KR20230160885A - T 림프구에서 효율적인 tcr 유전자 편집 - Google Patents

T 림프구에서 효율적인 tcr 유전자 편집 Download PDF

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KR20230160885A
KR20230160885A KR1020237036297A KR20237036297A KR20230160885A KR 20230160885 A KR20230160885 A KR 20230160885A KR 1020237036297 A KR1020237036297 A KR 1020237036297A KR 20237036297 A KR20237036297 A KR 20237036297A KR 20230160885 A KR20230160885 A KR 20230160885A
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cells
tcr
engineered
clause
cell
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Korean (ko)
Inventor
사스차 러츠
벤자민 조셉 헤일리
슈라반 마디레디
소영 오
데이비드 쇼
케이트 할리웰 센거
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제넨테크, 인크.
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
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    • A61K40/41—Vertebrate antigens
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    • A61K40/421—Immunoglobulin superfamily
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4242—Transcription factors, e.g. SOX or c-MYC
    • A61K40/4243—Wilms tumor 1 [WT1]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4269—NY-ESO
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2319/00—Fusion polypeptide
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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KR1020237036297A 2021-03-24 2022-03-24 T 림프구에서 효율적인 tcr 유전자 편집 Pending KR20230160885A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163165509P 2021-03-24 2021-03-24
US63/165,509 2021-03-24
US202263323065P 2022-03-24 2022-03-24
US63/323,065 2022-03-24
PCT/US2022/021820 WO2022204443A1 (en) 2021-03-24 2022-03-24 Efficient tcr gene editing in t lymphocytes

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KR20230160885A true KR20230160885A (ko) 2023-11-24

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US (2) US12239664B2 (https=)
JP (1) JP2024512608A (https=)
KR (1) KR20230160885A (https=)
AU (1) AU2022245323A1 (https=)
BR (1) BR112023019195A2 (https=)
CA (1) CA3214486A1 (https=)
WO (1) WO2022204443A1 (https=)

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US20250179505A1 (en) 2025-06-05
US12239664B2 (en) 2025-03-04
BR112023019195A2 (pt) 2023-10-17
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