AU2020355614B2 - Antigen binding proteins - Google Patents
Antigen binding proteins Download PDFInfo
- Publication number
- AU2020355614B2 AU2020355614B2 AU2020355614A AU2020355614A AU2020355614B2 AU 2020355614 B2 AU2020355614 B2 AU 2020355614B2 AU 2020355614 A AU2020355614 A AU 2020355614A AU 2020355614 A AU2020355614 A AU 2020355614A AU 2020355614 B2 AU2020355614 B2 AU 2020355614B2
- Authority
- AU
- Australia
- Prior art keywords
- seq
- acid sequence
- antibody
- amino acid
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962906876P | 2019-09-27 | 2019-09-27 | |
| US62/906,876 | 2019-09-27 | ||
| US202063057508P | 2020-07-28 | 2020-07-28 | |
| US63/057,508 | 2020-07-28 | ||
| PCT/EP2020/076834 WO2021058711A2 (en) | 2019-09-27 | 2020-09-25 | Antigen binding proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2020355614A1 AU2020355614A1 (en) | 2022-04-14 |
| AU2020355614B2 true AU2020355614B2 (en) | 2024-12-05 |
Family
ID=72840475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020355614A Active AU2020355614B2 (en) | 2019-09-27 | 2020-09-25 | Antigen binding proteins |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11479607B2 (enExample) |
| EP (1) | EP4034562B1 (enExample) |
| JP (3) | JP7280387B2 (enExample) |
| KR (1) | KR20220070011A (enExample) |
| CN (2) | CN119431581A (enExample) |
| AU (1) | AU2020355614B2 (enExample) |
| BR (1) | BR112022005787A2 (enExample) |
| CA (1) | CA3155173A1 (enExample) |
| CO (1) | CO2022003053A2 (enExample) |
| IL (1) | IL291364A (enExample) |
| MX (1) | MX2022003523A (enExample) |
| MY (1) | MY207830A (enExample) |
| PH (1) | PH12022550671A1 (enExample) |
| TW (1) | TWI865617B (enExample) |
| WO (1) | WO2021058711A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3155173A1 (en) * | 2019-09-27 | 2021-04-01 | Glaxosmithkline Intellectual Property Development Limited | Antigen binding proteins |
| WO2023245187A2 (en) | 2022-06-17 | 2023-12-21 | Apogee Biologics, Inc. | Antibodies that bind interleukin 13 and methods of use |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US6312700B1 (en) | 1998-02-24 | 2001-11-06 | Andrew D. Weinberg | Method for enhancing an antigen specific immune response with OX-40L |
| JP4210454B2 (ja) | 2001-03-27 | 2009-01-21 | 日本たばこ産業株式会社 | 炎症性腸疾患治療剤 |
| JP3871503B2 (ja) | 1999-08-30 | 2007-01-24 | 日本たばこ産業株式会社 | 免疫性疾患治療剤 |
| BR0110975A (pt) | 2000-05-19 | 2004-03-23 | Corixa Corp | Tratamento profilático e terapêutico de doenças infecciosas ou outras doenças com compostos à base de mono- e disacarìdeos |
| EP1311522B1 (en) | 2000-08-04 | 2006-03-22 | Corixa Corporation | New immunoeffector compounds |
| JP4212278B2 (ja) | 2001-03-01 | 2009-01-21 | 日本たばこ産業株式会社 | 移植片拒絶反応抑制剤 |
| US20050089932A1 (en) | 2001-04-26 | 2005-04-28 | Avidia Research Institute | Novel proteins with targeted binding |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| US6911434B2 (en) | 2002-02-04 | 2005-06-28 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds |
| US6525028B1 (en) | 2002-02-04 | 2003-02-25 | Corixa Corporation | Immunoeffector compounds |
| IL164376A0 (en) | 2002-04-03 | 2005-12-18 | Applied Research Systems | Ox4or binding agents, their preparation and pharmaceutical compositions containing them |
| US7550140B2 (en) | 2002-06-13 | 2009-06-23 | Crucell Holland B.V. | Antibody to the human OX40 receptor |
| US7595048B2 (en) | 2002-07-03 | 2009-09-29 | Ono Pharmaceutical Co., Ltd. | Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1 |
| WO2004056875A1 (en) | 2002-12-23 | 2004-07-08 | Wyeth | Antibodies against pd-1 and uses therefor |
| US7960522B2 (en) | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| EP1591527B1 (en) | 2003-01-23 | 2015-08-26 | Ono Pharmaceutical Co., Ltd. | Substance specific to human pd-1 |
| CA2543360A1 (en) | 2003-10-24 | 2005-05-06 | Joost A. Kolkman | Ldl receptor class a and egf domain monomers and multimers |
| DK2161336T4 (en) | 2005-05-09 | 2017-04-24 | Ono Pharmaceutical Co | Human monoclonal antibodies for programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapies |
| RS54271B1 (sr) | 2005-07-01 | 2016-02-29 | E. R. Squibb & Sons, L.L.C. | Humana monoklonska antitela za ligand programirane smrti 1 (pd-l1) |
| EP2097535B1 (en) | 2006-12-07 | 2016-09-21 | The Board of Trustees of the Leland Stanford Junior University | Identification and isolation of acute myeloid leukemia stem cells |
| JP5575636B2 (ja) | 2007-05-07 | 2014-08-20 | メディミューン，エルエルシー | 抗ｉｃｏｓ抗体ならびに、腫瘍、移植および自己免疫疾患の治療におけるその使用 |
| NZ582150A (en) | 2007-06-18 | 2012-08-31 | Msd Oss Bv | Antibodies to human programmed death receptor pd-1 |
| ES2425269T3 (es) | 2007-12-14 | 2013-10-14 | Bristol-Myers Squibb Company | Moléculas de unión al receptor OX40 humano |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| CN102057272B (zh) | 2008-04-09 | 2015-02-18 | 健泰科生物技术公司 | 用于免疫相关疾病的治疗的新组合物和方法 |
| CN102203125A (zh) | 2008-08-25 | 2011-09-28 | 安普利穆尼股份有限公司 | Pd-1拮抗剂及其使用方法 |
| MX2011003195A (es) | 2008-09-26 | 2011-08-12 | Dana Farber Cancer Inst Inc | Anticuerpos anti-pd-1, pd-l1 y pd-l2 humanos y usos de los mismos. |
| CN102438652B (zh) | 2008-11-12 | 2014-08-13 | 米迪缪尼有限公司 | 抗体制剂 |
| HRP20170908T1 (hr) | 2008-12-09 | 2017-09-22 | F. Hoffmann - La Roche Ag | Protutijela anti-pd-l1 i njihova uporaba za poboljšanje funkcije t-stanice |
| PT2504364T (pt) | 2009-11-24 | 2017-11-14 | Medimmune Ltd | Agentes de ligação direcionados contra b7-h1 |
| JP2013512251A (ja) | 2009-11-24 | 2013-04-11 | アンプリミューン、インコーポレーテッド | Ｐｄ−ｌ１／ｐｄ−ｌ２の同時阻害 |
| US20110280877A1 (en) | 2010-05-11 | 2011-11-17 | Koji Tamada | Inhibition of B7-H1/CD80 interaction and uses thereof |
| ME02678B (me) | 2010-08-23 | 2017-06-20 | Univ Texas | Antitijela na ox-40 i postupci njihove primjene |
| MX373443B (es) | 2011-03-31 | 2020-05-20 | Inst Nat Sante Rech Med | Anticuerpos dirigidos contra icos y usos de los mismos. |
| AU2012290121B2 (en) | 2011-08-01 | 2015-11-26 | Genentech, Inc. | Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors |
| CA2845810C (en) | 2011-08-23 | 2017-03-28 | Board Of Regents, The University Of Texas System | Anti-ox40 antibodies and methods of using the same |
| RS61033B1 (sr) | 2011-11-28 | 2020-12-31 | Merck Patent Gmbh | Antitela na pd-l1 i njihova upotreba |
| CA2873402C (en) | 2012-05-15 | 2023-10-24 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
| KR101947702B1 (ko) | 2012-10-04 | 2019-02-14 | 다나-파버 캔서 인스티튜트 인크. | 인간 단클론 항-pd-l1 항체 및 사용 방법 |
| AU2013355379B2 (en) | 2012-12-04 | 2018-08-09 | Oncomed Pharmaceuticals, Inc. | Immunotherapy with binding agents |
| MX384142B (es) | 2013-07-16 | 2025-03-14 | Genentech Inc | Antagonista de unión al eje pd-1 e inhibidores de tigit para usarse en el tratamiento de cáncer. |
| CN105636983A (zh) | 2013-08-22 | 2016-06-01 | 昆士兰医学研究所理事会 | 用于治疗癌症和病毒感染的免疫受体调节 |
| WO2015024060A1 (en) | 2013-08-22 | 2015-02-26 | The Council Of The Queensland Institute Of Medical Research | Immunoreceptor modulation for treating cancer and viral infections |
| EP3183267A1 (en) * | 2014-08-19 | 2017-06-28 | Merck Sharp & Dohme Corp. | Anti-tigit antibodies |
| CN107708741A (zh) * | 2015-06-12 | 2018-02-16 | 免疫医疗公司 | 用嵌合抗原受体(car)构建体和表达car构建体的t细胞(car‑t)或nk细胞(car‑nk)进行的疾病疗法 |
| US20200123503A1 (en) | 2017-01-06 | 2020-04-23 | Nantkwest, Inc. | Genetically modified nk-92 cells with decreased cd96/tigit expression |
| KR20200073203A (ko) * | 2017-08-11 | 2020-06-23 | 블링크 바이오메디컬 에스아에스 | 면역조절인자로서의 ｃｄ96-결합제 |
| EP3712170A4 (en) | 2017-11-10 | 2022-03-02 | Jiangsu Hengrui Medicine Co., Ltd. | CD96 ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF AND PHARMACEUTICAL USE THEREOF |
| TWI816729B (zh) * | 2017-12-30 | 2023-10-01 | 英屬開曼群島商百濟神州有限公司 | 抗tigit抗體及其作為治療和診斷的用途 |
| AR117327A1 (es) | 2018-12-20 | 2021-07-28 | 23Andme Inc | Anticuerpos anti-cd96 y métodos de uso de estos |
| CN114585644A (zh) | 2019-08-30 | 2022-06-03 | 艾吉纳斯公司 | 抗cd96抗体及其使用方法 |
| CA3155173A1 (en) * | 2019-09-27 | 2021-04-01 | Glaxosmithkline Intellectual Property Development Limited | Antigen binding proteins |
-
2020
- 2020-09-25 CA CA3155173A patent/CA3155173A1/en active Pending
- 2020-09-25 AU AU2020355614A patent/AU2020355614B2/en active Active
- 2020-09-25 KR KR1020227014021A patent/KR20220070011A/ko active Pending
- 2020-09-25 WO PCT/EP2020/076834 patent/WO2021058711A2/en not_active Ceased
- 2020-09-25 CN CN202411387665.2A patent/CN119431581A/zh active Pending
- 2020-09-25 BR BR112022005787A patent/BR112022005787A2/pt unknown
- 2020-09-25 JP JP2021571490A patent/JP7280387B2/ja active Active
- 2020-09-25 MX MX2022003523A patent/MX2022003523A/es unknown
- 2020-09-25 MY MYPI2022001598A patent/MY207830A/en unknown
- 2020-09-25 PH PH1/2022/550671A patent/PH12022550671A1/en unknown
- 2020-09-25 TW TW109133431A patent/TWI865617B/zh active
- 2020-09-25 CN CN202080080763.5A patent/CN114729049B/zh active Active
- 2020-09-25 EP EP20789858.6A patent/EP4034562B1/en active Active
-
2021
- 2021-11-19 US US17/530,849 patent/US11479607B2/en active Active
-
2022
- 2022-03-14 IL IL291364A patent/IL291364A/en unknown
- 2022-03-16 CO CONC2022/0003053A patent/CO2022003053A2/es unknown
- 2022-09-02 US US17/902,305 patent/US20230279106A1/en active Pending
-
2023
- 2023-05-10 JP JP2023078141A patent/JP7546723B2/ja active Active
-
2024
- 2024-08-20 JP JP2024139180A patent/JP2024167261A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021058711A3 (en) | 2021-06-03 |
| WO2021058711A2 (en) | 2021-04-01 |
| JP7546723B2 (ja) | 2024-09-06 |
| JP7280387B2 (ja) | 2023-05-23 |
| KR20220070011A (ko) | 2022-05-27 |
| CN119431581A (zh) | 2025-02-14 |
| EP4034562C0 (en) | 2025-10-29 |
| EP4034562B1 (en) | 2025-10-29 |
| IL291364A (en) | 2022-05-01 |
| MX2022003523A (es) | 2022-04-25 |
| CN114729049B (zh) | 2024-10-25 |
| BR112022005787A2 (pt) | 2022-06-21 |
| US11479607B2 (en) | 2022-10-25 |
| AU2020355614A1 (en) | 2022-04-14 |
| PH12022550671A1 (en) | 2023-05-29 |
| US20230279106A1 (en) | 2023-09-07 |
| EP4034562A2 (en) | 2022-08-03 |
| CN114729049A (zh) | 2022-07-08 |
| JP2023103352A (ja) | 2023-07-26 |
| JP2022535034A (ja) | 2022-08-04 |
| TWI865617B (zh) | 2024-12-11 |
| US20220089728A1 (en) | 2022-03-24 |
| JP2024167261A (ja) | 2024-12-03 |
| CO2022003053A2 (es) | 2022-04-19 |
| TW202128755A (zh) | 2021-08-01 |
| MY207830A (en) | 2025-03-21 |
| CA3155173A1 (en) | 2021-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |