AU669103B2 - Improved process for the synthesis of oligomers - Google Patents

Improved process for the synthesis of oligomers

Info

Publication number
AU669103B2
AU669103B2 AU88753/91A AU8875391A AU669103B2 AU 669103 B2 AU669103 B2 AU 669103B2 AU 88753/91 A AU88753/91 A AU 88753/91A AU 8875391 A AU8875391 A AU 8875391A AU 669103 B2 AU669103 B2 AU 669103B2
Authority
AU
Australia
Prior art keywords
nucleoside
process according
water
per equivalent
oxygen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU88753/91A
Other languages
English (en)
Other versions
AU8875391A (en
Inventor
Robert E. Klem
William B Marvin
Timothy A Riley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genta Inc
Original Assignee
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genta Inc filed Critical Genta Inc
Publication of AU8875391A publication Critical patent/AU8875391A/en
Application granted granted Critical
Publication of AU669103B2 publication Critical patent/AU669103B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU88753/91A 1990-10-26 1991-10-21 Improved process for the synthesis of oligomers Ceased AU669103B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60579090A 1990-10-26 1990-10-26
PCT/US1991/007630 WO1992007864A1 (en) 1990-10-26 1991-10-21 Improved process for the synthesis of oligomers
US605790 2000-06-27

Publications (2)

Publication Number Publication Date
AU8875391A AU8875391A (en) 1992-05-26
AU669103B2 true AU669103B2 (en) 1996-05-30

Family

ID=24425218

Family Applications (1)

Application Number Title Priority Date Filing Date
AU88753/91A Ceased AU669103B2 (en) 1990-10-26 1991-10-21 Improved process for the synthesis of oligomers

Country Status (14)

Country Link
US (1) US5726300A (enExample)
EP (1) EP0592434B1 (enExample)
JP (1) JPH06509542A (enExample)
AT (1) ATE171947T1 (enExample)
AU (1) AU669103B2 (enExample)
CA (1) CA2094803A1 (enExample)
DE (1) DE69130331T2 (enExample)
DK (1) DK0592434T3 (enExample)
ES (1) ES2124231T3 (enExample)
IE (1) IE913761A1 (enExample)
IL (1) IL99844A (enExample)
NZ (1) NZ240325A (enExample)
TW (1) TW216423B (enExample)
WO (1) WO1992007864A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0616612A4 (en) 1991-12-12 1995-01-11 Gilead Sciences Inc NUCLEASE-STABLE OLIGOMERS SUITABLE FOR BINDING AND METHODS OF USE.
WO1994001446A2 (en) * 1992-07-09 1994-01-20 Beckman Instruments, Inc. Derivatized organic solid support for nucleic acid synthesis
FR2707296B1 (fr) * 1993-07-09 1995-09-29 Genset Sa Procédé de synthèse d'acides nucléiques sur support solide et composés utiles notamment comme support solide dans ledit procédé.
KR960704033A (ko) * 1993-07-19 1996-08-31 다니엘 엘. 캐시앙 인간 면역결핍 바이러스에 대한 활성을 갖는 올리고뉴클레오티드(Oligonucleotides with Activity against Humand Immunodeficiency Virus)
WO1995003427A2 (en) * 1993-07-19 1995-02-02 Gen-Probe Incorporated Oligonucleotide screening assay
US5739309A (en) * 1993-07-19 1998-04-14 Gen-Probe Incorporated Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens
US5733781A (en) 1994-07-19 1998-03-31 Gen-Probe Incorporated Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus
CA2209991C (en) * 1995-01-19 2005-04-12 Gen-Probe Incorporated Nucleic acid amplification oligonucleotides and probes to lyme disease associated borrelia
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US5674995A (en) * 1995-06-07 1997-10-07 Gen-Probe Incorporated Oligonucleotides specific for cytokine signal transducer gp130 mRNA
US5716846A (en) * 1995-06-07 1998-02-10 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to interleukin-6 receptor mRNA
US5747470A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
US5747252A (en) 1995-06-07 1998-05-05 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for Neisseria species
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US6146833A (en) * 1997-02-11 2000-11-14 Beckman Coulter, Inc. Polymeric reagents for immobilizing biopolymers
US7435390B2 (en) * 2001-01-26 2008-10-14 Third Wave Technologies, Inc. Nucleic acid synthesizers
US6932943B1 (en) 2001-01-26 2005-08-23 Third Wave Technologies Nucleic acid synthesizers
US20030072689A1 (en) * 2001-08-15 2003-04-17 Third Wave Technologies, Inc. Polymer synthesizer
WO2008016988A1 (en) 2006-08-01 2008-02-07 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
MX2010010881A (es) 2008-04-01 2011-03-04 Biosearch Tech Inc Sondas oscuras apagadoras de fluoroforo de acido nucleico estabilizado.
US10913767B2 (en) * 2010-04-22 2021-02-09 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising acyclic and abasic nucleosides and analogs
US9403865B2 (en) 2012-08-15 2016-08-02 Ionis Pharmaceuticals, Inc. Method of preparing oligomeric compounds using modified capping protocols
US10301310B2 (en) 2014-05-09 2019-05-28 Biosearch Technologies, Inc. Cosmic quenchers
US10618926B2 (en) 2015-04-02 2020-04-14 Merck Sharp & Dohme Process for making phosphoramidate protected nucleoside compounds
US10519485B2 (en) 2015-04-15 2019-12-31 Biosearch Technologies, Inc. Dual quencher probes
WO2018209068A1 (en) 2017-05-11 2018-11-15 Gen-Probe Incorporated Compositions and methods for isolating target nucleic acids
CN116287111A (zh) 2019-11-14 2023-06-23 简·探针公司 用于捕获靶核酸的组合物和方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4725677A (en) * 1983-08-18 1988-02-16 Biosyntech Gmbh Process for the preparation of oligonucleotides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US4668777A (en) * 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
US4923901A (en) * 1987-09-04 1990-05-08 Millipore Corporation Membranes with bound oligonucleotides and peptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4725677A (en) * 1983-08-18 1988-02-16 Biosyntech Gmbh Process for the preparation of oligonucleotides

Also Published As

Publication number Publication date
WO1992007864A1 (en) 1992-05-14
ES2124231T3 (es) 1999-02-01
ATE171947T1 (de) 1998-10-15
DE69130331T2 (de) 1999-03-04
AU8875391A (en) 1992-05-26
NZ240325A (en) 1993-06-25
IE913761A1 (en) 1992-05-22
US5726300A (en) 1998-03-10
TW216423B (enExample) 1993-11-21
JPH06509542A (ja) 1994-10-27
EP0592434B1 (en) 1998-10-07
CA2094803A1 (en) 1992-04-27
EP0592434A4 (en) 1996-04-24
EP0592434A1 (en) 1994-04-20
DE69130331D1 (de) 1998-11-12
IL99844A (en) 1995-07-31
DK0592434T3 (da) 1999-06-21

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired