AU2021208493B2 - FimH mutant, compositions therewith and use thereof - Google Patents

FimH mutant, compositions therewith and use thereof Download PDF

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Publication number
AU2021208493B2
AU2021208493B2 AU2021208493A AU2021208493A AU2021208493B2 AU 2021208493 B2 AU2021208493 B2 AU 2021208493B2 AU 2021208493 A AU2021208493 A AU 2021208493A AU 2021208493 A AU2021208493 A AU 2021208493A AU 2021208493 B2 AU2021208493 B2 AU 2021208493B2
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AU
Australia
Prior art keywords
polypeptide
fimh
lectin domain
polynucleotide
pharmaceutical composition
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2021208493A
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English (en)
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AU2021208493A1 (en
Inventor
Kellen Cristhina Fae
Louris Jakob Feitsma
Jeroen GEURTSEN
Jan GRIJPSTRA
Eveline Marleen WEERDENBURG
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Janssen Pharmaceuticals Inc
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Janssen Pharmaceuticals Inc
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Publication date
Application filed by Janssen Pharmaceuticals Inc filed Critical Janssen Pharmaceuticals Inc
Publication of AU2021208493A1 publication Critical patent/AU2021208493A1/en
Application granted granted Critical
Publication of AU2021208493B2 publication Critical patent/AU2021208493B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
    • C07K16/1232—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0266—Klebsiella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
AU2021208493A 2020-01-16 2021-01-14 FimH mutant, compositions therewith and use thereof Ceased AU2021208493B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20152217 2020-01-16
EP20152217.4 2020-01-16
PCT/EP2021/050707 WO2021144369A1 (en) 2020-01-16 2021-01-14 Fimh mutant, compositions therewith and use thereof

Publications (2)

Publication Number Publication Date
AU2021208493A1 AU2021208493A1 (en) 2022-06-30
AU2021208493B2 true AU2021208493B2 (en) 2023-03-30

Family

ID=69174406

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021208493A Ceased AU2021208493B2 (en) 2020-01-16 2021-01-14 FimH mutant, compositions therewith and use thereof

Country Status (25)

Country Link
US (3) US11421003B2 (enExample)
EP (2) EP4461744A3 (enExample)
JP (2) JP7485771B2 (enExample)
KR (1) KR20220128372A (enExample)
CN (1) CN115038461A (enExample)
AR (1) AR121066A1 (enExample)
AU (1) AU2021208493B2 (enExample)
BR (1) BR112022013720A2 (enExample)
CA (1) CA3168108A1 (enExample)
DK (1) DK4090363T3 (enExample)
ES (1) ES2987890T3 (enExample)
FI (1) FI4090363T3 (enExample)
HR (1) HRP20241370T1 (enExample)
HU (1) HUE068985T2 (enExample)
IL (1) IL294445B2 (enExample)
LT (1) LT4090363T (enExample)
MX (1) MX2022008830A (enExample)
MY (1) MY209568A (enExample)
PL (1) PL4090363T3 (enExample)
PT (1) PT4090363T (enExample)
RS (1) RS66031B1 (enExample)
SA (1) SA522433319B1 (enExample)
SI (1) SI4090363T1 (enExample)
TW (2) TWI868297B (enExample)
WO (1) WO2021144369A1 (enExample)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
US11260119B2 (en) 2018-08-24 2022-03-01 Pfizer Inc. Escherichia coli compositions and methods thereof
MY209568A (en) 2020-01-16 2025-07-22 Janssen Pharmaceuticals Inc Fimh mutant, compositions therewith and use thereof
KR20220143910A (ko) 2020-02-23 2022-10-25 화이자 인코포레이티드 에스케리키아 콜라이 조성물 및 그의 방법
US12138302B2 (en) 2020-10-27 2024-11-12 Pfizer Inc. Escherichia coli compositions and methods thereof
US12357681B2 (en) * 2020-12-23 2025-07-15 Pfizer Inc. E. coli FimH mutants and uses thereof
CN116888140A (zh) 2021-01-12 2023-10-13 杨森制药公司 FimH突变体、其组合物及其用途
EP4448002A1 (en) * 2021-12-17 2024-10-23 Pfizer Inc. Polynucleotide compositions and uses thereof
CA3248209A1 (en) 2022-05-25 2023-11-30 CureVac SE Escherichia coli Antigenic Polypeptide-Based Nucleic Acid Vaccine (FIMH)
JP7656656B2 (ja) * 2022-06-20 2025-04-03 ファイザー・インク 大腸菌ＦｉｍＨ変異体およびその使用

Citations (1)

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WO2002102974A2 (en) * 2000-12-08 2002-12-27 Medimmune, Inc. Mutant proteins, high potency inhibitory antibodies and fimch crystal structure

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Also Published As

Publication number Publication date
IL294445B1 (en) 2023-06-01
TW202537972A (zh) 2025-10-01
ES2987890T3 (es) 2024-11-18
WO2021144369A1 (en) 2021-07-22
EP4461744A3 (en) 2025-01-08
BR112022013720A2 (pt) 2022-10-11
US11421003B2 (en) 2022-08-23
EP4090363B1 (en) 2024-09-04
PT4090363T (pt) 2024-09-19
JP7485771B2 (ja) 2024-05-16
LT4090363T (lt) 2024-09-25
CN115038461A (zh) 2022-09-09
JP2023500749A (ja) 2023-01-10
US20230049056A1 (en) 2023-02-16
EP4090363A1 (en) 2022-11-23
MX2022008830A (es) 2022-10-07
IL294445B2 (en) 2023-10-01
KR20220128372A (ko) 2022-09-20
TWI868297B (zh) 2025-01-01
HUE068985T2 (hu) 2025-02-28
AU2021208493A1 (en) 2022-06-30
MY209568A (en) 2025-07-22
IL294445A (en) 2022-09-01
US12428449B2 (en) 2025-09-30
PL4090363T3 (pl) 2024-11-25
JP2024045126A (ja) 2024-04-02
AR121066A1 (es) 2022-04-13
FI4090363T3 (fi) 2024-09-25
SI4090363T1 (sl) 2024-10-30
US20240294582A1 (en) 2024-09-05
TW202140521A (zh) 2021-11-01
DK4090363T3 (da) 2024-09-30
US12012435B2 (en) 2024-06-18
US20210221856A1 (en) 2021-07-22
EP4461744A2 (en) 2024-11-13
CA3168108A1 (en) 2021-07-22
SA522433319B1 (ar) 2024-07-10
RS66031B1 (sr) 2024-11-29
HRP20241370T1 (hr) 2024-12-20

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired