC10.html)
DK (1) DK0624594T3 (cg-RX-API-DMAC10.html)
ES (1) ES2136677T3 (cg-RX-API-DMAC10.html)
FI (1) FI942077L (cg-RX-API-DMAC10.html)
GR (1) GR3031541T3 (cg-RX-API-DMAC10.html)
HU (1) HUT67574A (cg-RX-API-DMAC10.html)
IL (1) IL109580A (cg-RX-API-DMAC10.html)
NO (1) NO304794B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ260471A (cg-RX-API-DMAC10.html)
TW (1) TW289021B (cg-RX-API-DMAC10.html)

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US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
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DE19845403B4 (de) * 1998-10-02 2005-02-10 Aventis Pharma Deutschland Gmbh Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19849722A1 (de) * 1998-10-28 2000-05-04 Aventis Pharma Gmbh Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6462091B1 (en) 1998-12-23 2002-10-08 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
DK1140185T3 (da) 1998-12-23 2003-09-29 Searle Llc Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer
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ATE242007T1 (de) 1998-12-23 2003-06-15 Searle Llc Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen
EP1342475A1 (en) 1998-12-23 2003-09-10 G.D. Searle LLC. Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
EA200100704A1 (ru) * 1998-12-23 2002-02-28 Джи.Ди.Сирл Ллс Комбинация для применения по сердечно-сосудистым показаниям
KR20010099937A (ko) 1998-12-23 2001-11-09 윌리암스 로저 에이 심혈관 징후용 콜레스테릴 에스테르 전달 단백질 억제제및 피브르산 유도체의 조합물
KR20010102965A (ko) 1998-12-23 2001-11-17 윌리암스 로저 에이 심장혈관의 징후에 대한 회장 담즙산 수송 저해제 및담즙산 격리제의 병용
DE19941764A1 (de) 1999-09-02 2001-03-15 Aventis Pharma Gmbh Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente
RU2247125C2 (ru) * 1999-09-22 2005-02-27 Авентис Фарма Дойчланд Гмбх Конъюгаты 4-бензиламинохинолинов с желчной кислотой и их гетероаналоги, способ их получения и лекарственные средства на основе этих соединений
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US6624155B2 (en) * 2001-05-01 2003-09-23 Board Of Trustees Of The University Of Arkansas Hybrid cholinergic agents and compositions
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US417725A (en) * 1889-12-24 Coffin
US489423A (en) * 1893-01-03 Electric time-alarm
US3859437A (en) * 1972-06-02 1975-01-07 Intellectual Property Dev Corp Reducing cholesterol levels

Also Published As

Publication number Publication date
EP0624594B1 (de) 1999-08-11
DK0624594T3 (da) 1999-12-13
AU6194994A (en) 1994-11-10
NO304794B1 (no) 1999-02-15
CZ113794A3 (en) 1994-11-16
IL109580A0 (en) 1994-08-26
FI942077A0 (fi) 1994-05-05
TW289021B (cg-RX-API-DMAC10.html) 1996-10-21
FI942077A7 (fi) 1994-11-09
CA2123052A1 (en) 1994-11-09
HU9401408D0 (en) 1994-08-29
GR3031541T3 (en) 2000-01-31
JP3424978B2 (ja) 2003-07-07
CA2123052C (en) 2005-04-26
FI942077L (fi) 1994-11-09
CZ289209B6 (cs) 2001-12-12
NO941680D0 (no) 1994-05-06
HUT67574A (en) 1995-04-28
JPH072891A (ja) 1995-01-06
US5610151A (en) 1997-03-11
EP0624594A2 (de) 1994-11-17
IL109580A (en) 1999-03-12
NO941680L (no) 1994-11-09
NZ260471A (en) 1995-04-27
DE59408602D1 (de) 1999-09-16
KR100333151B1 (ko) 2002-09-04
ATE183191T1 (de) 1999-08-15
ES2136677T3 (es) 1999-12-01
EP0624594A3 (de) 1996-05-01

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