AU2021244918A1 - Treatment of type 2 diabetes or obesity or overweight with 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl} piperidin-1-yl)methyl]-1-[(2S)-oxetan-2-ylmethyl]-1H-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof - Google Patents
Treatment of type 2 diabetes or obesity or overweight with 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl} piperidin-1-yl)methyl]-1-[(2S)-oxetan-2-ylmethyl]-1H-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof Download PDFInfo
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- AU2021244918A1 AU2021244918A1 AU2021244918A AU2021244918A AU2021244918A1 AU 2021244918 A1 AU2021244918 A1 AU 2021244918A1 AU 2021244918 A AU2021244918 A AU 2021244918A AU 2021244918 A AU2021244918 A AU 2021244918A AU 2021244918 A1 AU2021244918 A1 AU 2021244918A1
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- Australia
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- pharmaceutical composition
- compound
- pyridin
- oxy
- oxetan
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- Abandoned
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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- Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Public Health (AREA)
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| US63/135,870 | 2021-01-11 | ||
| PCT/IB2021/052430 WO2021191812A1 (en) | 2020-03-27 | 2021-03-24 | Treatment of type 2 diabetes or obesity or overweight with 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl} piperidin-1-yl)methyl]-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof |
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| EP3883928A4 (en) | 2018-11-22 | 2022-06-29 | Qilu Regor Therapeutics Inc. | Glp-1r agonists and uses thereof |
| US10954221B2 (en) | 2019-04-12 | 2021-03-23 | Qilu Regor Therapeutics Inc. | GLP-1R agonists and uses thereof |
| PH12022550932A1 (en) | 2019-10-25 | 2023-06-14 | Gilead Sciences Inc | Glp-1r modulating compounds |
| AU2021212669B2 (en) | 2020-01-29 | 2023-10-26 | Gilead Sciences, Inc. | GLP-1R modulating compounds |
| WO2022109182A1 (en) | 2020-11-20 | 2022-05-27 | Gilead Sciences, Inc. | Polyheterocyclic glp-1 r modulating compounds |
| US12180197B2 (en) | 2021-03-11 | 2024-12-31 | Gilead Sciences, Inc. | GLP-1R modulating compounds |
| WO2022192428A1 (en) | 2021-03-11 | 2022-09-15 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
| AU2022263410B2 (en) | 2021-04-21 | 2024-08-01 | Gilead Sciences, Inc. | Carboxy-benzimidazole glp-1r modulating compounds |
| AU2022375634A1 (en) | 2021-10-25 | 2024-06-06 | Terns Pharmaceuticals, Inc. | Compounds as glp-1r agonists |
| JP2025523949A (ja) * | 2022-07-22 | 2025-07-25 | ファイザー・インク | ２－［（４－｛６－［（４－シアノ－２－フルオロベンジル）オキシ］ピリジン－２－イル｝ピペリジン－１－イル）メチル］－１－［（２ｓ）－オキセタン－２－イルメチル］－１ｈ－ベンズイミダゾール－６－カルボン酸、１，３－ジヒドロキシ－２－（ヒドロキシメチル）プロパン－２－アミン塩を調製するための方法および中間体 |
| KR20250166323A (ko) | 2023-04-07 | 2025-11-27 | 테른스 파마슈티칼스, 인크. | 간 장애 또는 심장대사 질환의 치료에 사용하기 위한 thr베타 효현제 및 glp-1r 효현제를 포함하는 조합 |
| CN116675680B (zh) * | 2023-08-02 | 2023-10-20 | 药康众拓(北京)医药科技有限公司 | 一种氘代化合物及其制备方法、药物和应用 |
| US12234236B1 (en) | 2023-09-14 | 2025-02-25 | Ascletis Pharma (China) Co., Limited | GLP-1R agonist and therapeutic method thereof |
| WO2025099561A1 (en) | 2023-11-07 | 2025-05-15 | Pfizer Inc. | Oral controlled-release matrix formulations of 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof |
| TW202521534A (zh) | 2023-11-24 | 2025-06-01 | 香港商歌禮製藥(中國)有限公司 | Glp-1r 激動劑及其治療方法 |
| WO2025224648A1 (en) * | 2024-04-26 | 2025-10-30 | Pfizer Inc. | Oral compositions/formulations of 2-({4-[(2s)-2-(4-chloro-2-fluorophenyl)-2-methyl-1,3-benzodioxol-4-yl]piperidin-1-yl}methyl)-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| JPWO2002040010A1 (ja) * | 2000-10-24 | 2004-06-03 | 味の素株式会社 | ナテグリニド含有親水性医薬製剤 |
| CH702192A1 (de) | 2009-11-04 | 2011-05-13 | New Dent Ag | Keramisches Implantat. |
| ES2602111T3 (es) | 2010-09-30 | 2017-02-17 | Pfizer Inc | Inhibidores de acetil-CoA carboxilasas de N1-pirazoloespirocetona |
| CU24152B1 (es) | 2010-12-20 | 2016-02-29 | Irm Llc | 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr |
| TWI538748B (zh) * | 2011-11-16 | 2016-06-21 | 鴻海精密工業股份有限公司 | 鏡頭除塵裝置 |
| WO2013117963A1 (en) * | 2012-02-09 | 2013-08-15 | Piramal Enterprises Limited | Stable oral tablet dosage form of an antidiabetic compound |
| AU2015204597B2 (en) * | 2014-01-09 | 2020-04-30 | Pfizer Inc. | Compositions and methods for treatment of abnormal cell growth |
| JP5871294B1 (ja) * | 2015-02-27 | 2016-03-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 即時放出経口錠剤 |
| CN108473469B (zh) | 2015-12-29 | 2020-11-03 | 辉瑞公司 | 作为己酮糖激酶抑制剂的被取代的3-氮杂双环[3.1.0]己烷 |
| EP3435987A1 (en) * | 2016-03-31 | 2019-02-06 | Lupin Limited | Pharmaceutical composition of dapagliflozin |
| AR109179A1 (es) | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
| CN106271089B (zh) | 2016-09-30 | 2019-01-25 | 英诺激光科技股份有限公司 | 一种激光薄膜刻蚀装置及方法 |
| CN110325530B (zh) | 2016-12-16 | 2022-01-11 | 辉瑞大药厂 | Glp-1受体激动剂及其用途 |
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| US20230201185A1 (en) | 2023-06-29 |
| JP2021155415A (ja) | 2021-10-07 |
| ES3031577T3 (en) | 2025-07-09 |
| CN115348863A (zh) | 2022-11-15 |
| EP4537816A2 (en) | 2025-04-16 |
| BR112022017578A2 (pt) | 2022-10-18 |
| TWI823072B (zh) | 2023-11-21 |
| IL296694A (en) | 2022-11-01 |
| KR20220157486A (ko) | 2022-11-29 |
| TW202202139A (zh) | 2022-01-16 |
| MX2022010811A (es) | 2022-09-27 |
| CA3176569A1 (en) | 2021-09-30 |
| EP4125896A1 (en) | 2023-02-08 |
| EP4537816A3 (en) | 2025-06-25 |
| EP4125896B1 (en) | 2025-05-07 |
| WO2021191812A1 (en) | 2021-09-30 |
| JP2025118943A (ja) | 2025-08-13 |
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