AU642537B2 - 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof - Google Patents

2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof

Info

Publication number
AU642537B2
AU642537B2 AU86083/91A AU8608391A AU642537B2 AU 642537 B2 AU642537 B2 AU 642537B2 AU 86083/91 A AU86083/91 A AU 86083/91A AU 8608391 A AU8608391 A AU 8608391A AU 642537 B2 AU642537 B2 AU 642537B2
Authority
AU
Australia
Prior art keywords
alkyl
alkoxy
alkylene
phenyl
alkylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU86083/91A
Other languages
English (en)
Other versions
AU8608391A (en
Inventor
Malcolm Rice Bell
Neil Warren Boaz
John Joseph Court
Rajit Chimanlal Desai
Richard Paul Dunlap
Dennis John Hlasta
Virendra Kumar
Albert Joseph Mura
Manohar Tukram Saindane
Chakrapani Subramanyam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Publication of AU8608391A publication Critical patent/AU8608391A/en
Application granted granted Critical
Publication of AU642537B2 publication Critical patent/AU642537B2/en
Assigned to SANOFI reassignment SANOFI Alteration of Name(s) in Register under S187 Assignors: STERLING WINTHROP INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
AU86083/91A 1990-11-01 1991-10-24 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof Ceased AU642537B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60806890A 1990-11-01 1990-11-01
US608068 1990-11-01

Publications (2)

Publication Number Publication Date
AU8608391A AU8608391A (en) 1992-05-07
AU642537B2 true AU642537B2 (en) 1993-10-21

Family

ID=24434891

Family Applications (1)

Application Number Title Priority Date Filing Date
AU86083/91A Ceased AU642537B2 (en) 1990-11-01 1991-10-24 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof

Country Status (17)

Country Link
EP (1) EP0483928A1 (enExample)
JP (1) JPH04273866A (enExample)
KR (1) KR920009807A (enExample)
AU (1) AU642537B2 (enExample)
CA (1) CA2054653A1 (enExample)
FI (1) FI103112B1 (enExample)
HU (2) HUT63399A (enExample)
IE (1) IE913827A1 (enExample)
IL (1) IL99913A (enExample)
MX (1) MX9101861A (enExample)
MY (1) MY131053A (enExample)
NO (1) NO300373B1 (enExample)
NZ (1) NZ240444A (enExample)
PT (1) PT99411B (enExample)
RU (1) RU2114843C1 (enExample)
SG (1) SG69977A1 (enExample)
TW (1) TW221294B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU648938B2 (en) * 1991-12-27 1994-05-05 Sanofi Novel 2-saccharinylmethyl and 4,5,6,7-tetrahydro -2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU670635B2 (en) * 1992-12-08 1996-07-25 Sanofi Novel 2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU679446B2 (en) * 1992-10-23 1997-07-03 Sanofi Novel 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method ofuse thereof

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0183397B1 (ko) * 1989-05-04 1999-05-01 존 엠. 스피나토 단백질 분해 효소 저해제로서 유용한 사카린 유도체들 및 그의 제조방법
US5512589A (en) * 1990-11-01 1996-04-30 Sterling Winthrop Inc. 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU656027B2 (en) * 1991-11-15 1995-01-19 Sanofi Saccharin derivative proteolytic enzime inhibitors
AU668694B2 (en) * 1991-12-19 1996-05-16 Sanofi-Synthelabo Saccharin derivative proteolytic enzyme inhibitors
US5378720A (en) * 1991-12-19 1995-01-03 Sterling Winthrop Inc. Saccharin derivative proteolytic enzyme inhibitors
TW226016B (enExample) * 1991-12-30 1994-07-01 Sterling Winthrop Inc
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5684195A (en) * 1994-07-14 1997-11-04 G. D. Searle & Co. Method of preparing sulfmonamides from sulfones
DE4427996A1 (de) * 1994-08-08 1996-02-15 Basf Ag Verfahren zur Herstellung von Saccharincarbonsäuren und -carbonsäureestern
DE19533643A1 (de) * 1995-09-12 1997-03-13 Nycomed Arzneimittel Gmbh Neue cyclische Derivate von Benzolsulfonamiden
MY147790A (en) * 2005-04-28 2013-01-31 Takeda Pharmaceutical Stable emulsion composition
JP6239458B2 (ja) * 2014-07-22 2017-11-29 日本曹達株式会社 ２−（ベンジルスルフィニル）−１−シクロアルケン−１−カルボン酸エステルの製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU637614B2 (en) * 1989-05-04 1993-06-03 Sanofi Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276298A (en) * 1978-03-24 1981-06-30 Merck & Co., Inc. 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
DE3617976A1 (de) * 1986-05-28 1988-01-14 Alter Sa 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten
US4783473A (en) * 1987-09-02 1988-11-08 E. R. Squibb & Sons, Inc. Geminally substituted cyclic ether carboxylic acids, derivatives thereof, compositions containing same and method of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU637614B2 (en) * 1989-05-04 1993-06-03 Sanofi Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU648938B2 (en) * 1991-12-27 1994-05-05 Sanofi Novel 2-saccharinylmethyl and 4,5,6,7-tetrahydro -2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU679446B2 (en) * 1992-10-23 1997-07-03 Sanofi Novel 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method ofuse thereof
AU670635B2 (en) * 1992-12-08 1996-07-25 Sanofi Novel 2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof

Also Published As

Publication number Publication date
HU913430D0 (en) 1992-01-28
SG69977A1 (en) 2000-01-25
RU2114843C1 (ru) 1998-07-10
PT99411B (pt) 1999-04-30
FI103112B (fi) 1999-04-30
KR920009807A (ko) 1992-06-25
MY131053A (en) 2007-07-31
HUT63399A (en) 1993-08-30
JPH04273866A (ja) 1992-09-30
TW221294B (enExample) 1994-02-21
PT99411A (pt) 1992-10-30
IE913827A1 (en) 1992-05-22
EP0483928A1 (en) 1992-05-06
NO300373B1 (no) 1997-05-20
AU8608391A (en) 1992-05-07
IL99913A0 (en) 1992-08-18
NO914288L (no) 1992-05-04
NO914288D0 (no) 1991-11-01
MX9101861A (es) 1992-07-08
FI915163A0 (fi) 1991-11-01
HU211929A9 (en) 1996-01-29
FI915163A7 (fi) 1992-05-02
NZ240444A (en) 1994-06-27
CA2054653A1 (en) 1992-05-02
FI103112B1 (fi) 1999-04-30
IL99913A (en) 1996-11-14

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired