AU649217B2 - Method for site-specifically incorporating unnatural amino acids into proteins - Google Patents
Method for site-specifically incorporating unnatural amino acids into proteinsInfo
- Publication number
- AU649217B2 AU649217B2 AU47412/90A AU4741290A AU649217B2 AU 649217 B2 AU649217 B2 AU 649217B2 AU 47412/90 A AU47412/90 A AU 47412/90A AU 4741290 A AU4741290 A AU 4741290A AU 649217 B2 AU649217 B2 AU 649217B2
- Authority
- AU
- Australia
- Prior art keywords
- trna
- protein
- amino acid
- aminoacyl
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27345588A | 1988-11-18 | 1988-11-18 | |
US273455 | 1988-11-18 | ||
US33760189A | 1989-04-13 | 1989-04-13 | |
US337601 | 1989-04-13 | ||
PCT/US1989/005256 WO1990005785A1 (fr) | 1988-11-18 | 1989-11-15 | Procede d'incorporation sur un site specifique, d'aminoacides non naturels dans des proteines |
Publications (2)
Publication Number | Publication Date |
---|---|
AU4741290A AU4741290A (en) | 1990-06-12 |
AU649217B2 true AU649217B2 (en) | 1994-05-19 |
Family
ID=26956206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU47412/90A Ceased AU649217B2 (en) | 1988-11-18 | 1989-11-15 | Method for site-specifically incorporating unnatural amino acids into proteins |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0446299A4 (fr) |
JP (1) | JPH04504651A (fr) |
KR (1) | KR900702044A (fr) |
AU (1) | AU649217B2 (fr) |
WO (1) | WO1990005785A1 (fr) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990005749A1 (fr) * | 1988-11-18 | 1990-05-31 | The Regents Of The University Of California | Polypeptides conjugues, leurs procedes de preparation et d'utilisation |
US6943034B1 (en) | 1991-11-22 | 2005-09-13 | Affymetrix, Inc. | Combinatorial strategies for polymer synthesis |
DE69233331T3 (de) * | 1991-11-22 | 2007-08-30 | Affymetrix, Inc., Santa Clara | Kombinatorische Strategien zur Polymersynthese |
US5922545A (en) * | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
US6358689B1 (en) | 1994-05-11 | 2002-03-19 | Boston University | Detection of markers in nascent proteins |
US5986076A (en) * | 1994-05-11 | 1999-11-16 | Trustees Of Boston University | Photocleavable agents and conjugates for the detection and isolation of biomolecules |
US5643722A (en) | 1994-05-11 | 1997-07-01 | Trustees Of Boston University | Methods for the detection and isolation of proteins |
US6210941B1 (en) | 1997-06-27 | 2001-04-03 | The Trustees Of Boston University | Methods for the detection and isolation of proteins |
US6239273B1 (en) | 1995-02-27 | 2001-05-29 | Affymetrix, Inc. | Printing molecular library arrays |
US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
DE69720041T2 (de) * | 1996-11-14 | 2004-01-08 | Affymetrix, Inc., Santa Clara | Chemische amplifizierung zur synthese von musterordnungen |
GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
US6653126B1 (en) | 1999-06-04 | 2003-11-25 | Massachusetts Insititute Of Technology | Compositions and methods for the screening of compounds to enhance or reduce apoptosis |
US6306628B1 (en) | 1999-08-25 | 2001-10-23 | Ambergen, Incorporated | Methods for the detection, analysis and isolation of Nascent proteins |
WO2001068835A2 (fr) * | 2000-03-13 | 2001-09-20 | Aptagen | Technique de modification d'un acide nucleique |
US7252932B1 (en) | 2000-08-23 | 2007-08-07 | Ambergen, Inc. | Methods for the detection, analysis and isolation of nascent proteins |
KR100401296B1 (ko) * | 2000-12-27 | 2003-10-11 | 드림바이오젠 주식회사 | 수식물질에 의해 수식된 단백질 변이체 및 이것의 제조방법 |
JP4061043B2 (ja) | 2000-12-28 | 2008-03-12 | 株式会社ポストゲノム研究所 | invitro転写/翻訳系によるペプチド等の製造方法 |
WO2002059601A1 (fr) * | 2001-01-23 | 2002-08-01 | President And Fellows Of Harvard College | Reseaux de proteines a acide nucleique programmable |
EP1401850A1 (fr) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Derives nucleosidiques pour elaboration de bibliotheque combinatoire |
GB0115841D0 (en) | 2001-06-28 | 2001-08-22 | Medical Res Council | Ligand |
EP1440083B1 (fr) | 2001-10-25 | 2013-01-02 | Medical Research Council | Molecules |
AU2002349296A1 (en) * | 2001-11-30 | 2003-06-10 | Novozymes A/S | Method for generating a site-specific library of variants |
US7288372B2 (en) | 2002-01-17 | 2007-10-30 | Ambergen, Inc. | Methods for the preparation of chemically misaminoacylated tRNA via protective groups |
CN101006177B (zh) | 2002-03-15 | 2011-10-12 | 纽韦卢森公司 | 改善的用于合成模制分子的方法 |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
US10730906B2 (en) | 2002-08-01 | 2020-08-04 | Nuevolutions A/S | Multi-step synthesis of templated molecules |
ES2640279T3 (es) | 2002-10-30 | 2017-11-02 | Nuevolution A/S | Procedimiento para la síntesis de un complejo bifuncional |
US9121110B2 (en) | 2002-12-19 | 2015-09-01 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
WO2004074429A2 (fr) | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Procede de production d'une banque de deuxieme generation |
DK2236606T3 (da) | 2003-03-20 | 2014-02-10 | Nuevolution As | Kodning af små molekyler ved ligering |
DE10336705A1 (de) * | 2003-08-06 | 2005-03-10 | Rina Netzwerk Rna Technologien | Verfahren zur Herstellung eines Lysats zur zellfreien Proteinbiosynthese |
DE602004023960D1 (de) | 2003-09-18 | 2009-12-17 | Nuevolution As | Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen |
JP2007519422A (ja) | 2004-02-02 | 2007-07-19 | アンブレツクス・インコーポレイテツド | 修飾されたヒト四螺旋バンドルポリペプチド及びそれらの使用 |
DK1730277T3 (da) | 2004-03-22 | 2010-03-01 | Nuevolution As | Kodning ved ligering under anvendelse af byggebloksoligonukleotider |
MXPA06014684A (es) | 2004-06-18 | 2007-02-12 | Ambrx Inc | Novedosos polipeptidos de enlace antigeno y sus usos. |
CN101724071A (zh) | 2004-10-08 | 2010-06-09 | 杜门蒂斯有限公司 | 抗肿瘤坏死因子受体1的单域抗体及其使用方法 |
BRPI0519430A2 (pt) | 2004-12-22 | 2009-02-10 | Ambrx Inc | hormânio do crescimento humano modificado |
ATE541934T1 (de) | 2004-12-22 | 2012-02-15 | Ambrx Inc | Zusammensetzungen von aminoacyl-trna-synthetase und verwendungen davon |
SG161210A1 (en) | 2004-12-22 | 2010-05-27 | Ambrx Inc | Methods for expression and purification of recombinant human growth hormone |
WO2006069246A2 (fr) | 2004-12-22 | 2006-06-29 | Ambrx, Inc. | Compositions contenant des acides amines non naturels et des polypeptides, procedes impliquant ces acides amines non naturels et polypeptides, et utilisations desdits acides amines non naturels et polypeptides |
AU2005322019B2 (en) | 2004-12-22 | 2010-08-26 | Ambrx, Inc. | Formulations of human growth hormone comprising a non-naturally encoded amino acid |
EP1863531A1 (fr) | 2005-03-19 | 2007-12-12 | Medical Research Council | Ameliorations dans ou concernant le traitement et la prevention d'infections virales |
KR20080026135A (ko) | 2005-06-03 | 2008-03-24 | 암브룩스, 인코포레이티드 | 개선된 인간 인터페론 분자 및 이의 용도 |
PT1954710E (pt) | 2005-11-08 | 2011-06-07 | Ambrx Inc | Aceleradores para a modificação de aminoácidos nãonaturais e polipeptídeos de aminoácidos não-naturais |
EP2339014B1 (fr) | 2005-11-16 | 2015-05-27 | Ambrx, Inc. | Procédés et compositions comprenant des acides aminés non naturels |
SI2341140T1 (sl) | 2005-12-01 | 2017-12-29 | Nuevolution A/S | Postopki encimskega kodiranja za učinkovito sintezo velikih knjižnic |
KR101423898B1 (ko) | 2005-12-14 | 2014-07-28 | 암브룩스, 인코포레이티드 | 비-천연 아미노산 및 폴리펩티드를 함유하는 조성물, 비-천연 아미노산 및 폴리펩티드를 포함하는 방법, 및 비-천연 아미노산 및 폴리펩티드의 용도 |
US8178316B2 (en) | 2006-06-29 | 2012-05-15 | President And Fellows Of Harvard College | Evaluating proteins |
US8420792B2 (en) | 2006-09-08 | 2013-04-16 | Ambrx, Inc. | Suppressor tRNA transcription in vertebrate cells |
NZ574721A (en) | 2006-09-08 | 2012-02-24 | Ambrx Inc | Hybrid suppressor trna for vertebrate cells |
EP2069396B1 (fr) | 2006-09-08 | 2015-10-21 | Ambrx, Inc. | Polypeptide plasmatique humain modifie ou squelettes de fc et leurs utilisations |
CA2669084A1 (fr) | 2006-11-10 | 2008-05-29 | Massachusetts Institute Of Technology | Modulateurs de pak |
BRPI0809583B1 (pt) | 2007-03-30 | 2022-02-22 | Ambrx, Inc | Polipeptídeo fgf-21 modificado, composição compreendendo o mesmo, método para produzir o referido polipetídeo fgf-21 e célula compreendendo um polinucleotídeo |
CA2685596A1 (fr) | 2007-05-02 | 2008-11-13 | Ambrx, Inc. | Polypeptides d'interferon beta modifies et leurs utilisations |
NZ603812A (en) | 2007-11-20 | 2014-06-27 | Ambrx Inc | Modified insulin polypeptides and their uses |
SG188143A1 (en) | 2008-02-08 | 2013-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
EP2096174A1 (fr) | 2008-02-28 | 2009-09-02 | Centro De Investigación Cooperativa En Biociencias CiC bioGune | Polypeptides se liant à l'ubiquitine |
JP2010043063A (ja) | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
NZ591235A (en) | 2008-07-23 | 2012-07-27 | Ambrx Inc | Modified bovine g-csf polypeptides comprising non natural amino acid and their uses treating infections such as mastitis |
TR201802361T4 (tr) | 2008-09-26 | 2018-03-21 | Ambrx Inc | Doğal olmayan amino asit replikasyonuna bağımlı mikroorganizmalar ve aşılar. |
PL2342223T3 (pl) | 2008-09-26 | 2017-09-29 | Ambrx, Inc. | Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania |
EP2501414B1 (fr) | 2009-11-17 | 2018-01-10 | The Trustees Of The University Of Pennsylvania | Dégron smndelta7 : nouvelles compositions et procédés d'utilisation |
NZ600361A (en) | 2009-12-21 | 2014-06-27 | Ambrx Inc | Modified bovine somatotropin polypeptides and their uses |
CN104017063A (zh) | 2009-12-21 | 2014-09-03 | Ambrx公司 | 经过修饰的猪促生长素多肽和其用途 |
LT2558577T (lt) | 2010-04-16 | 2019-03-12 | Nuevolution A/S | Bifunkciniai kompleksai ir tokių kompleksų gamybos ir naudojimo būdai |
MY162837A (en) | 2010-08-17 | 2017-07-31 | Ambrx Inc | Modified relaxin polypeptides and their uses |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
AR083006A1 (es) | 2010-09-23 | 2013-01-23 | Lilly Co Eli | Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas |
ES2525573T3 (es) | 2011-05-24 | 2014-12-26 | Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune | Trampas de SUMO de alta afinidad |
KR101646728B1 (ko) * | 2014-08-27 | 2016-08-09 | 동국대학교 산학협력단 | 디제너러시 리프로그래밍을 통한 비천연 단백질 합성 방법 |
UY36370A (es) | 2014-10-24 | 2016-04-29 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Polipéptidos fgf-21 modificados y sus usos |
MA41629A (fr) | 2015-03-04 | 2018-01-09 | Center For Human Reproduction | Compositions et méthodes d'utilisation de l'hormone anti-müllérienne pour le traitement de l'infertilité |
ES2963839T3 (es) | 2017-02-08 | 2024-04-02 | Bristol Myers Squibb Co | Polipéptidos de relaxina modificados que comprenden un potenciador farmacocinético y usos de los mismos |
CN112119092A (zh) | 2018-02-12 | 2020-12-22 | 无糖尿病公司 | 改进的拮抗性抗人cd40单克隆抗体 |
US20210387020A1 (en) | 2018-10-19 | 2021-12-16 | University Of Rochester | Immune modulators in combination with radiation treatment for advanced pancreatic cancer |
WO2020102454A1 (fr) | 2018-11-13 | 2020-05-22 | Regents Of The University Of Minnesota | Peptides ciblant le cd40 et leurs utilisations |
WO2020140007A1 (fr) | 2018-12-28 | 2020-07-02 | University Of Rochester | Thérapie génique pour mutations dominantes best1 |
EP3917571A4 (fr) | 2019-01-31 | 2022-10-12 | Agency For Science, Technology And Research | Inhibiteur cnx/erp57 destiné à être utilisé dans le traitement ou la prévention du cancer |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4568640A (en) * | 1981-05-11 | 1986-02-04 | Harvey Rubin | Method of inserting amino acid analogs into proteins |
US4687737A (en) * | 1982-11-12 | 1987-08-18 | Massachusetts Institute Of Technology | Mammalian suppressor genes |
-
1989
- 1989-11-15 AU AU47412/90A patent/AU649217B2/en not_active Ceased
- 1989-11-15 JP JP2501284A patent/JPH04504651A/ja active Pending
- 1989-11-15 WO PCT/US1989/005256 patent/WO1990005785A1/fr not_active Application Discontinuation
- 1989-11-15 EP EP19900901230 patent/EP0446299A4/en not_active Withdrawn
-
1990
- 1990-07-18 KR KR1019900701546A patent/KR900702044A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR900702044A (ko) | 1990-12-05 |
JPH04504651A (ja) | 1992-08-20 |
EP0446299A1 (fr) | 1991-09-18 |
EP0446299A4 (en) | 1992-05-13 |
WO1990005785A1 (fr) | 1990-05-31 |
AU4741290A (en) | 1990-06-12 |
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