ES8402809A1 - Procedimiento para la preparacion de carbaciclinas. - Google Patents
Procedimiento para la preparacion de carbaciclinas.Info
- Publication number
- ES8402809A1 ES8402809A1 ES522632A ES522632A ES8402809A1 ES 8402809 A1 ES8402809 A1 ES 8402809A1 ES 522632 A ES522632 A ES 522632A ES 522632 A ES522632 A ES 522632A ES 8402809 A1 ES8402809 A1 ES 8402809A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- chem
- free
- carbon atoms
- functionally modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XZFRIPGNUQRGPI-WLPVIMDJSA-N Carbacyclin Chemical class C1\C(=C\CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 XZFRIPGNUQRGPI-WLPVIMDJSA-N 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 hydroxy-methylene group Chemical class 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polyesters Or Polycarbonates (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Road Signs Or Road Markings (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE CARBACICLINAS, DE FORMULA GENERAL (I).CONSISTE EN ESTERIFICAR, EN PRESENCIA DE UNA BASE, UN COMPUESTO DE FORMULA (II), EN LA QUE R2, R3, X, A, W, D Y E TIENEN LOS SIGNIFICADOS YA MENCIONADOS, CON UNA BVB-HALOGENOCETONA, DE FORMULA GENERAL (III), EN LA QUE R1 TIENE EL SIGNIFICADO YA MENCIONADO; Y HAL REPRESENTA LOS HALOGENOS CL O BR.DE APLICACION EN EL TRATAMIENTO TERAPEUTICO DE ANIMALES MAMIFEROS, INCLUIDO EL HOMBRE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823221193 DE3221193A1 (de) | 1982-05-28 | 1982-05-28 | Neue carbacyclinester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES522632A0 ES522632A0 (es) | 1984-03-01 |
| ES8402809A1 true ES8402809A1 (es) | 1984-03-01 |
Family
ID=6165375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES522632A Expired ES8402809A1 (es) | 1982-05-28 | 1983-05-23 | Procedimiento para la preparacion de carbaciclinas. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4618626A (es) |
| EP (1) | EP0099850B1 (es) |
| JP (1) | JPS58225041A (es) |
| AT (1) | ATE70531T1 (es) |
| AU (1) | AU567877B2 (es) |
| CA (1) | CA1246557A (es) |
| CS (1) | CS240962B2 (es) |
| DD (1) | DD209806A5 (es) |
| DE (2) | DE3221193A1 (es) |
| DK (1) | DK207383A (es) |
| ES (1) | ES8402809A1 (es) |
| FI (1) | FI831890L (es) |
| GR (1) | GR77466B (es) |
| HU (1) | HU190722B (es) |
| IE (1) | IE58301B1 (es) |
| IL (1) | IL68715A0 (es) |
| NO (1) | NO831908L (es) |
| ZA (1) | ZA833883B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3225288A1 (de) * | 1982-07-02 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4876279A (en) * | 1986-05-05 | 1989-10-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| GB2192395B (en) * | 1986-07-08 | 1990-11-14 | Kotobuki Seiyaku Co Ltd | Carbacyclin derivatives |
| US4730078A (en) * | 1987-05-13 | 1988-03-08 | G. D. Searle & Co. | Allenic prostacyclins |
| ATE122563T1 (de) * | 1989-07-27 | 1995-06-15 | Ueno Seiyaku Oyo Kenkyujo Kk | Verwendung von 15-keto-prostansäure-derivaten zur herstellung eines medikaments für die verbesserung der ausscheidung des kaliumions. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3979440A (en) * | 1974-08-14 | 1976-09-07 | The Upjohn Company | Phenacyl-type esters of phenyl-substituted PGE-type compounds |
| US4238414A (en) * | 1978-02-13 | 1980-12-09 | The Upjohn Company | 2-Decarboxy-2-aminomethyl-6a-carba-PGI2 compounds |
| US4705806A (en) * | 1978-02-13 | 1987-11-10 | Morton Jr Douglas R | Prostacyclin analogs |
| DE3104044A1 (de) * | 1981-02-02 | 1982-08-26 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue prostacyclin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| GR77976B (es) * | 1982-03-12 | 1984-09-25 | Schering Ag |
-
1982
- 1982-05-28 DE DE19823221193 patent/DE3221193A1/de not_active Withdrawn
-
1983
- 1983-05-10 DK DK207383A patent/DK207383A/da not_active Application Discontinuation
- 1983-05-17 IL IL68715A patent/IL68715A0/xx unknown
- 1983-05-20 AU AU14813/83A patent/AU567877B2/en not_active Ceased
- 1983-05-20 DD DD83251139A patent/DD209806A5/de unknown
- 1983-05-23 ES ES522632A patent/ES8402809A1/es not_active Expired
- 1983-05-25 CS CS833698A patent/CS240962B2/cs unknown
- 1983-05-26 IE IE124283A patent/IE58301B1/en not_active IP Right Cessation
- 1983-05-26 GR GR71466A patent/GR77466B/el unknown
- 1983-05-26 FI FI831890A patent/FI831890L/fi not_active Application Discontinuation
- 1983-05-26 JP JP58091648A patent/JPS58225041A/ja active Granted
- 1983-05-27 AT AT83730052T patent/ATE70531T1/de not_active IP Right Cessation
- 1983-05-27 HU HU831891A patent/HU190722B/hu unknown
- 1983-05-27 ZA ZA833883A patent/ZA833883B/xx unknown
- 1983-05-27 DE DE8383730052T patent/DE3382479D1/de not_active Expired - Lifetime
- 1983-05-27 CA CA000429033A patent/CA1246557A/en not_active Expired
- 1983-05-27 NO NO831908A patent/NO831908L/no unknown
- 1983-05-27 EP EP83730052A patent/EP0099850B1/en not_active Expired - Lifetime
-
1985
- 1985-09-16 US US06/777,535 patent/US4618626A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HU190722B (en) | 1986-10-28 |
| IE58301B1 (en) | 1993-10-06 |
| IE831242L (en) | 1983-11-28 |
| IL68715A0 (en) | 1983-09-30 |
| AU567877B2 (en) | 1987-12-10 |
| DK207383D0 (da) | 1983-05-10 |
| DE3382479D1 (de) | 1992-01-30 |
| JPS58225041A (ja) | 1983-12-27 |
| CA1246557A (en) | 1988-12-13 |
| JPH0355461B2 (es) | 1991-08-23 |
| US4618626A (en) | 1986-10-21 |
| FI831890A0 (fi) | 1983-05-26 |
| NO831908L (no) | 1983-11-29 |
| AU1481383A (en) | 1983-12-01 |
| CS369883A2 (en) | 1985-06-13 |
| DD209806A5 (de) | 1984-05-23 |
| ATE70531T1 (de) | 1992-01-15 |
| FI831890L (fi) | 1983-11-29 |
| EP0099850B1 (en) | 1991-12-18 |
| ES522632A0 (es) | 1984-03-01 |
| DK207383A (da) | 1983-11-29 |
| EP0099850A1 (en) | 1984-02-01 |
| CS240962B2 (en) | 1986-03-13 |
| DE3221193A1 (de) | 1983-12-01 |
| GR77466B (es) | 1984-09-24 |
| ZA833883B (en) | 1984-04-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8300090A1 (es) | "procedimiento para la preparacion de derivados de carbaciclina". | |
| ES2004543A6 (es) | Procedimiento para la preparacion de clatratos con ciclodextrinas de derivados de carbaciclina | |
| ES8402809A1 (es) | Procedimiento para la preparacion de carbaciclinas. | |
| ES8304056A1 (es) | "procedimiento para la preparacion de derivados de carbaciclina". | |
| EP0069049A3 (en) | Delta-8,9-prostaglandin derivatives, process for their preparation and their use as medicaments | |
| ZA85985B (en) | Novel carbacyclins,process for the preparation thereof,and their use as medicinal agents | |
| GR3002075T3 (en) | 4-hydroxy-4-(substituted alkenyl)-cyclohexane carboxylic acid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970519 |