AU2020352609A1 - Cbl inhibitors and compositions for expansion of immune cells - Google Patents

Cbl inhibitors and compositions for expansion of immune cells Download PDF

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Publication number
AU2020352609A1
AU2020352609A1 AU2020352609A AU2020352609A AU2020352609A1 AU 2020352609 A1 AU2020352609 A1 AU 2020352609A1 AU 2020352609 A AU2020352609 A AU 2020352609A AU 2020352609 A AU2020352609 A AU 2020352609A AU 2020352609 A1 AU2020352609 A1 AU 2020352609A1
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AU
Australia
Prior art keywords
cells
days
expansion
cbl
cell
Prior art date
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Abandoned
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AU2020352609A
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English (en)
Inventor
Jennifa Gosling
Michael LOTZE
Arthur T. Sands
Sarah Anne Whelan
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Nurix Therapeutics Inc
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Nurix Therapeutics Inc
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Publication date
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Publication of AU2020352609A1 publication Critical patent/AU2020352609A1/en
Abandoned legal-status Critical Current

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
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  • Immunology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
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AU2020352609A 2019-09-24 2020-09-23 Cbl inhibitors and compositions for expansion of immune cells Abandoned AU2020352609A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201962905124P 2019-09-24 2019-09-24
US62/905,124 2019-09-24
US201962954323P 2019-12-27 2019-12-27
US62/954,323 2019-12-27
US202062961596P 2020-01-15 2020-01-15
US62/961,596 2020-01-15
US202062978254P 2020-02-18 2020-02-18
US62/978,254 2020-02-18
US202063032462P 2020-05-29 2020-05-29
US63/032,462 2020-05-29
PCT/US2020/052335 WO2021061870A1 (en) 2019-09-24 2020-09-23 Cbl inhibitors and compositions for expansion of immune cells

Publications (1)

Publication Number Publication Date
AU2020352609A1 true AU2020352609A1 (en) 2022-03-31

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AU2020352609A Abandoned AU2020352609A1 (en) 2019-09-24 2020-09-23 Cbl inhibitors and compositions for expansion of immune cells
AU2020353015A Abandoned AU2020353015A1 (en) 2019-09-24 2020-09-23 CBL inhibitors and compositions for use in adoptive cell therapy

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AU2020353015A Abandoned AU2020353015A1 (en) 2019-09-24 2020-09-23 CBL inhibitors and compositions for use in adoptive cell therapy

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US (2) US12121540B2 (https=)
EP (2) EP4034141A1 (https=)
JP (2) JP2022549303A (https=)
KR (2) KR20220068227A (https=)
CN (2) CN114786687A (https=)
AU (2) AU2020352609A1 (https=)
CA (2) CA3152281A1 (https=)
IL (2) IL291579A (https=)
WO (2) WO2021061870A1 (https=)

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WO2019148005A1 (en) * 2018-01-26 2019-08-01 Nurix Therapeutics, Inc. Inhibitors of cbl-b and methods of use thereof
JP7600123B2 (ja) 2018-10-15 2024-12-16 ニューリックス セラピューティクス，インコーポレイテッド ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物
WO2020167518A1 (en) 2019-02-13 2020-08-20 Nurix Therapeutics, Inc. Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
EP3953346A1 (en) 2019-04-09 2022-02-16 Nurix Therapeutics, Inc. 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus
EP3969447A1 (en) 2019-05-17 2022-03-23 Nurix Therapeutics, Inc. Cyano cyclobutyl compounds for cbl-b inhibition and uses thereof
MX2021015675A (es) 2019-06-26 2022-02-03 Nurix Therapeutics Inc Compuestos de bencil-triazol sustituidos para la inhibicion de cbl-b y otros usos de los mismos.
EP4034141A1 (en) 2019-09-24 2022-08-03 Nurix Therapeutics, Inc. Cbl inhibitors and compositions for expansion of immune cells
US11820781B2 (en) 2019-12-04 2023-11-21 Nurix Therapeutics, Inc. Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
US12365871B2 (en) 2020-04-28 2025-07-22 Lyell Immunopharma, Inc. Methods for culturing cells
US12016860B2 (en) 2021-04-08 2024-06-25 Nurix Therapeutics, Inc. Combination therapies with Cbl-b inhibitor compounds
AU2022379494A1 (en) 2021-10-26 2024-05-30 Nurix Therapeutics, Inc. Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk
JP2024542117A (ja) * 2021-11-05 2024-11-13 ジェネンテック， インコーポレイテッド Ｃ－ｃｂｌに対して選択的なｃｂｌ－ｂ阻害剤としてのラクタム
TW202342013A (zh) * 2022-02-10 2023-11-01 英屬開曼群島商百濟神州有限公司 雜環化合物、其組成物及用其進行治療之方法
CN119212724A (zh) * 2022-05-09 2024-12-27 上海先博生物科技有限公司 工程化免疫效应细胞及其与CBL-b抑制剂联用的应用
WO2023250097A1 (en) * 2022-06-22 2023-12-28 Nurix Therapeutics, Inc. Combination therapies with cbl-b inhibitor compounds and antiemetic agents
JP2025525947A (ja) 2022-08-16 2025-08-07 グレンマーク ファーマシューティカルズ エルティーディー Ｃｂｌ－ｂ阻害剤としての置換ピリジノン化合物
WO2024062363A1 (en) * 2022-09-21 2024-03-28 Glenmark Pharmaceuticals Ltd Bicyclic heterocyclic compounds as cbl-b inhibitors

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