AU644148B2 - Treatment of cataract with 15-keto-prostaglandin compounds - Google Patents

Treatment of cataract with 15-keto-prostaglandin compounds Download PDF

Info

Publication number
AU644148B2
AU644148B2 AU74047/91A AU7404791A AU644148B2 AU 644148 B2 AU644148 B2 AU 644148B2 AU 74047/91 A AU74047/91 A AU 74047/91A AU 7404791 A AU7404791 A AU 7404791A AU 644148 B2 AU644148 B2 AU 644148B2
Authority
AU
Australia
Prior art keywords
alkyl
compound
substituted
unsubstituted
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU74047/91A
Other languages
English (en)
Other versions
AU7404791A (en
Inventor
Ruyji Ueno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sucampo GmbH
Original Assignee
R Tech Ueno Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R Tech Ueno Ltd filed Critical R Tech Ueno Ltd
Publication of AU7404791A publication Critical patent/AU7404791A/en
Assigned to R-TECH UENO, LTD. reassignment R-TECH UENO, LTD. Alteration of Name(s) of Applicant(s) under S113 Assignors: KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO
Application granted granted Critical
Publication of AU644148B2 publication Critical patent/AU644148B2/en
Assigned to SUCAMPO AG reassignment SUCAMPO AG Alteration of Name(s) in Register under S187 Assignors: R-TECH UENO, LTD.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU74047/91A 1990-04-04 1991-04-03 Treatment of cataract with 15-keto-prostaglandin compounds Expired AU644148B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP9089590 1990-04-04
JP2-90895 1990-04-04
JP22164690 1990-08-22
JP2-221646 1990-08-22
JP2931091 1991-01-29
JP3-29310 1991-01-29

Publications (2)

Publication Number Publication Date
AU7404791A AU7404791A (en) 1991-10-10
AU644148B2 true AU644148B2 (en) 1993-12-02

Family

ID=27286510

Family Applications (1)

Application Number Title Priority Date Filing Date
AU74047/91A Expired AU644148B2 (en) 1990-04-04 1991-04-03 Treatment of cataract with 15-keto-prostaglandin compounds

Country Status (11)

Country Link
US (2) US5212324A (OSRAM)
EP (1) EP0453127B1 (OSRAM)
KR (1) KR970005172B1 (OSRAM)
AT (1) ATE169219T1 (OSRAM)
AU (1) AU644148B2 (OSRAM)
CA (1) CA2039420C (OSRAM)
DE (1) DE69129921T2 (OSRAM)
DK (1) DK0453127T3 (OSRAM)
ES (1) ES2119762T3 (OSRAM)
GR (1) GR3027666T3 (OSRAM)
TW (2) TW249226B (OSRAM)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW205508B (OSRAM) * 1990-08-02 1993-05-11 Kabushikaisha Ueno Seiyaku Oyo Kenkyujo
US5688819A (en) * 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5972991A (en) 1992-09-21 1999-10-26 Allergan Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5328933A (en) * 1992-10-28 1994-07-12 Allergan, Inc. Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues
SE9303627D0 (sv) * 1993-11-03 1993-11-03 Kabi Pharmacia Ab Method and means for prevention of cataract
DE69434617D1 (de) * 1993-11-19 2006-04-06 Univ Sydney Verfahren zur prophylaxe oder kontrolle des katarakts
SE9403160D0 (sv) * 1994-09-21 1994-09-21 Pharmacia Ab Method and means for prevention and treatment of secondary cataract
CN102126998B (zh) * 1996-06-10 2013-06-12 苏坎波公司 内皮素拮抗剂
DE69809268T2 (de) * 1997-09-09 2003-08-28 The Procter & Gamble Co., Cincinnati Aromatische c16-c20-substituierte tetrahydro-prostaglandine und ihre verwendung als prostaglandin f agonisten
BR9811774A (pt) * 1997-09-09 2000-08-29 Procter & Gamble Tetraidroprostaglandinas aromáticas substituìdas por c16-c20 úteis como agonistas fp
DE69839767D1 (de) * 1997-11-28 2008-09-04 Sucampo Ag Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten
ATE281432T1 (de) 1999-03-05 2004-11-15 Univ Duke C-16 ungesätigte fp-selektive prostaglandin analoge
TWI225398B (en) * 1999-07-14 2004-12-21 R Tech Ueno Ltd Composition for treatment of external secretion disorders
US6458836B1 (en) 2000-03-16 2002-10-01 Sucampo, A.G. Treatment of ocular hypertension and glaucoma
EP1272194A2 (en) * 2000-03-16 2003-01-08 Sucampo AG Composition for use in treatment of ocular hypertension and glaucoma
WO2001070233A2 (en) 2000-03-24 2001-09-27 Sucampo Ag Apoptosis inhibiting composition comprising a 15-keto-prostaglandin or derivative thereof
US20020146439A1 (en) * 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) * 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
CN1241570C (zh) 2000-04-06 2006-02-15 苏坎波公司 胆汁分泌促进组合物
TWI302100B (en) 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
JP2004521960A (ja) * 2001-08-23 2004-07-22 スキャンポ・アーゲー 高眼圧症および緑内障の処置のための方法および組成物
WO2003030912A1 (en) 2001-08-31 2003-04-17 Sucampo Ag Prostaglandin analogs as chloride channel opener
US8580851B2 (en) * 2002-08-21 2013-11-12 Sucampo Ag Ophthalmic solution
JP4705782B2 (ja) * 2002-10-23 2011-06-22 スキャンポ・アーゲー 肥満の処置のためのプロスタグランジン化合物
JP4889219B2 (ja) 2002-12-27 2012-03-07 スキャンポ・アーゲー 腹部不快感の処置のためのプロスタグランジン誘導体
EP1641462B1 (en) * 2003-07-03 2010-11-24 Sucampo AG Enteric coated composition comprising prostaglandin analogs as chloride channel opener
TWI495471B (zh) * 2003-08-12 2015-08-11 R Tech Ueno Ltd 促進毛髮生長之組成物及方法
EP1661573B1 (en) 2003-08-21 2013-09-25 Sucampo AG Ophtalmic composition comprising unoprostone ispopropyl ester and a viscosity agent
SE0303179D0 (sv) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
JP4690814B2 (ja) * 2004-08-02 2011-06-01 株式会社アールテック・ウエノ プロスタグランジン誘導体の製造法
NZ556710A (en) 2005-01-27 2010-08-27 Sucampo Ag Method and composition for treating central nervous system disorders
NZ561414A (en) 2005-03-04 2010-10-29 Sucampo Ag Method and composition for treating peripheral vascular diseases
US7851504B2 (en) 2005-03-16 2010-12-14 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
US9241918B2 (en) 2005-03-16 2016-01-26 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
US20060281818A1 (en) 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
EP1871380B1 (en) * 2005-04-12 2011-10-19 Sucampo AG Combined use of prostaglandin compound and proton pump inhibitor for the treatment of gastrointestinal disorders
EP2682130A1 (en) 2006-01-24 2014-01-08 R-Tech Ueno, Ltd. Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound
NZ570191A (en) * 2006-01-24 2010-09-30 R Tech Ueno Ltd Soft-gelatin capsule formulation comprising a keto-prostaglandin compound
CN104224704A (zh) 2006-03-13 2014-12-24 株式会社·R-技术上野 水性组合物
US8871752B2 (en) 2008-02-19 2014-10-28 Sucampo Ag Method for modulating stem cell growth
US8722739B2 (en) * 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8609729B2 (en) 2009-04-15 2013-12-17 Sucampo Ag Method for treating macular degeneration
US8569279B2 (en) * 2009-05-27 2013-10-29 Sucampo Ag Method for modulating claudin mediated functions
US9084815B2 (en) * 2009-09-16 2015-07-21 Sucampo Ag Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure
EP2694077A4 (en) 2011-04-07 2015-01-21 Sucampo Ag METHOD FOR TREATING ASTHENOPY
CN107903173A (zh) 2011-08-05 2018-04-13 苏坎波公司 治疗精神分裂症的方法
AR092821A1 (es) 2012-04-20 2015-05-06 Sucampo Ag Conjugado de derivado de acido graso-polimero
US20150057351A1 (en) 2013-08-22 2015-02-26 Sucampo Ag Method for treating neuropathic pain
WO2016203317A1 (en) 2015-06-19 2016-12-22 Sucampo Ag Pharmaceutical compositions comprising fatty acid derivative

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU604156B2 (en) * 1988-09-14 1990-12-06 R-Tech Ueno, Ltd. Prostaglandins of the F series
AU625718B2 (en) * 1988-05-11 1992-07-16 Sucampo Ag Tracheobronchodilator

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3505386A (en) * 1965-12-29 1970-04-07 Upjohn Co Compounds related to prostaglandins
US3974195A (en) * 1974-10-02 1976-08-10 The Upjohn Company 2A,2B-Dihomo-15-alkyl-PGF2.sub.α analogs
EP0153858A3 (en) * 1984-02-29 1985-12-11 The Upjohn Company The therapeutic use of prostaglandins
CA1323364C (en) * 1987-01-28 1993-10-19 Ryuzo Ueno Prostaglandins e and anti ulcer agents containing same
CA1322749C (en) * 1987-01-28 1993-10-05 Ryuzo Ueno Prostaglandins of the d series, and tranquilizers and soporifics containing the same
CA1324129C (en) * 1987-04-30 1993-11-09 Ryuzo Ueno Prostaglandins of the f series
DE3869471D1 (de) * 1987-05-15 1992-04-30 Ueno Seiyaku Oyo Kenkyujo Kk Fiebersteigende zusammensetzung.
DE3850676T2 (de) * 1987-09-18 1994-11-03 Ueno Seiyaku Oyo Kenkyujo Kk Hypotensive okulare Mittel.
DE3873007T2 (de) * 1987-10-02 1992-12-03 Ueno Seiyaku Oyo Kenkyujo Kk Kathartica.
JP2597629B2 (ja) * 1988-02-26 1997-04-09 株式会社 上野製薬応用研究所 １３，１４−ジヒドロ−１５−ケトプロスタグランジン類の安定化
AU619543B2 (en) * 1988-05-11 1992-01-30 Sucampo Ag Use of 15-ketoprostaglandin e or f compounds for uterine contraction
DE68906193T2 (de) * 1988-05-23 1993-08-05 Ueno Seiyaku Oyo Kenkyujo Kk Hypersphyxia verursachende zusammensetzung.
ATE162074T1 (de) * 1988-10-01 1998-01-15 R Tech Ueno Ltd Oculare hypotensive mittel
TW205508B (OSRAM) * 1990-08-02 1993-05-11 Kabushikaisha Ueno Seiyaku Oyo Kenkyujo

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU625718B2 (en) * 1988-05-11 1992-07-16 Sucampo Ag Tracheobronchodilator
AU604156B2 (en) * 1988-09-14 1990-12-06 R-Tech Ueno, Ltd. Prostaglandins of the F series

Also Published As

Publication number Publication date
KR970005172B1 (ko) 1997-04-14
EP0453127A3 (en) 1992-12-09
US5212324A (en) 1993-05-18
EP0453127A2 (en) 1991-10-23
GR3027666T3 (en) 1998-11-30
TW224942B (OSRAM) 1994-06-11
KR910018027A (ko) 1991-11-30
US5686487A (en) 1997-11-11
EP0453127B1 (en) 1998-08-05
CA2039420C (en) 1996-12-10
CA2039420A1 (en) 1991-10-05
ATE169219T1 (de) 1998-08-15
DE69129921T2 (de) 1999-01-14
DE69129921D1 (de) 1998-09-10
TW249226B (OSRAM) 1995-06-11
AU7404791A (en) 1991-10-10
ES2119762T3 (es) 1998-10-16
DK0453127T3 (da) 1998-10-26

Similar Documents

Publication Publication Date Title
AU644148B2 (en) Treatment of cataract with 15-keto-prostaglandin compounds
US5432174A (en) Treatment of ocular hypertension
US5426115A (en) Use of 15-keto-prostaglandin compound for improvement of encephalic function
US5252605A (en) Promotion of wound-healing with 15-keto-prostaglandin compounds
US5164415A (en) Treatment of pancreatic disease with 15-keto-prostaglandin compounds
US5346921A (en) Treatment of inflammation with 15-keto-prostaglandin compounds
EP0342003B1 (en) Use of 15-ketoprostaglandin e or f compounds for uterine contraction
KR0127297B1 (ko) 15-케토-프로스타글란딘 화합물을 이용한 간 담즙성 질병의 치료
KR960010435B1 (ko) 상승병용을 이용한 안고혈압 치료
EP0430551B1 (en) Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds
EP0469782B1 (en) Treatment of cataract with prostacyclin compounds
US5185374A (en) Use of 15-ketoprostaglandin E or F compounds for uterine contraction