AU2021380754A1 - Methods of treating heart failure by administering omecamtiv mecarbil - Google Patents
Methods of treating heart failure by administering omecamtiv mecarbil Download PDFInfo
- Publication number
- AU2021380754A1 AU2021380754A1 AU2021380754A AU2021380754A AU2021380754A1 AU 2021380754 A1 AU2021380754 A1 AU 2021380754A1 AU 2021380754 A AU2021380754 A AU 2021380754A AU 2021380754 A AU2021380754 A AU 2021380754A AU 2021380754 A1 AU2021380754 A1 AU 2021380754A1
- Authority
- AU
- Australia
- Prior art keywords
- patient
- heart failure
- omecamtiv mecarbil
- less
- patients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/38—Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
- A61N1/39—Heart defibrillators
- A61N1/3956—Implantable devices for applying electric shocks to the heart, e.g. for cardioversion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063112995P | 2020-11-12 | 2020-11-12 | |
| US63/112,995 | 2020-11-12 | ||
| US202163154077P | 2021-02-26 | 2021-02-26 | |
| US63/154,077 | 2021-02-26 | ||
| US202163187084P | 2021-05-11 | 2021-05-11 | |
| US63/187,084 | 2021-05-11 | ||
| US202163202873P | 2021-06-28 | 2021-06-28 | |
| US63/202,873 | 2021-06-28 | ||
| US202163203436P | 2021-07-22 | 2021-07-22 | |
| US63/203,436 | 2021-07-22 | ||
| PCT/US2021/058988 WO2022103966A1 (en) | 2020-11-12 | 2021-11-11 | Methods of treating heart failure by administering omecamtiv mecarbil |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2021380754A1 true AU2021380754A1 (en) | 2023-06-22 |
| AU2021380754A9 AU2021380754A9 (en) | 2024-10-24 |
Family
ID=78822539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021380754A Pending AU2021380754A1 (en) | 2020-11-12 | 2021-11-11 | Methods of treating heart failure by administering omecamtiv mecarbil |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US12194039B2 (https=) |
| EP (2) | EP4243825B1 (https=) |
| JP (1) | JP2024500616A (https=) |
| KR (1) | KR20230107282A (https=) |
| AU (1) | AU2021380754A1 (https=) |
| CA (1) | CA3200673A1 (https=) |
| CL (2) | CL2023001351A1 (https=) |
| DK (1) | DK4243825T3 (https=) |
| ES (1) | ES3060408T3 (https=) |
| FI (1) | FI4243825T3 (https=) |
| HR (1) | HRP20251568T1 (https=) |
| IL (1) | IL302850A (https=) |
| LT (1) | LT4243825T (https=) |
| MX (1) | MX2023005455A (https=) |
| NZ (1) | NZ800220A (https=) |
| PL (1) | PL4243825T3 (https=) |
| PT (1) | PT4243825T (https=) |
| RS (1) | RS67558B1 (https=) |
| SI (1) | SI4243825T1 (https=) |
| SM (1) | SMT202600073T1 (https=) |
| TW (1) | TW202233189A (https=) |
| WO (1) | WO2022103966A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2522579T3 (es) | 2004-06-17 | 2014-11-17 | Cytokinetics, Inc. | Compuestos, composiciones y métodos |
| SG11201507258PA (en) | 2013-03-14 | 2015-10-29 | Amgen Inc | Heterocyclic compounds and their uses |
| AU2018294254C1 (en) | 2017-06-30 | 2022-10-13 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
| DK3645002T3 (da) | 2017-06-30 | 2024-12-16 | Amgen Inc | Fremgangsmåder til behandling af hjertesvigt med hjerte-sarkomer-aktivatorer |
| PT3594199T (pt) | 2018-07-09 | 2020-09-04 | Amgen Inc | 2-fluoro-3-nitrotolueno cristalino e processo para a sua preparação |
| MA53226A (fr) | 2018-08-17 | 2021-11-24 | Amgen Inc | Sel et formes cristallines d'omecamtiv mecarbil |
| WO2020131574A1 (en) | 2018-12-18 | 2020-06-25 | Amgen Inc. | Method of reducing aromatic nitro compounds |
| DK4243825T3 (da) | 2020-11-12 | 2025-12-01 | Amgen Inc | Omecamtiv mecarbil til behandling af hjerteinsattsvigt hos udvalgte patientgrupper |
| IL305751A (en) | 2021-03-10 | 2023-11-01 | Amgen Inc | SYNTHESIS OF OMECAMTIV MECARBIL |
| US20250161298A1 (en) * | 2022-02-22 | 2025-05-22 | Yale University | Methods of treating, ameliorating, or preventing heart failure, and methods of promoting heart muscle growth |
| WO2024081611A1 (en) * | 2022-10-11 | 2024-04-18 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
| US11986474B1 (en) | 2023-06-27 | 2024-05-21 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
| WO2026050494A1 (en) * | 2024-08-29 | 2026-03-05 | Cytokinetics, Incorporated | Omecamtiv mecarbil for use in treating heart failure by activating cardiac sarcomere |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450150A (en) | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
| EP1053752A1 (en) | 1998-02-10 | 2000-11-22 | Yoshitomi Pharmaceutical Industries, Ltd. | Preparations with controlled release |
| GB2344287A (en) | 1998-12-03 | 2000-06-07 | Ferring Bv | Controlled release pharmaceutical formulation |
| AU2003279842A1 (en) | 2002-10-04 | 2004-05-04 | Microchips, Inc. | Medical device for controlled drug delivery and cardiac monitoring and/or stimulation |
| ES2522579T3 (es) | 2004-06-17 | 2014-11-17 | Cytokinetics, Inc. | Compuestos, composiciones y métodos |
| ES2419007T3 (es) | 2005-12-15 | 2013-08-19 | Cytokinetics, Inc. | Ciertas entidades químicas, composiciones y procedimientos |
| US20080031957A1 (en) | 2006-05-15 | 2008-02-07 | Deluca Hector F | Pulmonary delivery of 1alpha,25-dihydroxyvitamin D3 and co-administration of parathyroid hormone or calcitonin |
| FR2902092B1 (fr) | 2006-06-07 | 2008-09-05 | Sapelem Soc Par Actions Simpli | Appareil de manutention de charge |
| WO2008130158A1 (en) | 2007-04-19 | 2008-10-30 | Dong-A Pharmaceutical. Co., Ltd | A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof |
| US9895308B2 (en) | 2013-03-14 | 2018-02-20 | Amgen Inc. | Heterocyclic compounds and their uses |
| SG11201507258PA (en) | 2013-03-14 | 2015-10-29 | Amgen Inc | Heterocyclic compounds and their uses |
| EP3250557B1 (en) | 2015-01-29 | 2024-11-20 | Signal Pharmaceuticals, LLC | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| US10543215B2 (en) | 2015-06-26 | 2020-01-28 | Amgen Inc. | Combination therapy of cardiac myosin activator and sinus node if current inhibitor |
| CA3052625A1 (en) | 2017-02-06 | 2018-08-09 | Acceleron Pharma Inc. | Compositions and methods for treating heart failure |
| AU2018294254C1 (en) | 2017-06-30 | 2022-10-13 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
| DK3645002T3 (da) | 2017-06-30 | 2024-12-16 | Amgen Inc | Fremgangsmåder til behandling af hjertesvigt med hjerte-sarkomer-aktivatorer |
| PT3594199T (pt) | 2018-07-09 | 2020-09-04 | Amgen Inc | 2-fluoro-3-nitrotolueno cristalino e processo para a sua preparação |
| EP3820851A1 (en) | 2018-07-12 | 2021-05-19 | Assia Chemical Industries Ltd | Solid state forms of omecamtiv mecarbil & omecamtiv mecarbil dihcl |
| FI3599243T3 (fi) | 2018-07-26 | 2023-06-22 | Cvie Therapeutics Ltd | 17beeta-heterosyklyylidigitaliksen kaltaisia yhdisteitä sydämen vajaatoiminnan hoitoon |
| MA53226A (fr) | 2018-08-17 | 2021-11-24 | Amgen Inc | Sel et formes cristallines d'omecamtiv mecarbil |
| WO2020131574A1 (en) | 2018-12-18 | 2020-06-25 | Amgen Inc. | Method of reducing aromatic nitro compounds |
| MX2021010483A (es) | 2019-03-05 | 2021-10-01 | Windtree Therapeutics Inc | Formulacion intravenosa que contiene istaroxima para el tratamiento de insuficiencia cardiaca aguda (ahf). |
| WO2021053175A1 (en) | 2019-09-19 | 2021-03-25 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
| EP4031541A1 (en) | 2019-09-19 | 2022-07-27 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
| EP4041710A1 (en) | 2019-10-09 | 2022-08-17 | Dr. Reddy's Laboratories Limited | Alternate processes for the preparation of omecamtiv mecarbil |
| WO2021070123A1 (en) | 2019-10-09 | 2021-04-15 | Dr. Reddy’S Laboratories Limited | Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof |
| EP4054588A4 (en) | 2019-11-10 | 2023-12-13 | MyoKardia, Inc. | Methods of treatment with myosin modulator |
| GB201918853D0 (en) | 2019-12-19 | 2020-02-05 | Lund Lars H | Methods of treatment |
| CN114929671B (zh) | 2020-01-03 | 2024-04-16 | 苏州科睿思制药有限公司 | 化合物i二盐酸盐的共晶及其制备方法和用途 |
| US20230090391A1 (en) | 2020-02-10 | 2023-03-23 | Amgen Inc. | Omecamtiv mecarbil tablet |
| DK4243825T3 (da) | 2020-11-12 | 2025-12-01 | Amgen Inc | Omecamtiv mecarbil til behandling af hjerteinsattsvigt hos udvalgte patientgrupper |
| IL305751A (en) | 2021-03-10 | 2023-11-01 | Amgen Inc | SYNTHESIS OF OMECAMTIV MECARBIL |
| WO2023205291A2 (en) | 2022-04-21 | 2023-10-26 | The Board Of Regents Of The University Of Oklahoma | Targeting myocardial tissue for delivery of therapeutic and imaging agents |
| WO2024081611A1 (en) | 2022-10-11 | 2024-04-18 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
| US11986474B1 (en) | 2023-06-27 | 2024-05-21 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
-
2021
- 2021-11-11 DK DK21820408.9T patent/DK4243825T3/da active
- 2021-11-11 PL PL21820408.9T patent/PL4243825T3/pl unknown
- 2021-11-11 WO PCT/US2021/058988 patent/WO2022103966A1/en not_active Ceased
- 2021-11-11 SM SM20260073T patent/SMT202600073T1/it unknown
- 2021-11-11 FI FIEP21820408.9T patent/FI4243825T3/fi active
- 2021-11-11 MX MX2023005455A patent/MX2023005455A/es unknown
- 2021-11-11 ES ES21820408T patent/ES3060408T3/es active Active
- 2021-11-11 LT LTEPPCT/US2021/058988T patent/LT4243825T/lt unknown
- 2021-11-11 AU AU2021380754A patent/AU2021380754A1/en active Pending
- 2021-11-11 EP EP21820408.9A patent/EP4243825B1/en active Active
- 2021-11-11 PT PT218204089T patent/PT4243825T/pt unknown
- 2021-11-11 US US17/454,592 patent/US12194039B2/en active Active
- 2021-11-11 EP EP25214250.0A patent/EP4706638A3/en active Pending
- 2021-11-11 JP JP2023528276A patent/JP2024500616A/ja active Pending
- 2021-11-11 HR HRP20251568TT patent/HRP20251568T1/hr unknown
- 2021-11-11 IL IL302850A patent/IL302850A/en unknown
- 2021-11-11 TW TW110142070A patent/TW202233189A/zh unknown
- 2021-11-11 SI SI202130373T patent/SI4243825T1/sl unknown
- 2021-11-11 KR KR1020237019053A patent/KR20230107282A/ko active Pending
- 2021-11-11 CA CA3200673A patent/CA3200673A1/en active Pending
- 2021-11-11 NZ NZ800220A patent/NZ800220A/en unknown
- 2021-11-11 RS RS20251248A patent/RS67558B1/sr unknown
-
2023
- 2023-05-10 CL CL2023001351A patent/CL2023001351A1/es unknown
-
2024
- 2024-02-15 CL CL2024000466A patent/CL2024000466A1/es unknown
- 2024-12-03 US US18/967,331 patent/US20250205228A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| LT4243825T (lt) | 2026-01-12 |
| WO2022103966A1 (en) | 2022-05-19 |
| WO2022103966A9 (en) | 2022-08-18 |
| US12194039B2 (en) | 2025-01-14 |
| SI4243825T1 (sl) | 2026-01-30 |
| EP4706638A3 (en) | 2026-04-22 |
| JP2024500616A (ja) | 2024-01-10 |
| AU2021380754A9 (en) | 2024-10-24 |
| PT4243825T (pt) | 2026-01-30 |
| CL2023001351A1 (es) | 2023-10-20 |
| DK4243825T3 (da) | 2025-12-01 |
| MX2023005455A (es) | 2023-07-27 |
| EP4706638A2 (en) | 2026-03-11 |
| SMT202600073T1 (it) | 2026-03-09 |
| PL4243825T3 (pl) | 2026-03-23 |
| CA3200673A1 (en) | 2022-05-19 |
| HRP20251568T1 (hr) | 2026-03-13 |
| EP4243825B1 (en) | 2025-11-12 |
| RS67558B1 (sr) | 2026-01-30 |
| KR20230107282A (ko) | 2023-07-14 |
| IL302850A (en) | 2023-07-01 |
| NZ800220A (en) | 2026-02-27 |
| FI4243825T3 (fi) | 2025-12-15 |
| US20250205228A1 (en) | 2025-06-26 |
| ES3060408T3 (en) | 2026-03-26 |
| TW202233189A (zh) | 2022-09-01 |
| US20220184068A1 (en) | 2022-06-16 |
| EP4243825A1 (en) | 2023-09-20 |
| CL2024000466A1 (es) | 2024-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SREP | Specification republished |