WO1989007939A3 - Coumarines permettant d'inhiber la transcriptase inverse chez les etres humains - Google Patents

Coumarines permettant d'inhiber la transcriptase inverse chez les etres humains Download PDF

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Publication number
WO1989007939A3
WO1989007939A3 PCT/US1989/000450 US8900450W WO8907939A3 WO 1989007939 A3 WO1989007939 A3 WO 1989007939A3 US 8900450 W US8900450 W US 8900450W WO 8907939 A3 WO8907939 A3 WO 8907939A3
Authority
WO
WIPO (PCT)
Prior art keywords
coumarin
carbamoyl
bromo
alpha
coumarins
Prior art date
Application number
PCT/US1989/000450
Other languages
English (en)
Other versions
WO1989007939A2 (fr
Inventor
Fritz Reusser
William G Tarpley
Lester Dolak
Irene W Althaus
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of WO1989007939A2 publication Critical patent/WO1989007939A2/fr
Publication of WO1989007939A3 publication Critical patent/WO1989007939A3/fr
Priority to DK195690A priority Critical patent/DK195690A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Les composés suivants, à savoir 6-bromo-3-[(m-chlorophényle)carbamoyl]-coumarine, 6-bromo-3-[(alpha,alpha,alpha-trifluoro-m-toluyle)carbamoyle]coumarine, 6-bromo-3-[(2,5-dichlorophényle)carbamoyle]coumarine, [[bis(4-hydroxy-2-oxo-2H-1-benzopyrane-3-yl)-méthyl]cyclopentadiényle]cyclopentadiényle-fer, 3-cinnamoyle-4-hydroxy-coumarine, héxachlorocoumarine, 7-acétoxycoumarine ou phénylméthylester de l'acide [1-(2-oxo-2H-1-benzopyrane-3-yl)éthylidène]-hydrazinecarboxylique ou leurs sels pharmaceutiquement acceptables peuvent être utilisés pour traiter des êtres humains infectés par une ou plusieurs souches d'un virus d'immunodéficience humaine.
PCT/US1989/000450 1988-03-01 1989-02-08 Coumarines permettant d'inhiber la transcriptase inverse chez les etres humains WO1989007939A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK195690A DK195690A (da) 1988-03-01 1990-08-16 Anvendelse af coumarinderivater til fremstilling af et laegemiddel mod human immundefekt-virus

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16255388A 1988-03-01 1988-03-01
US162,553 1988-03-01
US19003888A 1988-05-04 1988-05-04
US190,038 1988-05-04

Publications (2)

Publication Number Publication Date
WO1989007939A2 WO1989007939A2 (fr) 1989-09-08
WO1989007939A3 true WO1989007939A3 (fr) 1989-10-19

Family

ID=26858857

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/000450 WO1989007939A2 (fr) 1988-03-01 1989-02-08 Coumarines permettant d'inhiber la transcriptase inverse chez les etres humains

Country Status (5)

Country Link
EP (1) EP0403535A1 (fr)
JP (1) JPH03503635A (fr)
AU (1) AU4074789A (fr)
DK (1) DK195690A (fr)
WO (1) WO1989007939A2 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05503073A (ja) * 1989-09-26 1993-05-27 オクタマー，インコーポレイテッド ウイルス性疾患の治療に有用な６―アミノ―１，２―ベンゾピロン
IL99731A0 (en) * 1990-10-18 1992-08-18 Merck & Co Inc Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them
US5484951A (en) * 1990-10-19 1996-01-16 Octamer, Incorporated 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents
EP0533902A1 (fr) * 1991-04-10 1993-03-31 Octamer, Inc. Procede d'inhibition de la replication retrovirale
US5753674A (en) * 1991-10-22 1998-05-19 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents, anti-retroviral agents and anti-tumor agents
US5482975A (en) * 1991-10-22 1996-01-09 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5877185A (en) * 1991-10-22 1999-03-02 Octamer, Inc. Synergistic compositions useful as anti-tumor agents
US5516941A (en) * 1991-10-22 1996-05-14 Octamer, Inc. Specific inactivators of "retroviral" (asymmetric) zinc fingers
DE4136900C1 (fr) * 1991-11-09 1993-07-29 Schaper & Bruemmer Gmbh & Co Kg, 3320 Salzgitter, De
US5262564A (en) * 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
US5783599A (en) * 1993-02-24 1998-07-21 Octamer Inc Methods of treating cancer and viral infections with 5-iodo-6-amino-and 5-iodo-6-nitroso-1 2-benzopyrones
US5637589A (en) * 1993-10-29 1997-06-10 University Of North Carolina At Chapel Hill Suksdorfin, analogs, compositions thereof, and methods for making and using thereof
US5504104A (en) * 1993-11-19 1996-04-02 Warner-Lambert Company Tricyclic pyrone derivatives as protease inhibitors and antiviral agents
RU2160733C2 (ru) * 1993-11-19 2000-12-20 Парк, Дэвис энд Компани Производные пирона и их фармацевтически приемлемые соли, промежуточные соединения для их получения, фармацевтическая композиция с антивирусной и антибактериальной активностью на их основе, способ лечения вызванных ретровирусом инфекции или заболевания
US6005103A (en) * 1993-11-19 1999-12-21 Warner-Lambert Company Pyrone derivatives as protease inhibitors and antiviral agents
US5510375A (en) * 1993-11-19 1996-04-23 Warner-Lambert Company Coumarin derivatives as protease inhibitors and antiviral agents
US5840751A (en) * 1993-11-19 1998-11-24 Warner-Lambert Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
US6319929B1 (en) 1994-04-29 2001-11-20 The University Of North Carolina At Chapel Hill Suksdorfin analogs, compositions thereof, and methods for making and using thereof
IL129871A (en) 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
US5455110A (en) * 1994-06-29 1995-10-03 Kimberly-Clark Corporation Nonwoven laminated fabrics
WO1997035565A1 (fr) * 1996-03-27 1997-10-02 Toray Industries, Inc. Derives de cetone et usage medicinal
CN1506359A (zh) * 2002-12-05 2004-06-23 �й�ҽѧ��ѧԺҩ���о��� 新的香豆素酰胺衍生物及其制法和其药物组合物与用途
WO2005028441A1 (fr) * 2003-09-17 2005-03-31 Sumitomo Chemical Company, Limited Derives de cinnamoyle et utilisation de ceux-ci
WO2006037468A1 (fr) * 2004-09-30 2006-04-13 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Inhibiteurs de la transcriptase inverse du vih
WO2007124617A1 (fr) * 2006-04-28 2007-11-08 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations
JP5269086B2 (ja) 2007-11-15 2013-08-21 ギリアード サイエンシス インコーポレーテッド ヒト免疫不全ウイルスの複製阻害薬
UA100250C2 (uk) 2007-11-16 2012-12-10 Гілеад Сайнсіз, Інк. Інгібітори реплікації вірусу імунодефіциту людини
CN113402491A (zh) * 2021-06-15 2021-09-17 山东大学苏州研究院 一种香豆素酰胺类化合物及其制备方法与应用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Chemical and Pharmaceutical Bulletin, vol. 36, no. 6, June 1988 (Tokyo, JP), Tsutomu Hatano et al.: "Anti-human immunodeficiency virus phenolics from locorice", pages 2286-2288, see the abstract; page 2287, formulas *
Microbiologica, vol. 8, 1985, O.E. Varnier et al.: "Antiviral activity of coumermycin identification of resistant and sensitive retrovirus strains", pages 283-287, see the abstract; page 286, lines 12-17 *
Proceedings of AACR, vol. 29, March 1988, B. Omarbasha et al.: "Decrease prostatic size in response to Coumarin treatment", page 372, abstract 1479, see the abstract *
Rev. Bras. de Pesquisas Méd. e Biol., vol. 8, nos. 5-6, 1975, F.W. Eichbaum: "Anticoagulents and cancer. A review", pages 489-496, see page 491, column 2, lines 26-30 *

Also Published As

Publication number Publication date
DK195690D0 (da) 1990-08-16
WO1989007939A2 (fr) 1989-09-08
JPH03503635A (ja) 1991-08-15
EP0403535A1 (fr) 1990-12-27
DK195690A (da) 1990-08-16
AU4074789A (en) 1989-09-22

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