CN106490365B - Chinese herbal medicine feed additive for preventing and treating pork pig digestive tract diseases - Google Patents
Chinese herbal medicine feed additive for preventing and treating pork pig digestive tract diseases Download PDFInfo
- Publication number
- CN106490365B CN106490365B CN201610963536.2A CN201610963536A CN106490365B CN 106490365 B CN106490365 B CN 106490365B CN 201610963536 A CN201610963536 A CN 201610963536A CN 106490365 B CN106490365 B CN 106490365B
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Abstract
The invention belongs to the technical field of pork pig feed, and particularly relates to a Chinese herbal medicine feed additive for preventing and treating pork pig digestive tract diseases and a preparation method thereof. The preparation method comprises the following steps: sequentially extracting semen Raphani, Coicis semen, radix aucklandiae, fructus Chebulae and pericarpium Citri Tangerinae with 60-90% ethanol and drinking water under reflux, mixing extractive solutions, mixing water extracts of flos populi Davidianae, herba Portulacae, radix Pulsatillae, Poria, cortex Magnolia officinalis, Atractylodis rhizoma, flos Sophorae Immaturus, semen euryales, radix astragali, radix Codonopsis, Scutellariae radix, rhizoma Atractylodis, fructus crataegi and Glycyrrhrizae radix, concentrating the mixed solution, drying to obtain dry powder, mixing with pulverized parched fructus Hordei Germinatus powder and thallus laminariae powder, and packaging. The Chinese herbal medicine feed additive provided by the invention is scientific and reasonable in raw materials, strong in operability in the preparation process, good in palatability, and capable of effectively preventing the occurrence of pork pig digestive tract diseases, improving the production performance, anti-stress performance and immunity of pork pigs, and improving the quality and nutritive value of pork.
Description
Technical Field
The invention belongs to the technical field of pork pig feed, and particularly relates to a Chinese herbal medicine feed additive for preventing and treating pork pig digestive tract diseases and a preparation method thereof.
Background
The Chinese herbal medicine is a natural green plant, has two attributes of nutrition and medicine, has the functions of promoting the growth and development of animals, improving the utilization rate of feed and the like, and is already applied to the feeding of pork pigs, but the traditional Chinese herbal medicine feed additive mainly aims at the aspects of the production performance and the immunity of the pork pigs, but aims at the aspects of preventing the digestive tract diseases of the pork pigs, and has an unobvious effect; digestive tract diseases such as diarrhea are one of the frequently-occurring pig diseases in recent years, the growth and even death of pork pigs are seriously influenced, and great economic loss is caused to breeding enterprises or farmers; meanwhile, the prescription of a plurality of Chinese herbal medicine feed additives is not scientific and rigorous enough, the palatability is poor, the Chinese herbal medicine feed additives are powder prepared by drying, crushing and mixing, the preparation process is laggard, and the addition amount is too large, so that the popularization and the application of the Chinese herbal medicine feed additives for pork pigs are restricted.
Disclosure of Invention
The invention aims to provide the Chinese herbal medicine feed additive for preventing and treating the digestive tract diseases of the pork pigs and the preparation method thereof, the raw materials are scientific and reasonable, the operability of the preparation process is strong, the prepared additive has good palatability, the occurrence of the digestive tract diseases of the pork pigs can be effectively prevented, the production performance, the anti-stress performance and the immunity of the pork pigs are improved, and the quality and the nutritional value of the pork are improved.
A Chinese herbal medicine feed additive for preventing meat pig digestive tract diseases comprises the following raw material components in parts by weight: 4-10 parts of poplar flower, 4-10 parts of purslane, 4-10 parts of Chinese pulsatilla root, 4-10 parts of radish seed, 4-10 parts of coarse coix seed, 4-10 parts of poria cocos, 2-8 parts of mangnolia officinalis, 2-8 parts of bighead atractylodes rhizome, 2-8 parts of elecampane, 2-8 parts of sophora flower, 2-8 parts of myrobalan, 2-8 parts of gordon euryale seed, 2-6 parts of astragalus membranaceus, 2-6 parts of codonopsis pilosula, 2-6 parts of scutellaria baicalensis, 2-6 parts of rhizoma atractylodis, 1-5 parts of roasted malt, 1-5 parts of kelp, 1-3 parts of hawthorn, 1-3 parts of dried orange peel and 1-3 parts of liquorice.
The preparation method of the Chinese herbal medicine feed additive comprises the following steps: sequentially extracting semen Raphani, Coicis semen, radix aucklandiae, fructus Chebulae and pericarpium Citri Tangerinae with 60-90% ethanol and drinking water under reflux, mixing extractive solutions, mixing water extracts of flos populi Davidianae, herba Portulacae, radix Pulsatillae, Poria, cortex Magnolia officinalis, Atractylodis rhizoma, flos Sophorae Immaturus, semen euryales, radix astragali, radix Codonopsis, Scutellariae radix, rhizoma Atractylodis, fructus crataegi and Glycyrrhrizae radix, concentrating the mixed solution, drying to obtain dry powder, mixing with pulverized parched fructus Hordei Germinatus powder and thallus laminariae powder, and packaging.
The method comprises the following specific steps:
(1) and crushing: pulverizing parched fructus Hordei Germinatus and thallus laminariae, and sieving with 80-160 mesh sieve;
(2) and leaching: reflux-extracting Raphani semen, Coicis semen, radix aucklandiae, fructus Chebulae and pericarpium Citri Tangerinae with 60% -90% ethanol with weight concentration of 4-8 times of the weight volume of the medicine for 0.5-1.5 hr, collecting ethanol extractive solution a, reflux-extracting with drinking water with weight volume of 4-8 times of the medicine for 2-3 times at 85-95 deg.C for 0.5-1.5 hr each time, and collecting extractive solution b; decocting poplar flower, purslane, Chinese pulsatilla root, poria cocos, mangnolia officinalis, bighead atractylodes rhizome, sophora flower, gordon euryale seed, astragalus, codonopsis pilosula, scutellaria baicalensis, rhizoma atractylodis, hawthorn and liquorice in 4-8 times of drinking water by weight volume of the medicines for 2-3 times, wherein each time lasts for 0.5-1.5 hours, and the temperature is 85-95 ℃, and collecting an extracting solution c;
(3) and (3) concentrating, namely mixing the extracting solutions a, b and c obtained in the step ⑵, and concentrating to obtain a concentrated solution with the relative density of 1.05-1.10 at the temperature of 40-60 ℃;
(4) and (3) spray drying: adding dextrin accounting for 1-3% of the weight of the concentrated solution, uniformly stirring, and carrying out spray drying;
(5) and (3) preparation: adding 0.02-0.05% of CMC and 0.03-0.05% of phospholipid by weight ratio into the dried powder after spray drying, and uniformly mixing;
(6) and sieving: sieving with 80-160 mesh sieve;
(7) and mixing: and (3) uniformly mixing the dry powder sieved in the step (6) with the fried malt powder and the laminaria powder obtained in the step (1), and packaging.
The application of the Chinese herbal medicine feed additive of the invention is as follows: the additive is added into daily feed (powder) of the pork pig according to the proportion that the weight ratio of the feed amount of the pork pig is 0.1-0.5%, the feed is carried out after the feed is evenly mixed, the feed can also be added into basic ration formula of the pork pig in the form of premix and granulated into granulated feed for feeding, and the Chinese herbal medicine feed additive is continuously added from 40kg of the pork pig in the whole process.
The invention has the following remarkable advantages:
(1) the preparation method adopts the extraction, concentration and spraying methods, can realize the micro-quantization and high-efficiency of the feed additive, is convenient to produce, transport and feed, meets the requirement of large-scale breeding of modern pork pigs, and simultaneously adopts the extraction method of extracting ethanol and then extracting water for the medicinal materials such as radish seeds, coix seeds, elecampane, myrobalam, dried orange peels and the like, so as to ensure that the fat-soluble components and the water-soluble components of the medicinal materials are extracted together, thereby furthest ensuring the efficacy of the Chinese herbal medicine feed additive.
(2) The Chinese herbal medicine feed additive is scientific in formula and reasonable in matching, poplar flower, purslane, Chinese pulsatilla root, myrobalan and gorgon fruit in the Chinese herbal medicine feed additive formula respectively have the effects of clearing heat, removing toxicity, eliminating dampness, stopping dysentery, eliminating dampness, relieving diarrhea and the like in different degrees, and the Chinese herbal medicine feed additive has good effects of preventing and treating digestive tract system diseases such as dysentery and diarrhea and the like by synergistic application, and has good anti-inflammatory, bacteriostatic and antiviral effects; radish seed, magnolia officinalis, elecampane, kelp, roasted malt and hawthorn respectively have the effects of promoting qi circulation, helping digestion, removing distension, relieving stasis and the like in different degrees, and the synergistic application has good treatment effect on various symptoms caused by digestive tract system diseases; the coix lacryma-jobi seed, the bighead atractylodes rhizome, the sophora flower, the scutellaria baicalensis, the rhizoma atractylodis, the roasted malt, the dried orange peel and the like respectively have the efficacies of strengthening spleen, stimulating appetite, eliminating dampness, inducing diuresis and the like in different degrees, and have good effects of preventing and relieving various symptoms caused by digestive tract system diseases by synergistic application; the astragalus, the bighead atractylodes rhizome, the poria cocos, the kelp, the roasted malt, the dried orange peel, the hawthorn and the liquorice respectively have the effects of tonifying middle-jiao and Qi, soothing nerves and calming the heart to different degrees, and have the functions of promoting growth, resisting stress and improving immunity by synergistic application.
(3) The invention has obvious prevention effect on the digestive tract diseases of the pork pigs, and the diarrhea incidence rate is reduced by 41.9-85.0 percent compared with a control group (no medicine is added in the conventional way); the feed conversion ratio is reduced by 12..0% -23.3%, the content of immunoglobulin IgA in pork pig serum is improved by 14.5% -23.4%, the content of immunoglobulin IgM is improved by 9.7% -18.6%, and the content of immunoglobulin IgG is improved by 10.2% -14.3% compared with a control group; meanwhile, the pork quality is also improved, and compared with a control group, the eye muscle area is improved by 10.0-19.6%, the cooked meat rate is improved by 5.8-8.7%, the total amino acid content is improved by 8.5-12.3%, and the content of the intermuscular fatty acid is improved by 15.2-23.5%.
(4) The traditional Chinese medicine composition has an obvious treatment effect on digestive tract diseases of pork pigs, the total effective rate of the treatment is 78.5-91.0%, the traditional Chinese medicine composition is similar to western medicine compositions (amoxicillin, amikacin, gentamicin sulfate and multivitamin), the growth performance of piglets can be improved and the pork quality can be improved while the treatment is carried out, and compared with western medicine compositions, the feed-meat ratio is reduced by 7.0-13.27%, the eye muscle area is improved by 8.5-13.0%, the cooked meat rate is improved by 4.5-6.5%, the total amino acid content is improved by 8.6-11.7%, and the content of intermuscular fatty acid is improved by 10.5-19.1%.
Detailed Description
The present invention will be further described with reference to a few specific examples thereof, but the present invention is not limited thereto.
Example 1
A Chinese herbal medicine feed additive for preventing and treating meat pig digestive tract diseases comprises the following raw material components in parts by weight: 10 parts of poplar flower, 10 parts of purslane, 10 parts of Chinese pulsatilla root, 4 parts of radish seed, 4 parts of coarse coix seed, 4 parts of poria cocos, 8 parts of mangnolia officinalis, 8 parts of bighead atractylodes rhizome, 8 parts of elecampane, 2 parts of sophora flower, 2 parts of myrobalan, 2 parts of gordon euryale seed, 6 parts of astragalus membranaceus, 6 parts of codonopsis pilosula, 2 parts of scutellaria baicalensis, 2 parts of rhizoma atractylodis, 5 parts of roasted malt, 1 part of kelp, 1 part of hawthorn, 2 parts of dried orange peel and 3 parts of liquorice. (Total 100 parts)
The preparation method of the Chinese herbal medicine feed additive comprises the following specific steps:
(1) crushing: pulverizing parched fructus Hordei Germinatus and thallus laminariae, and sieving with 80 mesh sieve;
(2) leaching: reflux-extracting Raphani semen, Coicis semen, radix aucklandiae, fructus Chebulae and pericarpium Citri Tangerinae with 8 times of weight and volume of 60% ethanol for 1.5 hr, collecting ethanol extractive solution a, reflux-extracting with 8 times of weight and volume of drinking water for 2 times at 85 deg.C for 1.5 hr each time, and collecting extractive solution b; decocting poplar flower, purslane, Chinese pulsatilla root, poria cocos, mangnolia officinalis, bighead atractylodes rhizome, sophora flower, gordon euryale seed, astragalus, codonopsis pilosula, scutellaria baicalensis, rhizoma atractylodis, hawthorn and liquorice in drinking water with the weight and volume 4 times of that of the medicines for 2 times, 1.5 hours each time, and collecting an extracting solution c at the temperature of 85 ℃;
(3) concentration: mixing the extracting solutions a, b and c in the step (2), and concentrating to obtain a concentrated solution with the relative density of 1.05 at 40 ℃;
(4) spray drying: adding dextrin accounting for 1 percent of the weight of the concentrated solution into the concentrated solution, uniformly stirring, and carrying out spray drying;
(5) preparation: adding 0.02 wt% of CMC and 0.05 wt% of phospholipid into the spray-dried dry powder, and mixing uniformly;
(6) sieving: sieving with 80 mesh sieve;
(7) mixing: and (3) uniformly mixing the dry powder sieved in the step (6) with the fried malt powder and the laminaria powder obtained in the step (1), and packaging.
The application of the Chinese herbal medicine feed additive comprises the following steps: the Chinese herbal medicine feed additive is added into the daily feed of the pork pig according to the proportion that the feed amount of the pork pig is 0.1 percent by weight, the feed is carried out after the feed is evenly mixed, and the Chinese herbal medicine feed additive is continuously added in the whole process from 40kg of the pork pig.
Example 2
A Chinese herbal medicine feed additive for preventing and treating meat pig digestive tract diseases comprises the following raw material components in parts by weight: 7 parts of poplar flower, 7 parts of purslane, 7 parts of Chinese pulsatilla root, 7 parts of radish seed, 7 parts of coarse coix seed, 7 parts of poria cocos, 5 parts of mangnolia officinalis, 5 parts of bighead atractylodes rhizome, 5 parts of elecampane, 5 parts of sophora flower, 5 parts of myrobalan, 5 parts of gordon euryale seed, 4 parts of astragalus membranaceus, 4 parts of codonopsis pilosula, 4 parts of scutellaria baicalensis, 4 parts of rhizoma atractylodis, 3 parts of fried malt, 3 parts of kelp, 3 parts of hawthorn, 1 part of dried orange peel and 2 parts of liquorice. (Total 100 parts)
The preparation method of the Chinese herbal medicine feed additive comprises the following specific steps:
(1) crushing: pulverizing parched fructus Hordei Germinatus and thallus laminariae, and sieving with 120 mesh sieve;
(2) leaching: reflux-extracting Raphani semen, Coicis semen, radix aucklandiae, fructus Chebulae and pericarpium Citri Tangerinae with 80% ethanol with mass concentration of 6 times of the weight and volume of the medicine for 1.0 hr, collecting ethanol extractive solution a, reflux-extracting with drinking water of 6 times of the weight and volume of the medicine for 2 times at 90 deg.C for 1.0 hr each time, and collecting extractive solution b; decocting poplar flower, purslane, Chinese pulsatilla root, poria cocos, mangnolia officinalis, bighead atractylodes rhizome, sophora flower, gordon euryale seed, astragalus, codonopsis pilosula, scutellaria baicalensis, rhizoma atractylodis, hawthorn and liquorice in drinking water with the weight and volume 6 times of that of the medicines for 2 times, 1.0 hour each time, and collecting an extracting solution c at the temperature of 90 ℃;
(3) concentration: mixing the extracting solutions a, b and c in the step (2), and concentrating to obtain a concentrated solution with the relative density of 1.05 at 50 ℃;
(4) spray drying: adding dextrin accounting for 2 percent of the weight of the concentrated solution into the concentrated solution, uniformly stirring, and carrying out spray drying;
(5) preparation: adding 0.03 weight percent of CMC and 0.04 weight percent of phospholipid into the dried powder after spray drying, and uniformly mixing;
(6) sieving: sieving with 120 mesh sieve;
(7) mixing: and (3) uniformly mixing the dry powder sieved in the step (6) with the fried malt powder and the laminaria powder obtained in the step (1), and packaging.
The application of the Chinese herbal medicine feed additive comprises the following steps: the Chinese herbal medicine feed additive is added into a basal ration formula of the pork pig in a premix form and granulated into a granulated feed for feeding, the adding amount of the Chinese herbal medicine feed additive accounts for 0.3 percent of the weight ratio, and the Chinese herbal medicine feed additive is added continuously in the whole process from 40kg of the pork pig.
Example 3
A Chinese herbal medicine feed additive for preventing and treating meat pig digestive tract diseases comprises the following raw material components in parts by weight: 4 parts of poplar flower, 4 parts of purslane, 4 parts of Chinese pulsatilla root, 10 parts of radish seed, 10 parts of coarse coix seed, 10 parts of poria cocos, 2 parts of mangnolia officinalis, 2 parts of bighead atractylodes rhizome, 2 parts of elecampane, 8 parts of sophora flower, 8 parts of myrobalan, 8 parts of gordon euryale seed, 2 parts of astragalus membranaceus, 2 parts of codonopsis pilosula, 6 parts of scutellaria baicalensis, 6 parts of rhizoma atractylodis, 1 part of roasted malt, 5 parts of kelp, 2 parts of hawthorn, 3 parts of dried orange peel and 1 part of liquorice. (Total 100 parts)
The preparation method of the Chinese herbal medicine feed additive comprises the following specific steps:
(1) crushing: pulverizing parched fructus Hordei Germinatus and thallus laminariae, and sieving with 160 mesh sieve;
(2) leaching: reflux-extracting Raphani semen, Coicis semen, radix aucklandiae, fructus Chebulae and pericarpium Citri Tangerinae with 90% ethanol with mass concentration of 4 times of the weight and volume of the medicine for 0.5 hr, collecting ethanol extractive solution a, reflux-extracting with drinking water of 4 times of the weight and volume of the medicine for 3 times at 95 deg.C for 0.5 hr each time, and collecting extractive solution b; decocting poplar flower, purslane, Chinese pulsatilla root, poria cocos, mangnolia officinalis, bighead atractylodes rhizome, sophora flower, gordon euryale seed, astragalus, codonopsis pilosula, scutellaria baicalensis, rhizoma atractylodis, hawthorn and liquorice in 8 times of drinking water by weight and volume of the medicines for 3 times, 0.5 hour each time at the temperature of 95 ℃, and collecting an extracting solution c;
(3) concentration: mixing the extracting solutions a, b and c in the step (2), and concentrating to obtain a concentrated solution with the relative density of 1.10 at 60 ℃;
(4) spray drying: adding dextrin which accounts for 3 percent of the weight of the concentrated solution into the concentrated solution, uniformly stirring, and carrying out spray drying;
(5) preparation: adding 0.05% of CMC and 0.03% of phospholipid by weight into the dried powder after spray drying, and uniformly mixing;
(6) sieving: sieving with 160 mesh sieve;
(7) mixing: and (3) uniformly mixing the dry powder sieved in the step (6) with the fried malt powder and the laminaria powder obtained in the step (1), and packaging.
The application of the Chinese herbal medicine feed additive comprises the following steps: the Chinese herbal medicine feed additive is added into the daily feed of the pork pig according to the proportion that the feed amount of the pork pig is 0.5 percent by weight, the feed is carried out after the feed is evenly mixed, and the Chinese herbal medicine feed additive is continuously added in the whole process from 40kg of the pork pig.
Effects of the invention
The invention has obvious prevention effect on the digestive tract diseases of the pork pigs, and the diarrhea incidence rate is reduced by 41.9-85.0 percent compared with a control group (without adding medicaments in the conventional way); the feed conversion ratio is reduced by 12..0% -23.3%, the content of immunoglobulin IgA in pork pig serum is improved by 14.5% -23.4%, the content of immunoglobulin IgM is improved by 9.7% -18.6%, and the content of immunoglobulin IgG is improved by 10.2% -14.3% compared with a control group; meanwhile, the pork quality is also improved, and compared with a control group, the eye muscle area is improved by 10.0-19.6%, the cooked meat rate is improved by 5.8-8.7%, the total amino acid content is improved by 8.5-12.3%, and the content of the intermuscular fatty acid is improved by 15.2-23.5%.
The traditional Chinese medicine composition has an obvious treatment effect on digestive tract diseases of pork pigs, the total effective rate of the treatment is 78.5-91.0%, the traditional Chinese medicine composition is similar to western medicine compositions (amoxicillin, amikacin, gentamicin sulfate and multivitamin), the growth performance of piglets can be improved and the pork quality can be improved while the treatment is carried out, and compared with the western medicine compositions, the feed-meat ratio is reduced by 7.0-13.27%, the eye muscle area is improved by 8.5-13.0%, the cooked meat rate is improved by 4.5-6.5%, the total amino acid content is improved by 8.6-11.7%, and the content of intermuscular fatty acid is improved by 10.5-19.1%.
The above description is only a preferred embodiment of the present invention, and all equivalent changes and modifications made in accordance with the claims of the present invention should be covered by the present invention.
Claims (3)
1. A Chinese herbal medicine feed additive for preventing and treating pork pig digestive tract diseases is characterized in that: the additive comprises the following raw material components in parts by weight: 4-10 parts of poplar flower, 4-10 parts of purslane, 4-10 parts of Chinese pulsatilla root, 4-10 parts of radish seed, 4-10 parts of coarse coix seed, 4-10 parts of poria cocos, 2-8 parts of mangnolia officinalis, 2-8 parts of bighead atractylodes rhizome, 2-8 parts of elecampane, 2-8 parts of sophora flower, 2-8 parts of myrobalan, 2-8 parts of gordon euryale seed, 2-6 parts of astragalus membranaceus, 2-6 parts of codonopsis pilosula, 2-6 parts of scutellaria baicalensis, 2-6 parts of rhizoma atractylodis, 1-5 parts of roasted malt, 1-5 parts of kelp, 1-3 parts of hawthorn, 1-3 parts of dried orange peel and 1-3 parts of liquorice.
2. A method for preparing the Chinese herbal medicine feed additive of claim 1, which is characterized in that: the preparation method comprises the following steps: sequentially extracting semen Raphani, Coicis semen, radix aucklandiae, fructus Chebulae and pericarpium Citri Tangerinae with 60-90% ethanol and drinking water under reflux, mixing extractive solutions, mixing water extracts of flos populi Davidianae, herba Portulacae, radix Pulsatillae, Poria, cortex Magnolia officinalis, Atractylodis rhizoma, flos Sophorae Immaturus, semen euryales, radix astragali, radix Codonopsis, Scutellariae radix, rhizoma Atractylodis, fructus crataegi and Glycyrrhrizae radix, concentrating the mixed solution, drying to obtain dry powder, mixing with pulverized parched fructus Hordei Germinatus powder and thallus laminariae powder, and packaging.
3. The method for preparing the Chinese herbal medicine feed additive according to claim 2, which is characterized in that: the method comprises the following specific steps:
(1) crushing: pulverizing parched fructus Hordei Germinatus and thallus laminariae, and sieving with 80-160 mesh sieve;
(2) leaching: reflux-extracting Raphani semen, Coicis semen, radix aucklandiae, fructus Chebulae and pericarpium Citri Tangerinae with 60% -90% ethanol with mass concentration of 4-8 times of the weight and volume of the medicine for 0.5-1.5 hr, collecting ethanol extractive solution a, reflux-extracting with drinking water of 4-8 times of the weight and volume of the medicine for 2-3 times at 85-95 deg.C for 0.5-1.5 hr each time, and collecting extractive solution b; decocting poplar flower, purslane, Chinese pulsatilla root, poria cocos, mangnolia officinalis, bighead atractylodes rhizome, sophora flower, gordon euryale seed, astragalus, codonopsis pilosula, scutellaria baicalensis, rhizoma atractylodis, hawthorn and liquorice in drinking water with the weight and volume 4-8 times of that of the medicines for 2-3 times, 0.5-1.5 hours each time, and collecting an extracting solution c at the temperature of 85-95 ℃;
(3) concentration: mixing the extracting solutions a, b and c in the step (2), and concentrating to obtain a concentrated solution with the relative density of 1.05-1.10 at the temperature of 40-60 ℃;
(4) spray drying: adding dextrin which accounts for 1 to 3 weight percent of the concentrated solution into the concentrated solution, uniformly stirring, and carrying out spray drying;
(5) preparation: adding 0.02-0.05% of CMC and 0.03-0.05% of phospholipid by weight ratio into the dried powder after spray drying, and uniformly mixing;
(6) sieving: sieving with 80-160 mesh sieve;
(7) mixing: and (3) uniformly mixing the dry powder sieved in the step (6) with the fried malt powder and the laminaria powder obtained in the step (1), and packaging.
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CN109527217A (en) * | 2018-12-31 | 2019-03-29 | 昆明内外驱兽药有限公司 | A kind of Chinese herbal feed additive |
CN111449173A (en) * | 2019-12-19 | 2020-07-28 | 何先清 | Plant extract and preparation method and application thereof |
CN113229400A (en) * | 2021-06-11 | 2021-08-10 | 福建省农业科学院农业生态研究所 | Preparation method of Chinese herbal medicine feed additive for piglets |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101313730A (en) * | 2008-06-28 | 2008-12-03 | 康玉玺 | Pig feed containing Chinese medicinal herb and preparation method thereof |
CN101396462A (en) * | 2007-09-30 | 2009-04-01 | 天津瑞普生物技术集团有限公司 | Traditional Chinese medicine oral liquid for treating livestock and poultry digestive canal disease |
CN101396453A (en) * | 2007-09-30 | 2009-04-01 | 天津瑞普生物技术集团有限公司 | Traditional Chinese medicine oral liquid for treating livestock and poultry respiratory passage and digestive canal infection |
CN103445001A (en) * | 2013-09-22 | 2013-12-18 | 金陵科技学院 | Traditional Chinese medicine feed additive capable of improving growth and function development of animal gastrointestinal tract, preparing method thereof and application thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101396443A (en) * | 2007-09-30 | 2009-04-01 | 天津瑞普生物技术集团有限公司 | Traditional Chinese medicine oral liquid for treating livestock and poultry alimentary tract disease |
EP2668849A1 (en) * | 2012-05-29 | 2013-12-04 | Dr. Bata Ltd. | Feed additive of plant origin |
CN102805271A (en) * | 2012-08-28 | 2012-12-05 | 安徽农业大学 | Anti-stress anti-diarrhea growth-promotion Chinese herbal medicine feed additive for weaned pig and preparation |
-
2016
- 2016-10-28 CN CN201610963536.2A patent/CN106490365B/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101396462A (en) * | 2007-09-30 | 2009-04-01 | 天津瑞普生物技术集团有限公司 | Traditional Chinese medicine oral liquid for treating livestock and poultry digestive canal disease |
CN101396453A (en) * | 2007-09-30 | 2009-04-01 | 天津瑞普生物技术集团有限公司 | Traditional Chinese medicine oral liquid for treating livestock and poultry respiratory passage and digestive canal infection |
CN101313730A (en) * | 2008-06-28 | 2008-12-03 | 康玉玺 | Pig feed containing Chinese medicinal herb and preparation method thereof |
CN103445001A (en) * | 2013-09-22 | 2013-12-18 | 金陵科技学院 | Traditional Chinese medicine feed additive capable of improving growth and function development of animal gastrointestinal tract, preparing method thereof and application thereof |
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