AU2022245323A1 - Efficient tcr gene editing in t lymphocytes - Google Patents

Efficient tcr gene editing in t lymphocytes Download PDF

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Publication number
AU2022245323A1
AU2022245323A1 AU2022245323A AU2022245323A AU2022245323A1 AU 2022245323 A1 AU2022245323 A1 AU 2022245323A1 AU 2022245323 A AU2022245323 A AU 2022245323A AU 2022245323 A AU2022245323 A AU 2022245323A AU 2022245323 A1 AU2022245323 A1 AU 2022245323A1
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cells
tcr
engineered
cell
alpha
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AU2022245323A
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AU2022245323A9 (en
Inventor
Benjamin Joseph Haley
Shravan MADIREDDI
Soyoung Oh
Sascha Rutz
Kate Halliwell SENGER
David Shaw
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Genentech Inc
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Genentech Inc
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Publication of AU2022245323A1 publication Critical patent/AU2022245323A1/en
Publication of AU2022245323A9 publication Critical patent/AU2022245323A9/en
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4242—Transcription factors, e.g. SOX or c-MYC
    • A61K40/4243—Wilms tumor 1 [WT1]
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4269—NY-ESO
    • A—HUMAN NECESSITIES
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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AU2022245323A 2021-03-24 2022-03-24 Efficient tcr gene editing in t lymphocytes Pending AU2022245323A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163165509P 2021-03-24 2021-03-24
US63/165,509 2021-03-24
US202263323065P 2022-03-24 2022-03-24
US63/323,065 2022-03-24
PCT/US2022/021820 WO2022204443A1 (en) 2021-03-24 2022-03-24 Efficient tcr gene editing in t lymphocytes

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AU2022245323A1 true AU2022245323A1 (en) 2023-09-28
AU2022245323A9 AU2022245323A9 (en) 2024-01-25

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US (2) US12239664B2 (https=)
JP (1) JP2024512608A (https=)
KR (1) KR20230160885A (https=)
AU (1) AU2022245323A1 (https=)
BR (1) BR112023019195A2 (https=)
CA (1) CA3214486A1 (https=)
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AU2024228388A1 (en) 2023-02-27 2025-10-02 Adaptive Biotechnologies Corp. Therapeutic t cell receptors targeting kras g12d
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TW202544244A (zh) * 2024-03-06 2025-11-16 美商Ｒ Ｐ 先靈爾科技公司 使用連續遞送對哺乳動物細胞基因工程化之方法
WO2025217891A1 (zh) * 2024-04-19 2025-10-23 深圳市先康达生命科学有限公司 IFN-γ基因片段及其应用

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CA3214486A1 (en) 2022-09-29
US20230041268A1 (en) 2023-02-09
WO2022204443A1 (en) 2022-09-29
US20250179505A1 (en) 2025-06-05
US12239664B2 (en) 2025-03-04
BR112023019195A2 (pt) 2023-10-17
KR20230160885A (ko) 2023-11-24
JP2024512608A (ja) 2024-03-19
AU2022245323A9 (en) 2024-01-25

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