AU576253B2 - Tricyclic dihydropyridazinones - Google Patents

Tricyclic dihydropyridazinones

Info

Publication number
AU576253B2
AU576253B2 AU44814/85A AU4481485A AU576253B2 AU 576253 B2 AU576253 B2 AU 576253B2 AU 44814/85 A AU44814/85 A AU 44814/85A AU 4481485 A AU4481485 A AU 4481485A AU 576253 B2 AU576253 B2 AU 576253B2
Authority
AU
Australia
Prior art keywords
compound
formula
pyridazin
compounds
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU44814/85A
Other languages
English (en)
Other versions
AU4481485A (en
Inventor
Giorgio Cignarella
Piervitto Cipolla
Carmelo A. Gandolfi
Odoardo Tofanetti
Sergio Tognella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Italia SpA
Original Assignee
Boehringer Biochemia Robin SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Biochemia Robin SpA filed Critical Boehringer Biochemia Robin SpA
Publication of AU4481485A publication Critical patent/AU4481485A/en
Application granted granted Critical
Publication of AU576253B2 publication Critical patent/AU576253B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/36—Benzo-cinnolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
AU44814/85A 1984-07-27 1985-07-11 Tricyclic dihydropyridazinones Ceased AU576253B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB08419253A GB2164643B (en) 1984-07-27 1984-07-27 Tricyclic dihydropyridazinones and pharmaceutical compositions containing them
GB8419253 1984-07-27

Publications (2)

Publication Number Publication Date
AU4481485A AU4481485A (en) 1986-01-30
AU576253B2 true AU576253B2 (en) 1988-08-18

Family

ID=10564580

Family Applications (1)

Application Number Title Priority Date Filing Date
AU44814/85A Ceased AU576253B2 (en) 1984-07-27 1985-07-11 Tricyclic dihydropyridazinones

Country Status (18)

Country Link
US (1) US4692447A (enExample)
EP (1) EP0169443A3 (enExample)
JP (1) JPS6147468A (enExample)
KR (1) KR880000728B1 (enExample)
CN (1) CN85107017A (enExample)
AU (1) AU576253B2 (enExample)
DD (1) DD238972A5 (enExample)
DK (1) DK327685A (enExample)
ES (1) ES8609274A1 (enExample)
FI (1) FI852699A7 (enExample)
GB (1) GB2164643B (enExample)
GR (1) GR851722B (enExample)
HU (1) HU195193B (enExample)
IL (1) IL75864A (enExample)
NO (1) NO852981L (enExample)
NZ (1) NZ212721A (enExample)
PT (1) PT80854B (enExample)
ZA (1) ZA855430B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2164643B (en) * 1984-07-27 1988-11-02 Boehringer Biochemia Srl Tricyclic dihydropyridazinones and pharmaceutical compositions containing them
JPH06763B2 (ja) * 1984-08-28 1994-01-05 吉富製薬株式会社 ベンゾ〔ｈ〕シンノリン誘導体
AU578496B2 (en) * 1984-11-01 1988-10-27 Smith Kline & French Laboratories Limited Tricyclic heterocyclic compounds
US4861773A (en) * 1986-04-28 1989-08-29 Smith Kline & French Laboratories Limited Heterocyclic compounds
EP0281045B1 (en) * 1987-03-02 1991-12-27 Yoshitomi Pharmaceutical Industries, Ltd. Benzothiepino (5,4-c) pyridazine compounds and their pharmaceutical uses
ATE92476T1 (de) * 1987-11-02 1993-08-15 Yoshitomi Pharmaceutical Kondensierte pyridazin-verbindungen und deren verwendung als arzneimittel.
JP2717687B2 (ja) * 1988-02-13 1998-02-18 日本曹達株式会社 ピリダジノン誘導体及びその製造方法
US5153194A (en) * 1988-09-21 1992-10-06 Yoshitomi Pharmaceutical Industries, Ltd. Thienocycloheptapyridazine compounds and their pharmaceutical use
FR2692895A1 (fr) * 1992-06-26 1993-12-31 Adir Nouveaux 1-oxo 2,4,5,6-tétrahydro 2,3,7-triazaphénalènes leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
US5731324A (en) * 1993-07-22 1998-03-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
US6448269B1 (en) 1993-07-22 2002-09-10 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicyclic compounds and pharmaceutical compositions containing them
US6137002A (en) 1993-07-22 2000-10-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
US8304415B2 (en) * 2010-02-25 2012-11-06 National Defense Medical Center 1, 2-disubstituted amido-anthraquinone derivatives, preparation method and application thereof
CA2938615A1 (en) * 2014-02-06 2015-08-13 Basf Se Insulating assembly for a storage vessel and process for its preparation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2649684A (en) * 1983-04-22 1984-11-08 Warner-Lambert Company Substituted indenopyridazones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670043C3 (de) * 1966-01-07 1975-05-22 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 3-(Aminophenyl)-pyridazon-(6)-derivaten
US3464988A (en) * 1968-01-11 1969-09-02 Bristol Myers Co 3-hydrazinobenzo(h)cinnolines and 3 - hydrazinobenzocyclohepta-(5,6-c)pyridazines
GB2164643B (en) * 1984-07-27 1988-11-02 Boehringer Biochemia Srl Tricyclic dihydropyridazinones and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2649684A (en) * 1983-04-22 1984-11-08 Warner-Lambert Company Substituted indenopyridazones

Also Published As

Publication number Publication date
US4692447A (en) 1987-09-08
ES8609274A1 (es) 1986-07-16
IL75864A (en) 1990-07-26
PT80854A (en) 1985-08-01
DK327685D0 (da) 1985-07-18
CN85107017A (zh) 1987-04-01
GB2164643A (en) 1986-03-26
AU4481485A (en) 1986-01-30
PT80854B (en) 1987-01-09
EP0169443A2 (en) 1986-01-29
GB2164643B (en) 1988-11-02
GR851722B (enExample) 1985-11-26
ES545574A0 (es) 1986-07-16
NZ212721A (en) 1989-01-06
GB8419253D0 (en) 1984-08-30
FI852699A0 (fi) 1985-07-08
FI852699L (fi) 1986-01-28
KR860001076A (ko) 1986-02-22
DK327685A (da) 1986-01-28
FI852699A7 (fi) 1986-01-28
KR880000728B1 (ko) 1988-04-29
ZA855430B (en) 1986-03-26
JPS6147468A (ja) 1986-03-07
IL75864A0 (en) 1985-11-29
HUT38915A (en) 1986-07-28
HU195193B (en) 1988-04-28
NO852981L (no) 1986-01-28
DD238972A5 (de) 1986-09-10
EP0169443A3 (en) 1986-12-30

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