AU611141B2 - Tertiary arylethyl amine derivatives having opiate-antagonistic activity - Google Patents

Tertiary arylethyl amine derivatives having opiate-antagonistic activity Download PDF

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Publication number
AU611141B2
AU611141B2 AU14344/88A AU1434488A AU611141B2 AU 611141 B2 AU611141 B2 AU 611141B2 AU 14344/88 A AU14344/88 A AU 14344/88A AU 1434488 A AU1434488 A AU 1434488A AU 611141 B2 AU611141 B2 AU 611141B2
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AU
Australia
Prior art keywords
group
atoms
alkyl
hydrogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU14344/88A
Other languages
English (en)
Other versions
AU1434488A (en
Inventor
Jacobus A.J. Den Hartog
Marinus W. Lobbezoo
Martinus T.M. Tulp
Ineke Van Wijngaarden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Publication of AU1434488A publication Critical patent/AU1434488A/en
Application granted granted Critical
Publication of AU611141B2 publication Critical patent/AU611141B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU14344/88A 1987-04-10 1988-04-07 Tertiary arylethyl amine derivatives having opiate-antagonistic activity Ceased AU611141B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8700842A NL8700842A (OSRAM) 1987-04-10 1987-04-10
NL8700842 1987-04-10

Publications (2)

Publication Number Publication Date
AU1434488A AU1434488A (en) 1988-10-13
AU611141B2 true AU611141B2 (en) 1991-06-06

Family

ID=19849836

Family Applications (1)

Application Number Title Priority Date Filing Date
AU14344/88A Ceased AU611141B2 (en) 1987-04-10 1988-04-07 Tertiary arylethyl amine derivatives having opiate-antagonistic activity

Country Status (8)

Country Link
EP (1) EP0289070A1 (OSRAM)
JP (1) JPS63290848A (OSRAM)
AU (1) AU611141B2 (OSRAM)
DK (1) DK187288A (OSRAM)
IL (1) IL85996A (OSRAM)
NL (1) NL8700842A (OSRAM)
NZ (1) NZ224170A (OSRAM)
ZA (1) ZA882385B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU641394B2 (en) * 1989-06-02 1993-09-23 John Wyeth & Brother Limited Amines

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2249548B (en) * 1988-06-03 1992-10-14 Wyeth John & Brother Ltd Aralkyl amine intermediates
GB8813185D0 (en) * 1988-06-03 1988-07-06 Wyeth John & Brother Ltd New method & amines used therein
FR2681322B1 (fr) * 1991-09-12 1993-12-17 Laboratorios Dr Esteve Sa Derives d'aryl-heteroaryl-{n-[2-(3,4-dimethoxyphenyl)-ethyl]-n-methyl-3-aminopropoxy}-methane leur preparation et leur application en tant que medicaments .
GB9324244D0 (en) * 1993-11-25 1994-01-12 Merck Sharp & Dohme Therapeutic agents
IT1269826B (it) * 1994-05-24 1997-04-15 Paolo Minoia Uso di antagonisti degli oppiacei e di sali di calcio per la preparazione di medicamenti per il trattamento di forme patologiche endorfino-mediate
US7101980B2 (en) 2002-03-01 2006-09-05 Roche Diagnostics Operations, Inc. Derivatives, conjugates, and antibodies for detecting ecstasy-class analytes
US20030170917A1 (en) * 2002-03-01 2003-09-11 Roche Diagnostics Corporation Compounds, antibodies, reagent kits, methods of producing antibodies, and methods of detecting analytes
HRP20150037T4 (hr) 2003-04-08 2022-09-02 Progenics Pharmaceuticals, Inc. Farmaceutske formulacije koje sadrže metilnaltrekson
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
CN101171010B (zh) 2005-03-07 2014-09-17 芝加哥大学 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
CA2682129A1 (en) 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Crystal forms and uses thereof
PT2139890E (pt) 2007-03-29 2014-09-03 Wyeth Llc Antagonistas do receptor opióide periférico e respectivas utilizações
US8546418B2 (en) 2007-03-29 2013-10-01 Progenics Pharmaceuticals, Inc. Peripheral opioid receptor antagonists and uses thereof
EP2240489A1 (en) 2008-02-06 2010-10-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
EP2278966B1 (en) 2008-03-21 2019-10-09 The University of Chicago Treatment with opioid antagonists and mtor inhibitors
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034103A (en) * 1974-04-08 1977-07-05 U.S. Philips Corporation Aralkylamino sulfones having spasmolytic activities
GB1500434A (en) * 1974-04-08 1978-02-08 Philips Nv Tertiary amines
AU578557B2 (en) * 1986-05-01 1988-10-27 Pfizer Limited Sulfonamide antiarrhythmic agents and intermediates therefor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB586645A (en) * 1944-07-19 1947-03-26 Burroughs Wellcome Co Improvements relating to the synthesis of amino acid derivatives and salts thereof
GB587244A (en) * 1944-07-21 1947-04-18 Burroughs Wellcome Co Improvements relating to the synthesis of amino acid derivatives and salts thereof
DE1493602B2 (de) * 1965-04-13 1976-08-26 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Verfahren zur herstellung von aminoketonen
SE365200B (OSRAM) * 1968-05-02 1974-03-18 Degussa
US4097500A (en) * 1977-07-25 1978-06-27 Morton-Norwich Products, Inc. N-Methyl-5-(4-nitrophenyl)-N-(a-methylphenethyl)furfurylamine hydrochloride
US4337207A (en) * 1980-09-04 1982-06-29 Regents Of The University Of California Biologically active catecholamine derivatives
NL8202810A (nl) * 1982-07-12 1984-02-01 Duphar Int Res Spasmolytisch werkzaam (+)-secoverine.
NL8300392A (nl) * 1983-02-03 1984-09-03 Duphar Int Res Nieuwe spasmolytisch werkzame propylcyclohexylketonderivaten.
EP0211254A3 (de) * 1985-07-31 1988-05-04 ASTA Pharma Aktiengesellschaft Neue cycloaliphatische Ketoamine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034103A (en) * 1974-04-08 1977-07-05 U.S. Philips Corporation Aralkylamino sulfones having spasmolytic activities
GB1500434A (en) * 1974-04-08 1978-02-08 Philips Nv Tertiary amines
AU578557B2 (en) * 1986-05-01 1988-10-27 Pfizer Limited Sulfonamide antiarrhythmic agents and intermediates therefor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU641394B2 (en) * 1989-06-02 1993-09-23 John Wyeth & Brother Limited Amines

Also Published As

Publication number Publication date
ZA882385B (en) 1988-09-23
NL8700842A (OSRAM) 1988-11-01
IL85996A0 (en) 1988-09-30
DK187288D0 (da) 1988-04-06
AU1434488A (en) 1988-10-13
NZ224170A (en) 1991-06-25
IL85996A (en) 1991-12-12
DK187288A (da) 1988-10-11
EP0289070A1 (en) 1988-11-02
JPS63290848A (ja) 1988-11-28

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