ES8701780A1 - Procedimiento para disociar peptidos y proteinas en el enla-ce metionilo - Google Patents

Procedimiento para disociar peptidos y proteinas en el enla-ce metionilo

Info

Publication number
ES8701780A1
ES8701780A1 ES548617A ES548617A ES8701780A1 ES 8701780 A1 ES8701780 A1 ES 8701780A1 ES 548617 A ES548617 A ES 548617A ES 548617 A ES548617 A ES 548617A ES 8701780 A1 ES8701780 A1 ES 8701780A1
Authority
ES
Spain
Prior art keywords
peptides
proteins
methionyl
cleaving
link
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548617A
Other languages
English (en)
Other versions
ES548617A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8701780A1 publication Critical patent/ES8701780A1/es
Publication of ES548617A0 publication Critical patent/ES548617A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C07K1/126—Aminolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier

Abstract

PROCEDIMIENTO PARA LA DISOCIACION DE PEPTIDOS Y PROTEINAS EN EL ENLACE METIONILO CON AYUDA DE CLORURO DE CIANOGENO. CONSISTE EN EL USO DE CLCN PARA LA DISOCIACION NO ENZIMATICA DE PROTEINAS. EL CLCN ES UN GAS CON VENTAJAS DE SEGURIDAD PARA SU UTILIZACION TECNICA, EN SU UTILIZACION Y DOSIFICACION. TERMINADA LA REACCION, EL EXCESO PUEDE SER ELIMINADO DE LA MEZCLA INSUFLANCO UN GAS APROPIADO Y ANTIESPUMANTES. SU EVACUACION A VERTEDEROS ES ASIMISMO MAS SEGURA. EL CLCN SE UTILIZA EN UN EXCESO DE 2 A 30 VECES LA CANTIDAD EQUIMOLECULAR POR ENLACE METIONILO A DISOCIAR. LA MEZCLA DE REACCION ES DE AGUA Y UN ACIDO MINERAL U ORGANICO.
ES548617A 1984-11-09 1985-11-07 Procedimiento para disociar peptidos y proteinas en el enla-ce metionilo Expired ES8701780A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843440988 DE3440988A1 (de) 1984-11-09 1984-11-09 Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung

Publications (2)

Publication Number Publication Date
ES8701780A1 true ES8701780A1 (es) 1986-12-01
ES548617A0 ES548617A0 (es) 1986-12-01

Family

ID=6249917

Family Applications (1)

Application Number Title Priority Date Filing Date
ES548617A Expired ES8701780A1 (es) 1984-11-09 1985-11-07 Procedimiento para disociar peptidos y proteinas en el enla-ce metionilo

Country Status (15)

Country Link
US (1) US4644057A (es)
EP (1) EP0180920B1 (es)
JP (1) JPH0714960B2 (es)
KR (1) KR930007428B1 (es)
AT (1) ATE71109T1 (es)
AU (1) AU580348B2 (es)
CA (1) CA1247081A (es)
DE (2) DE3440988A1 (es)
DK (1) DK166546C (es)
ES (1) ES8701780A1 (es)
FI (1) FI85494C (es)
GR (1) GR852693B (es)
IE (1) IE58683B1 (es)
PT (1) PT81445B (es)
ZA (1) ZA858603B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745178A (en) * 1987-04-22 1988-05-17 Eli Lilly And Company Process for selective peptide bond cleavage using sulfoxides and CF3 CO
DE3726655A1 (de) * 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
US4945157A (en) * 1988-05-27 1990-07-31 University Of Florida Novel Extraction procedure for protein G
NZ239652A (en) 1990-09-05 1992-09-25 Hoechst Ag Hydrolysis of preproinsulin to insulin and analogues using clostripain and optionally carboxypeptidase
PT821006E (pt) 1996-07-26 2004-09-30 Aventis Pharma Gmbh Derivados de insulina com ligacao a zinco aumentada
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
US7193035B2 (en) * 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
US9090705B2 (en) 2008-08-07 2015-07-28 Biocon Limited Process for preparation of insulin compounds
PT3228320T (pt) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
TR201809460T4 (tr) 2009-11-13 2018-07-23 Sanofi Aventis Deutschland Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
JP5973918B2 (ja) 2009-11-13 2016-08-23 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｇｌｐ−１アゴニスト及びメチオニンを含む薬学的組成物
JP6199186B2 (ja) 2010-08-30 2017-09-20 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ２型糖尿病の治療用の医薬の製造のためのａｖｅ００１０の使用
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es) 2011-08-29 2014-04-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CA2970200A1 (en) 2014-12-12 2016-06-16 Sanofi-Aventis Deutschland Gmbh Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE337223B (es) * 1967-05-23 1971-08-02 Pharmacia Ab
US3935072A (en) * 1972-08-10 1976-01-27 Tanabe Seiyaku Co., Ltd. Purification of coenzyme A
US3876501A (en) * 1973-05-17 1975-04-08 Baxter Laboratories Inc Binding enzymes to activated water-soluble carbohydrates
US3919049A (en) * 1974-06-27 1975-11-11 Tokyo Tanabe Co Process for preparing {62 -galactosidase
SE8302758L (sv) * 1983-05-17 1984-11-18 Pharmacia Ab Sett for uppspjelkning av disulfidbindningar och derigenom erhallen forening
GB8317697D0 (en) * 1983-06-29 1983-08-03 Shell Int Research Dissolution of peptides in non-aqueous and mixed non-aqueous/aqueous solvents
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer

Also Published As

Publication number Publication date
JPH0714960B2 (ja) 1995-02-22
AU4971385A (en) 1986-05-15
FI854383A (fi) 1986-05-10
DK516485D0 (da) 1985-11-08
EP0180920A3 (en) 1989-01-04
IE852795L (en) 1986-05-09
IE58683B1 (en) 1993-11-03
EP0180920B1 (de) 1992-01-02
PT81445A (de) 1985-12-01
US4644057A (en) 1987-02-17
ATE71109T1 (de) 1992-01-15
KR860003832A (ko) 1986-06-13
GR852693B (es) 1986-03-10
DK166546B (da) 1993-06-07
DK166546C (da) 1993-10-25
PT81445B (pt) 1987-12-30
FI854383A0 (fi) 1985-11-07
KR930007428B1 (ko) 1993-08-10
JPS61115096A (ja) 1986-06-02
FI85494B (fi) 1992-01-15
EP0180920A2 (de) 1986-05-14
DK516485A (da) 1986-05-10
DE3585078D1 (de) 1992-02-13
ES548617A0 (es) 1986-12-01
DE3440988A1 (de) 1986-07-10
FI85494C (fi) 1992-04-27
CA1247081A (en) 1988-12-20
AU580348B2 (en) 1989-01-12
ZA858603B (en) 1986-07-30

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