AU4074789A - Coumarins to inhibit reverse transcriptase in humans - Google Patents

Coumarins to inhibit reverse transcriptase in humans

Info

Publication number
AU4074789A
AU4074789A AU40747/89A AU4074789A AU4074789A AU 4074789 A AU4074789 A AU 4074789A AU 40747/89 A AU40747/89 A AU 40747/89A AU 4074789 A AU4074789 A AU 4074789A AU 4074789 A AU4074789 A AU 4074789A
Authority
AU
Australia
Prior art keywords
coumarin
compound
bromo
carbamoyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU40747/89A
Other languages
English (en)
Inventor
Irene W. Althaus
Lester Dolak
Fritz Reusser
William G. Tarpley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AU4074789A publication Critical patent/AU4074789A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
AU40747/89A 1988-03-01 1989-02-08 Coumarins to inhibit reverse transcriptase in humans Abandoned AU4074789A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16255388A 1988-03-01 1988-03-01
US162553 1988-03-01
US19003888A 1988-05-04 1988-05-04
US190038 1988-05-04

Publications (1)

Publication Number Publication Date
AU4074789A true AU4074789A (en) 1989-09-22

Family

ID=26858857

Family Applications (1)

Application Number Title Priority Date Filing Date
AU40747/89A Abandoned AU4074789A (en) 1988-03-01 1989-02-08 Coumarins to inhibit reverse transcriptase in humans

Country Status (5)

Country Link
EP (1) EP0403535A1 (fr)
JP (1) JPH03503635A (fr)
AU (1) AU4074789A (fr)
DK (1) DK195690A (fr)
WO (1) WO1989007939A2 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05503073A (ja) * 1989-09-26 1993-05-27 オクタマー，インコーポレイテッド ウイルス性疾患の治療に有用な６―アミノ―１，２―ベンゾピロン
IL99731A0 (en) * 1990-10-18 1992-08-18 Merck & Co Inc Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them
US5484951A (en) * 1990-10-19 1996-01-16 Octamer, Incorporated 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents
EP0533902A1 (fr) * 1991-04-10 1993-03-31 Octamer, Inc. Procede d'inhibition de la replication retrovirale
US5753674A (en) * 1991-10-22 1998-05-19 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents, anti-retroviral agents and anti-tumor agents
US5482975A (en) * 1991-10-22 1996-01-09 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5877185A (en) * 1991-10-22 1999-03-02 Octamer, Inc. Synergistic compositions useful as anti-tumor agents
US5516941A (en) * 1991-10-22 1996-05-14 Octamer, Inc. Specific inactivators of "retroviral" (asymmetric) zinc fingers
DE4136900C1 (fr) * 1991-11-09 1993-07-29 Schaper & Bruemmer Gmbh & Co Kg, 3320 Salzgitter, De
US5262564A (en) * 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
US5783599A (en) * 1993-02-24 1998-07-21 Octamer Inc Methods of treating cancer and viral infections with 5-iodo-6-amino-and 5-iodo-6-nitroso-1 2-benzopyrones
US5637589A (en) * 1993-10-29 1997-06-10 University Of North Carolina At Chapel Hill Suksdorfin, analogs, compositions thereof, and methods for making and using thereof
US5504104A (en) * 1993-11-19 1996-04-02 Warner-Lambert Company Tricyclic pyrone derivatives as protease inhibitors and antiviral agents
RU2160733C2 (ru) * 1993-11-19 2000-12-20 Парк, Дэвис энд Компани Производные пирона и их фармацевтически приемлемые соли, промежуточные соединения для их получения, фармацевтическая композиция с антивирусной и антибактериальной активностью на их основе, способ лечения вызванных ретровирусом инфекции или заболевания
US6005103A (en) * 1993-11-19 1999-12-21 Warner-Lambert Company Pyrone derivatives as protease inhibitors and antiviral agents
US5510375A (en) * 1993-11-19 1996-04-23 Warner-Lambert Company Coumarin derivatives as protease inhibitors and antiviral agents
US5840751A (en) * 1993-11-19 1998-11-24 Warner-Lambert Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
US6319929B1 (en) 1994-04-29 2001-11-20 The University Of North Carolina At Chapel Hill Suksdorfin analogs, compositions thereof, and methods for making and using thereof
IL129871A (en) 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
US5455110A (en) * 1994-06-29 1995-10-03 Kimberly-Clark Corporation Nonwoven laminated fabrics
WO1997035565A1 (fr) * 1996-03-27 1997-10-02 Toray Industries, Inc. Derives de cetone et usage medicinal
CN1506359A (zh) * 2002-12-05 2004-06-23 �й�ҽѧ��ѧԺҩ���о��� 新的香豆素酰胺衍生物及其制法和其药物组合物与用途
WO2005028441A1 (fr) * 2003-09-17 2005-03-31 Sumitomo Chemical Company, Limited Derives de cinnamoyle et utilisation de ceux-ci
WO2006037468A1 (fr) * 2004-09-30 2006-04-13 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Inhibiteurs de la transcriptase inverse du vih
WO2007124617A1 (fr) * 2006-04-28 2007-11-08 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations
JP5269086B2 (ja) 2007-11-15 2013-08-21 ギリアード サイエンシス インコーポレーテッド ヒト免疫不全ウイルスの複製阻害薬
UA100250C2 (uk) 2007-11-16 2012-12-10 Гілеад Сайнсіз, Інк. Інгібітори реплікації вірусу імунодефіциту людини
CN113402491A (zh) * 2021-06-15 2021-09-17 山东大学苏州研究院 一种香豆素酰胺类化合物及其制备方法与应用

Also Published As

Publication number Publication date
DK195690D0 (da) 1990-08-16
WO1989007939A3 (fr) 1989-10-19
WO1989007939A2 (fr) 1989-09-08
JPH03503635A (ja) 1991-08-15
EP0403535A1 (fr) 1990-12-27
DK195690A (da) 1990-08-16

Similar Documents

Publication Publication Date Title
AU4074789A (en) Coumarins to inhibit reverse transcriptase in humans
Merluzzi et al. Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor
Sarin et al. Inhibition of replication of the etiologic agent of acquired immune deficiency syndrome (human T-lymphotropic retrovirus/lymphadenopathy-associated virus) by avarol and avarone
US6046228A (en) Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof
JP2001500471A (ja) プロテアーゼインヒビターの生物学的及び抗ウイルス活性を改善する方法
US4835140A (en) Method for treating pneumocystis carinii pneumonia patients with clindamycin and primaquine
JP2720169B2 (ja) 抗レトロウイルス活性をもつ糖タンパク処理抑制剤
AU640511B2 (en) Hexa-n-(o-hydroxybenzyl) neomycin b for inhibiting human retroviruses and for the treatment of aids
TURANO et al. Inhibitory effect of papaverine on HIV replication in vitro
US5057325A (en) Method of inhibiting replication of HIV with water-soluble melanins
WO1999049830A2 (fr) Action antivirale de la propolis par inhibition des polymerases d'acides nucleiques viraux
KR20000069296A (ko) 항바이러스 활성을 갖는 살비아 종의 추출물
JPH03505579A (ja) ヒト免疫不全ウイルス（ｈｉｖ）のインビボにおける活性の阻害方法
WO1997037661A1 (fr) Medicament de prevention et de traitement des infections virales
WO2021208080A1 (fr) Utilisation d'ovatodiolide contre un nouveau coronavirus
DE4320597A1 (de) Verwendung von Polyphosphaten zur antiviralen Therapie und als Immunmodulatoren
WO1989007384A2 (fr) Composes a base d'iodure de 2-methylisoquinolinium utilises dans le traitement contre le sida
JP2927932B2 (ja) ピリジニルオキサゾール―２―オン類による糖蛋白エンベロープを着たウィルスの感染力の防止
WO1989002741A2 (fr) Inhibiteurs de la transcriptase inverse de l'hiv servant au traitement du sida
AU3423989A (en) Antiviral composition containing aromatic polycyclic diones and nucleoside analogs and method for treating retrovirus infections
JPH03209320A (ja) 抗レトロウイルス薬
JPH03209321A (ja) 抗レトロウイルス薬
KR101049856B1 (ko) Ｈｉｖ－１ 잠복성 세포주, 이의 제조방법 및 잠복성 ｈｉｖ 감염의 진단방법
KR0131323B1 (ko) Bu-3608을 함유한 인체면역결핍 바이러스에 대한 항바이러스 조성물
KR101049858B1 (ko) Ｈｉｖ－１ 잠복성 세포주, 이의 제조방법 및 잠복성 ｈｉｖ 감염의 진단방법