AU628674B2 - Polymer complexes of a sugar response type - Google Patents

Polymer complexes of a sugar response type Download PDF

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Publication number
AU628674B2
AU628674B2 AU64754/90A AU6475490A AU628674B2 AU 628674 B2 AU628674 B2 AU 628674B2 AU 64754/90 A AU64754/90 A AU 64754/90A AU 6475490 A AU6475490 A AU 6475490A AU 628674 B2 AU628674 B2 AU 628674B2
Authority
AU
Australia
Prior art keywords
polymer
complex
acid
groups
boronic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU64754/90A
Other languages
English (en)
Other versions
AU6475490A (en
Inventor
Kazunori Kataoka
Shigeru Kitano
Yoshiyuki Koyama
Tsuyoshi Miyazaki
Yoshishige Murata
Teruo Okano
Yasuhisa Sakurai
Daijiro Shiino
Kazunori Waki
Masayuki Yokoyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOF Corp
Original Assignee
Nippon Oil and Fats Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP02241192A external-priority patent/JP3087293B2/ja
Priority claimed from JP2241191A external-priority patent/JP2874309B2/ja
Application filed by Nippon Oil and Fats Co Ltd filed Critical Nippon Oil and Fats Co Ltd
Publication of AU6475490A publication Critical patent/AU6475490A/en
Application granted granted Critical
Publication of AU628674B2 publication Critical patent/AU628674B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU64754/90A 1989-10-19 1990-10-18 Polymer complexes of a sugar response type Ceased AU628674B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP27021589 1989-10-19
JP1-270215 1989-10-19
JP02241192A JP3087293B2 (ja) 1990-09-13 1990-09-13 糖応答型高分子複合体
JP2-241192 1990-09-13
JP2-241191 1990-09-13
JP2241191A JP2874309B2 (ja) 1990-09-13 1990-09-13 糖応答性高分子複合体

Publications (2)

Publication Number Publication Date
AU6475490A AU6475490A (en) 1991-07-11
AU628674B2 true AU628674B2 (en) 1992-09-17

Family

ID=27332917

Family Applications (1)

Application Number Title Priority Date Filing Date
AU64754/90A Ceased AU628674B2 (en) 1989-10-19 1990-10-18 Polymer complexes of a sugar response type

Country Status (8)

Country Link
US (1) US5478575A (enrdf_load_stackoverflow)
EP (1) EP0424168B1 (enrdf_load_stackoverflow)
KR (1) KR930001305B1 (enrdf_load_stackoverflow)
AU (1) AU628674B2 (enrdf_load_stackoverflow)
CA (1) CA2027930C (enrdf_load_stackoverflow)
DE (1) DE69003068T2 (enrdf_load_stackoverflow)
DK (1) DK0424168T3 (enrdf_load_stackoverflow)
TW (1) TW218353B (enrdf_load_stackoverflow)

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CA2251008C (en) * 1996-04-05 2007-11-13 The Board Of Trustees Of The University Of Illinois Macromolecular complexes for drug delivery
US5935599A (en) * 1996-10-28 1999-08-10 The Board Of Trustees Of The University Of Illinois Polymer-associated liposomes for drug delivery and method of manufacturing the same
US7316999B2 (en) * 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
JP2003535106A (ja) * 2000-06-02 2003-11-25 ノボ ノルディスク アクティーゼルスカブ グルコース検知性インスリン誘導体からの、インスリンのグルコース依存性放出
US6417237B1 (en) 2000-06-08 2002-07-09 The Board Of Trustees Of The University Of Illinois Macromolecular drug complexes and compositions containing the same
KR100431536B1 (ko) * 2001-02-14 2004-05-20 박상규 ｐＨ변화를 이용한 식품 품질 식별표시계
WO2002098445A1 (en) * 2001-05-30 2002-12-12 Chugai Seiyaku Kabushiki Kaisha Protein preparation
EP1453860A2 (en) * 2001-12-02 2004-09-08 Novo Nordisk A/S Novel glucose-dependant insulins
US7317000B2 (en) 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
GB0305587D0 (en) * 2003-03-11 2003-04-16 Smart Holograms Ltd Sensor
WO2006010268A1 (en) * 2004-07-30 2006-02-02 Basf Ag Polymeric boronic acid derivatives and their use for papermaking
CA2507121A1 (en) * 2005-05-12 2006-11-12 Le Groupe Lysac Inc. Galactomannan hydrophobic complexes as superabsorbent polymers
GB0519169D0 (en) * 2005-09-21 2005-10-26 Leuven K U Res & Dev Novel anti-viral strategy
JP5269766B2 (ja) * 2006-05-09 2013-08-21 ノボ・ノルデイスク・エー／エス インスリン誘導体
EP2049149B1 (en) 2006-07-31 2015-04-15 Novo Nordisk A/S Pegylated extended insulins
EP2404934A1 (en) * 2006-09-22 2012-01-11 Novo Nordisk A/S Protease resistant insulin analogues
JP5496082B2 (ja) * 2007-04-30 2014-05-21 ノボ・ノルデイスク・エー／エス タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
WO2008145732A1 (en) * 2007-06-01 2008-12-04 Novo Nordisk A/S Stable non-aqueous pharmaceutical compositions
JP5762001B2 (ja) * 2008-03-14 2015-08-12 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化インスリンアナログ
CA2718738C (en) 2008-03-18 2019-05-07 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
US9050370B2 (en) 2009-01-28 2015-06-09 Smartcells, Inc. Conjugate based systems for controlled drug delivery
EP2391216A4 (en) 2009-01-28 2013-06-19 Smartcells Inc EXTINGUISHING EXTRACTED SUBSTANCES AND THEIR USE
US8940690B2 (en) 2009-01-28 2015-01-27 National Institutes Of Health (Nih) Synthetic conjugates and uses thereof
KR20140054404A (ko) 2009-01-28 2014-05-08 스마트쎌스, 인크. 결정질 인슐린-접합체
WO2010107520A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
AU2010226243A1 (en) 2009-03-20 2011-09-22 Smartcells, Inc. Terminally-functionalized conjugates and uses thereof
EP2448962B1 (en) 2009-06-30 2016-10-19 Novo Nordisk A/S Insulin derivatives
WO2011159161A2 (en) 2010-06-18 2011-12-22 Universiteit Twente Boronated polymers
US8933207B2 (en) 2010-07-28 2015-01-13 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
JP2013541500A (ja) 2010-07-28 2013-11-14 スマートセルズ・インコーポレイテツド 組換えレクチン、結合部位修飾レクチンおよびそれらの用途
EP2598527A4 (en) 2010-07-28 2014-01-08 Smartcells Inc RECOMBINANT EXPRESSED INSULIN POLYPEPTIDES AND APPLICATIONS THEREOF
JP6199956B2 (ja) 2012-04-11 2017-09-20 ノヴォ ノルディスク アー／エス インスリン製剤
US10240083B2 (en) * 2012-05-11 2019-03-26 Schlumberger Technology Corporation Thickening of fluids
US10376644B2 (en) 2013-04-05 2019-08-13 Novo Nordisk A/S Dose logging device for a drug delivery device
RU2676307C2 (ru) 2013-10-04 2018-12-27 Мерк Шарп И Доум Корп. Чувствительные к глюкозе конъюгаты инсулина
ES2676065T3 (es) 2013-10-07 2018-07-16 Novo Nordisk A/S Nuevo derivado de un análogo de la insulina
CN105153347B (zh) * 2015-08-11 2017-07-07 台州学院 糖响应的单分散聚合物空心微球的制备方法
CN108367254B (zh) * 2015-12-22 2021-08-24 罗门哈斯公司 悬浮聚合分布在水性介质中的液滴的方法
TWI700092B (zh) 2016-12-16 2020-08-01 丹麥商諾佛．儂迪克股份有限公司 含胰島素醫藥組成物
EP3634470A4 (en) 2017-06-02 2021-03-10 North Carolina State University GLUCOSE SENSITIVE COMPOSITIONS FOR DRUG ADMINISTRATION
CN107556509B (zh) * 2017-08-28 2020-07-14 上海第二工业大学 一种二维光子晶体葡萄糖传感薄膜的制备方法
CN117624207A (zh) 2017-11-09 2024-03-01 诺和诺德股份有限公司 葡萄糖敏感性白蛋白结合衍生物
CN108102004B (zh) * 2018-01-03 2020-02-14 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 一种葡聚糖聚合物、聚合物胶束和药物载体系统
CN110452390B (zh) * 2018-05-03 2021-04-06 清华大学深圳研究生院 一种胰岛素智能给药制剂
EP3586876A1 (en) 2018-06-21 2020-01-01 Gubra ApS Glucose-sensitive peptide hormones
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CN110483691B (zh) * 2019-09-25 2021-11-09 安徽大学 一种三元共聚物交联剂及其在扩散渗析专用阳离子膜制备中的应用
CN115975224B (zh) * 2023-03-16 2023-08-08 四川大学 一种pH/ROS双响应的组织粘附载药水凝胶及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0159521A1 (en) * 1984-03-22 1985-10-30 Sirac Srl Stable boron resins of high selective absorbent power
EP0284959A1 (en) * 1987-04-03 1988-10-05 INALCO SpA Stable boron resins of high selective absorbent power
EP0284960A1 (en) * 1987-04-03 1988-10-05 INALCO SpA Boron resins of high selective absorbent power

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EP0110879A1 (en) * 1982-05-26 1984-06-20 The Children's Medical Center Corporation Reporter compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0159521A1 (en) * 1984-03-22 1985-10-30 Sirac Srl Stable boron resins of high selective absorbent power
EP0284959A1 (en) * 1987-04-03 1988-10-05 INALCO SpA Stable boron resins of high selective absorbent power
EP0284960A1 (en) * 1987-04-03 1988-10-05 INALCO SpA Boron resins of high selective absorbent power

Also Published As

Publication number Publication date
US5478575A (en) 1995-12-26
CA2027930C (en) 1998-06-30
EP0424168A1 (en) 1991-04-24
DE69003068T2 (de) 1993-12-16
TW218353B (enrdf_load_stackoverflow) 1994-01-01
DE69003068D1 (de) 1993-10-07
DK0424168T3 (da) 1993-12-13
KR930001305B1 (ko) 1993-02-25
EP0424168B1 (en) 1993-09-01
CA2027930A1 (en) 1991-04-20
KR910007545A (ko) 1991-05-30
AU6475490A (en) 1991-07-11

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired