CN115038461A - FimH突变体、其组合物及其用途 - Google Patents

FimH突变体、其组合物及其用途 Download PDF

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Publication number
CN115038461A
CN115038461A CN202180009530.0A CN202180009530A CN115038461A CN 115038461 A CN115038461 A CN 115038461A CN 202180009530 A CN202180009530 A CN 202180009530A CN 115038461 A CN115038461 A CN 115038461A
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CN
China
Prior art keywords
polypeptide
fimh
polynucleotide
lectin domain
pharmaceutical composition
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Pending
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CN202180009530.0A
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English (en)
Chinese (zh)
Inventor
J·格里杰普斯特拉
E·M·韦登堡
J·戈尔特森
K·C·法埃
L·J·费特斯马
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Janssen Pharmaceuticals Inc
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Janssen Pharmaceuticals Inc
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Publication of CN115038461A publication Critical patent/CN115038461A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
    • C07K16/1232—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0266—Klebsiella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CN202180009530.0A 2020-01-16 2021-01-14 FimH突变体、其组合物及其用途 Pending CN115038461A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20152217 2020-01-16
EP20152217.4 2020-01-16
PCT/EP2021/050707 WO2021144369A1 (en) 2020-01-16 2021-01-14 Fimh mutant, compositions therewith and use thereof

Publications (1)

Publication Number Publication Date
CN115038461A true CN115038461A (zh) 2022-09-09

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CN202180009530.0A Pending CN115038461A (zh) 2020-01-16 2021-01-14 FimH突变体、其组合物及其用途

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EP (2) EP4461744A3 (enExample)
JP (2) JP7485771B2 (enExample)
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CN (1) CN115038461A (enExample)
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PT (1) PT4090363T (enExample)
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SA (1) SA522433319B1 (enExample)
SI (1) SI4090363T1 (enExample)
TW (2) TWI868297B (enExample)
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US11260119B2 (en) 2018-08-24 2022-03-01 Pfizer Inc. Escherichia coli compositions and methods thereof
MY209568A (en) 2020-01-16 2025-07-22 Janssen Pharmaceuticals Inc Fimh mutant, compositions therewith and use thereof
KR20220143910A (ko) 2020-02-23 2022-10-25 화이자 인코포레이티드 에스케리키아 콜라이 조성물 및 그의 방법
US12138302B2 (en) 2020-10-27 2024-11-12 Pfizer Inc. Escherichia coli compositions and methods thereof
US12357681B2 (en) * 2020-12-23 2025-07-15 Pfizer Inc. E. coli FimH mutants and uses thereof
CN116888140A (zh) 2021-01-12 2023-10-13 杨森制药公司 FimH突变体、其组合物及其用途
EP4448002A1 (en) * 2021-12-17 2024-10-23 Pfizer Inc. Polynucleotide compositions and uses thereof
CA3248209A1 (en) 2022-05-25 2023-11-30 CureVac SE Escherichia coli Antigenic Polypeptide-Based Nucleic Acid Vaccine (FIMH)
JP7656656B2 (ja) * 2022-06-20 2025-04-03 ファイザー・インク 大腸菌ＦｉｍＨ変異体およびその使用

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WO2016183501A1 (en) * 2015-05-13 2016-11-17 University Of Washington Compositions and methods for treatment and prevention of uropathogenic e. coli infection

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WO2016183501A1 (en) * 2015-05-13 2016-11-17 University Of Washington Compositions and methods for treatment and prevention of uropathogenic e. coli infection

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IL294445B1 (en) 2023-06-01
TW202537972A (zh) 2025-10-01
ES2987890T3 (es) 2024-11-18
WO2021144369A1 (en) 2021-07-22
EP4461744A3 (en) 2025-01-08
BR112022013720A2 (pt) 2022-10-11
US11421003B2 (en) 2022-08-23
EP4090363B1 (en) 2024-09-04
PT4090363T (pt) 2024-09-19
JP7485771B2 (ja) 2024-05-16
LT4090363T (lt) 2024-09-25
JP2023500749A (ja) 2023-01-10
US20230049056A1 (en) 2023-02-16
EP4090363A1 (en) 2022-11-23
MX2022008830A (es) 2022-10-07
IL294445B2 (en) 2023-10-01
KR20220128372A (ko) 2022-09-20
TWI868297B (zh) 2025-01-01
HUE068985T2 (hu) 2025-02-28
AU2021208493B2 (en) 2023-03-30
AU2021208493A1 (en) 2022-06-30
MY209568A (en) 2025-07-22
IL294445A (en) 2022-09-01
US12428449B2 (en) 2025-09-30
PL4090363T3 (pl) 2024-11-25
JP2024045126A (ja) 2024-04-02
AR121066A1 (es) 2022-04-13
FI4090363T3 (fi) 2024-09-25
SI4090363T1 (sl) 2024-10-30
US20240294582A1 (en) 2024-09-05
TW202140521A (zh) 2021-11-01
DK4090363T3 (da) 2024-09-30
US12012435B2 (en) 2024-06-18
US20210221856A1 (en) 2021-07-22
EP4461744A2 (en) 2024-11-13
CA3168108A1 (en) 2021-07-22
SA522433319B1 (ar) 2024-07-10
RS66031B1 (sr) 2024-11-29
HRP20241370T1 (hr) 2024-12-20

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Application publication date: 20220909