WO1989007939A3 - Coumarins to inhibit reverse transcriptase in humans - Google Patents

Coumarins to inhibit reverse transcriptase in humans Download PDF

Info

Publication number
WO1989007939A3
WO1989007939A3 PCT/US1989/000450 US8900450W WO8907939A3 WO 1989007939 A3 WO1989007939 A3 WO 1989007939A3 US 8900450 W US8900450 W US 8900450W WO 8907939 A3 WO8907939 A3 WO 8907939A3
Authority
WO
WIPO (PCT)
Prior art keywords
coumarin
carbamoyl
bromo
alpha
coumarins
Prior art date
Application number
PCT/US1989/000450
Other languages
French (fr)
Other versions
WO1989007939A2 (en
Inventor
Fritz Reusser
William G Tarpley
Lester Dolak
Irene W Althaus
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of WO1989007939A2 publication Critical patent/WO1989007939A2/en
Publication of WO1989007939A3 publication Critical patent/WO1989007939A3/en
Priority to DK195690A priority Critical patent/DK195690A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

The following compounds: 6-bromo-3-[(m-chlorophenyl)carbamoyl]-coumarin, 6-bromo-3-[(alpha,alpha,alpha-trifluoro-m-toluyl)carbamoyl]coumarin, 6-bromo-3-[(2,5-dichlorophenyl)carbamoyl]coumarin, [[bis(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-methyl]cyclopentadienyl]cyclopentadienyl-iron, 3-cinnamoyl-4-hydroxy-coumarin, hexachlorocoumarin, 7-acetoxy-coumarin or [1-(2-oxo-2H-1-benzopyran-3-yl)ethylidene]-hydrazinecarboxylic acid phenylmethyl ester or pharmaceutically acceptable salts thereof can be used to treat humans infected with one or more than one strain of a human immunodeficiency virus.
PCT/US1989/000450 1988-03-01 1989-02-08 Coumarins to inhibit reverse transcriptase in humans WO1989007939A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK195690A DK195690A (en) 1988-03-01 1990-08-16 USE OF COUMARIN DERIVATIVES FOR THE PREPARATION OF A MEDICINE AGAINST HUMAN IMMUNDEFECT VIRUS

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16255388A 1988-03-01 1988-03-01
US162,553 1988-03-01
US19003888A 1988-05-04 1988-05-04
US190,038 1988-05-04

Publications (2)

Publication Number Publication Date
WO1989007939A2 WO1989007939A2 (en) 1989-09-08
WO1989007939A3 true WO1989007939A3 (en) 1989-10-19

Family

ID=26858857

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/000450 WO1989007939A2 (en) 1988-03-01 1989-02-08 Coumarins to inhibit reverse transcriptase in humans

Country Status (5)

Country Link
EP (1) EP0403535A1 (en)
JP (1) JPH03503635A (en)
AU (1) AU4074789A (en)
DK (1) DK195690A (en)
WO (1) WO1989007939A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0494231A4 (en) * 1989-09-26 1992-09-16 The Regents Of The University Of California 6-amino-1,2-benzopyrones useful for treatment of viral diseases
IL99731A0 (en) * 1990-10-18 1992-08-18 Merck & Co Inc Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them
US5484951A (en) * 1990-10-19 1996-01-16 Octamer, Incorporated 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents
EP0533902A1 (en) * 1991-04-10 1993-03-31 Octamer, Inc. A method for inhibition of retroviral replication
US5482975A (en) * 1991-10-22 1996-01-09 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5877185A (en) * 1991-10-22 1999-03-02 Octamer, Inc. Synergistic compositions useful as anti-tumor agents
US5753674A (en) * 1991-10-22 1998-05-19 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents, anti-retroviral agents and anti-tumor agents
US5516941A (en) * 1991-10-22 1996-05-14 Octamer, Inc. Specific inactivators of "retroviral" (asymmetric) zinc fingers
DE4136900C1 (en) * 1991-11-09 1993-07-29 Schaper & Bruemmer Gmbh & Co Kg, 3320 Salzgitter, De
US5262564A (en) * 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
US5783599A (en) * 1993-02-24 1998-07-21 Octamer Inc Methods of treating cancer and viral infections with 5-iodo-6-amino-and 5-iodo-6-nitroso-1 2-benzopyrones
US5637589A (en) * 1993-10-29 1997-06-10 University Of North Carolina At Chapel Hill Suksdorfin, analogs, compositions thereof, and methods for making and using thereof
US5504104A (en) * 1993-11-19 1996-04-02 Warner-Lambert Company Tricyclic pyrone derivatives as protease inhibitors and antiviral agents
US5840751A (en) * 1993-11-19 1998-11-24 Warner-Lambert Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
US5510375A (en) * 1993-11-19 1996-04-23 Warner-Lambert Company Coumarin derivatives as protease inhibitors and antiviral agents
US6005103A (en) * 1993-11-19 1999-12-21 Warner-Lambert Company Pyrone derivatives as protease inhibitors and antiviral agents
JP3698435B2 (en) * 1993-11-19 2005-09-21 パーク・デイビス・アンド・カンパニー 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
US6319929B1 (en) 1994-04-29 2001-11-20 The University Of North Carolina At Chapel Hill Suksdorfin analogs, compositions thereof, and methods for making and using thereof
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
US5455110A (en) * 1994-06-29 1995-10-03 Kimberly-Clark Corporation Nonwoven laminated fabrics
CA2222471A1 (en) * 1996-03-27 1997-10-02 Toray Industries, Inc. Ketone derivatives and medical application thereof
CN1506359A (en) * 2002-12-05 2004-06-23 �й�ҽѧ��ѧԺҩ���о��� Coumarin amide derivative and its prepn, medicinal composition and use
WO2005028441A1 (en) * 2003-09-17 2005-03-31 Sumitomo Chemical Company, Limited Cinnamoyl derivatives and use thereof
WO2006037468A1 (en) * 2004-09-30 2006-04-13 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv reverse transcriptase inhibitors
WO2007124617A1 (en) * 2006-04-28 2007-11-08 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Coumarin derivatives, their preparation methods and their pharmaceutic compositions and uses
CA2705318C (en) 2007-11-15 2013-12-31 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
JP5285709B2 (en) 2007-11-16 2013-09-11 ギリアード サイエンシス インコーポレーテッド Human immunodeficiency virus replication inhibitor
CN113402491A (en) * 2021-06-15 2021-09-17 山东大学苏州研究院 Coumarin amide compound and preparation method and application thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Chemical and Pharmaceutical Bulletin, vol. 36, no. 6, June 1988 (Tokyo, JP), Tsutomu Hatano et al.: "Anti-human immunodeficiency virus phenolics from locorice", pages 2286-2288, see the abstract; page 2287, formulas *
Microbiologica, vol. 8, 1985, O.E. Varnier et al.: "Antiviral activity of coumermycin identification of resistant and sensitive retrovirus strains", pages 283-287, see the abstract; page 286, lines 12-17 *
Proceedings of AACR, vol. 29, March 1988, B. Omarbasha et al.: "Decrease prostatic size in response to Coumarin treatment", page 372, abstract 1479, see the abstract *
Rev. Bras. de Pesquisas Méd. e Biol., vol. 8, nos. 5-6, 1975, F.W. Eichbaum: "Anticoagulents and cancer. A review", pages 489-496, see page 491, column 2, lines 26-30 *

Also Published As

Publication number Publication date
DK195690D0 (en) 1990-08-16
DK195690A (en) 1990-08-16
WO1989007939A2 (en) 1989-09-08
EP0403535A1 (en) 1990-12-27
AU4074789A (en) 1989-09-22
JPH03503635A (en) 1991-08-15

Similar Documents

Publication Publication Date Title
WO1989007939A3 (en) Coumarins to inhibit reverse transcriptase in humans
ZA894728B (en) A new pharmaceutical formulation as well as a process for its preparation
MX9804597A (en) Naphthyl-substituted benzimidazole derivatives as anticoagulants.
BG102048A (en) Tetrahydrofuran-containing sulphonamides as aspartylprotease inhibitors
NO863636L (en) PROCEDURE FOR THE PREPARATION OF TRANSDERMAL RESORABLE PREPARATIONS OF ARYLPROPIONIC ACID DERIVATIVES.
EP0893437A4 (en) Tryptase inhibitor and novel guanidino derivatives
CA2067381A1 (en) Treatment of hiv infections and compounds useful therein
NO306599B1 (en) Antithrombotic therapy and / or cancer prophylaxis
CA2130577A1 (en) Combinations of ace inhibitors and diuretics
AU672262B2 (en) Heterocyclically substituted phenyl-cyclohexane-carboxylic acid derivatives
CA2040865A1 (en) Method for preventing, stabilizing or causing regression of atherosclerosis employing a combination of a cholesterol lowering drug and an ace inhibitor
DK0380331T3 (en) Use of di-tert.butylhydroxyphenylthio derivatives for the manufacture of a medicament for the treatment or prevention of atherosclerosis or atherosclerosis
AU1968992A (en) Preparation of fatty acid medicaments
EP1262182A3 (en) Methods and compositions for treating hypertension, angina and other disorders using optically pure(-) amlodipine
EP0375628A3 (en) Use of acetyl l-carnitine in the therapeutic treatment of cataract, and pharmaceutical compositions useful in such treatment
KR910000158A (en) Medicinal Compounds and How to Use Them
WO1996028185A3 (en) Composition containing amlodipine, or a salt, or felodipine and an ace inhibitor
ZA894392B (en) Pharmaceutical products
ES2026304A6 (en) Dosage form for administering calcium antagonist.
AU4059485A (en) Substituted benzopyrans
BG60101B2 (en) Method for preparing of 4-fluoro-2-[[(4-methoxy-2-pyridinyl)methyl]thionil]-1h-benzimidazo le
DE3867042D1 (en) PHARMACEUTICAL PREPARATIONS.
RU94045248A (en) Method for inhibition of activation of virus of human immunodefficiency in vivo
IE890244L (en) Protecting tissue from reperfusion injury
AU570552B2 (en) 1,4-dihydropyridine-3-carboxylates and salts thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU DK FI JP KR NO US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE FR GB IT LU NL SE

AK Designated states

Kind code of ref document: A3

Designated state(s): AU DK FI JP KR NO US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE FR GB IT LU NL SE

WWE Wipo information: entry into national phase

Ref document number: 1989903438

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1989903438

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1989903438

Country of ref document: EP