AU500542B2 - Imidazlidine derivatives and pharmaceutical compositions containing same which have antiandrogenic activity - Google Patents
Imidazlidine derivatives and pharmaceutical compositions containing same which have antiandrogenic activityInfo
- Publication number
- AU500542B2 AU500542B2 AU19095/76A AU1909576A AU500542B2 AU 500542 B2 AU500542 B2 AU 500542B2 AU 19095/76 A AU19095/76 A AU 19095/76A AU 1909576 A AU1909576 A AU 1909576A AU 500542 B2 AU500542 B2 AU 500542B2
- Authority
- AU
- Australia
- Prior art keywords
- imidazlidine
- derivatives
- pharmaceutical compositions
- compositions containing
- containing same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Electromechanical Clocks (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FRFRU)75-33 | 1975-01-29 | ||
FR7533084A FR2329276A1 (fr) | 1975-10-29 | 1975-10-29 | Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant |
Publications (2)
Publication Number | Publication Date |
---|---|
AU1909576A AU1909576A (en) | 1978-05-04 |
AU500542B2 true AU500542B2 (en) | 1979-05-24 |
Family
ID=9161795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU19095/76A Expired AU500542B2 (en) | 1975-01-29 | 1976-10-28 | Imidazlidine derivatives and pharmaceutical compositions containing same which have antiandrogenic activity |
Country Status (18)
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MC1220A1 (fr) * | 1977-10-28 | 1979-07-20 | Hoffmann La Roche | Nouveaux derives d'imidazolidine |
CA1138334A (en) * | 1977-10-28 | 1982-12-28 | Karl Bernauer | Pharmaceutical preparations containing certain urea derivatives |
FI801184A (fi) * | 1979-04-24 | 1980-10-25 | Hoffmann La Roche | Foerfarande foer framstaellning av imidazolidinderivat |
US4666885A (en) * | 1985-02-08 | 1987-05-19 | Fernand Labrie | Combination therapy for treatment of female breast cancer |
US4775660A (en) * | 1984-08-02 | 1988-10-04 | Fernand Labrie | Treatment of breast cancer by combination therapy |
US4760053A (en) * | 1984-08-02 | 1988-07-26 | Fernand Labrie | Combination therapy for selected sex steroid dependent cancers |
ATE75947T1 (de) * | 1984-08-02 | 1992-05-15 | Labrie Fernand | Pharmazeutische zusammensetzung fuer die kombinationstherapie von hormonabhaengigem krebs. |
IT1214735B (it) * | 1986-11-04 | 1990-01-18 | Roussel Maestretti Spa | Impiego di 1-(3'-trifluorometil 4'nitrofenil) 4,4-dimetilimidazolin2,5-dione per il trattamento di cancri ormonodipendenti diverso da quello della prostata |
US5084472A (en) * | 1986-11-04 | 1992-01-28 | Roussel | Application of 1-(3'-trifluoromethyl-4'-nitrophenyl)-4,4'-dimethylimidazoline 2,5-dione in the treatment of hormone-dependent cancers other than that of the prostate |
FR2619381B1 (fr) * | 1987-08-13 | 1989-12-08 | Roussel Uclaf | Nouvelles imidazolidines substituees par un radical hydroxymethyle et un radical phenyl substitue, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant et un intermediaire pour leur preparation |
US4895715A (en) * | 1988-04-14 | 1990-01-23 | Schering Corporation | Method of treating gynecomastia |
FR2656302B1 (fr) * | 1989-12-22 | 1992-05-07 | Roussel Uclaf | Nouveau procede de preparation de l'anandron et derives de l'anandron. |
FR2693461B1 (fr) * | 1992-07-08 | 1994-09-02 | Roussel Uclaf | Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
USRE35956E (en) * | 1991-01-09 | 1998-11-10 | Roussel Uclaf | Phenylimidazolidines having antiandrogenic activity |
FR2671348B1 (fr) * | 1991-01-09 | 1993-03-26 | Roussel Uclaf | Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant. |
US5411981A (en) * | 1991-01-09 | 1995-05-02 | Roussel Uclaf | Phenylimidazolidines having antiandrogenic activity |
FR2706456B1 (fr) | 1993-06-18 | 1996-06-28 | Rhone Poulenc Agrochimie | Dérivés optiquement actifs de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides. |
US6002016A (en) * | 1991-12-20 | 1999-12-14 | Rhone-Poulenc Agrochimie | Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones |
FR2685328B1 (fr) * | 1991-12-20 | 1995-12-01 | Rhone Poulenc Agrochimie | Derives de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides. |
FR2694290B1 (fr) * | 1992-07-08 | 1994-09-02 | Roussel Uclaf | Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
US6008370A (en) * | 1992-11-25 | 1999-12-28 | Rhone-Poulenc Agrochimie | Fungicidal-2-alkoxy/haloalkoxy-1-(mono- or disubstituted)amino-4,4-disubstituted-2-imidazolin-5-ones |
FR2715402B1 (fr) * | 1994-01-05 | 1996-10-04 | Roussel Uclaf | Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
TW521073B (en) * | 1994-01-05 | 2003-02-21 | Hoechst Marion Roussel Inc | New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them |
FR2724169B1 (fr) * | 1994-09-06 | 1997-01-03 | Roussel Uclaf | Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
FR2725206B1 (fr) * | 1994-09-29 | 1996-12-06 | Roussel Uclaf | Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
US5656651A (en) * | 1995-06-16 | 1997-08-12 | Biophysica Inc. | Androgenic directed compositions |
US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
US7001911B2 (en) | 2000-06-28 | 2006-02-21 | Bristol-Myers Squibb Company | Fused cyclic modulators of nuclear hormone receptor function |
US20040077605A1 (en) | 2001-06-20 | 2004-04-22 | Salvati Mark E. | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
MXPA02012605A (es) * | 2000-06-28 | 2003-05-14 | Squibb Bristol Myers Co | Moduladores selectivos del receptor androgeno y metodo para su identificacion, dise°o y uso. |
US6953679B2 (en) | 2000-09-19 | 2005-10-11 | Bristol-Myers Squibb Company | Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof |
EP1854798A3 (en) | 2000-09-19 | 2007-11-28 | Bristol-Myers Squibb Company | Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
US20040087548A1 (en) | 2001-02-27 | 2004-05-06 | Salvati Mark E. | Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function |
WO2003005889A2 (en) * | 2001-07-10 | 2003-01-23 | Ams Research Corporation | Surgical kit for treating prostate tissue |
ES2310622T3 (es) * | 2001-12-19 | 2009-01-16 | Bristol-Myers Squibb Company | Compuestos heterociclicos condensados y analogos de los mismos, moduladores de la funcion de los receptores nucleares de hormonas. |
US7354933B2 (en) * | 2003-01-31 | 2008-04-08 | Aventis Pharma Sa | Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
FR2850652B1 (fr) * | 2003-01-31 | 2008-05-30 | Aventis Pharma Sa | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
MXPA06001751A (es) * | 2003-08-22 | 2006-05-12 | Ligand Pharm Inc | Derivados de 6-cicloamino-2-quinolinona como compuestos moduladores de receptor de androgeno. |
US7829552B2 (en) | 2003-11-19 | 2010-11-09 | Metabasis Therapeutics, Inc. | Phosphorus-containing thyromimetics |
DE602004031881D1 (de) * | 2003-12-19 | 2011-04-28 | Univ California | Verfahren und materialien zur beurteilung von prostatakrebstherapien |
WO2005099693A2 (en) * | 2004-02-24 | 2005-10-27 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies and compounds |
US8519158B2 (en) * | 2004-03-12 | 2013-08-27 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
WO2006031715A2 (en) * | 2004-09-10 | 2006-03-23 | Janssen Pharmaceutica N.V. | Novel imidazolidin-2-one derivatives as selective androgen receptor modulators (sarms) |
RS52274B2 (sr) | 2005-05-13 | 2018-05-31 | Univ California | Jedinjenje diarilhidantoina |
US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
KR101293935B1 (ko) * | 2005-06-17 | 2013-08-08 | 리간드 파마슈티칼스 인코포레이티드 | 안드로겐 수용체 조절 화합물 및 방법 |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
FR2896503B1 (fr) * | 2006-01-23 | 2012-07-13 | Aventis Pharma Sa | Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
DK2656842T3 (en) | 2006-03-27 | 2016-11-07 | Univ California | Androgen receptor MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND androgen receptor-ASSOCIATED DISEASES |
SG10201408699TA (en) | 2006-03-29 | 2015-02-27 | Univ California | Diarylthiohydantoin compounds |
JP5498168B2 (ja) | 2006-12-01 | 2014-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | アテローム性動脈硬化および循環器疾患の治療のためのcetp阻害剤としてのn−((3−ベンジル)−2,2−(ビス−フェニル)−プロパン−1−アミン誘導体 |
US9232959B2 (en) | 2007-01-02 | 2016-01-12 | Aquabeam, Llc | Multi fluid tissue resection methods and devices |
EP2099375B1 (en) | 2007-01-02 | 2014-09-24 | AquaBeam LLC | Minimally invasive devices for the treatment of prostate diseases |
US20080245375A1 (en) * | 2007-04-05 | 2008-10-09 | Medtronic Vascular, Inc. | Benign Prostatic Hyperplasia Treatments |
UY31432A1 (es) | 2007-10-26 | 2009-05-29 | Compuestos de diarilhidantoina | |
JP5506702B2 (ja) | 2008-03-06 | 2014-05-28 | アクアビーム エルエルシー | 流体流れ内を伝達される光学エネルギーによる組織切除および焼灼 |
WO2010093601A1 (en) | 2009-02-10 | 2010-08-19 | Metabasis Therapeutics, Inc. | Novel sulfonic acid-containing thyromimetics, and methods for their use |
US9848904B2 (en) | 2009-03-06 | 2017-12-26 | Procept Biorobotics Corporation | Tissue resection and treatment with shedding pulses |
FR2944524B1 (fr) * | 2009-04-17 | 2012-11-30 | Ipsen Pharma Sas | Derives d'imidazolidine-2,4-dione et leur utilisation comme medicament |
MX355915B (es) | 2010-02-16 | 2018-05-04 | Aragon Pharmaceuticals Inc | Moduladores del receptor de androgenos y usos de los mismos. |
EP2907504B1 (en) | 2011-02-08 | 2017-06-28 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
JP6080872B2 (ja) | 2012-02-29 | 2017-02-15 | プロセプト バイオロボティクス コーポレイション | 自動化された画像誘導組織切除および治療 |
EA202190820A1 (ru) | 2012-09-26 | 2021-10-29 | Арагон Фармасьютикалз, Инк. | Антиандрогены для лечения неметастатического кастрационно-резистентного рака простаты |
JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
CN105431096B (zh) | 2013-02-14 | 2018-07-31 | 普罗赛普特生物机器人公司 | 液体消融液体束眼外科手术的方法和装置 |
EP2959013A2 (en) | 2013-02-25 | 2015-12-30 | Novartis AG | Novel androgen receptor mutation |
CN109965976B (zh) | 2013-09-06 | 2022-05-31 | 普罗赛普特生物机器人公司 | 利用致脱脉冲的用于消融组织的装置 |
BR112016031037B1 (pt) | 2014-06-30 | 2023-02-07 | Procept Biorobotics Corporation | Aparelho para ablação de tecido vascular |
BR112017004431B1 (pt) | 2014-09-05 | 2022-11-01 | Procept Biorobotics Corporation | Aparelho para tratar um paciente |
TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
WO2018037310A1 (en) | 2016-08-20 | 2018-03-01 | Ftf Pharma Private Limited | Pharmaceutical composition comprising an androgen receptor inhibitor |
CN107216290B (zh) * | 2017-06-12 | 2021-03-16 | 陕西科技大学 | 一种3-丁基-5,5-二甲基海因咪唑季铵盐及其制备方法 |
WO2019078920A1 (en) | 2017-10-16 | 2019-04-25 | Aragon Pharmaceuticals, Inc. | ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC RESISTANT PROSTATE CANCER |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB997037A (en) * | 1962-03-19 | 1965-06-30 | Ici Ltd | New hydrantoin derivatives |
JPS4920973B1 (US07655688-20100202-C00299.png) * | 1970-05-28 | 1974-05-29 | ||
JPS5136332B1 (US07655688-20100202-C00299.png) * | 1970-12-09 | 1976-10-07 | ||
IL45459A (en) * | 1973-09-03 | 1978-01-31 | Ciba Geigy Ag | 1-(dichlorofluoromethylthio)-3-phenyl-imidazolidine-2,4-dione derivatives their preparation and their use as bactericides and fungicides |
-
1975
- 1975-10-29 FR FR7533084A patent/FR2329276A1/fr active Granted
-
1976
- 1976-09-30 SE SE7610859A patent/SE430502B/xx not_active IP Right Cessation
- 1976-10-20 NL NLAANVRAGE7611576,A patent/NL187102C/xx not_active IP Right Cessation
- 1976-10-21 SU SU762414002A patent/SU596165A3/ru active
- 1976-10-21 US US05/734,557 patent/US4097578A/en not_active Expired - Lifetime
- 1976-10-27 ES ES452746A patent/ES452746A1/es not_active Expired
- 1976-10-28 LU LU76085A patent/LU76085A1/xx unknown
- 1976-10-28 CA CA264,606A patent/CA1086751A/fr not_active Expired
- 1976-10-28 DK DK487476A patent/DK152125C/da not_active IP Right Cessation
- 1976-10-28 AU AU19095/76A patent/AU500542B2/en not_active Expired
- 1976-10-28 BE BE171876A patent/BE847742A/xx not_active IP Right Cessation
- 1976-10-29 IE IE2419/76A patent/IE43875B1/en not_active IP Right Cessation
- 1976-10-29 JP JP51129586A patent/JPS6011701B2/ja not_active Expired
- 1976-10-29 DE DE2649925A patent/DE2649925C2/de not_active Expired
- 1976-10-29 CH CH1369176A patent/CH599164A5/de active Protection Beyond IP Right Term
- 1976-10-29 GB GB45034/76A patent/GB1518444A/en not_active Expired
-
1993
- 1993-06-03 LU LU88282C patent/LU88282I2/fr unknown
- 1993-06-17 NL NL930079C patent/NL930079I2/nl unknown
- 1993-09-09 GE GEAP19931536A patent/GEP19970948B/en unknown
-
1994
- 1994-02-22 BG BG98507A patent/BG60533B2/bg unknown
Also Published As
Publication number | Publication date |
---|---|
ES452746A1 (es) | 1977-10-01 |
DE2649925A1 (de) | 1977-05-12 |
GB1518444A (en) | 1978-07-19 |
FR2329276B1 (US07655688-20100202-C00299.png) | 1979-09-14 |
LU76085A1 (US07655688-20100202-C00299.png) | 1977-05-31 |
DE2649925C2 (de) | 1986-08-28 |
NL930079I2 (nl) | 1993-10-01 |
AU1909576A (en) | 1978-05-04 |
IE43875L (en) | 1977-04-29 |
IE43875B1 (en) | 1981-06-17 |
GEP19970948B (en) | 1997-04-18 |
BE847742A (fr) | 1977-04-28 |
JPS5257176A (en) | 1977-05-11 |
SE430502B (sv) | 1983-11-21 |
NL187102C (nl) | 1991-06-03 |
FR2329276A1 (fr) | 1977-05-27 |
CH599164A5 (US07655688-20100202-C00299.png) | 1978-05-12 |
DK152125C (da) | 1988-06-20 |
JPS6011701B2 (ja) | 1985-03-27 |
NL930079I1 (nl) | 1993-09-16 |
SE7610859L (sv) | 1977-04-30 |
US4097578A (en) | 1978-06-27 |
NL187102B (nl) | 1991-01-02 |
BG60533B2 (bg) | 1995-07-28 |
LU88282I2 (fr) | 1994-05-04 |
DK152125B (da) | 1988-02-01 |
SU596165A3 (ru) | 1978-02-28 |
NL7611576A (nl) | 1977-05-03 |
DK487476A (da) | 1977-04-30 |
CA1086751A (fr) | 1980-09-30 |
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