AU666142B2 - Viral recombinant vectors for expression in muscle cells - Google Patents
Viral recombinant vectors for expression in muscle cells Download PDFInfo
- Publication number
- AU666142B2 AU666142B2 AU27902/92A AU2790292A AU666142B2 AU 666142 B2 AU666142 B2 AU 666142B2 AU 27902/92 A AU27902/92 A AU 27902/92A AU 2790292 A AU2790292 A AU 2790292A AU 666142 B2 AU666142 B2 AU 666142B2
- Authority
- AU
- Australia
- Prior art keywords
- nucleic acid
- adenovirus
- acid sequence
- muscle cells
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9111947 | 1991-09-27 | ||
| FR9111947A FR2681786A1 (fr) | 1991-09-27 | 1991-09-27 | Vecteurs recombinants d'origine virale, leur procede d'obtention et leur utilisation pour l'expression de polypeptides dans des cellules musculaires. |
| PCT/FR1992/000898 WO1993006223A1 (fr) | 1991-09-27 | 1992-09-25 | Vecteurs recombinants viraux pour l'expression dans des cellules musculaires |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2790292A AU2790292A (en) | 1993-04-27 |
| AU666142B2 true AU666142B2 (en) | 1996-02-01 |
Family
ID=9417378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU27902/92A Expired AU666142B2 (en) | 1991-09-27 | 1992-09-25 | Viral recombinant vectors for expression in muscle cells |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0559884B2 (OSRAM) |
| JP (1) | JP3487597B2 (OSRAM) |
| AT (1) | ATE192500T1 (OSRAM) |
| AU (1) | AU666142B2 (OSRAM) |
| CA (1) | CA2097185C (OSRAM) |
| DE (1) | DE69230993T3 (OSRAM) |
| DK (1) | DK0559884T4 (OSRAM) |
| ES (1) | ES2147553T5 (OSRAM) |
| FR (1) | FR2681786A1 (OSRAM) |
| GR (1) | GR3034094T3 (OSRAM) |
| SG (1) | SG49081A1 (OSRAM) |
| WO (1) | WO1993006223A1 (OSRAM) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5538722A (en) * | 1989-06-13 | 1996-07-23 | Stanford University | Isolation, growth, differentiation and genetic engineering of human muscle cells |
| WO1994010322A1 (en) * | 1992-10-29 | 1994-05-11 | Board Of Regents, The University Of Texas System | Adenovirus-mediated ldl receptor gene transfer and targeting |
| EP0668913B1 (en) * | 1992-11-18 | 2002-01-30 | Arch Development Corporation | Adenovirus-mediated gene transfer to cardiac and vascular smooth muscle |
| FR2705361B1 (fr) * | 1993-05-18 | 1995-08-04 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| US6133028A (en) * | 1993-05-28 | 2000-10-17 | Transgene S.A. | Defective adenoviruses and corresponding complementation lines |
| US20020136708A1 (en) | 1993-06-24 | 2002-09-26 | Graham Frank L. | System for production of helper dependent adenovirus vectors based on use of endonucleases |
| US6140087A (en) * | 1993-06-24 | 2000-10-31 | Advec, Inc. | Adenovirus vectors for gene therapy |
| US6120764A (en) * | 1993-06-24 | 2000-09-19 | Advec, Inc. | Adenoviruses for control of gene expression |
| US6730507B1 (en) | 1993-06-24 | 2004-05-04 | Merck & Co., Inc. | Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration |
| WO1995000655A1 (en) * | 1993-06-24 | 1995-01-05 | Mc Master University | Adenovirus vectors for gene therapy |
| US6080569A (en) | 1993-06-24 | 2000-06-27 | Merck & Co., Inc. | Adenovirus vectors generated from helper viruses and helper-dependent vectors |
| US5919676A (en) * | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
| US7045347B2 (en) | 1993-06-24 | 2006-05-16 | Advec, Inc. | Helper dependent adenovirus vectors based on integrase family site-specific recombinases |
