AU647627B2 - 7-Azaisoindolinyl-quinolone- and-naphthyridonecarboxylic acid derivatives - Google Patents

7-Azaisoindolinyl-quinolone- and-naphthyridonecarboxylic acid derivatives Download PDF

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Publication number
AU647627B2
AU647627B2 AU18030/92A AU1803092A AU647627B2 AU 647627 B2 AU647627 B2 AU 647627B2 AU 18030/92 A AU18030/92 A AU 18030/92A AU 1803092 A AU1803092 A AU 1803092A AU 647627 B2 AU647627 B2 AU 647627B2
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AU
Australia
Prior art keywords
methyl
dihydro
carbon atoms
acid
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU18030/92A
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English (en)
Other versions
AU1803092A (en
Inventor
Klaus-Dieter Bremm
Rainer Endermann
Klaus Grohe
Andreas Krebs
Uwe Petersen
Thomas Schenke
Karl-Joachim Zeiler
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Bayer AG
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Bayer AG
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Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU1803092A publication Critical patent/AU1803092A/en
Application granted granted Critical
Publication of AU647627B2 publication Critical patent/AU647627B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU18030/92A 1991-06-27 1992-06-04 7-Azaisoindolinyl-quinolone- and-naphthyridonecarboxylic acid derivatives Ceased AU647627B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4121214A DE4121214A1 (de) 1991-06-27 1991-06-27 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
DE4121214 1991-06-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU53040/94A Division AU5304094A (en) 1991-06-27 1994-01-06 Intermediates useful in the preparation of 7-azaisoindolinyl-quinolone- and-naphthyridonecarboxylic acid derivatives

Publications (2)

Publication Number Publication Date
AU1803092A AU1803092A (en) 1993-01-07
AU647627B2 true AU647627B2 (en) 1994-03-24

Family

ID=6434855

Family Applications (2)

Application Number Title Priority Date Filing Date
AU18030/92A Ceased AU647627B2 (en) 1991-06-27 1992-06-04 7-Azaisoindolinyl-quinolone- and-naphthyridonecarboxylic acid derivatives
AU53040/94A Abandoned AU5304094A (en) 1991-06-27 1994-01-06 Intermediates useful in the preparation of 7-azaisoindolinyl-quinolone- and-naphthyridonecarboxylic acid derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU53040/94A Abandoned AU5304094A (en) 1991-06-27 1994-01-06 Intermediates useful in the preparation of 7-azaisoindolinyl-quinolone- and-naphthyridonecarboxylic acid derivatives

Country Status (17)

Country Link
US (2) US5312823A (enExample)
EP (1) EP0520277A3 (enExample)
JP (1) JPH05213947A (enExample)
KR (1) KR930000514A (enExample)
CN (1) CN1068114A (enExample)
AU (2) AU647627B2 (enExample)
CA (1) CA2072207A1 (enExample)
CZ (1) CZ192892A3 (enExample)
DE (1) DE4121214A1 (enExample)
FI (1) FI922953A7 (enExample)
HU (1) HUT61545A (enExample)
IE (1) IE922099A1 (enExample)
IL (1) IL102288A0 (enExample)
MX (1) MX9203228A (enExample)
NO (1) NO922291L (enExample)
TW (1) TW209218B (enExample)
ZA (1) ZA924743B (enExample)

