AU523050B2 - Cyclopeptides - Google Patents

Cyclopeptides

Info

Publication number
AU523050B2
AU523050B2 AU40229/78A AU4022978A AU523050B2 AU 523050 B2 AU523050 B2 AU 523050B2 AU 40229/78 A AU40229/78 A AU 40229/78A AU 4022978 A AU4022978 A AU 4022978A AU 523050 B2 AU523050 B2 AU 523050B2
Authority
AU
Australia
Prior art keywords
cyclopeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU40229/78A
Other languages
English (en)
Other versions
AU4022978A (en
Inventor
Bruno Kamber And Peter Sieber Hans Rink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of AU4022978A publication Critical patent/AU4022978A/en
Application granted granted Critical
Publication of AU523050B2 publication Critical patent/AU523050B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU40229/78A 1977-09-28 1978-09-27 Cyclopeptides Expired AU523050B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LULU78191 1977-09-28
LU78191A LU78191A1 (de) 1977-09-28 1977-09-28 Verfahren zur herstellung von neuen cyclopeptiden

Publications (2)

Publication Number Publication Date
AU4022978A AU4022978A (en) 1980-04-03
AU523050B2 true AU523050B2 (en) 1982-07-08

Family

ID=19728716

Family Applications (1)

Application Number Title Priority Date Filing Date
AU40229/78A Expired AU523050B2 (en) 1977-09-28 1978-09-27 Cyclopeptides

Country Status (18)

Country Link
US (1) US4238481A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0001295B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5459293A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT370090B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU523050B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1111841A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD140142A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2861672D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK151034C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES473677A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI68246C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU184612B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE47380B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL55643A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU78191A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO148957C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ188517A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA785488B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328214A (en) * 1979-07-04 1982-05-04 Ciba-Geigy Corporation Cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture
NZ195303A (en) * 1979-10-31 1984-10-19 Merck & Co Inc Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions
US4369179A (en) * 1979-12-14 1983-01-18 Ciba-Geigy Corporation Acylpeptides
US4358439A (en) * 1979-12-21 1982-11-09 Ciba-Geigy Corporation Cyclooctapeptides
US4360516A (en) * 1981-04-13 1982-11-23 Merck & Co., Inc. Modified D-retro cyclic hexapeptide somatostatin analogs
ATE14226T1 (de) * 1981-12-24 1985-07-15 Ciba Geigy Ag Cyclische octapeptide und pharmazeutische praeparate davon, sowie verfahren zur herstellung derselben und ihre anwendung.
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
US4798821A (en) * 1987-03-02 1989-01-17 Merck & Co., Inc. Antihypertensive therapy for diabetics
DE3845000C2 (de) * 1987-07-10 1998-11-19 Novartis Ag Anwendung von Octreotid zur Behandlung von Brustkrebs
CA2053250A1 (en) * 1989-04-26 1990-10-27 David H. Coy Linear somatostatin analogs
US5633263A (en) * 1989-04-26 1997-05-27 The Administrators Of The Tulane Educational Fund Linear somatostatin analogs
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
RU2177006C2 (ru) * 1995-09-29 2001-12-20 Биомежер Инкорпорэйтед Циклические пептидные аналоги соматостатина
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
PT981363E (pt) * 1997-05-13 2003-12-31 Conseils De Rec Appl Scient S Somatostatina e agonistas da somatostatina para reduzir o peso corporal
ATE262921T1 (de) * 1997-05-13 2004-04-15 Sod Conseils Rech Applic Somatostatin und somatostatin agoniste zur behandlung der insulinsunempfindlichkeit und syndrome x
WO1998051330A1 (en) * 1997-05-13 1998-11-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) Method and compositions for treating hyperlipidemia and other conditions
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
MXPA03011321A (es) 2001-06-08 2004-12-06 Conseils De Rech S Et D Aplica Analogos quimericos de somatostatina-dopamina.
ES2237356T3 (es) * 2003-04-07 2007-04-01 Novetide Ltd. Procedimiento para la produccion de peptidos ciclicos.
AU2004232314B2 (en) 2003-04-22 2007-11-22 Ipsen Pharma S.A.S. Peptide vectors
ES2732205T3 (es) 2008-06-12 2019-11-21 Ipsen Bioinnovation Ltd Proteínas de fusión para uso en el tratamiento del cáncer
CN104328100B (zh) 2008-06-12 2019-08-23 益普生生物创新有限公司 神经内分泌病的抑制
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
US9035022B2 (en) 2010-12-22 2015-05-19 Salk Institute For Biological Studies Cyclic CRF antagonist peptides
US20160129089A1 (en) 2013-06-13 2016-05-12 Antisense Therapeutics Ltd Combination therapy
WO2025128794A1 (en) 2023-12-15 2025-06-19 Neurocrine Biosciences, Inc. Fatty acid conjugated cyclic peptides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011182A (en) * 1975-03-21 1977-03-08 American Home Products Corporation Cyclic undecapeptide analogs of somatostatin and intermediates
US4000259A (en) * 1975-06-16 1976-12-28 American Home Products Corporation Cyclic dodecapeptide analogs of somatostatin and intermediates
NL7607987A (nl) * 1975-08-08 1977-02-10 Merck & Co Inc Werkwijze voor het bereiden van peptiden.
US3988304A (en) * 1975-08-25 1976-10-26 American Home Products Corporation Cyclic dodecapeptide derivatives of somatostatin and intermediates thereof
US4133805A (en) * 1975-12-16 1979-01-09 American Home Products Corporation Cyclic undecapeptides related to somatostatin and intermediates therefor
US4054558A (en) * 1976-05-24 1977-10-18 American Home Products Corporation Cyclic dodecapeptide and intermediates therefor
EP0000053B1 (en) * 1977-06-08 1981-05-27 Merck & Co. Inc. Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them
US4115554A (en) * 1977-08-29 1978-09-19 Merck & Co., Inc. Somatostatin analogs

Also Published As

Publication number Publication date
FI68246B (fi) 1985-04-30
DE2861672D1 (en) 1982-04-15
EP0001295B1 (de) 1982-03-17
FI68246C (fi) 1985-08-12
NZ188517A (en) 1981-04-24
AU4022978A (en) 1980-04-03
ES473677A1 (es) 1980-05-16
US4238481A (en) 1980-12-09
DD140142A5 (de) 1980-02-13
IL55643A0 (en) 1978-12-17
ZA785488B (en) 1979-09-26
EP0001295A2 (de) 1979-04-04
IE781931L (en) 1979-03-28
AT370090B (de) 1983-02-25
FI782907A7 (fi) 1979-03-29
NO148957B (no) 1983-10-10
CA1111841A (en) 1981-11-03
IL55643A (en) 1981-12-31
NO148957C (no) 1984-01-18
EP0001295A3 (en) 1979-06-13
HU184612B (en) 1984-09-28
LU78191A1 (de) 1979-05-25
DK151034C (da) 1988-02-22
JPS5459293A (en) 1979-05-12
IE47380B1 (en) 1984-03-07
ATA698278A (de) 1982-07-15
DK428478A (da) 1979-03-29
DK151034B (da) 1987-10-12
JPS6218560B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1987-04-23
NO783268L (no) 1979-03-29

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