AU628674B2 - Polymer complexes of a sugar response type - Google Patents

Polymer complexes of a sugar response type Download PDF

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Publication number
AU628674B2
AU628674B2 AU64754/90A AU6475490A AU628674B2 AU 628674 B2 AU628674 B2 AU 628674B2 AU 64754/90 A AU64754/90 A AU 64754/90A AU 6475490 A AU6475490 A AU 6475490A AU 628674 B2 AU628674 B2 AU 628674B2
Authority
AU
Australia
Prior art keywords
polymer
complex
acid
groups
boronic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU64754/90A
Other languages
English (en)
Other versions
AU6475490A (en
Inventor
Kazunori Kataoka
Shigeru Kitano
Yoshiyuki Koyama
Tsuyoshi Miyazaki
Yoshishige Murata
Teruo Okano
Yasuhisa Sakurai
Daijiro Shiino
Kazunori Waki
Masayuki Yokoyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOF Corp
Original Assignee
Nippon Oil and Fats Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2241191A external-priority patent/JP2874309B2/ja
Priority claimed from JP02241192A external-priority patent/JP3087293B2/ja
Application filed by Nippon Oil and Fats Co Ltd filed Critical Nippon Oil and Fats Co Ltd
Publication of AU6475490A publication Critical patent/AU6475490A/en
Application granted granted Critical
Publication of AU628674B2 publication Critical patent/AU628674B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU64754/90A 1989-10-19 1990-10-18 Polymer complexes of a sugar response type Ceased AU628674B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP1-270215 1989-10-19
JP27021589 1989-10-19
JP2241191A JP2874309B2 (ja) 1990-09-13 1990-09-13 糖応答性高分子複合体
JP02241192A JP3087293B2 (ja) 1990-09-13 1990-09-13 糖応答型高分子複合体
JP2-241191 1990-09-13
JP2-241192 1990-09-13

Publications (2)

Publication Number Publication Date
AU6475490A AU6475490A (en) 1991-07-11
AU628674B2 true AU628674B2 (en) 1992-09-17

Family

ID=27332917

Family Applications (1)

Application Number Title Priority Date Filing Date
AU64754/90A Ceased AU628674B2 (en) 1989-10-19 1990-10-18 Polymer complexes of a sugar response type

Country Status (8)

Country Link
US (1) US5478575A (enrdf_load_stackoverflow)
EP (1) EP0424168B1 (enrdf_load_stackoverflow)
KR (1) KR930001305B1 (enrdf_load_stackoverflow)
AU (1) AU628674B2 (enrdf_load_stackoverflow)
CA (1) CA2027930C (enrdf_load_stackoverflow)
DE (1) DE69003068T2 (enrdf_load_stackoverflow)
DK (1) DK0424168T3 (enrdf_load_stackoverflow)
TW (1) TW218353B (enrdf_load_stackoverflow)

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WO1997037680A1 (en) * 1996-04-05 1997-10-16 The Board Of Trustees Of The University Of Illinois Macromolecular complexes for drug delivery
US5935599A (en) * 1996-10-28 1999-08-10 The Board Of Trustees Of The University Of Illinois Polymer-associated liposomes for drug delivery and method of manufacturing the same
WO2001092334A1 (en) * 2000-06-02 2001-12-06 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US7316999B2 (en) * 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US6417237B1 (en) 2000-06-08 2002-07-09 The Board Of Trustees Of The University Of Illinois Macromolecular drug complexes and compositions containing the same
KR100431536B1 (ko) * 2001-02-14 2004-05-20 박상규 ｐＨ변화를 이용한 식품 품질 식별표시계
EP1391209A4 (en) * 2001-05-30 2009-12-16 Chugai Pharmaceutical Co Ltd PROTEIN PREPARATION
US7317000B2 (en) 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
AU2002349295A1 (en) * 2001-12-02 2003-06-17 Novo Nordisk A/S Glucose dependant release of insulin from glucose sensing insulin derivatives
GB0305587D0 (en) * 2003-03-11 2003-04-16 Smart Holograms Ltd Sensor
US7943713B2 (en) * 2004-07-30 2011-05-17 Basf Aktiengesellschaft Polymeric boronic acid derivatives and their use for papermaking
CA2507121A1 (en) * 2005-05-12 2006-11-12 Le Groupe Lysac Inc. Galactomannan hydrophobic complexes as superabsorbent polymers
GB0519169D0 (en) * 2005-09-21 2005-10-26 Leuven K U Res & Dev Novel anti-viral strategy
WO2007128815A1 (en) * 2006-05-09 2007-11-15 Novo Nordisk A/S Insulin derivative
WO2008015099A2 (en) 2006-07-31 2008-02-07 Novo Nordisk A/S Pegylated, extended insulins
KR101699370B1 (ko) * 2006-09-22 2017-02-14 노보 노르디스크 에이/에스 프로테아제 내성 인슐린 유사체
WO2008132224A2 (en) * 2007-04-30 2008-11-06 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
WO2008145730A1 (en) * 2007-06-01 2008-12-04 Novo Nordisk A/S Stable non-aqueous pharmaceutical compositions
EP2254905B1 (en) * 2008-03-14 2016-12-14 Novo Nordisk A/S Protease-stabilized insulin analogues
HUE032287T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease-stabilized, acylated insulin analogues
WO2010088268A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
CA2750262C (en) 2009-01-28 2016-08-09 Smartcells, Inc. Conjugate based systems for controlled drug delivery
MX2011007930A (es) 2009-01-28 2011-09-06 Smartcells Inc Conjugados de insulina cristalina.
WO2010088286A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Synthetic conjugates and uses thereof
WO2010107520A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
US8623345B2 (en) 2009-03-20 2014-01-07 Smartcells Terminally-functionalized conjugates and uses thereof
EP2448962B1 (en) 2009-06-30 2016-10-19 Novo Nordisk A/S Insulin derivatives
US20130157926A1 (en) 2010-06-18 2013-06-20 Johannes Franciscus Joseph Engbersen Boronated polymers
US8933207B2 (en) 2010-07-28 2015-01-13 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
WO2012015691A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinant lectins, binding-site modified lectins and uses thereof
CA2806399A1 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
CA2870313A1 (en) 2012-04-11 2013-10-17 Novo Nordisk A/S Insulin formulations
US10240083B2 (en) * 2012-05-11 2019-03-26 Schlumberger Technology Corporation Thickening of fluids
JP6364067B2 (ja) 2013-04-05 2018-07-25 ノボ・ノルデイスク・エー／エス 薬剤送達装置の投与記録装置
WO2015051052A2 (en) 2013-10-04 2015-04-09 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
CN105153347B (zh) * 2015-08-11 2017-07-07 台州学院 糖响应的单分散聚合物空心微球的制备方法
RU2731490C2 (ru) * 2015-12-22 2020-09-03 Ром Энд Хаас Компани Способ суспензионной полимеризации капель, распределенных в водной среде
ES2930149T3 (es) 2016-12-16 2022-12-07 Novo Nordisk As Composiciones farmacéuticas que contienen insulina
CN111315399B (zh) * 2017-06-02 2024-05-10 北卡罗莱纳州立大学 用于药物递送的葡萄糖敏感性组合物
CN107556509B (zh) * 2017-08-28 2020-07-14 上海第二工业大学 一种二维光子晶体葡萄糖传感薄膜的制备方法
MA50552A (fr) 2017-11-09 2020-09-16 Novo Nordisk As Dérivés de liaison à l'albumine sensibles au glucose
CN108102004B (zh) * 2018-01-03 2020-02-14 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 一种葡聚糖聚合物、聚合物胶束和药物载体系统
CN110452390B (zh) * 2018-05-03 2021-04-06 清华大学深圳研究生院 一种胰岛素智能给药制剂
EP3586876A1 (en) 2018-06-21 2020-01-01 Gubra ApS Glucose-sensitive peptide hormones
JP7640462B2 (ja) * 2019-03-29 2025-03-05 ノヴォ ノルディスク アー／エス グルコース感受性インスリン誘導体
CN110483691B (zh) * 2019-09-25 2021-11-09 安徽大学 一种三元共聚物交联剂及其在扩散渗析专用阳离子膜制备中的应用
CN115975224B (zh) * 2023-03-16 2023-08-08 四川大学 一种pH/ROS双响应的组织粘附载药水凝胶及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0159521A1 (en) * 1984-03-22 1985-10-30 Sirac Srl Stable boron resins of high selective absorbent power
EP0284959A1 (en) * 1987-04-03 1988-10-05 INALCO SpA Stable boron resins of high selective absorbent power
EP0284960A1 (en) * 1987-04-03 1988-10-05 INALCO SpA Boron resins of high selective absorbent power

Family Cites Families (1)

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EP0110879A1 (en) * 1982-05-26 1984-06-20 The Children's Medical Center Corporation Reporter compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0159521A1 (en) * 1984-03-22 1985-10-30 Sirac Srl Stable boron resins of high selective absorbent power
EP0284959A1 (en) * 1987-04-03 1988-10-05 INALCO SpA Stable boron resins of high selective absorbent power
EP0284960A1 (en) * 1987-04-03 1988-10-05 INALCO SpA Boron resins of high selective absorbent power

Also Published As

Publication number Publication date
DE69003068D1 (de) 1993-10-07
KR930001305B1 (ko) 1993-02-25
CA2027930A1 (en) 1991-04-20
DK0424168T3 (da) 1993-12-13
US5478575A (en) 1995-12-26
DE69003068T2 (de) 1993-12-16
AU6475490A (en) 1991-07-11
KR910007545A (ko) 1991-05-30
EP0424168B1 (en) 1993-09-01
TW218353B (enrdf_load_stackoverflow) 1994-01-01
CA2027930C (en) 1998-06-30
EP0424168A1 (en) 1991-04-24

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Legal Events

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired