AU540024B2 - Antiinflammatory 4,5-diaryl-alpha-(polyfluoroalkyl)-1h- pyrrole-2-methanamines - Google Patents

Antiinflammatory 4,5-diaryl-alpha-(polyfluoroalkyl)-1h- pyrrole-2-methanamines

Info

Publication number
AU540024B2
AU540024B2 AU69632/81A AU6963281A AU540024B2 AU 540024 B2 AU540024 B2 AU 540024B2 AU 69632/81 A AU69632/81 A AU 69632/81A AU 6963281 A AU6963281 A AU 6963281A AU 540024 B2 AU540024 B2 AU 540024B2
Authority
AU
Australia
Prior art keywords
compound
mammal
antiinflammatory
amount
treating inflammation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU69632/81A
Other languages
English (en)
Other versions
AU6963281A (en
Inventor
Saul Carl Cherkofsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of AU6963281A publication Critical patent/AU6963281A/en
Application granted granted Critical
Publication of AU540024B2 publication Critical patent/AU540024B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU69632/81A 1980-04-18 1981-04-16 Antiinflammatory 4,5-diaryl-alpha-(polyfluoroalkyl)-1h- pyrrole-2-methanamines Ceased AU540024B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14166480A 1980-04-18 1980-04-18
US141664 1980-04-18
US06/237,638 US4335136A (en) 1980-04-18 1981-03-04 Anti-inflammatory 4,5-diaryl-α-(polyfluoroalkyl)-1H-pyrrole-2-methanamines
US237638 1981-03-04

Publications (2)

Publication Number Publication Date
AU6963281A AU6963281A (en) 1981-10-22
AU540024B2 true AU540024B2 (en) 1984-10-25

Family

ID=26839336

Family Applications (1)

Application Number Title Priority Date Filing Date
AU69632/81A Ceased AU540024B2 (en) 1980-04-18 1981-04-16 Antiinflammatory 4,5-diaryl-alpha-(polyfluoroalkyl)-1h- pyrrole-2-methanamines

Country Status (17)

Country Link
US (1) US4335136A (enExample)
EP (1) EP0038536B1 (enExample)
AR (1) AR228270A1 (enExample)
AU (1) AU540024B2 (enExample)
CA (1) CA1144551A (enExample)
DE (1) DE3162089D1 (enExample)
DK (1) DK159681A (enExample)
ES (1) ES8206465A1 (enExample)
FI (1) FI811191A7 (enExample)
GR (1) GR74514B (enExample)
HU (1) HU184851B (enExample)
IL (1) IL62660A (enExample)
NO (1) NO811321L (enExample)
NZ (1) NZ196860A (enExample)
PH (1) PH16105A (enExample)
PT (1) PT72883B (enExample)
YU (1) YU100381A (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4477463A (en) * 1982-05-10 1984-10-16 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 1-alkyl-4,5-diaryl-2-fluoroalkyl-1H-pyrroles
US4652582A (en) * 1985-01-09 1987-03-24 E. I. Du Pont De Nemours And Company Antiinflammatory-2-halo-4,5-diarylpyrroles
US5908858A (en) 1996-04-05 1999-06-01 Sankyo Company, Limited 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses
ES2208964T3 (es) * 1996-12-10 2004-06-16 G.D. SEARLE & CO. Compuestos de pirrolilo substituidos para el tratamiento de la inflamacion.
CA2316953A1 (en) 1997-12-26 1999-07-08 Nissin Food Products Co., Ltd. 5-arylpyrrole derivatives
DE19963174A1 (de) 1999-12-27 2001-07-12 Gruenenthal Gmbh Substituierte Pyrrol-Mannichbasen
DE10261130A1 (de) * 2002-12-20 2004-07-01 Grünenthal GmbH Arzneimittel enthaltend substituierte 2,5-Diaminomethyl-1H-pyrrole
FR2874012B1 (fr) 2004-08-09 2008-08-22 Sanofi Synthelabo Derives de pyrrole, leur preparation et leur utlisation en therapeutique
FR2887548B1 (fr) * 2005-06-27 2007-09-21 Sanofi Aventis Sa Derives de 4,5-diarylpyrrole, leur preparation et leur application en therapeutique
JP2010533205A (ja) 2007-07-12 2010-10-21 トラガラ ファーマシューティカルズ，インク． 癌、腫瘍、および腫瘍関連障害を治療するための方法および組成物
KR102490154B1 (ko) * 2016-12-21 2023-01-18 고쿠리쓰다이가쿠호진 규슈다이가쿠 발광 재료, 화합물 및 유기 발광 소자

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3564016A (en) * 1968-03-07 1971-02-16 Endo Lab Method of decarbonylation
US3709906A (en) * 1968-07-26 1973-01-09 Sankyo Co 2-alkyl-4,5-diphenylpyrrole derivatives
JPS4838705B1 (enExample) * 1969-09-11 1973-11-19
JPS4843117B1 (enExample) * 1969-09-16 1973-12-17
DE2062985A1 (de) * 1970-01-23 1971-07-29 Perstorp Ab Verfahren zur Herstellung von stabi len Trioxan Copolymeren
SE435278B (sv) * 1977-12-08 1984-09-17 Sagami Chem Res 5-cyano-1-legre(c?711?71-?714)alkyl-pyrrol-2-ettiksyra, framstellning derav och anvendningen som mellanprodukt vid framstellning av terapeutiskt verksamma pyrrolderivat

Also Published As

Publication number Publication date
PH16105A (en) 1983-06-30
AR228270A1 (es) 1983-02-15
FI811191L (fi) 1981-10-19
ES501432A0 (es) 1982-08-16
ES8206465A1 (es) 1982-08-16
PT72883A (en) 1981-05-01
NO811321L (no) 1981-10-19
IL62660A (en) 1984-06-29
HU184851B (en) 1984-10-29
GR74514B (enExample) 1984-06-29
CA1144551A (en) 1983-04-12
PT72883B (en) 1983-02-28
NZ196860A (en) 1984-05-31
EP0038536A1 (en) 1981-10-28
FI811191A7 (fi) 1981-10-19
AU6963281A (en) 1981-10-22
EP0038536B1 (en) 1984-02-01
US4335136A (en) 1982-06-15
DE3162089D1 (de) 1984-03-08
IL62660A0 (en) 1981-06-29
YU100381A (en) 1983-12-31
DK159681A (da) 1981-10-19

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