AU2020261207A1 - Monoclonal antibody that specifically binds to GITR - Google Patents
Monoclonal antibody that specifically binds to GITR Download PDFInfo
- Publication number
- AU2020261207A1 AU2020261207A1 AU2020261207A AU2020261207A AU2020261207A1 AU 2020261207 A1 AU2020261207 A1 AU 2020261207A1 AU 2020261207 A AU2020261207 A AU 2020261207A AU 2020261207 A AU2020261207 A AU 2020261207A AU 2020261207 A1 AU2020261207 A1 AU 2020261207A1
- Authority
- AU
- Australia
- Prior art keywords
- seq
- amino acid
- antibody
- acid sequence
- monoclonal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2019112296A RU2734432C1 (ru) | 2019-04-23 | 2019-04-23 | Моноклональное антитело, которое специфически связывается с GITR |
| RU2019112296 | 2019-04-23 | ||
| PCT/RU2020/050080 WO2020218951A2 (ru) | 2019-04-23 | 2020-04-23 | Моноклональное антитело, которое специфически связывается с gitr |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2020261207A1 true AU2020261207A1 (en) | 2021-12-23 |
Family
ID=69821666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020261207A Pending AU2020261207A1 (en) | 2019-04-23 | 2020-04-23 | Monoclonal antibody that specifically binds to GITR |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US12410257B2 (https=) |
| EP (1) | EP3964525A4 (https=) |
| JP (1) | JP7695200B2 (https=) |
| KR (1) | KR20220010501A (https=) |
| CN (1) | CN110903392B (https=) |
| AR (1) | AR118763A1 (https=) |
| AU (1) | AU2020261207A1 (https=) |
| BR (1) | BR112021021281A2 (https=) |
| CA (1) | CA3137822A1 (https=) |
| CL (1) | CL2021002792A1 (https=) |
| CO (1) | CO2021014153A2 (https=) |
| EA (1) | EA202192907A1 (https=) |
| IL (1) | IL287531A (https=) |
| JO (1) | JOP20210286A1 (https=) |
| MA (2) | MA54969B2 (https=) |
| MX (1) | MX2021012962A (https=) |
| MY (1) | MY210018A (https=) |
| PE (1) | PE20220144A1 (https=) |
| PY (1) | PY2018606A (https=) |
| RU (1) | RU2734432C1 (https=) |
| TW (1) | TWI803718B (https=) |
| UY (1) | UY38672A (https=) |
| WO (1) | WO2020218951A2 (https=) |
| ZA (1) | ZA202109374B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2724470C1 (ru) * | 2019-11-11 | 2020-06-23 | Автономная некоммерческая образовательная организация высшего образования Сколковский институт науки и технологий | Применение cas9 белка из бактерии pasteurella pneumotropica для модификации геномной днк в клетках |
| CN111732658B (zh) * | 2020-06-28 | 2022-04-26 | 英诺湖医药(杭州)有限公司 | 一组gitr单克隆抗体及其医药用途 |
| CN112540179B (zh) * | 2020-08-06 | 2023-07-07 | 武汉天德生物科技有限公司 | 一种测试ApoE4蛋白含量的ELISA试剂盒 |
| CN112362876B (zh) * | 2020-08-06 | 2023-12-15 | 武汉天德生物科技有限公司 | 一种检测早期老年痴呆症的胶体金试纸条及其制备方法 |
| CN111763257B (zh) * | 2020-09-01 | 2020-12-15 | 北京百奥赛图基因生物技术有限公司 | 抗gitr抗体及其用途 |
| CN114891111A (zh) * | 2020-12-31 | 2022-08-12 | 中元汇吉生物技术股份有限公司 | 特异性结合人IgG4的蛋白及其应用 |
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| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4510245A (en) | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
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| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| AU584417B2 (en) | 1985-04-01 | 1989-05-25 | Lonza Group Ag | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
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| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
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| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
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| EP3383431A4 (en) | 2015-12-02 | 2019-08-28 | Agenus Inc. | ANTI-GITR ANTIBODIES AND METHOD OF USE THEREOF |
| US10738126B2 (en) | 2016-06-10 | 2020-08-11 | Regeneron Pharmaceuticals, Inc. | Anti-GITR antibodies and uses thereof |
| CN109641967A (zh) | 2016-07-01 | 2019-04-16 | 戊瑞治疗有限公司 | 用GITR激动剂和CpG的组合的抗肿瘤疗法 |
| CN109843916B (zh) | 2016-08-12 | 2023-10-31 | 詹森生物科技公司 | 具有增强的激动活性的Fc工程化抗TNFR超家族成员抗体及其使用方法 |
| CA3042727A1 (en) * | 2016-11-19 | 2018-05-24 | Potenza Therapeutics, Inc. | Anti-gitr antigen-binding proteins and methods of use thereof |
| JP7231549B2 (ja) | 2017-02-06 | 2023-03-01 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 抗体媒介性受容体シグナル伝達を増強するための組成物及び方法 |
| RU2019127550A (ru) * | 2017-03-03 | 2021-04-05 | Ринат Ньюросайенс Корп. | Анти-gitr антитела и способы их использования |
| TWI788340B (zh) * | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
-
2019
- 2019-04-23 RU RU2019112296A patent/RU2734432C1/ru active
- 2019-12-03 CN CN201911222245.8A patent/CN110903392B/zh active Active
- 2019-12-03 TW TW108144110A patent/TWI803718B/zh active
-
2020
- 2020-04-22 UY UY0001038672A patent/UY38672A/es unknown
- 2020-04-23 MA MA54969A patent/MA54969B2/fr unknown
- 2020-04-23 JP JP2021563239A patent/JP7695200B2/ja active Active
- 2020-04-23 BR BR112021021281A patent/BR112021021281A2/pt unknown
- 2020-04-23 CA CA3137822A patent/CA3137822A1/en active Pending
- 2020-04-23 US US17/605,933 patent/US12410257B2/en active Active
- 2020-04-23 MX MX2021012962A patent/MX2021012962A/es unknown
- 2020-04-23 MY MYPI2021006363A patent/MY210018A/en unknown
- 2020-04-23 EP EP20794288.9A patent/EP3964525A4/en active Pending
- 2020-04-23 EA EA202192907A patent/EA202192907A1/ru unknown
- 2020-04-23 PE PE2021001765A patent/PE20220144A1/es unknown
- 2020-04-23 WO PCT/RU2020/050080 patent/WO2020218951A2/ru not_active Ceased
- 2020-04-23 AR ARP200101146A patent/AR118763A1/es unknown
- 2020-04-23 KR KR1020217038209A patent/KR20220010501A/ko active Pending
- 2020-04-23 AU AU2020261207A patent/AU2020261207A1/en active Pending
- 2020-05-06 PY PY202002018606A patent/PY2018606A/es unknown
- 2020-06-30 MA MA55390A patent/MA55390B1/fr unknown
-
2021
- 2021-10-22 CL CL2021002792A patent/CL2021002792A1/es unknown
- 2021-10-22 CO CONC2021/0014153A patent/CO2021014153A2/es unknown
- 2021-10-24 JO JOP/2021/0286A patent/JOP20210286A1/ar unknown
- 2021-10-24 IL IL287531A patent/IL287531A/en unknown
- 2021-11-22 ZA ZA2021/09374A patent/ZA202109374B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN110903392B (zh) | 2024-02-13 |
| MA55390A1 (fr) | 2022-05-31 |
| PE20220144A1 (es) | 2022-01-27 |
| JP7695200B2 (ja) | 2025-06-18 |
| CL2021002792A1 (es) | 2022-06-24 |
| TW202100554A (zh) | 2021-01-01 |
| WO2020218951A2 (ru) | 2020-10-29 |
| MY210018A (en) | 2025-08-21 |
| US20220213209A1 (en) | 2022-07-07 |
| RU2734432C1 (ru) | 2020-10-16 |
| TWI803718B (zh) | 2023-06-01 |
| ZA202109374B (en) | 2022-12-21 |
| EP3964525A4 (en) | 2022-12-28 |
| AR118763A1 (es) | 2021-10-27 |
| MA55390B1 (fr) | 2022-10-31 |
| IL287531A (en) | 2021-12-01 |
| JOP20210286A1 (ar) | 2021-10-24 |
| MA54969A1 (fr) | 2022-08-31 |
| MX2021012962A (es) | 2021-12-15 |
| CA3137822A1 (en) | 2020-10-29 |
| JP2022532991A (ja) | 2022-07-21 |
| PY2018606A (es) | 2023-09-15 |
| UY38672A (es) | 2020-10-30 |
| BR112021021281A2 (pt) | 2022-03-08 |
| KR20220010501A (ko) | 2022-01-25 |
| WO2020218951A3 (ru) | 2020-12-24 |
| EP3964525A2 (en) | 2022-03-09 |
| CN110903392A (zh) | 2020-03-24 |
| MA54969B2 (fr) | 2025-10-31 |
| EA202192907A1 (ru) | 2022-01-25 |
| CO2021014153A2 (es) | 2021-10-29 |
| US12410257B2 (en) | 2025-09-09 |
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