AU580348B2 - A process for the cleavage of peptides and proteins at the methionyl bond - Google Patents

A process for the cleavage of peptides and proteins at the methionyl bond

Info

Publication number
AU580348B2
AU580348B2 AU49713/85A AU4971385A AU580348B2 AU 580348 B2 AU580348 B2 AU 580348B2 AU 49713/85 A AU49713/85 A AU 49713/85A AU 4971385 A AU4971385 A AU 4971385A AU 580348 B2 AU580348 B2 AU 580348B2
Authority
AU
Australia
Prior art keywords
cleavage
peptides
proteins
methionyl
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU49713/85A
Other languages
English (en)
Other versions
AU4971385A (en
Inventor
Richard Bicker
Gerhard Seipke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU4971385A publication Critical patent/AU4971385A/en
Application granted granted Critical
Publication of AU580348B2 publication Critical patent/AU580348B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/126—Aminolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU49713/85A 1984-11-09 1985-11-08 A process for the cleavage of peptides and proteins at the methionyl bond Ceased AU580348B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3440988 1984-11-09
DE19843440988 DE3440988A1 (de) 1984-11-09 1984-11-09 Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung

Publications (2)

Publication Number Publication Date
AU4971385A AU4971385A (en) 1986-05-15
AU580348B2 true AU580348B2 (en) 1989-01-12

Family

ID=6249917

Family Applications (1)

Application Number Title Priority Date Filing Date
AU49713/85A Ceased AU580348B2 (en) 1984-11-09 1985-11-08 A process for the cleavage of peptides and proteins at the methionyl bond

Country Status (15)

Country Link
US (1) US4644057A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0180920B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH0714960B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR930007428B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE71109T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU580348B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1247081A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3440988A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK166546C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8701780A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI85494C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR852693B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE58683B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT81445B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA858603B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745178A (en) * 1987-04-22 1988-05-17 Eli Lilly And Company Process for selective peptide bond cleavage using sulfoxides and CF3 CO
DE3726655A1 (de) * 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
US4945157A (en) * 1988-05-27 1990-07-31 University Of Florida Novel Extraction procedure for protein G
SK279686B6 (sk) * 1990-09-05 1999-02-11 Hoechst Aktiengesellschaft Spôsob hydrolýzy reťazca aminokyselín preproinzulí
EP0821006B1 (de) 1996-07-26 2004-04-21 Aventis Pharma Deutschland GmbH Insulinderivate mit erhöhter Zinkbindung
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
US7193035B2 (en) * 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
CN102159588B (zh) 2008-08-07 2015-09-02 拜康有限公司 一种用于制备胰岛素化合物的方法
NZ592283A (en) 2008-10-17 2012-09-28 Sanofi Aventis Deutschland Combination of an insulin and the GLP-1 agonist AVE0010
CN107308442B (zh) 2009-11-13 2022-10-18 赛诺菲-安万特德国有限公司 包含glp-1激动剂、胰岛素和甲硫氨酸的药物组合物
DK2498801T3 (en) 2009-11-13 2018-05-07 Sanofi Aventis Deutschland PHARMACEUTICAL COMPOSITION INCLUDING desPro36Exendin-4 (1-39) -Lys6-NH2 AND METHIONIN
BR112013004756B1 (pt) 2010-08-30 2020-04-28 Sanofi Aventis Deutschland uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
JP6367115B2 (ja) 2011-08-29 2018-08-01 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ２型糖尿病患者の血糖コントロールに使用する組合せ医薬
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
US9950039B2 (en) 2014-12-12 2018-04-24 Sanofi-Aventis Deutschland Gmbh Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0128885A1 (en) * 1983-05-17 1984-12-19 Pharmacia Ab A method for splitting di-sulphide bonds
EP0136728A2 (en) * 1983-06-29 1985-04-10 Shell Internationale Researchmaatschappij B.V. Process for the dissolution of peptides and proteins, solutions thereby obtained and their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE337223B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1967-05-23 1971-08-02 Pharmacia Ab
US3935072A (en) * 1972-08-10 1976-01-27 Tanabe Seiyaku Co., Ltd. Purification of coenzyme A
US3876501A (en) * 1973-05-17 1975-04-08 Baxter Laboratories Inc Binding enzymes to activated water-soluble carbohydrates
US3919049A (en) * 1974-06-27 1975-11-11 Tokyo Tanabe Co Process for preparing {62 -galactosidase
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0128885A1 (en) * 1983-05-17 1984-12-19 Pharmacia Ab A method for splitting di-sulphide bonds
EP0136728A2 (en) * 1983-06-29 1985-04-10 Shell Internationale Researchmaatschappij B.V. Process for the dissolution of peptides and proteins, solutions thereby obtained and their use

Also Published As

Publication number Publication date
FI85494B (fi) 1992-01-15
JPH0714960B2 (ja) 1995-02-22
KR860003832A (ko) 1986-06-13
DE3585078D1 (de) 1992-02-13
US4644057A (en) 1987-02-17
FI854383L (fi) 1986-05-10
FI85494C (fi) 1992-04-27
ES8701780A1 (es) 1986-12-01
JPS61115096A (ja) 1986-06-02
DK516485D0 (da) 1985-11-08
CA1247081A (en) 1988-12-20
PT81445B (pt) 1987-12-30
IE58683B1 (en) 1993-11-03
PT81445A (de) 1985-12-01
IE852795L (en) 1986-05-09
FI854383A0 (fi) 1985-11-07
DK166546B (da) 1993-06-07
EP0180920B1 (de) 1992-01-02
ZA858603B (en) 1986-07-30
EP0180920A3 (en) 1989-01-04
ATE71109T1 (de) 1992-01-15
EP0180920A2 (de) 1986-05-14
AU4971385A (en) 1986-05-15
DK166546C (da) 1993-10-25
GR852693B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1986-03-10
KR930007428B1 (ko) 1993-08-10
ES548617A0 (es) 1986-12-01
DE3440988A1 (de) 1986-07-10
DK516485A (da) 1986-05-10

Similar Documents

Publication Publication Date Title
AU580348B2 (en) A process for the cleavage of peptides and proteins at the methionyl bond
AU7486887A (en) Novel procoagulant proteins
PL268173A1 (en) The method of peptide derivative manufacture
FI864427A7 (fi) Menetelmä polypeptidin valmistamiseksi, joka on komplementaarinen ainakin osalle alkuperäistä peptidiä tai proteiinia, ja komplementaarisen polypeptidin käyttö
AU3330384A (en) Human Y interferon fragment and production from recombinant microbes
NZ212155A (en) Purification of protein/peptide material by electroseparation
NO174816C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL78885A0 (en) Removal of the n-terminal methionine from methionyl proteins
NZ213615A (en) Separation of protein from its n-terminal methionine analogue
AU575562B2 (en) Cyanogen bromide cleavage of peptides
HU896448D0 (en) Process for the preparation of anticoagulant peptides
AU1704988A (en) Peptide production by protein engineering
IL86093A0 (en) Process for selective peptide bond cleavage
DE3568298D1 (en) Process for hydrolysis of peptide or protein
PT79853A (en) Process for the preparation of an highly solubilized protein
AU7440391A (en) Method for enhancing recovery of recombinant proteins
EP0325691A3 (en) Process for the solubilization of insoluble protein
ES2002161A6 (es) Procedimiento para preparar 1,3-diazabiciclo (4.4.0)dec-2-en-4-onas antiarritmicas
PT86162A (en) Recombinant protein expression
HUT37109A (en) Process for the phosphinoylation of amino gropus of amino-acids, peptides and esters thereof
WO1992004448A3 (de) Humanes mitochondriales nad(p)+-abhängiges malatenzym
BG51941B2 (en) Method for the preparation of hydrolysate protein concentrate
NZ221725A (en) Peptide fragments of hp-grf

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired