AU615003B2 - Enhancing drug delivery to the brain - Google Patents

Enhancing drug delivery to the brain Download PDF

Info

Publication number
AU615003B2
AU615003B2 AU24271/88A AU2427188A AU615003B2 AU 615003 B2 AU615003 B2 AU 615003B2 AU 24271/88 A AU24271/88 A AU 24271/88A AU 2427188 A AU2427188 A AU 2427188A AU 615003 B2 AU615003 B2 AU 615003B2
Authority
AU
Australia
Prior art keywords
brain
alkyl
effective amount
compound according
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU24271/88A
Other languages
English (en)
Other versions
AU2427188A (en
Inventor
Nigel H. Grieg
Stanley I. Rapoport
Daniel J. Sweeney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of Commerce
Original Assignee
US Department of Health and Human Services
Government of the United States of America
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services, Government of the United States of America filed Critical US Department of Health and Human Services
Publication of AU2427188A publication Critical patent/AU2427188A/en
Application granted granted Critical
Publication of AU615003B2 publication Critical patent/AU615003B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU24271/88A 1987-08-21 1988-08-19 Enhancing drug delivery to the brain Ceased AU615003B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/088,982 US4835182A (en) 1987-08-21 1987-08-21 Enhancing drug delivery to the brain
US088982 1987-08-21

Publications (2)

Publication Number Publication Date
AU2427188A AU2427188A (en) 1989-03-09
AU615003B2 true AU615003B2 (en) 1991-09-19

Family

ID=22214651

Family Applications (1)

Application Number Title Priority Date Filing Date
AU24271/88A Ceased AU615003B2 (en) 1987-08-21 1988-08-19 Enhancing drug delivery to the brain

Country Status (13)

Country Link
US (1) US4835182A (enExample)
EP (1) EP0304341B1 (enExample)
JP (1) JPH0655700B2 (enExample)
AT (1) ATE77078T1 (enExample)
AU (1) AU615003B2 (enExample)
CA (1) CA1327051C (enExample)
DE (1) DE3871879T2 (enExample)
DK (1) DK42590D0 (enExample)
ES (1) ES2042755T3 (enExample)
GR (1) GR3005338T3 (enExample)
IE (1) IE60689B1 (enExample)
PT (1) PT88309B (enExample)
WO (1) WO1989001331A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227511A (en) * 1988-12-23 1993-07-13 Hodogaya Chemical Co., Ltd. Benzamide derivatives and plant growth regulants containing them
AU639758B2 (en) * 1990-02-09 1993-08-05 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Branched alkyl esters of 4-bis (chloroethyl) aminophenyl-alkyl carboxylic acids for treatment of primary and metastatic tumors of the lymphatic system, and of cancers of the breast and ovaries

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA573957A (en) * 1959-04-14 C. J. Ross Walter P-nn-di-(2-chloroethyl)-aminophenylbutyrates
GB727336A (en) * 1952-11-20 1955-03-30 Nat Res Dev Improvements in or relating to chemotherapeutic agents
GB750155A (en) * 1953-03-17 1956-06-13 Nat Res Dev Substituted alanines
DE1126399B (de) * 1959-10-22 1962-03-29 Nat Res Dev Verfahren zur Herstellung cytostatisch wirkender Derivate des p-[Bis-(2-chloraethyl)-amino]-phenylalanins
US4261910A (en) * 1978-08-14 1981-04-14 Kureha Kagaku Kogyo Kabushiki Kaisha Process for the preparation of Chlorambucil derivatives

Also Published As

Publication number Publication date
US4835182A (en) 1989-05-30
CA1327051C (en) 1994-02-15
ATE77078T1 (de) 1992-06-15
EP0304341A2 (en) 1989-02-22
IE60689B1 (en) 1994-08-10
DE3871879T2 (de) 1993-01-14
US4835182B1 (enExample) 1991-11-05
JPH03500646A (ja) 1991-02-14
WO1989001331A1 (en) 1989-02-23
EP0304341B1 (en) 1992-06-10
JPH0655700B2 (ja) 1994-07-27
GR3005338T3 (enExample) 1993-05-24
DK42590A (da) 1990-02-16
DE3871879D1 (de) 1992-07-16
AU2427188A (en) 1989-03-09
ES2042755T3 (es) 1993-12-16
PT88309A (pt) 1989-06-30
EP0304341A3 (en) 1989-11-23
DK42590D0 (da) 1990-02-16
IE882535L (en) 1989-02-21
PT88309B (pt) 1994-07-29

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired