AU2020403443B2 - New methylquinazolinone derivatives - Google Patents

New methylquinazolinone derivatives Download PDF

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Publication number
AU2020403443B2
AU2020403443B2 AU2020403443A AU2020403443A AU2020403443B2 AU 2020403443 B2 AU2020403443 B2 AU 2020403443B2 AU 2020403443 A AU2020403443 A AU 2020403443A AU 2020403443 A AU2020403443 A AU 2020403443A AU 2020403443 B2 AU2020403443 B2 AU 2020403443B2
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AU
Australia
Prior art keywords
compound
formula
cancer
treatment
braf
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AU2020403443A
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AU2020403443A1 (en
Inventor
Cosimo Dolente
David Stephen HEWINGS
Daniel Hunziker
Daniela Krummenacher
Piergiorgio Francesco Tommaso PETTAZZONI
Juergen Wichmann
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Combines (AREA)
  • Harvester Elements (AREA)
AU2020403443A 2019-12-10 2020-12-08 New methylquinazolinone derivatives Active AU2020403443B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19214941.7 2019-12-10
EP19214941 2019-12-10
PCT/EP2020/084976 WO2021116055A1 (en) 2019-12-10 2020-12-08 New methylquinazolinone derivatives

Publications (2)

Publication Number Publication Date
AU2020403443A1 AU2020403443A1 (en) 2022-05-12
AU2020403443B2 true AU2020403443B2 (en) 2023-02-23

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AU2020403443A Active AU2020403443B2 (en) 2019-12-10 2020-12-08 New methylquinazolinone derivatives

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US (2) US12116349B2 (enExample)
EP (2) EP4483882A3 (enExample)
JP (2) JP7108146B2 (enExample)
KR (1) KR102836833B1 (enExample)
CN (2) CN114787156B (enExample)
AR (1) AR122351A1 (enExample)
AU (1) AU2020403443B2 (enExample)
CL (1) CL2022001529A1 (enExample)
CO (1) CO2022008968A2 (enExample)
CR (1) CR20220251A (enExample)
DK (1) DK4073065T3 (enExample)
ES (1) ES3023264T3 (enExample)
FI (1) FI4073065T3 (enExample)
HR (1) HRP20250418T1 (enExample)
HU (1) HUE071148T2 (enExample)
IL (2) IL292161B2 (enExample)
LT (1) LT4073065T (enExample)
MA (1) MA58087B1 (enExample)
MX (1) MX2022006783A (enExample)
PE (1) PE20221778A1 (enExample)
PH (1) PH12022551119A1 (enExample)
PL (1) PL4073065T3 (enExample)
PT (1) PT4073065T (enExample)
RS (1) RS66721B1 (enExample)
SI (1) SI4073065T1 (enExample)
TW (2) TWI877268B (enExample)
UA (1) UA128299C2 (enExample)
WO (1) WO2021116055A1 (enExample)
ZA (2) ZA202204675B (enExample)

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FI4073065T3 (fi) 2019-12-10 2025-04-16 Hoffmann La Roche Uusia metyylikinatsolinonijohdannaisia
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AU2021289163B2 (en) 2020-06-09 2024-05-02 Array Biopharma Inc. 4-oxo-3,4-dihydroquinazolinon compounds for the treatment of BRAF-associated diseases and disorders
JP2024523839A (ja) 2021-06-08 2024-07-02 シーフォー セラピューティクス， インコーポレイテッド 突然変異体ｂｒａｆを分解する療法薬
EP4351582B1 (en) * 2021-06-09 2025-10-08 F. Hoffmann-La Roche AG Combination of a particular braf inhibitor (paradox breaker) and a pd-1 axis binding antagonist for use in the treatment of cancer
CN117642166A (zh) * 2021-06-09 2024-03-01 中外制药株式会社 用于癌症治疗的组合疗法
TW202313589A (zh) * 2021-06-09 2023-04-01 瑞士商赫孚孟拉羅股份公司 （３ｒ）－ｎ－〔２－氰基－４－氟－３－（－３－甲基－４－側氧－喹唑啉－６－基）氧－苯基〕－３－氟－吡咯啶－１－磺醯胺之新穎固體形式
MX2024000965A (es) 2021-07-27 2024-02-09 Toray Industries Medicamento para el tratamiento y/o prevencion de cancer.
EP4426305A1 (en) 2021-11-04 2024-09-11 F. Hoffmann-La Roche AG Novel use of quinazolinone compound for the treatment of cancer
TW202409040A (zh) 2022-07-19 2024-03-01 大陸商西藏海思科製藥有限公司 作為激酶抑制劑的喹唑啉酮衍生物的製備及其用途
CN120265291A (zh) 2022-11-18 2025-07-04 豪夫迈·罗氏有限公司 喹唑啉酮化合物的新用途和制剂
WO2024126660A1 (en) * 2022-12-15 2024-06-20 F. Hoffmann-La Roche Ag Combination therapy for cancer treatment
AR131372A1 (es) * 2022-12-15 2025-03-12 Hoffmann La Roche Procedimiento para la preparación de un derivado de quinazolinona
KR20260032991A (ko) 2023-07-04 2026-03-10 에프. 호프만-라 로슈 아게 (3r)-n-[2-시아노-4-플루오로-3-(3-메틸-4-옥소-퀴나졸린-6-일)옥시-페닐]-3-플루오로-피롤리딘-1-설폰아미드의신규 고체 형태
WO2025108405A1 (zh) * 2023-11-22 2025-05-30 西藏海思科制药有限公司 作为激酶抑制剂的喹唑啉酮衍生物的制备及其用途
TW202545530A (zh) * 2024-01-17 2025-12-01 大陸商海思科醫藥集團股份有限公司 含ｂｒａｆ抑制劑的藥物組合物及其在醫藥上的應用
WO2026037755A1 (en) 2024-08-13 2026-02-19 F. Hoffmann-La Roche Ag New methylquinazolinone derivatives
WO2026046946A1 (en) 2024-08-28 2026-03-05 F. Hoffmann-La Roche Ag New solid forms of (3r)-n-[2-cyano-4-fluoro-3-(3-methyl-4-oxo-quinazolin-6-yl)oxy-phenyl]-3-fluoro-pyrrolidine-1-sulfonamide

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PL3359541T3 (pl) 2015-10-09 2021-01-11 AbbVie Overseas S.à r.l. N-SULFONYLOWANE PIRAZOLO[3,4-b]PIRYDYNO-6-KARBOKSAMIDY I SPOSÓB ZASTOSOWANIA
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KR20220112777A (ko) 2019-12-10 2022-08-11 에프. 호프만-라 로슈 아게 패러독스 파괴제로서의 새로운 braf 억제제
FI4073065T3 (fi) 2019-12-10 2025-04-16 Hoffmann La Roche Uusia metyylikinatsolinonijohdannaisia
AU2021289163B2 (en) 2020-06-09 2024-05-02 Array Biopharma Inc. 4-oxo-3,4-dihydroquinazolinon compounds for the treatment of BRAF-associated diseases and disorders
WO2022129259A1 (en) 2020-12-18 2022-06-23 F. Hoffmann-La Roche Ag New quinazolinone derivatives
EP4263541A1 (en) 2020-12-18 2023-10-25 F. Hoffmann-La Roche AG New aryl-pyrido-pyrimidin-one derivatives
JP2024523839A (ja) 2021-06-08 2024-07-02 シーフォー セラピューティクス， インコーポレイテッド 突然変異体ｂｒａｆを分解する療法薬
JP2024545073A (ja) 2021-12-08 2024-12-05 アレイ バイオファーマ インコーポレイテッド Ｎ－（２－クロロ－３－（（５－クロロ－３－メチル－４－オキソ－３，４－ジヒドロキナゾリン－６－イル）アミノ）－４－フルオロフェニル）－３－フルオロアゼチジン－１－スルホンアミドの結晶形態

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Also Published As

Publication number Publication date
EP4073065A1 (en) 2022-10-19
ES3023264T3 (en) 2025-05-30
US20240174621A1 (en) 2024-05-30
JP7802514B2 (ja) 2026-01-20
EP4483882A3 (en) 2025-03-05
PH12022551119A1 (en) 2023-08-23
KR102836833B1 (ko) 2025-07-22
IL292161B1 (en) 2024-12-01
BR112022011123A2 (pt) 2022-08-23
EP4483882A2 (en) 2025-01-01
FI4073065T3 (fi) 2025-04-16
TWI908405B (zh) 2025-12-11
CA3162883A1 (en) 2021-06-17
LT4073065T (lt) 2025-04-25
PL4073065T3 (pl) 2025-05-19
JP2022124458A (ja) 2022-08-25
WO2021116055A1 (en) 2021-06-17
JP2022531609A (ja) 2022-07-07
MX2022006783A (es) 2022-07-11
US12116349B2 (en) 2024-10-15
UA128299C2 (uk) 2024-05-29
US20220298119A1 (en) 2022-09-22
HRP20250418T1 (hr) 2025-06-06
CN114787156B (zh) 2024-07-26
TWI877268B (zh) 2025-03-21
JP7108146B2 (ja) 2022-07-27
AU2020403443A1 (en) 2022-05-12
CR20220251A (es) 2022-07-11
ZA202204675B (en) 2022-12-21
TW202136245A (zh) 2021-10-01
RS66721B1 (sr) 2025-05-30
TW202504895A (zh) 2025-02-01
EP4073065B1 (en) 2025-02-19
IL316473A (en) 2024-12-01
SI4073065T1 (sl) 2025-06-30
HUE071148T2 (hu) 2025-08-28
IL292161A (en) 2022-06-01
CL2022001529A1 (es) 2023-02-10
ZA202206923B (en) 2024-10-30
CO2022008968A2 (es) 2022-07-19
CN118791472A (zh) 2024-10-18
AR122351A1 (es) 2022-09-07
MA58087B1 (fr) 2025-04-30
CN114787156A (zh) 2022-07-22
IL292161B2 (en) 2025-04-01
NZ787393A (en) 2025-07-25
PE20221778A1 (es) 2022-11-16
PT4073065T (pt) 2025-04-15
DK4073065T3 (da) 2025-04-22
KR20220110554A (ko) 2022-08-08

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