AU2021104712A4 - Composition of Chinese traditional medicine for the prevention of transport stress in sheep - Google Patents
Composition of Chinese traditional medicine for the prevention of transport stress in sheep Download PDFInfo
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- AU2021104712A4 AU2021104712A4 AU2021104712A AU2021104712A AU2021104712A4 AU 2021104712 A4 AU2021104712 A4 AU 2021104712A4 AU 2021104712 A AU2021104712 A AU 2021104712A AU 2021104712 A AU2021104712 A AU 2021104712A AU 2021104712 A4 AU2021104712 A4 AU 2021104712A4
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- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 241001494479 Pecora Species 0.000 title claims abstract description 39
- 230000002265 prevention Effects 0.000 title description 3
- 241000218176 Corydalis Species 0.000 claims abstract description 13
- 239000009636 Huang Qi Substances 0.000 claims abstract description 13
- 241000132012 Atractylodes Species 0.000 claims abstract description 12
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000009754 Vitis X bourquina Nutrition 0.000 claims abstract description 12
- 235000012333 Vitis X labruscana Nutrition 0.000 claims abstract description 12
- 235000014787 Vitis vinifera Nutrition 0.000 claims abstract description 12
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims abstract description 12
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 12
- 210000000582 semen Anatomy 0.000 claims abstract description 12
- 229940079593 drug Drugs 0.000 claims abstract description 9
- 235000018958 Gardenia augusta Nutrition 0.000 claims abstract description 8
- 241001412304 Ixeris Species 0.000 claims abstract description 8
- 240000006365 Vitis vinifera Species 0.000 claims abstract 3
- 239000000843 powder Substances 0.000 claims description 48
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 40
- 239000007788 liquid Substances 0.000 claims description 23
- 238000001556 precipitation Methods 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000000706 filtrate Substances 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- 150000003138 primary alcohols Chemical class 0.000 claims description 5
- 150000003333 secondary alcohols Chemical class 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
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- 238000007873 sieving Methods 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 244000111489 Gardenia augusta Species 0.000 claims 1
- 240000001972 Gardenia jasminoides Species 0.000 abstract description 7
- 239000002994 raw material Substances 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 230000002411 adverse Effects 0.000 abstract description 3
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- 241000721047 Danaus plexippus Species 0.000 abstract description 2
- 230000036039 immunity Effects 0.000 abstract description 2
- 210000000936 intestine Anatomy 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 239000000273 veterinary drug Substances 0.000 abstract description 2
- -1 Herba Taraxaci Chemical compound 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
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- 241000219095 Vitis Species 0.000 description 9
- 206010047700 Vomiting Diseases 0.000 description 7
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- 239000000126 substance Substances 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 241000157835 Gardenia Species 0.000 description 3
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- 208000024891 symptom Diseases 0.000 description 3
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- 206010011224 Cough Diseases 0.000 description 1
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- 239000002671 adjuvant Substances 0.000 description 1
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- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
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Classifications
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- A61K36/481—Astragalus (milkvetch)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention discloses a composition of traditional Chinese medicine for preventing
transportation stress among sheep, which belongs to the technical field of veterinary drugs. The
raw materials of the Chinese medicinal composition include Radix Astragali seu Hedysari,
grape pip, Gardenia jasminoides Ellis, Rhizome of Swordlike Atractylodes, roasted malt,
Rhizoma Corydalis, Radix Paeoniae Rubra, Semen Ziziphi Spinosae, Radix Salviae
Miltiorrhizae, Ixeris denticulata, mentholum, Herba Taraxaci, Gypsum Fibrosum, Herba
Pogostemonis and Folium Isatidis. According to the principle of monarch, minister, assistant
and envoy, the medicines are combined to give full play of their roles in improving tolerance
to long-distance transportation stress, enhancing immunity and regulating qi of stomach and
intestine; The traditional Chinese medicine composition is safe without toxic side effects and
does not adversely affect the growth of sheep.
Description
Composition of Chinese traditional medicine for the prevention of transport stress
in sheep
The invention belongs to the technical field of veterinary drugs, and particularly relates to
a traditional Chinese medicine composition for preventing sheep transportation stress.
During the sheep breeding, breeders have to purchases sheep from other places in pursuit
of good breeding of meat sheep. Sheep procured may experience various transportation
stress symptoms, including colds, coughs, runny nose, watery eyes, skipping food, rotten
mouth, and dysentery after long-distance transportation, environmental and feeding
management changes, etc. There is a high risk of mass casualties if sheep with such
symptoms were not treated in a timely manner, which may further result in large
economic losses to the sheep farmer. Currently, there are drugs available in the market to
treat the symptoms of transport stress in sheep, but even if the symptoms of transport
stress are treated, the growth and development of sheep are already affected to a certain
extent.
At present, the common prevention and treatment measures for transportation stress are to
buffer the transportation stress reaction with sedative and tranquilizing chemicals, but the
use of chemicals can easily cause drug residues and damage to the stomach, kidney, liver
and other viscera of sheep, which is not conducive to the growth of sheep.
In order to solve the problems in the prior art, the invention provides the traditional
Chinese medicine composition for preventing the transportation stress of sheep, which not only can effectively prevent the stress response of the sheep, but also has no toxic side effects and will not cause adverse effects on the growth of sheep.
In order to achieve the purpose, the invention provides the following technical scheme:
The invention provides a traditional Chinese medicine composition for preventing sheep
transportation stress, which comprises 20-30 parts of Radix Astragali seu Hedysari,
-30 parts of grape pip, 5~10 parts of Gardenia jasminoides Ellis, 15~18 parts of
Rhizome of Swordlike Atractylodes, 1518 parts of roasted malt, 5-8 parts of Rhizoma
Corydalis, 15~18 parts of Radix Paeoniae Rubra, 5~10 parts of Semen Ziziphi Spinosae,
~10 parts of Radix Salviae Miltiorrhizae, 2~5 parts of Ixeris denticulata, 15~18 parts of
mentholum, 1-5 parts of Herba Taraxaci, 5-10 parts of Gypsum Fibrosum, 20-30 parts
of Herba Pogostemonis and 5-10 parts of Folium Isatidis.
The invention also provides a preparation method of the traditional Chinese medicine
composition for preventing sheep transportation stress, which comprises the following
steps:
(1) Weigh grape pip, roasted malt, Semen Ziziphi Spinosae and Gypsum Fibrosum, mix
the materials evenly and grind to obtain medicine powder;
(2) Weigh Radix Astragali seu Hedysari, GardeniajasminoidesEllis, Rhizoma Corydalis,
Radix Salviae Miltiorrhizae,Herba Taraxaci and Herba Pogostemonis,mix the material
and grind them into powder, then soak the obtained powder with water; boil the soaked
medicines with strong fire, then boil with slow fire after decoction, and pour out the
liquid medicine; Then concentrating the liquid medicine into a paste and carrying out
alcohol precipitation, recover the ethanol in the filtrate after finish, then perform
concentration and spray drying on the rest liquid mixture to obtain dry powder;
(3) Weigh Rhizome of Swordlike Atractylodes, Radix Paeoniae Rubra, Herba
Pogostemonis, mentholum and Folium Isatidis to mix and grind into powder, soak the
obtained medicine powder in water, then filter to obtain liquid medicine;
(4) Mix the medicine powder obtained in the step (1) with the dry powder obtained in the
step (2), and add with the liquid medicine obtained in the step (3), stir the mixture before
drying to obtain the traditional Chinese medicine composition for preventing sheep
transportation stress.
Preferably, the grinding in the steps (1), (2) and (3) is followed by sieving with a 200
mesh sieve.
Preferably, the amount of water added for soaking in the water in the step (2) and the step
(3) is 4-6 times of the volume of the medicine powder, and the soaking time is 8-10 h.
Preferably, the time of decoction in step (2) is 40-60 min.
Preferably, the specific method for alcohol precipitation in the step (2) is as follows:
firstly, an ethanol solution with the volume fraction of 60-70% is added into the paste for
primary alcohol precipitation, and then the ethanol solution with the volume fraction of
-50% is used for secondary alcohol precipitation.
Preferably, the soaking temperature in step (3) is 50 to 60°C.
Preferably, the drying temperatures in the step (4) are 60-70°C, and the drying time is
18-24 h.
Compared with that prior art, the invention has the following beneficial effects:
The traditional Chinese medicine composition is prepared according to the principle of
monarch, minister, assistant and envoy, and takes Radix Astragali seu Hedysari, grape
pips and Herba Pogostemonis as sovereign medicines, Rhizome of Swordlike
Atractylodes, mentholum, Radix Paeoniae Rubra and roasted malt as ministerial drugs,
Gardeniajasminoides Ellis, Rhizoma Corydalis, Semen Ziziphi Spinosae, Radix Salviae
Miltiorrhizae, Gypsum Fibrosum, and Folium Isatidis as adjuvant drugs, and Ixeris
denticulataand Herba Taraxaci as envoy drugs. The combined application of these drugs
can enhance the tolerance to long-distance transportation stress, and improve the
immunity as well as regulate the qi of the stomach and intestine.
The invention achieves synergistic effects by extracting the active ingredients of each
herbal medicine to a greater extent and combining them rationally, and at the same time,
the traditional Chinese medicine composition obtained from the invention are safe and
non-toxic and will not adversely affect the growth of sheep.
Various exemplary embodiments of the present invention are now described in detail,
which should not be construed as limiting the invention, but rather as a more detailed
description of certain aspects, features, and embodiments of the invention. It is to be
understood that the terminology used herein is for the purpose of describing particular
embodiments only and is not intended to be limiting of the invention.
Embodiment 1
The traditional Chinese medicine composition for preventing sheep transportation stress
was prepared from the following raw materials in parts by weight:
parts of Radix Astragali seu Hedysari, 25 parts of grape pip, 7 parts of Gardenia
jasminoides Ellis, 16 parts of Rhizome of Swordlike Atractylodes, 16 parts of roasted
malt, 6 parts of Rhizoma Corydalis, 17 parts of Radix Paeoniae Rubra, 8 parts of Semen
Ziziphi Spinosae, 8 parts of Radix Salviae Miltiorrhizae, 3 parts of Ixeris denticulata, 17 parts of mentholum, 3 parts of Herba Taraxaci, 8 parts of Gypsum Fibrosum, 25 parts of
HerbaPogostemonis and 7 parts of Folium Isatidis.
The preparation method comprised that following step:
(1) Grape pip, roasted malt, Semen Ziziphi Spinosae and Gypsum Fibrosum were weighed
and mixed, then the mixture was ground and sieved with 200 mesh sieve to obtain
medicine powder;
(2) Radix Astragali seu Hedysari, Gardeniajasminoides Ellis, Rhizoma Corydalis, Radix
Salviae Miltiorrhizae, Herba Taraxaci, and Herba Pogostemonis were weighed and
mixed, then the mixture was ground and sieved with 200 mesh sieve to obtain medicine
powder, the obtained medicine powder was soaked in water 5 times the volume of the
powder for 9 h; Then the soaked medicine was boiled with strong fire at first and with
slow fire for 50 min after decoction, the liquid medicine was then poured out for
concentration into a paste, and then alcohol precipitation was performed on the
concentrated paste, wherein the alcohol precipitation comprised: firstly, an ethanol
solution with the volume fraction of 65% was added into the paste for primary alcohol
precipitation, the the solution was filtered to collect the filtrate, which was then used to
perform secondary alcohol precipitation by using the ethanol solution with the volume
fraction of 45%, the solution was filtered and the filtrate was collected, the filtrates of the
first and second precipitation were merged and distilled to recover ethanol, the remaining
liquid mixture was concentrated under reduced pressure at 90°C to obtain dry substance
of 35 wt%, and the dry powder was obtained after spray drying;
(3) Rhizome of Swordlike Atractylodes, Radix Paeoniae Rubra, Herba Pogostemonis,
mentholum and Folium Isatidis were mixed and ground, and the sieved with 200 mesh sieve to obtain powder, which was added with water 5 times of the volume of the powder with the temperature of 65C, and soaked at constant temperature for 9 h, and filtered to obtain medicinal liquid;
(4) The powder obtained in the step (1) was mixed with the dry powder obtained in the
step (2), and added with the liquid medicine obtained in the step (3), the mixture was
stirred and dried at 65C for 20 h to obtain the traditional Chinese medicine composition
for preventing sheep transportation stress.
Embodiment 2
The traditional Chinese medicine composition for preventing sheep transportation stress
was prepared from the following raw materials in parts by weight:
parts of Radix Astragali seu Hedysari, 20 parts of grape pip, 5 parts of Gardenia
jasminoides Ellis, 15 parts of Rhizome of Swordlike Atractylodes, 15 parts of roasted
malt, 5 parts of Rhizoma Corydalis, 15 parts of Radix Paeoniae Rubra, 5 parts of Semen
Ziziphi Spinosae, 5 parts of Radix Salviae Miltiorrhizae, 5 parts of Ixeris denticulata, 15
parts of mentholum, 1 parts of Herba Taraxaci, 5 parts of Gypsum Fibrosum, 20 parts of
HerbaPogostemonis and 5 parts of Folium Isatidis.
The preparation method comprised that following step:
(1) Grape pip, roasted malt, Semen Ziziphi Spinosae and Gypsum Fibrosum were weighed
and mixed, then the mixture was ground and sieved with 200 mesh sieve to obtain
medicine powder;
(2) Radix Astragali seu Hedysari, Gardeniajasminoides Ellis, Rhizoma Corydalis, Radix
Salviae Miltiorrhizae, Herba Taraxaci, and Herba Pogostemonis were weighed and
mixed, then the mixture was ground and sieved with 200 mesh sieve to obtain medicine powder, the obtained medicine powder was soaked in water 4 times the volume of the powder for 10 h; Then the soaked medicine was boiled with strong fire at first and with slow fire for 40 min after decoction, the liquid medicine was then poured out for concentration into a paste, and then alcohol precipitation was performed on the concentrated paste, wherein the alcohol precipitation comprised: firstly, an ethanol solution with the volume fraction of 70% was added into the paste for primary alcohol precipitation, the the solution was filtered to collect the filtrate, which was then used to perform secondary alcohol precipitation by using the ethanol solution with the volume fraction of 50%, the solution was filtered and the filtrate was collected, the filtrates of the first and second precipitation were merged and distilled to recover ethanol, the remaining liquid mixture was concentrated under reduced pressure at 90°C to obtain dry substance of 40 wt%, and the dry powder was obtained after spray drying;
(3) Rhizome of Swordlike Atractylodes, Radix Paeoniae Rubra, Herba Pogostemonis,
mentholum and Folium Isatidis were mixed and ground, and the sieved with 200 mesh
sieve to obtain powder, which was added with water 4 times of the volume of the powder
with the temperature of 70°C, and soaked at constant temperature for 8 h, and filtered to
obtain medicinal liquid;
(4) The powder obtained in the step (1) was mixed with the dry powder obtained in the
step (2), and added with the liquid medicine obtained in the step (3), the mixture was
stirred and dried at 60°Cfor 24 h to obtain the traditional Chinese medicine composition
for preventing sheep transportation stress.
Embodiment 3
The traditional Chinese medicine composition for preventing sheep transportation stress
is prepared from the following raw materials in parts by weight:
parts of Radix Astragali seu Hedysari, 30 parts of grape pip, 10 parts of Gardenia
jasminoides Ellis, 18 parts of Rhizome of Swordlike Atractylodes, 18 parts of roasted
malt, 8 parts of Rhizoma Corydalis, 18 parts of Radix Paeoniae Rubra, 10 parts of Semen
Ziziphi Spinosae, 10 parts of Radix Salviae Miltiorrhizae,5 parts of Ixeris denticulata, 18
parts of mentholum, 5 parts of Herba Taraxaci, 10 parts of Gypsum Fibrosum, 30 parts of
HerbaPogostemonis and 10 parts of Folium Isatidis.