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DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
AU4272793A (en) * 1993-04-24 1994-11-21 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
DE4339134A1 (de) * 1993-11-16 1995-05-18 Bayer Ag 1-(2-Fluorcyclopropyl)-chinolon- und -naphthyridoncarbonsäure-Derivate
KR950018003A (ko) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 신규한 퀴놀론 유도체 및 그의 제조 방법
DE4427530A1 (de) * 1994-08-04 1996-02-08 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
DE4435479A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
DE19500792A1 (de) * 1995-01-13 1996-07-18 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
EP1358185A2 (en) 2001-02-07 2003-11-05 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods
EP2305696A3 (en) 2005-07-25 2011-10-12 Intermune, Inc. Macrocyclic inhibitors of Hepatitis C virus replication
FR2891274B1 (fr) * 2005-09-27 2007-11-23 Pierre Fabre Medicament Sa Procede de preparation du (3-chloro-4-fluoro-phenyl)-(4- fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}- piperidin-1-yl)-methanone et nouveaux derives pyrimidiniques intermediaires.
CN102443015A (zh) * 2010-10-13 2012-05-09 南京明生医药技术有限公司 一种7-取代喹啉羧酸衍生物及其制备方法和在抗菌抗结核上的应用
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
CN103351348A (zh) * 2013-07-15 2013-10-16 黄河三角洲京博化工研究院有限公司 一种2-甲胺基嘧啶盐酸盐的合成方法
AU2014356583B2 (en) 2013-11-26 2019-02-28 F. Hoffmann-La Roche Ag New octahydro-cyclobuta (1,2-c;3,4-c')dipyrrol-2-yl
DK3102576T3 (da) 2014-02-03 2019-07-22 Vitae Pharmaceuticals Llc Dihydropyrrolopyridininhibitorer af ror-gamma
MA50635A (fr) 2014-03-26 2020-08-12 Hoffmann La Roche Nouveaux composés bicycliques comme inhibiteurs de la production d'autotaxin (atx) et de l'acide lysophosphatidique
WO2016046837A1 (en) * 2014-09-22 2016-03-31 Cadila Healthcare Limited An improved process for preparation of pyrrolo[3,4- c] pyrrole compounds and intermediates thereof
SI3207043T1 (sl) 2014-10-14 2019-04-30 Vitae Pharmaceuticals, Inc. Dihidropirolopiridinovi inhibitorji za ROR-gama
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
EP3331876B1 (en) 2015-08-05 2020-10-07 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
EP3344619B1 (en) 2015-09-04 2020-10-28 H. Hoffnabb-La Roche Ag Phenoxymethyl derivatives
BR112018006080A2 (pt) * 2015-09-24 2018-10-09 F. Hoffmann-La Roche Ag novos compostos bicíclicos como inibidores de dupla ação de atx/ca
MA42918A (fr) 2015-09-24 2018-08-01 Hoffmann La Roche Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
WO2017050747A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag New bicyclic compounds as dual atx/ca inhibitors
EP3868750A1 (en) 2015-11-20 2021-08-25 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
RU2019132254A (ru) 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
EP3596060B1 (en) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG New bicyclic compounds as atx inhibitors
AR111295A1 (es) 2017-03-20 2019-06-26 Forma Therapeutics Inc Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr)
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
CN115716826A (zh) 2017-07-24 2023-02-28 生命医药有限责任公司 RORγ的抑制剂
WO2020061255A1 (en) 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Activating pyruvate kinase r
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
CN109942488A (zh) * 2019-04-04 2019-06-28 山东省联合农药工业有限公司 一种喹啉羧酸酯类化合物及其制备方法与用途
MX2022003025A (es) 2019-09-19 2022-04-07 Forma Therapeutics Inc Activacion de la piruvato cinasa r.
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
CN113307768B (zh) * 2021-04-29 2023-12-12 中国农业科学院兰州畜牧与兽药研究所 喹诺酮类衍生物及其制备方法和用途
CN116941624B (zh) * 2021-04-29 2026-01-30 山东省联合农药工业有限公司 一种杀菌杀虫组合物及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091384A (en) * 1989-10-23 1992-02-25 Korea Research Institute Of Chemical Technology Anti-bacterial quinolone- and naphthyridone-carboxylic acid compounds
AU2528692A (en) * 1988-07-15 1992-11-26 Bayer Schering Pharma Aktiengesellschaft Quinoline derivative and its salts derivatives
AU1966392A (en) * 1991-07-19 1993-01-21 Bayer Aktiengesellschaft 8-vinyl- and 8-ethinyl-quinolone-carboxylic acids

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JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
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EP0154780B1 (en) * 1984-01-26 1990-04-11 Abbott Laboratories Quinoline antibacterial compounds
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
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DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
WO1993013091A1 (fr) * 1991-12-27 1993-07-08 Wakunaga Seiyaku Kabushiki Kaisha Nouveau derive de quinolone ou sel de ce derive et agent antibacterien contenant ce derive
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AU2528692A (en) * 1988-07-15 1992-11-26 Bayer Schering Pharma Aktiengesellschaft Quinoline derivative and its salts derivatives
US5091384A (en) * 1989-10-23 1992-02-25 Korea Research Institute Of Chemical Technology Anti-bacterial quinolone- and naphthyridone-carboxylic acid compounds
AU1966392A (en) * 1991-07-19 1993-01-21 Bayer Aktiengesellschaft 8-vinyl- and 8-ethinyl-quinolone-carboxylic acids

Also Published As

Publication number Publication date
CA2072207A1 (en) 1992-12-28
AU5304094A (en) 1994-03-03
NO922291L (no) 1992-12-28
DE4121214A1 (de) 1993-01-14
FI922953A7 (fi) 1992-12-28
MX9203228A (es) 1992-12-01
HUT61545A (en) 1993-01-28
CZ192892A3 (en) 1993-01-13
HU9202145D0 (en) 1992-10-28
EP0520277A2 (de) 1992-12-30
KR930000514A (ko) 1993-01-15
EP0520277A3 (en) 1993-01-13
US5312823A (en) 1994-05-17
CN1068114A (zh) 1993-01-20
FI922953A0 (fi) 1992-06-25
TW209218B (enExample) 1993-07-11
AU1803092A (en) 1993-01-07
IE922099A1 (en) 1992-12-30
ZA924743B (en) 1993-03-31
US5371090A (en) 1994-12-06
IL102288A0 (en) 1993-01-14
JPH05213947A (ja) 1993-08-24
NO922291D0 (no) 1992-06-11

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