JP2024512608A - Ｔリンパ球における効率的なｔｃｒ遺伝子編集 - Google Patents

Ｔリンパ球における効率的なｔｃｒ遺伝子編集 Download PDF

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JP2024512608A
JP2024512608A JP2023558899A JP2023558899A JP2024512608A JP 2024512608 A JP2024512608 A JP 2024512608A JP 2023558899 A JP2023558899 A JP 2023558899A JP 2023558899 A JP2023558899 A JP 2023558899A JP 2024512608 A JP2024512608 A JP 2024512608A
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cells
tcr
engineered
cell
alpha
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JP2024512608A5 (https=
Inventor
ルッツ，サーシャ
ジョセフ ヘイリー，ベンジャミン
マディレディ，シュラバン
オ，ソヨン
ショー，デイビッド
ハリウェル センガー，ケイト
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Genentech Inc
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Genentech Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/42—Cancer antigens
    • A61K40/4242—Transcription factors, e.g. SOX or c-MYC
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
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JP2023558899A 2021-03-24 2022-03-24 Ｔリンパ球における効率的なｔｃｒ遺伝子編集 Pending JP2024512608A (ja)

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Application Number Priority Date Filing Date Title
US202163165509P 2021-03-24 2021-03-24
US63/165,509 2021-03-24
US202263323065P 2022-03-24 2022-03-24
US63/323,065 2022-03-24
PCT/US2022/021820 WO2022204443A1 (en) 2021-03-24 2022-03-24 Efficient tcr gene editing in t lymphocytes

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JP2024512608A true JP2024512608A (ja) 2024-03-19
JP2024512608A5 JP2024512608A5 (https=) 2025-03-28

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US (2) US12239664B2 (https=)
JP (1) JP2024512608A (https=)
KR (1) KR20230160885A (https=)
AU (1) AU2022245323A1 (https=)
BR (1) BR112023019195A2 (https=)
CA (1) CA3214486A1 (https=)
WO (1) WO2022204443A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023002455A (es) * 2020-08-28 2023-05-16 Arsenal Biosciences Inc Células inmunitarias modificadas con receptores cebadores.
JP2024512608A (ja) 2021-03-24 2024-03-19 ジェネンテック， インコーポレイテッド Ｔリンパ球における効率的なｔｃｒ遺伝子編集
AU2024228388A1 (en) 2023-02-27 2025-10-02 Adaptive Biotechnologies Corp. Therapeutic t cell receptors targeting kras g12d
CN119320771A (zh) * 2023-07-17 2025-01-17 北京艺妙神州医药科技有限公司 用于敲除t细胞中的trac和b2m的试剂和方法
TW202544244A (zh) * 2024-03-06 2025-11-16 美商Ｒ Ｐ 先靈爾科技公司 使用連續遞送對哺乳動物細胞基因工程化之方法
WO2025217891A1 (zh) * 2024-04-19 2025-10-23 深圳市先康达生命科学有限公司 IFN-γ基因片段及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021501581A (ja) * 2017-10-30 2021-01-21 パクト ファーマ インコーポレイテッドＰａｃｔ Ｐｈａｒｍａ， Ｉｎｃ． 初代細胞の遺伝子編集

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
EP2364368B1 (en) 2008-11-07 2014-01-15 Sequenta, Inc. Methods of monitoring conditions by sequence analysis
EP2567226B1 (en) 2010-05-06 2016-08-10 Adaptive Biotechnologies Corporation Monitoring health and disease status using clonotype profiles
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
EP2768982A4 (en) 2011-10-21 2015-06-03 Adaptive Biotechnologies Corp QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
EP3372694A1 (en) 2012-03-05 2018-09-12 Adaptive Biotechnologies Corporation Determining paired immune receptor chains from frequency matched subunits
HUE029357T2 (en) 2012-05-08 2017-02-28 Adaptive Biotechnologies Corp Preparations and devices for measuring and calibrating amplification distortion in multiplex PCR reactions
JP2015519081A (ja) 2012-06-11 2015-07-09 シーケンタ インコーポレイテッド 配列タグを用いた配列決定法
SG11201408128WA (en) 2012-06-15 2015-01-29 Adaptive Biotechnologies Corp Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
EP3330384B1 (en) 2012-10-01 2019-09-25 Adaptive Biotechnologies Corporation Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
WO2015160439A2 (en) 2014-04-17 2015-10-22 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
JP6513035B2 (ja) 2013-02-22 2019-05-15 アダプティヴ バイオテクノロジーズ コーポレーション 希少クロノタイプおよびその用途
KR20150132479A (ko) 2013-03-15 2015-11-25 어댑티브 바이오테크놀로지스 코포레이션 복합 유전자 세트에서의 독특하게 태그되고 재배열된 적응 면역 수용체 유전자
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
AU2014337063A1 (en) 2013-10-18 2016-05-19 Adaptive Biotechnologies Corp. Predicting patient responsiveness to immune checkpoint inhibitors
US20160340729A1 (en) 2014-01-10 2016-11-24 Adaptive Biotechnologies Corp. Methods for defining and predicting immune response to allograft
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
AU2015353581A1 (en) 2014-11-25 2017-06-15 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
AU2016243583B2 (en) * 2015-03-27 2022-03-10 President And Fellows Of Harvard College Modified T cells and methods of making and using the same
EP3277294B1 (en) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
WO2017112944A1 (en) 2015-12-23 2017-06-29 Fred Hutchinson Cancer Research Center High affinity t cell receptors and uses thereof
US12359179B2 (en) * 2018-12-12 2025-07-15 The Regents Of The University Of California Compositions and methods for modifying a target nucleic acid
JP2024512608A (ja) 2021-03-24 2024-03-19 ジェネンテック， インコーポレイテッド Ｔリンパ球における効率的なｔｃｒ遺伝子編集

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021501581A (ja) * 2017-10-30 2021-01-21 パクト ファーマ インコーポレイテッドＰａｃｔ Ｐｈａｒｍａ， Ｉｎｃ． 初代細胞の遺伝子編集

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
LIFE SCIENCE ALLIANCE, vol. Vol.2, No.2, e201900367, JPN5025000256, 2019, pages 1 - 10, ISSN: 0005793359 *
NATURE BIOMEDICAL ENGINEERING, vol. 3, JPN5025000255, 2019, pages 974 - 984, ISSN: 0005793358 *
NATURE BIOTECHNOLOGY, vol. 38, JPN6026004340, 2020, pages 44 - 49, ISSN: 0005793360 *
NATURE, vol. 543, JPN6026004343, 2017, pages 113 - 117, ISSN: 0005793361 *
NATURE, vol. 559, JPN5025000254, 2018, pages 405 - 409, ISSN: 0005793357 *

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