AU659927B2 - TNF-muteins - Google Patents

TNF-muteins Download PDF

Info

Publication number
AU659927B2
AU659927B2 AU35611/93A AU3561193A AU659927B2 AU 659927 B2 AU659927 B2 AU 659927B2 AU 35611/93 A AU35611/93 A AU 35611/93A AU 3561193 A AU3561193 A AU 3561193A AU 659927 B2 AU659927 B2 AU 659927B2
Authority
AU
Australia
Prior art keywords
tnfa
mutein
thr
tnf
muteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU35611/93A
Other languages
English (en)
Other versions
AU3561193A (en
Inventor
Werner Lesslauer
Hansruedi Lotscher
Dietrich Stuber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU3561193A publication Critical patent/AU3561193A/en
Application granted granted Critical
Publication of AU659927B2 publication Critical patent/AU659927B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AU35611/93A 1992-04-02 1993-03-30 TNF-muteins Ceased AU659927B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92810249 1992-04-02
EP92810249 1992-04-02

Publications (2)

Publication Number Publication Date
AU3561193A AU3561193A (en) 1993-10-07
AU659927B2 true AU659927B2 (en) 1995-06-01

Family

ID=8211902

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35611/93A Ceased AU659927B2 (en) 1992-04-02 1993-03-30 TNF-muteins

Country Status (19)

Country Link
US (1) US5486463A (show.php)
EP (1) EP0563714A3 (show.php)
JP (1) JPH07285997A (show.php)
CN (1) CN1037844C (show.php)
AU (1) AU659927B2 (show.php)
BR (1) BR9301420A (show.php)
CA (1) CA2091313A1 (show.php)
CZ (1) CZ283533B6 (show.php)
FI (1) FI931488A7 (show.php)
HU (1) HUT69790A (show.php)
IL (1) IL105170A0 (show.php)
MX (1) MX9301700A (show.php)
NO (1) NO931141L (show.php)
NZ (1) NZ247265A (show.php)
PL (1) PL298345A1 (show.php)
SK (1) SK376492A3 (show.php)
TW (1) TW260707B (show.php)
UY (1) UY23561A1 (show.php)
ZA (1) ZA932177B (show.php)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970005042B1 (ko) * 1993-02-09 1997-04-11 한일합성섬유공업 주식회사 종양괴사인자-알파 뮤테인
CA2119089A1 (en) * 1993-03-29 1994-09-30 David Banner Tumor necrosis factor muteins
CN1049663C (zh) * 1994-09-01 2000-02-23 中国科学院上海生物工程研究中心 突变的人肿瘤坏死因子
US7070771B1 (en) 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
WO2001060397A1 (en) * 2000-02-16 2001-08-23 Genentech, Inc. Uses of agonists and antagonists to modulate activity of tnf-related molecules
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US6379708B1 (en) * 1999-11-20 2002-04-30 Cytologic, Llc Method for enhancing immune responses in mammals
KR20040019105A (ko) * 2001-08-03 2004-03-04 제넨테크, 인크. ＴＡＣＩｓ 및 ＢＲ3 폴리펩티드 및 이의 용도
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
US20030199024A1 (en) * 2002-04-19 2003-10-23 Hansen Ted H. Single chain trimers of class I MHC molecules
BR0313033A (pt) * 2002-07-25 2007-07-10 Genentech Inc anticorpos, anticorpos monoclonais, linhagens de células de hibridoma, anticorpos receptores de anti-taci isolados, anticorpos anti -taci, métodos de modulação da atividade biológica
JP4754219B2 (ja) * 2002-12-02 2011-08-24 アムジエン・フレモント・インコーポレイテツド 腫瘍壊死因子を対象とする抗体、およびそれらの使用
US20040121971A1 (en) * 2002-12-20 2004-06-24 Gang Chen Therapeutic use of tumor necrosis factor-alpha mutein
US20050163775A1 (en) * 2003-06-05 2005-07-28 Genentech, Inc. Combination therapy for B cell disorders
ES2537738T3 (es) * 2003-06-05 2015-06-11 Genentech, Inc. Terapia de combinación para trastornos de células B
CN100390200C (zh) * 2003-11-24 2008-05-28 中国医学科学院基础医学研究所 一种用于治疗获得性免疫缺陷综合征的重组靶向融合蛋白
TW200526780A (en) * 2004-01-06 2005-08-16 Hayashibara Biochem Lab TNF antagonists and TNF inhibitors comprising the same as the active ingredient
CN1752211B (zh) * 2004-09-23 2010-09-15 中国医学科学院基础医学研究所 用于治疗获得性免疫缺陷综合征的重组靶向融合蛋白
GB0425972D0 (en) 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
US7850960B2 (en) 2004-12-30 2010-12-14 University Of Washington Methods for regulation of stem cells
US20070065514A1 (en) * 2005-09-22 2007-03-22 Howell Mark D Method for enhancing immune responses in mammals
CA2629306A1 (en) * 2005-11-23 2007-05-31 Genentech, Inc. Methods and compositions related to b cell assays
US8518697B2 (en) * 2006-04-04 2013-08-27 Washington University Single chain trimers and uses therefor
US20100316626A1 (en) * 2006-08-11 2010-12-16 The Government Of The United States Of America As Represented By The Secretary Methods for treatment and diagnosis of psychiatric disorders
WO2008127515A1 (en) * 2007-03-01 2008-10-23 Cytologic, Inc. Compositions and method for enhancing immune responses in mammals
JP6367836B2 (ja) 2013-02-07 2018-08-01 ザ ジェネラル ホスピタル コーポレイション Ｔ制御性細胞の増殖または枯渇方法
GB201909390D0 (en) 2019-06-28 2019-08-14 Univ Oxford Innovation Ltd TNF muteins and uses thereof
CA3194403A1 (en) 2020-10-01 2022-04-07 Steven Josephs Reduced leaching of a ligand
US11224858B1 (en) 2020-10-01 2022-01-18 Immunicom, Inc. Reduced leaching of a ligand
WO2025163107A1 (en) 2024-02-01 2025-08-07 Institut Gustave Roussy Immune cells defective for znf217 and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07106158B2 (ja) * 1986-12-04 1995-11-15 サントリー株式会社 抗腫瘍活性を有する新規ポリペプチドおよびその製造法
CA2055168A1 (en) * 1990-11-21 1992-05-22 Walter Fiers Tnf-muteins

Also Published As

Publication number Publication date
CZ376492A3 (en) 1994-01-19
FI931488A0 (fi) 1993-04-01
SK376492A3 (en) 1995-06-07
HUT69790A (en) 1995-09-28
AU3561193A (en) 1993-10-07
EP0563714A2 (en) 1993-10-06
TW260707B (show.php) 1995-10-21
BR9301420A (pt) 1993-10-05
FI931488L (fi) 1993-10-03
HU9300843D0 (en) 1993-06-28
CA2091313A1 (en) 1993-10-03
CN1079225A (zh) 1993-12-08
MX9301700A (es) 1993-10-29
UY23561A1 (es) 1993-09-20
US5486463A (en) 1996-01-23
EP0563714A3 (en) 1993-11-10
FI931488A7 (fi) 1993-10-03
NO931141L (no) 1993-10-04
PL298345A1 (en) 1993-12-27
CN1037844C (zh) 1998-03-25
JPH07285997A (ja) 1995-10-31
NO931141D0 (no) 1993-03-26
ZA932177B (en) 1993-10-04
NZ247265A (en) 1995-10-26
IL105170A0 (en) 1993-07-08
CZ283533B6 (cs) 1998-04-15

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