| ES2310924T3 (es) * | 1993-07-13 | 2009-01-16 | Centelion | Vectores adenovirales defectivos y utilizacion en terapia genica. |
| FR2718749B1 (fr) * | 1994-04-18 | 1996-05-31 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| FR2707664B1 (fr) * | 1993-07-13 | 1995-09-29 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| FR2712812B1 (fr) * | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
| US6379943B1 (en) | 1999-03-05 | 2002-04-30 | Merck & Co., Inc. | High-efficiency Cre/loxp based system for construction of adenovirus vectors |
| US6465253B1 (en) | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| FR2730637B1 (fr) | 1995-02-17 | 1997-03-28 | Rhone Poulenc Rorer Sa | Composition pharmaceutique contenant des acides nucleiques, et ses utilisations |
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
| CN1136920C (zh) | 1995-02-28 | 2004-02-04 | 加利福尼亚大学董事会 | 基因转移介导的血管形成疗法 |
| US5792453A (en) * | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
| US6281010B1 (en) * | 1995-06-05 | 2001-08-28 | The Trustees Of The University Of Pennsylvania | Adenovirus gene therapy vehicle and cell line |
| US6974694B2 (en) | 1995-06-07 | 2005-12-13 | Advec, Inc. | Adenoviruses for control of gene expression |
| US6783980B2 (en) | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US5837534A (en) * | 1995-11-14 | 1998-11-17 | The Board Of Regents Of The University Of Texas System | Smooth muscle 22α promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells |
| US5866552A (en) * | 1996-09-06 | 1999-02-02 | The Trustees Of The University Of Pennsylvania | Method for expressing a gene in the absence of an immune response |
| US6544523B1 (en) | 1996-11-13 | 2003-04-08 | Chiron Corporation | Mutant forms of Fas ligand and uses thereof |
| BR9810369A (pt) | 1997-06-30 | 2000-09-05 | Rhone Poulenc Rorer Sa | Processo de transferência de ácido nucleico para o interior de um ou mais músculos estriados, in vivo, composição, ácido mucleico e campo elétrico, e, produto de combinação |
| US6914131B1 (en) | 1998-10-09 | 2005-07-05 | Chiron S.R.L. | Neisserial antigens |
| AU9363798A (en) | 1997-11-06 | 1999-05-31 | Chiron S.P.A. | Neisserial antigens |
| ES2333071T5 (es) | 1998-01-14 | 2015-08-17 | Novartis Vaccines And Diagnostics S.R.L. | Antígenos de Neisseria meningitidis |
| AU767662B2 (en) | 1998-02-06 | 2003-11-20 | Collateral Therapeutics, Inc. | Variants of the angiogenic factor vascular endothelial cell growth factor: VEGF |
| ES2304065T3 (es) | 1998-05-01 | 2008-09-01 | Novartis Vaccines And Diagnostics, Inc. | Antigenos y composiciones de neisseria meningitidis. |
| US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
| JP2002527066A (ja) | 1998-10-15 | 2002-08-27 | カイロン コーポレイション | 転移性乳癌および結腸癌調節遺伝子 |
| US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| WO2000036118A2 (en) | 1998-12-16 | 2000-06-22 | Chiron Corporation | HUMAN CYCLIN-DEPENDENT KINASE (hPNQALRE) |
| US6673601B1 (en) | 1999-04-15 | 2004-01-06 | Institut Pasteur | Chimeric lyssavirus nucleic acids and polypeptides |
| EP1721982B1 (en) | 1999-04-15 | 2013-04-10 | Boehringer Ingelheim Vetmedica GmbH | Chimeric lyssavirus nucleic acids and polypeptides |
| ES2477194T3 (es) | 1999-04-30 | 2014-07-16 | Novartis Vaccines And Diagnostics S.R.L. | Ant�genos neisseriales conservados |
| US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| CA2864069A1 (en) | 1999-10-29 | 2001-05-03 | Novartis Vaccines And Diagnostics S.R.L. | Neisserial antigenic peptides |