The preparation method comprised that following steps:
(1) Grape pip, roasted malt, Semen Ziziphi Spinosae and Gypsum Fibrosum were weighed
and mixed, then the mixture was ground and sieved with 200 mesh sieve to obtain
medicine powder;
(2) Radix Astragali seu Hedysari, Gardeniajasminoides Ellis, Rhizoma Corydalis, Radix
Salviae Miltiorrhizae, Herba Taraxaci, and Herba Pogostemonis were weighed and
mixed, then the mixture was ground and sieved with 200 mesh sieve to obtain medicine
powder, the obtained medicine powder was soaked in water 6 times the volume of the
powder for 8 h; Then the soaked medicine was boiled with strong fire at first and with
slow fire for 60 min after decoction, the liquid medicine was then poured out for
concentration into a paste, and then alcohol precipitation was performed on the
concentrated paste, wherein the alcohol precipitation comprised: firstly, an ethanol
solution with the volume fraction of 60% was added into the paste for primary alcohol
precipitation, the the solution was filtered to collect the filtrate, which was then used to
perform secondary alcohol precipitation by using the ethanol solution with the volume fraction of 40%, the solution was filtered and the filtrate was collected, the filtrates of the first and second precipitation were merged and distilled to recover ethanol, the remaining liquid mixture was concentrated under reduced pressure at 90°C to obtain dry substance of 40 wt%, and the dry powder was obtained after spray drying;
(3) Rhizome of Swordlike Atractylodes, Radix Paeoniae Rubra, Herba Pogostemonis,
mentholum and Folium Isatidis were mixed and ground, and the sieved with 200 mesh
sieve to obtain powder, which was added with water 6 times of the volume of the powder
with the temperature of 60°C, and soaked at constant temperature for 10 h, and filtered to
obtain medicinal liquid;
(4) The powder obtained in the step (1) was mixed with the dry powder obtained in the
step (2), and added with the liquid medicine obtained in the step (3), the mixture was
stirred and dried at 70°C for 18 h to obtain the traditional Chinese medicine composition
for preventing sheep transportation stress.
Comparative Embodiment 1
The same as in Embodiment 1 except that that raw material did not contain Ixeris
denticulata.
Comparative Embodiment 2
The method was the same as Embodiment 1 except that the step (2) was to weigh and mix
Radix Astragali seu Hedysari, Gardenia jasminoides Ellis, Rhizoma Corydalis, Radix
Salviae Miltiorrhizae,Herba Taraxaci, and Herba Pogostemonis, the mixture was ground
and sieved with a 200-mesh sieve to obtain powder, which was then soaked in water 5
times the volume of the powder for 9 h; the soaked medicine was boiled with strong fire at first, and then decocted with slow fire for 50 min, the liquid medicine was poured out for concentrate into a paste and spray-dried to obtain dry powder.
Effect verification
One hundred and eighty healthy sheep weighing 60+2kg were randomly divided into 6
groups from Group A-F. The Group A was set as the control group, wherein the
traditional Chinese medicine composition for preventing sheep transportation stress was
not added in the feed one month before long-distance transportation, i.e., the conventional
feed was adopted. Groups B to F were added respectively with 5 wt% of the traditional
Chinese medicine compositions for preventing transportation stress of sheep prepared in
Embodiments 1 to 3 and Comparative Embodiments 1 to 2 (that is, the feed contains 95
wt% of the conventional feed and 5 wt% of the traditional Chinese medicine composition
for preventing transportation stress of sheep) into the feed one month before long
distance transportation. One month later, the sheep of Groups A to F were transported for
a long distance to observe the conditions during transportation and the conditions within
days after the end of transportation, and the results are shown in Table 1.
Table 1
Groups During transportation days after transportation A 8 vomiting, 2 diarrhea, 3 5 vomiting, 3 cold diarrhea, 2 cold B Healthy, normal Healthy, normal C Healthy, normal 1 cold D Healthy, normal 1 Head vomiting E 4 vomiting, 3 cold, 1 4 vomiting, 1 diarrhea dysentery, 1 cold F 5 vomiting, 2 cold 3 vomiting, 1 diarrhea As shown in Table 1, the traditional Chinese medicine composition for preventing
transportation stress of sheep provided by the invention can effectively prevent various stress reactions of sheep caused by long-distance transportation, thereby effectively reducing casualties of sheep caused by long-distance transportation.
The above mentioned are only better specific implementations of the present invention,
and the scope of protection of the present invention is not limited thereto. Any equivalent
substitution or change made by any person skilled in the art according to the technical
solution of the present invention and its inventive concept within the scope of the
technology disclosed herein shall be covered by the protection of the present invention.
Claims (8)
1. A traditional Chinese medicine composition for preventing sheep transportation stress
comprises 20-30 parts of Radix Astragali seu Hedysari, 20-30 parts of grape pip, 5~10
parts of Gardeniajasminoides Ellis, 15~18 parts of Rhizome of Swordlike Atractylodes,
~18 parts of fried malt, 5-8 parts of Rhizoma Corydalis, 15~18 parts of Radix
Paeoniae Rubra, 5~10 parts of Semen Ziziphi Spinosae, 5~10 parts of Radix Salviae
Miltiorrhizae, 2-5 parts of Ixeris denticulata, 15-18 parts of mentholum, 1-5 parts of
Herba Taraxaci, 5-10 parts of Gypsum Fibrosum, 20-30 parts of Herba Pogostemonis
and 5~10 parts of Folium Isatidis.
2. A preparation method of the traditional Chinese medicine composition for preventing
sheep transportation stress according to claim 1 is characterized by comprising the
following steps:
(1) Weigh grape pip, roasted malt, Semen Ziziphi Spinosae and Gypsum Fibrosum, mix
the materials evenly and grind to obtain medicine powder;
(2) Weigh Radix Astragali seu Hedysari, GardeniajasminoidesEllis, Rhizoma Corydalis,
Radix Salviae Miltiorrhizae,Herba Taraxaci and Herba Pogostemonis,mix the material
and grind them into powder, then soak the obtained powder with water; boil the soaked
medicines with strong fire, then boil with slow fire after decoction, and pour out the
liquid medicine; Then concentrating the liquid medicine into a paste and carrying out
alcohol precipitation, recover the ethanol in the filtrate after finish, then perform
concentration and spray drying on the rest liquid mixture to obtain dry powder;
(3) Weigh Rhizome of Swordlike Atractylodes, Radix Paeoniae Rubra, Herba
Pogostemonis, mentholum and Folium Isatidis to mix and grind into powder, soak the
obtained medicine powder in water, then filter to obtain liquid medicine;
(4) Mix the medicine powder obtained in the step (1) with the dry powder obtained in the
step (2), and add with the liquid medicine obtained in the step (3), stir the mixture before
drying to obtain the traditional Chinese medicine composition for preventing sheep
transportation stress.
3. The preparation method according to claim 2, wherein the grinding in the step (1), the
step (2) and the step (3) is followed by sieving with a 200-mesh sieve.
4. The preparation method according to claim 2, wherein the amount of water added for
soaking in the step (2) and the step (3) is 4-6 times of the volume of the medicinal
powder, and the soaking time is 8-10 h.
5. The preparation method according to claim 2, wherein the decocting time in the step
(2) is 4060 min.
6. The preparation method according to claim 2 is characterized in that the specific
method for alcohol precipitation in the step (2) is as follows: firstly, an ethanol solution
with the volume fraction of 60-70% is added into the paste for primary alcohol
precipitation, and then the ethanol solution with the volume fraction of 40-50% is used
for secondary alcohol precipitation.
7. The preparation method according to claim 2, wherein the soaking temperature in the
step (3) is 50-60°C.
8. The preparation method according to claim 2, wherein the drying temperatures in the
step (4) is 6070°C, and the drying time is 1824 h.
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