AU2022305807B2 - Pyrimidine compounds for use as map4k1 inhibitors - Google Patents
Pyrimidine compounds for use as map4k1 inhibitors Download PDFInfo
- Publication number
- AU2022305807B2 AU2022305807B2 AU2022305807A AU2022305807A AU2022305807B2 AU 2022305807 B2 AU2022305807 B2 AU 2022305807B2 AU 2022305807 A AU2022305807 A AU 2022305807A AU 2022305807 A AU2022305807 A AU 2022305807A AU 2022305807 B2 AU2022305807 B2 AU 2022305807B2
- Authority
- AU
- Australia
- Prior art keywords
- amino
- chloro
- methoxy
- tetrahydroisoquinolin
- pyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202121030204 | 2021-07-06 | ||
| IN202121030204 | 2021-07-06 | ||
| PCT/IB2022/056248 WO2023281417A1 (en) | 2021-07-06 | 2022-07-06 | Pyrimidine compounds for use as map4k1 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2022305807A1 AU2022305807A1 (en) | 2024-01-04 |
| AU2022305807B2 true AU2022305807B2 (en) | 2024-09-05 |
Family
ID=82703212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2022305807A Expired - Fee Related AU2022305807B2 (en) | 2021-07-06 | 2022-07-06 | Pyrimidine compounds for use as map4k1 inhibitors |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US12577267B2 (https=) |
| EP (1) | EP4367123A1 (https=) |
| JP (1) | JP2024527565A (https=) |
| KR (1) | KR20240012538A (https=) |
| CN (1) | CN117730083A (https=) |
| AU (1) | AU2022305807B2 (https=) |
| CA (1) | CA3223874A1 (https=) |
| CL (1) | CL2023003791A1 (https=) |
| CO (1) | CO2024000572A2 (https=) |
| EC (1) | ECSP24007193A (https=) |
| IL (1) | IL309342A (https=) |
| MX (1) | MX2023015246A (https=) |
| PE (1) | PE20240585A1 (https=) |
| WO (1) | WO2023281417A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024231875A1 (en) | 2023-05-09 | 2024-11-14 | Glenmark Specialty S.A. | Hpk1 inhibitor for use in the treatment of cancer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018102366A1 (en) * | 2016-11-30 | 2018-06-07 | Ariad Pharmaceuticals, Inc. | Anilinopyrimidines as haematopoietic progenitor kinase 1 (hpk1) inhibitors |
| WO2021125803A1 (ko) * | 2019-12-16 | 2021-06-24 | 한국화학연구원 | 신규한 피리미딘 유도체 및 이의 용도 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2792979T3 (es) * | 2013-08-22 | 2020-11-12 | Jubilant Biosys Ltd | Compuestos de pirimidina sustituidos, composiciones y aplicaciones médicas de los mismos |
-
2022
- 2022-07-06 CA CA3223874A patent/CA3223874A1/en active Pending
- 2022-07-06 EP EP22747756.9A patent/EP4367123A1/en not_active Withdrawn
- 2022-07-06 US US17/912,729 patent/US12577267B2/en active Active
- 2022-07-06 AU AU2022305807A patent/AU2022305807B2/en not_active Expired - Fee Related
- 2022-07-06 PE PE2023003341A patent/PE20240585A1/es unknown
- 2022-07-06 WO PCT/IB2022/056248 patent/WO2023281417A1/en not_active Ceased
- 2022-07-06 CN CN202280048104.2A patent/CN117730083A/zh active Pending
- 2022-07-06 KR KR1020237044454A patent/KR20240012538A/ko not_active Ceased
- 2022-07-06 IL IL309342A patent/IL309342A/en unknown
- 2022-07-06 MX MX2023015246A patent/MX2023015246A/es unknown
- 2022-07-06 JP JP2024500151A patent/JP2024527565A/ja active Pending
-
2023
- 2023-12-19 CL CL2023003791A patent/CL2023003791A1/es unknown
-
2024
- 2024-01-24 CO CONC2024/0000572A patent/CO2024000572A2/es unknown
- 2024-01-26 EC ECSENADI20247193A patent/ECSP24007193A/es unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018102366A1 (en) * | 2016-11-30 | 2018-06-07 | Ariad Pharmaceuticals, Inc. | Anilinopyrimidines as haematopoietic progenitor kinase 1 (hpk1) inhibitors |
| WO2021125803A1 (ko) * | 2019-12-16 | 2021-06-24 | 한국화학연구원 | 신규한 피리미딘 유도체 및 이의 용도 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022305807A1 (en) | 2024-01-04 |
| JP2024527565A (ja) | 2024-07-25 |
| US20230227483A1 (en) | 2023-07-20 |
| MX2023015246A (es) | 2024-01-19 |
| CN117730083A (zh) | 2024-03-19 |
| US12577267B2 (en) | 2026-03-17 |
| WO2023281417A1 (en) | 2023-01-12 |
| CA3223874A1 (en) | 2023-01-12 |
| PE20240585A1 (es) | 2024-03-21 |
| CL2023003791A1 (es) | 2024-07-12 |
| CO2024000572A2 (es) | 2024-02-05 |
| IL309342A (en) | 2024-02-01 |
| KR20240012538A (ko) | 2024-01-29 |
| ECSP24007193A (es) | 2024-03-01 |
| EP4367123A1 (en) | 2024-05-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102589982B1 (ko) | Ｅｇｆｒ 억제제, 및 이의 제조 및 적용 | |
| CN113061132B (zh) | 一类稠环内酰胺类化合物、制备方法和用途 | |
| EP3600287B1 (en) | Inhibitors of kinase networks and uses thereof | |
| WO2012098068A1 (en) | Pyrazolo pyrimidines as dyrk1a and dyrk1b inhibitors | |
| RS60468B1 (sr) | Nova jedinjenja | |
| CN113316576A (zh) | 用于治疗癌症的作为HPK1抑制剂的2,3-二氢-1H-吡咯并[3,4-c]吡啶-1-酮衍生物 | |
| TWI601724B (zh) | 咪唑並喹啉類衍生物及其可藥用鹽、其製備方法及其在醫藥上的應用 | |
| JP2022502455A (ja) | Ｍａｐ４ｋ１阻害剤として使用するためのインドリノン化合物 | |
| CN114401955A (zh) | 细胞周期蛋白依赖性激酶的抑制剂 | |
| AU2020406824A1 (en) | Novel pyrimidine derivative and use thereof | |
| EP4225741A1 (en) | 7-azaindole compounds for inhibition of bcr-abl tyrosine kinases | |
| TW202241413A (zh) | 吡唑並喹唑啉類化合物、其製備方法及用途 | |
| CA3231988A1 (en) | Azaindazole macrocycle compound and use thereof | |
| CN107548393B (zh) | 适用于治疗癌症的1-(环)烷基吡啶-2-酮的三环稠合衍生物 | |
| KR102572704B1 (ko) | 신규한 피리미딘 유도체 및 이의 용도 | |
| AU2022305807B2 (en) | Pyrimidine compounds for use as map4k1 inhibitors | |
| CN113461670A (zh) | 作为转染期间重排激酶抑制剂的新的化合物 | |
| TW201900644A (zh) | Fgfr4抑制劑及其制備與應用 | |
| JP6977038B2 (ja) | Ｇｓｋ−３阻害剤 | |
| OA21470A (en) | Pyrimidine compounds for use as MAP4K1 inhibitors. | |
| EA048523B1 (ru) | Пиримидиновые соединения для применения в качестве ингибиторов map4k1 | |
| WO2025234404A1 (ja) | ピリミジン含有縮合環化合物及びその用途 | |
| CN118930543A (zh) | 三环类化合物及其药物组合物和用途 | |
| CN118420607A (zh) | 杂芳环化合物及其应用 | |
| JP2026511081A (ja) | Ａｔｍキナーゼ阻害剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK25 | Application lapsed reg. 22.2i(2) - failure to pay acceptance fee |