| DK1248647T3 (da) | 2000-01-17 | 2010-09-27 | Novartis Vaccines & Diagnostic | Ydre membranvesikel (OMV) vaccine omfattende N. meningitidis serogruppe B ydre membranproteiner |
| MXPA02008313A (es) | 2000-02-28 | 2002-12-09 | Chiron Spa | Expresion hibrida de proteinas de neisseria. |
| US7238672B1 (en) | 2000-04-17 | 2007-07-03 | Institut Pasteur | Chimeric lyssavirus nucleic acids and polypeptides |
| EP1950297A2 (en) | 2000-05-31 | 2008-07-30 | Novartis Vaccines and Diagnostics, Inc. | Compositions and methods for treating neoplastic disease using chemotherapy and radiation sensitizers |
| DE60138403D1 (de) | 2000-09-26 | 2009-05-28 | Crucell Holland Bv | Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten |
| EP1191104A1 (en) * | 2000-09-26 | 2002-03-27 | Introgene B.V. | Gene delivery vehicles and use thereof in the preparation of a medicament and/or vaccine |
| US20040053877A1 (en) * | 2000-10-06 | 2004-03-18 | Masayuki Fukumura | Paramyxovirus vector for transfering foreign gene into skeletal muscle |
| AU1412702A (en) | 2000-10-27 | 2002-05-06 | Chiron Spa | Nucleic acids and proteins from streptococcus groups a and b |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| FR2829136B1 (fr) | 2001-08-29 | 2006-11-17 | Aventis Pharma Sa | Derives lipidiques d'aminoglycosides |
| ES2312649T3 (es) | 2001-12-12 | 2009-03-01 | Novartis Vaccines And Diagnostics S.R.L. | Inmunizacion frente a chlamydia trachomatis. |
| NZ534866A (en) | 2002-04-25 | 2007-04-27 | Crucell Holland B | Means and methods for the production of adenovirus vectors |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| ES2407465T3 (es) | 2004-03-29 | 2013-06-12 | Galpharma Co., Ltd. | Nueva proteína galectina 9 modificada y uso de la misma |
| CA2582353A1 (en) | 2004-10-06 | 2006-04-20 | University Of Rochester | Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway |
| CA2595407A1 (en) | 2005-01-20 | 2006-07-27 | University Of Rochester | Thioredoxin interacting protein (txnip) as regulator of vascular function |
| US8026354B2 (en) | 2005-11-23 | 2011-09-27 | Institut Pasteur | Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use |
| US20100015168A1 (en) | 2006-06-09 | 2010-01-21 | Novartis Ag | Immunogenic compositions for streptococcus agalactiae |
| US8673859B2 (en) | 2007-03-20 | 2014-03-18 | New York University | GM-CSF cosmeceutical compositions and methods of use thereof |
| WO2010026537A1 (en) | 2008-09-05 | 2010-03-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Novel multimodular assembly useful for intracellular delivery |
| US8772238B2 (en) | 2009-03-18 | 2014-07-08 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Use of ixolaris, a tissue factor inhibitor, for the treatment of cancer |
| CA3120504A1 (en) | 2009-06-10 | 2010-12-16 | New York University | Immunological targeting of pathological tau proteins |
| EP2658567A4 (en) | 2010-12-28 | 2014-09-24 | Univ Rochester | METHOD FOR MODIFYING INSULIN SIGNAL TRANSMISSION BY BILIVERDINREDUCTASE (BVR) AND BVR-DERIVED PEPTIDES |
| EP3741384A1 (en) | 2011-09-07 | 2020-11-25 | Mount Sinai School Of Medicine | Ceramidase and cell differentiation |
| US9694050B2 (en) | 2012-10-21 | 2017-07-04 | University Of Rochester | THY1 (CD90) as a novel therapy to control adipose tissue accumulation |
| US9822418B2 (en) | 2013-04-22 | 2017-11-21 | Icahn School Of Medicine At Mount Sinai | Mutations in PDGFRB and NOTCH3 as causes of autosomal dominant infantile myofibromatosis |
| WO2017079442A1 (en) | 2015-11-04 | 2017-05-11 | Icahn School Of Medicine At Mount Sinai | Methods of treating tumors and cancer, and identifying candidate subjects for such treatment |
| EP3448881B1 (en) | 2016-04-26 | 2023-06-07 | Icahn School of Medicine at Mount Sinai | Treatment of hippo pathway mutant tumors and methods of identifying subjects as candidates for treatment |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU576907B2 (en) * | 1984-11-01 | 1988-09-08 | American Home Products Corporation | Oral vaccines comprising live recombinant adenoviruses |
| AU612983B2 (en) * | 1986-08-01 | 1991-07-25 | Australian National University, The | Recombinant vaccine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2573436B1 (fr) * | 1984-11-20 | 1989-02-17 | Pasteur Institut | Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins |
| DK0737750T3 (da) * | 1989-03-21 | 2003-09-01 | Vical Inc | Ekspression af exogene polynucleotidsekvenser i vertebrater |
| WO1990013640A1 (en) * | 1989-05-01 | 1990-11-15 | The University Of Notre Dame Du Lac | Methods and materials for expression of human plasminogen in a eukaryotic cell system |
| GB9001766D0 (en) * | 1990-01-25 | 1990-03-28 | Univ Court Of The University O | Vaccines |
-
1991
- 1991-09-27 FR FR9111947A patent/FR2681786A1/fr active Granted
-
1992
- 1992-09-25 AU AU27902/92A patent/AU666142B2/en not_active Expired
- 1992-09-25 CA CA002097185A patent/CA2097185C/fr not_active Expired - Lifetime
- 1992-09-25 EP EP92921684A patent/EP0559884B2/fr not_active Expired - Lifetime
- 1992-09-25 WO PCT/FR1992/000898 patent/WO1993006223A1/fr not_active Ceased
- 1992-09-25 DE DE69230993T patent/DE69230993T3/de not_active Expired - Lifetime
- 1992-09-25 ES ES92921684T patent/ES2147553T5/es not_active Expired - Lifetime
- 1992-09-25 DK DK92921684T patent/DK0559884T4/da active
- 1992-09-25 SG SG1996005855A patent/SG49081A1/en unknown
- 1992-09-25 AT AT92921684T patent/ATE192500T1/de active
- 1992-09-25 JP JP50585393A patent/JP3487597B2/ja not_active Expired - Lifetime
-
2000
- 2000-08-02 GR GR20000401791T patent/GR3034094T3/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU576907B2 (en) * | 1984-11-01 | 1988-09-08 | American Home Products Corporation | Oral vaccines comprising live recombinant adenoviruses |
| AU612983B2 (en) * | 1986-08-01 | 1991-07-25 | Australian National University, The | Recombinant vaccine |
Non-Patent Citations (1)
| Title |
|---|
| HUMAN GENE TRANSFER VOLUME 219 PP51-61 * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69230993T2 (de) | 2000-11-30 |
| WO1993006223A1 (fr) | 1993-04-01 |
| GR3034094T3 (en) | 2000-11-30 |
| AU2790292A (en) | 1993-04-27 |
| CA2097185A1 (fr) | 1993-03-28 |
| DK0559884T3 (da) | 2000-10-02 |
| DE69230993D1 (de) | 2000-06-08 |
| ATE192500T1 (de) | 2000-05-15 |
| JP3487597B2 (ja) | 2004-01-19 |
| ES2147553T5 (es) | 2004-11-16 |
| DK0559884T4 (da) | 2004-08-02 |
| CA2097185C (fr) | 2007-07-24 |
| EP0559884A1 (fr) | 1993-09-15 |
| SG49081A1 (en) | 1998-05-18 |
| JPH06502771A (ja) | 1994-03-31 |
| EP0559884B1 (fr) | 2000-05-03 |
| DE69230993T3 (de) | 2004-12-16 |
| FR2681786A1 (fr) | 1993-04-02 |
| FR2681786B1 (OSRAM) | 1995-05-12 |
| ES2147553T3 (es) | 2000-09-16 |
| EP0559884B2 (fr) | 2004-04-07 |
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