AU646762B2 - Cyclic-substituted imidazolyl-propenoic acid derivatives - Google Patents

Cyclic-substituted imidazolyl-propenoic acid derivatives

Info

Publication number
AU646762B2
AU646762B2 AU26025/92A AU2602592A AU646762B2 AU 646762 B2 AU646762 B2 AU 646762B2 AU 26025/92 A AU26025/92 A AU 26025/92A AU 2602592 A AU2602592 A AU 2602592A AU 646762 B2 AU646762 B2 AU 646762B2
Authority
AU
Australia
Prior art keywords
cyclic
acid derivatives
propenoic acid
substituted imidazolyl
imidazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU26025/92A
Other languages
English (en)
Other versions
AU2602592A (en
Inventor
Martin Dr. Beuck
Jurgen Dr. Dressel
Rudolf Dr. Hanko
Walter Dr. Hubsch
Stanislav Prof. Dr. Kazda
Andreas Dr. Knorr
Thomas Dr. Kramer
Ulrich Dr. Muller
Matthias dr. Muller-Gliemann
Johannes-Peter Dr. Stasch
Stefan Dr. Wohlfeil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU2602592A publication Critical patent/AU2602592A/en
Application granted granted Critical
Publication of AU646762B2 publication Critical patent/AU646762B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU26025/92A 1991-10-01 1992-09-29 Cyclic-substituted imidazolyl-propenoic acid derivatives Ceased AU646762B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4132633A DE4132633A1 (de) 1991-10-01 1991-10-01 Cyclisch substituierte imidazolyl-propensaeurederivate
DE4132633 1991-10-01

Publications (2)

Publication Number Publication Date
AU2602592A AU2602592A (en) 1993-04-08
AU646762B2 true AU646762B2 (en) 1994-03-03

Family

ID=6441875

Family Applications (1)

Application Number Title Priority Date Filing Date
AU26025/92A Ceased AU646762B2 (en) 1991-10-01 1992-09-29 Cyclic-substituted imidazolyl-propenoic acid derivatives

Country Status (14)

Country Link
US (1) US5225428A (cg-RX-API-DMAC7.html)
EP (1) EP0535465A1 (cg-RX-API-DMAC7.html)
JP (1) JPH05213937A (cg-RX-API-DMAC7.html)
KR (1) KR930007938A (cg-RX-API-DMAC7.html)
AU (1) AU646762B2 (cg-RX-API-DMAC7.html)
CA (1) CA2079266A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ297792A3 (cg-RX-API-DMAC7.html)
DE (1) DE4132633A1 (cg-RX-API-DMAC7.html)
HU (1) HUT62578A (cg-RX-API-DMAC7.html)
IL (1) IL103292A0 (cg-RX-API-DMAC7.html)
MX (1) MX9205434A (cg-RX-API-DMAC7.html)
NO (1) NO923581L (cg-RX-API-DMAC7.html)
TW (1) TW206966B (cg-RX-API-DMAC7.html)
ZA (1) ZA927499B (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
EP0754042A4 (en) * 1994-03-29 2004-06-23 Merck & Co Inc TREATING ATHEROSCLEROSIS WITH IMIDAZOLES BLOCKING THE ANGIOTENSIN II RECEPTOR
ES2154191B1 (es) * 1998-11-24 2001-10-16 Ferrer Int Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.
US6465502B1 (en) 1998-12-23 2002-10-15 Novartis Ag Additional therapeutic use
RU2412940C2 (ru) * 2005-02-03 2011-02-27 Рациофарм Гмбх Способ получения лосартана
EP1741711A1 (en) * 2005-07-04 2007-01-10 KRKA, D.D., Novo Mesto A process for the preparation of losartan derivatives by chlorination and reduction of the respective 1H-imidazole-5-carbaldehydes
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
CN107325052B (zh) * 2017-06-19 2020-01-10 广东药科大学 一类具有抗癌活性的咪唑酯类化合物及其衍生物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8043691A (en) * 1990-08-09 1992-02-13 Zeneca Limited Process for the manufacture of biphenylcarbonitriles
AU2602392A (en) * 1991-10-01 1993-04-08 Bayer Aktiengesellschaft Imidazolyl-propenoic acid derivatives
AU2602492A (en) * 1991-10-01 1993-04-08 Bayer Aktiengesellschaft Substituted imidazolyl-propenoic acid derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
ATE250587T1 (de) * 1989-06-14 2003-10-15 Smithkline Beecham Corp Imidazoalkensäure
CA2018443A1 (en) * 1989-06-14 1990-12-14 Joseph A. Finkelstein Imidazolyl-alkenoic acids
FI916130A7 (fi) * 1989-06-30 1991-12-27 Du Pont Aryylisubstituoituja imidatsoleja
RU2099330C1 (ru) * 1989-06-30 1997-12-20 Е.И.Дюпон Де Немур Энд Компани Замещенные имидазолы или их фармацевтически приемлемые соли и фармацевтическая композиция
AU640417B2 (en) * 1989-10-25 1993-08-26 Smithkline Beecham Corporation Substituted 5-((tetrazolyl)alkenyl)imidazoles
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8043691A (en) * 1990-08-09 1992-02-13 Zeneca Limited Process for the manufacture of biphenylcarbonitriles
AU2602392A (en) * 1991-10-01 1993-04-08 Bayer Aktiengesellschaft Imidazolyl-propenoic acid derivatives
AU2602492A (en) * 1991-10-01 1993-04-08 Bayer Aktiengesellschaft Substituted imidazolyl-propenoic acid derivatives

Also Published As

Publication number Publication date
KR930007938A (ko) 1993-05-20
NO923581L (no) 1993-04-02
MX9205434A (es) 1993-04-01
JPH05213937A (ja) 1993-08-24
NO923581D0 (no) 1992-09-15
EP0535465A1 (de) 1993-04-07
HU9203125D0 (en) 1992-12-28
TW206966B (cg-RX-API-DMAC7.html) 1993-06-01
HUT62578A (en) 1993-05-28
US5225428A (en) 1993-07-06
DE4132633A1 (de) 1993-04-08
IL103292A0 (en) 1993-02-21
CA2079266A1 (en) 1993-04-02
AU2602592A (en) 1993-04-08
CZ297792A3 (en) 1993-04-14
ZA927499B (en) 1993-05-03

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