AU571841B2 - Carbacyclin pharmaceutical preparations - Google Patents

Carbacyclin pharmaceutical preparations

Info

Publication number
AU571841B2
AU571841B2 AU16718/83A AU1671883A AU571841B2 AU 571841 B2 AU571841 B2 AU 571841B2 AU 16718/83 A AU16718/83 A AU 16718/83A AU 1671883 A AU1671883 A AU 1671883A AU 571841 B2 AU571841 B2 AU 571841B2
Authority
AU
Australia
Prior art keywords
group
oxa
tetradehydro
dihomo
yloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU16718/83A
Other languages
English (en)
Other versions
AU1671883A (en
Inventor
Jorge Casals-Stenzel
Bernd Raduchel
Werner Skuballa
Helmut Vorbruggen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU1671883A publication Critical patent/AU1671883A/en
Application granted granted Critical
Publication of AU571841B2 publication Critical patent/AU571841B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Drawers Of Furniture (AREA)
  • Ink Jet Recording Methods And Recording Media Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AU16718/83A 1982-07-13 1983-07-11 Carbacyclin pharmaceutical preparations Ceased AU571841B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3226550 1982-07-13
DE19823226550 DE3226550A1 (de) 1982-07-13 1982-07-13 Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
AU1671883A AU1671883A (en) 1984-01-19
AU571841B2 true AU571841B2 (en) 1988-04-28

Family

ID=6168531

Family Applications (1)

Application Number Title Priority Date Filing Date
AU16718/83A Ceased AU571841B2 (en) 1982-07-13 1983-07-11 Carbacyclin pharmaceutical preparations

Country Status (19)

Country Link
EP (1) EP0099538B1 (enExample)
JP (1) JPS5921636A (enExample)
AT (1) ATE67182T1 (enExample)
AU (1) AU571841B2 (enExample)
CA (1) CA1248525A (enExample)
CS (1) CS235329B2 (enExample)
DD (1) DD210027B3 (enExample)
DE (2) DE3226550A1 (enExample)
DK (1) DK163579C (enExample)
ES (1) ES524058A0 (enExample)
FI (1) FI77645C (enExample)
GR (1) GR78873B (enExample)
HU (1) HU191057B (enExample)
IE (1) IE57233B1 (enExample)
IL (1) IL69199A (enExample)
NZ (1) NZ204875A (enExample)
PH (1) PH25119A (enExample)
SU (1) SU1316555A3 (enExample)
ZA (1) ZA835109B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU573530B2 (en) * 1982-07-02 1988-06-16 Schering Aktiengesellschaft Carbacyclins

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS59141536A (ja) * 1983-02-01 1984-08-14 Sumitomo Chem Co Ltd 新規ビシクロオクタン誘導体
DE3405181A1 (de) * 1984-02-10 1985-08-22 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4971987A (en) * 1984-07-27 1990-11-20 Schering Aktiengesellschaft New carbacycline, process for their production and their use as a drug
DE3933523A1 (de) * 1989-10-05 1991-04-11 Schering Ag Antimetastatisch wirkende mittel
EP0431571A3 (en) * 1989-12-05 1992-01-02 Sagami Chemical Research Center Cis-bicyclo(4.3.0)non-2-ene derivatives
DE4104607A1 (de) * 1991-02-12 1992-08-13 Schering Ag Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen
DE60023144T2 (de) 1999-08-05 2006-07-06 Teijin Ltd. Mittel zur besserung der neuropathie, die als wirkstoff stickstoffhaltige verbindungen enthalten
EP2269611B1 (en) 2006-11-16 2016-03-23 Gemmus Pharma Inc. EP2 and EP4 agonists as agents for the treatment of influenza A viral infection
US20120190637A1 (en) 2009-10-14 2012-07-26 Gemmus Pharma, Inc. Combination therapy treatment for viral infections
CA2920856C (en) 2013-08-09 2026-03-03 Ardelyx, Inc. Ph modulating compounds for inhibiting gastrointestinal phosphate uptake
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1649983A (en) * 1982-07-02 1984-01-05 Schering Aktiengesellschaft Carbacyclin amides
AU548622B2 (en) * 1981-08-19 1985-12-19 Merrell Toraude Et Compagnie Fluorinated diamines
AU563881B2 (en) * 1982-02-18 1987-07-23 Schering Aktiengesellschaft Carbacycline, preparation and utilization thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2038333B (en) * 1978-01-26 1982-10-06 Erba Farmitalia 12 -formyl- (20 12)octanor-9-deoxy-9 -methylene pgi derivatives
US4705806A (en) * 1978-02-13 1987-11-10 Morton Jr Douglas R Prostacyclin analogs
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU548622B2 (en) * 1981-08-19 1985-12-19 Merrell Toraude Et Compagnie Fluorinated diamines
AU563881B2 (en) * 1982-02-18 1987-07-23 Schering Aktiengesellschaft Carbacycline, preparation and utilization thereof
AU1649983A (en) * 1982-07-02 1984-01-05 Schering Aktiengesellschaft Carbacyclin amides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU573530B2 (en) * 1982-07-02 1988-06-16 Schering Aktiengesellschaft Carbacyclins

Also Published As

Publication number Publication date
DK321283D0 (da) 1983-07-12
AU1671883A (en) 1984-01-19
CA1248525A (en) 1989-01-10
ZA835109B (en) 1984-08-29
JPS5921636A (ja) 1984-02-03
DK163579B (da) 1992-03-16
DE3382408D1 (de) 1991-10-17
ES8403865A1 (es) 1984-04-16
IL69199A0 (en) 1983-11-30
FI832557A0 (fi) 1983-07-13
PH25119A (en) 1991-02-19
IL69199A (en) 1987-08-31
NZ204875A (en) 1986-11-12
JPH0324457B2 (enExample) 1991-04-03
EP0099538A1 (de) 1984-02-01
DK321283A (da) 1984-01-14
DK163579C (da) 1992-08-03
FI77645B (fi) 1988-12-30
IE57233B1 (en) 1992-06-17
FI832557A7 (fi) 1984-01-14
ES524058A0 (es) 1984-04-16
DE3226550A1 (de) 1984-01-19
DD210027B3 (de) 1990-07-18
ATE67182T1 (de) 1991-09-15
HU191057B (en) 1986-12-28
FI77645C (fi) 1989-04-10
DD210027A5 (de) 1984-05-30
IE831630L (en) 1984-01-13
CS235329B2 (en) 1985-05-15
EP0099538B1 (de) 1991-09-11
SU1316555A3 (ru) 1987-06-07
GR78873B (enExample) 1984-10-02

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